Amino acid dipepetide frequency for Corynebacterium aurimucosum (strain ATCC 700975 / DSM 44827 / CIP 107346 / CN-1) (Corynebacterium nigricans)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.991AlaAla: 15.991 ± 0.204	0.954AlaCys: 0.954 ± 0.031	6.695AlaAsp: 6.695 ± 0.095	8.537AlaGlu: 8.537 ± 0.12	3.644AlaPhe: 3.644 ± 0.075	9.716AlaGly: 9.716 ± 0.129	2.385AlaHis: 2.385 ± 0.06	5.305AlaIle: 5.305 ± 0.106	4.018AlaLys: 4.018 ± 0.081	11.947AlaLeu: 11.947 ± 0.133	2.743AlaMet: 2.743 ± 0.065	2.804AlaAsn: 2.804 ± 0.063	5.225AlaPro: 5.225 ± 0.115	4.598AlaGln: 4.598 ± 0.084	6.943AlaArg: 6.943 ± 0.097	6.335AlaSer: 6.335 ± 0.11	6.673AlaThr: 6.673 ± 0.097	9.3AlaVal: 9.3 ± 0.116	1.556AlaTrp: 1.556 ± 0.048	2.301AlaTyr: 2.301 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.909CysAla: 0.909 ± 0.036	0.071CysCys: 0.071 ± 0.009	0.403CysAsp: 0.403 ± 0.022	0.429CysGlu: 0.429 ± 0.023	0.264CysPhe: 0.264 ± 0.018	0.768CysGly: 0.768 ± 0.034	0.182CysHis: 0.182 ± 0.015	0.341CysIle: 0.341 ± 0.021	0.167CysLys: 0.167 ± 0.015	0.589CysLeu: 0.589 ± 0.03	0.164CysMet: 0.164 ± 0.014	0.201CysAsn: 0.201 ± 0.013	0.398CysPro: 0.398 ± 0.024	0.254CysGln: 0.254 ± 0.018	0.399CysArg: 0.399 ± 0.024	0.529CysSer: 0.529 ± 0.024	0.459CysThr: 0.459 ± 0.025	0.53CysVal: 0.53 ± 0.028	0.073CysTrp: 0.073 ± 0.009	0.151CysTyr: 0.151 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.897AspAla: 6.897 ± 0.097	0.371AspCys: 0.371 ± 0.021	3.233AspAsp: 3.233 ± 0.072	4.135AspGlu: 4.135 ± 0.072	2.317AspPhe: 2.317 ± 0.054	4.883AspGly: 4.883 ± 0.081	1.131AspHis: 1.131 ± 0.038	3.35AspIle: 3.35 ± 0.064	2.271AspLys: 2.271 ± 0.065	5.228AspLeu: 5.228 ± 0.086	1.265AspMet: 1.265 ± 0.038	1.746AspAsn: 1.746 ± 0.054	3.314AspPro: 3.314 ± 0.057	1.491AspGln: 1.491 ± 0.044	3.102AspArg: 3.102 ± 0.063	3.518AspSer: 3.518 ± 0.065	3.292AspThr: 3.292 ± 0.06	4.781AspVal: 4.781 ± 0.089	0.777AspTrp: 0.777 ± 0.031	1.607AspTyr: 1.607 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	7.419GluAla: 7.419 ± 0.096	0.361GluCys: 0.361 ± 0.02	4.045GluAsp: 4.045 ± 0.076	5.608GluGlu: 5.608 ± 0.108	2.106GluPhe: 2.106 ± 0.052	4.952GluGly: 4.952 ± 0.088	1.767GluHis: 1.767 ± 0.048	3.237GluIle: 3.237 ± 0.061	2.766GluLys: 2.766 ± 0.07	7.269GluLeu: 7.269 ± 0.092	1.327GluMet: 1.327 ± 0.038	2.048GluAsn: 2.048 ± 0.051	3.102GluPro: 3.102 ± 0.075	2.776GluGln: 2.776 ± 0.057	4.417GluArg: 4.417 ± 0.086	3.559GluSer: 3.559 ± 0.066	3.325GluThr: 