Amino acid dipepetide frequency for Pedococcus dokdonensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.835AlaAla: 20.835 ± 0.229	0.908AlaCys: 0.908 ± 0.029	8.299AlaAsp: 8.299 ± 0.104	7.236AlaGlu: 7.236 ± 0.108	3.441AlaPhe: 3.441 ± 0.057	12.549AlaGly: 12.549 ± 0.119	2.616AlaHis: 2.616 ± 0.053	4.341AlaIle: 4.341 ± 0.07	3.176AlaLys: 3.176 ± 0.071	13.978AlaLeu: 13.978 ± 0.148	2.844AlaMet: 2.844 ± 0.053	2.112AlaAsn: 2.112 ± 0.047	6.623AlaPro: 6.623 ± 0.095	3.972AlaGln: 3.972 ± 0.061	9.505AlaArg: 9.505 ± 0.122	6.772AlaSer: 6.772 ± 0.08	8.484AlaThr: 8.484 ± 0.109	12.104AlaVal: 12.104 ± 0.13	1.961AlaTrp: 1.961 ± 0.044	2.596AlaTyr: 2.596 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.815CysAla: 0.815 ± 0.027	0.089CysCys: 0.089 ± 0.009	0.421CysAsp: 0.421 ± 0.021	0.313CysGlu: 0.313 ± 0.017	0.221CysPhe: 0.221 ± 0.015	0.796CysGly: 0.796 ± 0.025	0.175CysHis: 0.175 ± 0.013	0.176CysIle: 0.176 ± 0.012	0.103CysLys: 0.103 ± 0.009	0.624CysLeu: 0.624 ± 0.024	0.091CysMet: 0.091 ± 0.009	0.127CysAsn: 0.127 ± 0.01	0.429CysPro: 0.429 ± 0.019	0.175CysGln: 0.175 ± 0.012	0.482CysArg: 0.482 ± 0.021	0.388CysSer: 0.388 ± 0.019	0.46CysThr: 0.46 ± 0.02	0.562CysVal: 0.562 ± 0.021	0.106CysTrp: 0.106 ± 0.01	0.119CysTyr: 0.119 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.816AspAla: 7.816 ± 0.099	0.359AspCys: 0.359 ± 0.02	4.557AspAsp: 4.557 ± 0.079	4.121AspGlu: 4.121 ± 0.071	1.65AspPhe: 1.65 ± 0.04	6.431AspGly: 6.431 ± 0.081	1.623AspHis: 1.623 ± 0.04	1.841AspIle: 1.841 ± 0.044	1.211AspLys: 1.211 ± 0.033	7.05AspLeu: 7.05 ± 0.08	0.771AspMet: 0.771 ± 0.023	1.008AspAsn: 1.008 ± 0.037	4.491AspPro: 4.491 ± 0.07	1.959AspGln: 1.959 ± 0.044	4.736AspArg: 4.736 ± 0.076	2.807AspSer: 2.807 ± 0.06	3.045AspThr: 3.045 ± 0.056	5.691AspVal: 5.691 ± 0.069	0.97AspTrp: 0.97 ± 0.03	1.256AspTyr: 1.256 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	6.869GluAla: 6.869 ± 0.111	0.308GluCys: 0.308 ± 0.017	2.7GluAsp: 2.7 ± 0.058	2.678GluGlu: 2.678 ± 0.065	1.484GluPhe: 1.484 ± 0.037	4.25GluGly: 4.25 ± 0.063	1.501GluHis: 1.501 ± 0.037	1.911GluIle: 1.911 ± 0.047	1.142GluLys: 1.142 ± 0.037	6.086GluLeu: 6.086 ± 0.084	0.886GluMet: 0.886 ± 0.029	0.774GluAsn: 0.774 ± 0.028	2.979GluPro: 2.979 ± 0.06	2.302GluGln: 2.302 ± 0.051	4.865GluArg: 4.865 ± 0.079	2.755GluSer: 2.755 ± 0.057	2.597GluThr: 2.597 ± 0.046	5.346GluVal: 5.346 ± 0.074	0.754GluTrp: 0.754 ± 0.026	0.799GluTyr: 0.799 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	3.671PheAla: 3.671 ± 0.058	0.205PheCys: 0.205 ± 0.012	2.11PheAsp: 2.11 ± 0.046	1.517PheGlu: 1.517 ± 0.04	0.862PhePhe: 0.862 ± 0.035	3.077PheGly: 3.077 ± 0.062	0.545PheHis: 0.545 ± 0.021	0.866PheIle: 0.866 ± 0.025	0.537PheLys: 0.537 ± 0.021	2.418PheLeu: 2.418 ± 0.051	0.404PheMet: 0.404 ± 0.019	0.575PheAsn: 0.575 ± 0.023	1.237PhePro: 1.237 ± 0.033	0.631PheGln: 0.631 ± 0.023	1.645PheArg: 1.645 ± 0.04	1.538PheSer: 1.538 ± 0.042	1.924PheThr: 1.924 ± 0.045	2.639PheVal: 2.639 ± 0.049	0.419PheTrp: 0.419 ± 0.02	0.566PheTyr: 0.566 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	11.014GlyAla: 11.014 ± 0.105	0.708GlyCys: 0.708 ± 0.024	5.561GlyAsp: 5.561 ± 0.082	4.624GlyGlu: 4.624 ± 0.073	2.984GlyPhe: 2.984 ± 0.045	8.578GlyGly: 8.578 ± 0.11	2.188GlyHis: 2.188 ± 0.042	3.622GlyIle: 3.622 ± 0.059	2.383GlyLys: 2.383 ± 0.051	9.564GlyLeu: 9.564 ± 0.111	1.922GlyMet: 1.922 ± 0.043	1.721GlyAsn: 1.721 ± 0.052	4.762GlyPro: 4.762 ± 0.065	2.923GlyGln: 2.923 ± 0.05	7.035GlyArg: 7.035 ± 0.094	5.9GlySer: 5.9 ± 0.084	6.064GlyThr: 6.064 ± 0.094	7.998GlyVal: 7.998 ± 0.089	1.872GlyTrp: 1.872 ± 0.047	2.235GlyTyr: 2.235 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.494HisAla: 2.494 ± 0.045	0.18HisCys: 0.18 ± 0.013	1.589HisAsp: 1.589 ± 0.041	1.279HisGlu: 1.279 ± 0.033	0.554HisPhe: 0.554 ± 0.021	2.214HisGly: 2.214 ± 0.054	0.76HisHis: 0.76 ± 0.03	0.56HisIle: 0.56 ± 0.024	0.3HisLys: 0.3 ± 0.014	2.414HisLeu: 2.414 ± 0.043	0.309HisMet: 0.309 ± 0.016	0.335HisAsn: 0.335 ± 0.018	1.664HisPro: 1.664 ± 0.041	0.633HisGln: 0.633 ± 0.024	1.815HisArg: 1.815 ± 0.045	0.957HisSer: 0.957 ± 0.028	1.259HisThr: 1.259 ± 0.034	2.001HisVal: 2.001 ± 0.045	0.37HisTrp: 0.37 ± 0.019	0.434HisTyr: 0.434 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	4.735IleAla: 4.735 ± 0.071	0.27IleCys: 0.27 ± 0.014	2.42IleAsp: 2.42 ± 0.054	2.064IleGlu: 2.064 ± 0.05	0.829IlePhe: 0.829 ± 0.028	3.575IleGly: 3.575 ± 0.063	0.632IleHis: 0