3.325 ± 0.072	4.993GluVal: 4.993 ± 0.105	1.002GluTrp: 1.002 ± 0.04	1.465GluTyr: 1.465 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.742PheAla: 3.742 ± 0.072	0.259PheCys: 0.259 ± 0.019	2.41PheAsp: 2.41 ± 0.06	1.956PheGlu: 1.956 ± 0.049	1.327PhePhe: 1.327 ± 0.045	3.47PheGly: 3.47 ± 0.07	0.699PheHis: 0.699 ± 0.028	1.791PheIle: 1.791 ± 0.056	0.978PheLys: 0.978 ± 0.034	3.07PheLeu: 3.07 ± 0.077	0.71PheMet: 0.71 ± 0.03	1.098PheAsn: 1.098 ± 0.034	1.479PhePro: 1.479 ± 0.039	0.89PheGln: 0.89 ± 0.037	1.76PheArg: 1.76 ± 0.046	2.227PheSer: 2.227 ± 0.056	2.14PheThr: 2.14 ± 0.04	2.572PheVal: 2.572 ± 0.068	0.442PheTrp: 0.442 ± 0.024	0.836PheTyr: 0.836 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	8.653GlyAla: 8.653 ± 0.118	0.684GlyCys: 0.684 ± 0.029	4.391GlyAsp: 4.391 ± 0.077	5.475GlyGlu: 5.475 ± 0.102	3.232GlyPhe: 3.232 ± 0.07	6.552GlyGly: 6.552 ± 0.12	1.924GlyHis: 1.924 ± 0.055	4.531GlyIle: 4.531 ± 0.075	3.267GlyLys: 3.267 ± 0.071	7.954GlyLeu: 7.954 ± 0.115	2.114GlyMet: 2.114 ± 0.052	2.287GlyAsn: 2.287 ± 0.06	3.346GlyPro: 3.346 ± 0.074	2.827GlyGln: 2.827 ± 0.067	4.749GlyArg: 4.749 ± 0.078	5.071GlySer: 5.071 ± 0.094	5.255GlyThr: 5.255 ± 0.086	6.776GlyVal: 6.776 ± 0.111	1.334GlyTrp: 1.334 ± 0.043	2.243GlyTyr: 2.243 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	2.236HisAla: 2.236 ± 0.05	0.199HisCys: 0.199 ± 0.018	1.26HisAsp: 1.26 ± 0.038	1.334HisGlu: 1.334 ± 0.047	0.685HisPhe: 0.685 ± 0.027	1.893HisGly: 1.893 ± 0.053	0.573HisHis: 0.573 ± 0.026	1.015HisIle: 1.015 ± 0.038	0.618HisLys: 0.618 ± 0.032	1.996HisLeu: 1.996 ± 0.049	0.471HisMet: 0.471 ± 0.025	0.691HisAsn: 0.691 ± 0.028	1.417HisPro: 1.417 ± 0.042	0.613HisGln: 0.613 ± 0.029	1.446HisArg: 1.446 ± 0.044	1.356HisSer: 1.356 ± 0.043	1.258HisThr: 1.258 ± 0.036	1.636HisVal: 1.636 ± 0.047	0.269HisTrp: 0.269 ± 0.018	0.568HisTyr: 0.568 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.26IleAla: 6.26 ± 0.085	0.394IleCys: 0.394 ± 0.022	3.404IleAsp: 3.404 ± 0.069	3.2IleGlu: 3.2 ± 0.067	1.664IlePhe: 1.664 ± 0.057	4.234IleGly: 4.234 ± 0.087	0.976IleHis: 0.976 ± 0.033	2.731IleIle: 2.731 ± 0.068	1.618IleLys: 1.618 ± 0.049	4.048IleLeu: 4.048 ± 0.086	1.035IleMet: 1.035 ± 0.037	1.662IleAsn: 1.662 ± 0.046	2.625IlePro: 2.625 ± 0.062	1.27IleGln: 1.27 ± 0.038	2.466IleArg: 2.466 ± 0.058	2.838IleSer: 2.838 ± 0.066	3.177IleThr: 3.177 ± 0.072	4.109IleVal: 4.109 ± 0.088	0.499IleTrp: 0.499 ± 0.027	1.028IleTyr: 1.028 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	3.989LysAla: 3.989 ± 0.093	0.135LysCys: 0.135 ± 0.014	2.284LysAsp: 2.284 ± 0.052	2.527LysGlu: 2.527 ± 0.063	0.98LysPhe: 0.98 ± 0.04	2.469LysGly: 2.469 ± 0.066	0.761LysHis: 0.761 ± 0.031	1.534LysIle: 1.534 ± 0.051	1.887LysLys: 1.887 ± 0.058	3.288LysLeu: 3.288 ± 0.063	0.766LysMet: 0.766 ± 0.029	1.186LysAsn: 1.186 ± 0.041	1.954LysPro: 1.954 ± 0.066	1.305LysGln: 1.305 ± 0.045	2.269LysArg: 2.269 ± 0.076	1.805LysSer: 1.805 ± 0.052	1.961LysThr: 1.961 ± 0.051	2.663LysVal: 2.663 ± 0.062	0.392LysTrp: 0.392 ± 0.023	0.747LysTyr: 0.747 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	11.818LeuAla: 11.818 ± 0.135	0.764LeuCys: 0.764 ± 0.035	5.975LeuAsp: 5.975 ± 0.078	5.575LeuGlu: 5.575 ± 0.083	2.904LeuPhe: 2.904 ± 0.062	8.313LeuGly: 8.313 ± 0.118	1.984LeuHis: 1.984 ± 0.058	4.877LeuIle: 4.877 ± 0.086	3.124LeuLys: 3.124 ± 0.066	8.617LeuLeu: 8.617 ± 0.118	1.91LeuMet: 1.91 ± 0.051	2.855LeuAsn: 2.855 ± 0.064	5.142LeuPro: 5.142 ± 0.079	2.527LeuGln: 2.527 ± 0.059	6.116LeuArg: 6.116 ± 0.106	6.273LeuSer: 6.273 ± 0.095	5.9LeuThr: 5.9 ± 0.093	7.518LeuVal: 7.518 ± 0.092	1.151LeuTrp: 1.151 ± 0.04	1.949LeuTyr: 1.949 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	2.619MetAla: 2.619 ± 0.063	0.17MetCys: 0.17 ± 0.015	1.117MetAsp: 1.117 ± 0.038	1.175MetGlu: 1.175 ± 0.042	0.676MetPhe: 0.676 ± 0.029	1.803MetGly: 1.803 ± 0.047	0.422MetHis: 0.422 ± 0.023	0.982MetIle: 0.982 ± 0.038	0.783MetLys: 0.783 ± 0.031	2.12MetLeu: 2.12 ± 0.056	0.482MetMet: 0.482 ± 0.026	0.689MetAsn: 0.689 ± 0.025	1.192MetPro: 1.192 ± 0.04	0.625MetGln: 0.625 ± 0.028	1.438MetArg: 1.438 ± 0.038	1.8MetSer: 1.8 ± 0.045	1.716MetThr: 1.716 ± 0.047	1.692MetVal: 1.692 ± 0.044	0.297MetTrp: 0.297 ± 0.021	0.403MetTyr: 0.403 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.183AsnAla: 3.183 ± 0.064	0.182AsnCys: 0.182 ± 0.015	1.57AsnAsp: 1.57 ± 0.048	1.685AsnGlu: 1.685 ± 0.042	0.943AsnPhe: 0.943 ± 0.034	2.395AsnGly: 2.395 ± 0.064	0.662AsnHis: 0.662 ± 0.03	1.362AsnIle: 1.362 ± 0.035	1.023AsnLys: 1.023 ± 0.037	2.744AsnLeu: 2.744 ± 0.061	0.657AsnMet: 0.657 ± 0.03	0.977AsnAsn: 0.977 ± 0.039	2.182AsnPro: 2.182 ± 0.057	1.011AsnGln: 1.011 ± 0.034	1.652AsnArg: 1.652 ± 0.047	1.821AsnSer: 1.821 ± 0.048	1.758AsnThr: 1.758 ± 0.046	2.069AsnVal: 2.069 ± 0.052	0.365AsnTrp: 0.365 ± 0.019	0.786AsnTyr: 0.786 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	5.791ProAla: 5.791 ± 0.094	0.276ProCys: 0.276 ± 0.02	3.209ProAsp: 3.209 ± 0.068	4.486ProGlu: 4.486 ± 0.089	1.634ProPhe: 1.634 ± 0.044	4.425ProGly: 4.425 ± 0.092	1.066ProHis: 1.066 ± 0.036	2.066ProIle: 2.066 ± 0.051	1.652ProLys: 1.652 ± 0.056	4.371ProLeu: 4.371 ± 0.085	0.971ProMet: 0.971 ± 0.037	1.566ProAsn: 1.566 ± 0.039	1.867ProPro: 1.867 ± 0.06	1.939ProGln: 1.939 ± 0.059	2.753ProArg: 2.753 ± 0.06	2.955ProSer: 2.955 ± 0.071	3.333ProThr: 3.333 ± 0.069	4.137ProVal: 4.137 ± 0.068	0.752ProTrp: 0.752 ± 0.032	1.08ProTyr: 1.08 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	4.144GlnAla: 4.144 ± 0.083	0.191GlnCys: 0.191 ± 0.015	1.68GlnAsp: 1.68 ± 0.048	2.128GlnGlu: 2.128 ± 0.047	0.991GlnPhe: 0.991 ± 0.038	2.446GlnGly: 2.446 ± 0.064	0.779GlnHis: 0.779 ± 0.034	1.473GlnIle: 1.473 ± 0.033	1.097GlnLys: 1.097 ± 0.039	3.795GlnLeu: 3.795 ± 0.074	0.757GlnMet: 0.757 ± 0.03	0.852GlnAsn: 0.852 ± 0.032	1.777GlnPro: 1.777 ± 0.056	1.49GlnGln: 1.49 ± 0.053	2.703GlnArg: 2.703 ± 0.062	1.608GlnSer: 1.608 ± 0.048	1.455GlnThr: 1.455 ± 0.042	2.49GlnVal: 2.49 ± 0.059	0.547GlnTrp: 0.547 ± 0.026	0.643GlnTyr: 0.643 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	6.643ArgAla: 6.643 ± 0.102	0.367ArgCys: 0.367 ± 0.022	3.356ArgAsp: 3.356 ± 0.071	4.529ArgGlu: 4.529 ± 0.074	2.076ArgPhe: 2.076 ± 0.05	4.41ArgGly: 4.41 ± 0.076	1.348ArgHis: 1.348 ± 0.042	3.07ArgIle: 3.07 ± 0.061	2.239ArgLys: 2.239 ± 0.058	5.687ArgLeu: 5.687 ± 0.096	1.542ArgMet: 1.542 ± 0.045	1.719ArgAsn: 1.719 ± 0.052	2.836ArgPro: 2.836 ± 0.058	2.087ArgGln: 2.087 ± 0.05	4.75ArgArg: 4.75 ± 0.104	3.34ArgSer: 3.34 ± 0.063	3.595ArgThr: 3.595 ± 0.064	4.503ArgVal: 4.503 ± 0.081	0.915ArgTrp: 0.915 ± 0.032	1.549ArgTyr: 1.549 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	7.192SerAla: 7.192 ± 0.12	0.401SerCys: 0.401 ± 0.024	3.053SerAsp: 3.053 ± 0.068	3.717SerGlu: 3.717 ± 0.066	2.274SerPhe: 2.274 ± 0.055	5.36SerGly: 5.36 ± 0.088	1.293SerHis: 1.293 ± 0.041	2.744SerIle: 2.744 ± 0.059	1.935SerLys: 1.935 ± 0.055	5.638SerLeu: 5.638 ± 0.086	1.531SerMet: 1.531 ± 0.043	1.546SerAsn: 1.546 ± 0.044	3.044SerPro: 3.044 ± 0.067	2.137SerGln: 2.137 ± 0.055	3.427SerArg: 3.427 ± 0.066	4.124SerSer: 4.124 ± 0.087	3.947SerThr: 3.947 ± 0.08	4.476SerVal: 4.476 ± 0.068	0.875SerTrp: 0.875 ± 0.035	1.393SerTyr: 1.393 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	7.009ThrAla: 7.009 ± 0.093	0.468ThrCys: 0.468 ± 0.025	3.298ThrAsp: 3.298 ± 0.063	3.541ThrGlu: 3.541 ± 0.076	2.029ThrPhe: 2.029 ± 0.055	5.17ThrGly: 5.17 ± 0.078	1.272ThrHis: 1.272 ± 0.043	2.932ThrIle: 2.932 ± 0.063	1.94ThrLys: 1.94 ± 0.049	5.546ThrLeu: 5.546 ± 0.085	1.22ThrMet: 1.22 ± 0.039	1.657ThrAsn: 1.657 ± 0.049	3.748ThrPro: 3.748 ± 0.083	1.903ThrGln: 1.903 ± 0.047	3.343ThrArg: 3.343 ± 0.064	3.615ThrSer: 3.615 ± 0.072	4.012ThrThr: 4.012 ± 0.08	5.337ThrVal: 5.337 ± 0.077	0.875ThrTrp: 0.875 ± 0.034	1.49ThrTyr: 1.49 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	9.285ValAla: 9.285 ± 0.115	0.665ValCys: 0.665 ± 0.027	5.265ValAsp: 5.265 ± 0.085	5.272ValGlu: 5.272 ± 0.1	2.612ValPhe: 2.612 ± 0.063	6.38ValGly: 6.38 ± 0.1	1.574ValHis: 1.574 ± 0.048	4.237ValIle: 4.237 ± 0.083	2.372ValLys: 2.372 ± 0.062	7.673ValLeu: 7.673 ± 0.123	1.668ValMet: 1.668 ± 0.047	2.27ValAsn: 2.27 ± 0.061	3.891ValPro: 3.891 ± 0.073	1.95ValGln: 1.95 ± 0.046	4.463ValArg: 4.463 ± 0.09	4.976ValSer: 4.976 ± 0.071	5.045ValThr: 5.045 ± 0.088	6.861ValVal: 6.861 ± 0.107	1.002ValTrp: 1.002 ± 0.037	1.652ValTyr: 1.652 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	1.484TrpAla: 1.484 ± 0.051	0.159TrpCys: 0.159 ± 0.012	0.702TrpAsp: 0.702 ± 0.031	0.832TrpGlu: 0.832 ± 0.029	0.567TrpPhe: 0.567 ± 0.029	1.007TrpGly: 1.007 ± 0.034	0.288TrpHis: 0.288 ± 0.017	0.699TrpIle: 0.699 ± 0.03	0.461TrpLys: 0.461 ± 0.024	1.476TrpLeu: 1.476 ± 0.047	0.398TrpMet: 0.398 ± 0.022	0.467TrpAsn: 0.467 ± 0.024	0.645TrpPro: 0.645 ± 0.024	0.553TrpGln: 0.553 ± 0.027	0.894TrpArg: 0.894 ± 0.032	0.811TrpSer: 0.811 ± 0.032	0.715TrpThr: 0.715 ± 0.031	1.052TrpVal: 1.052 ± 0.043	0.313TrpTrp: 0.313 ± 0.02	0.263TrpTyr: 0.263 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.407TyrAla: 2.407 ± 0.057	0.206TyrCys: 0.206 ± 0.017	1.359TyrAsp: 1.359 ± 0.048	1.405TyrGlu: 1.405 ± 0.043	0.932TyrPhe: 0.932 ± 0.029	2.021TyrGly: 2.021 ± 0.048	0.446TyrHis: 0.446 ± 0.024	0.962TyrIle: 0.962 ± 0.037	0.685TyrLys: 0.685 ± 0.032	2.232TyrLeu: 2.232 ± 0.051	0.468TyrMet: 0.468 ± 0.025	0.709TyrAsn: 0.709 ± 0.037	1.145TyrPro: 1.145 ± 0.04	0.799TyrGln: 0.799 ± 0.035	1.472TyrArg: 1.472 ± 0.048	1.544TyrSer: 1.544 ± 0.047	1.389TyrThr: 1.389 ± 0.043	1.619TyrVal: 1.619 ± 0.048	0.353TyrTrp: 0.353 ± 0.02	0.579TyrTyr: 0.579 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2528 proteins (822074 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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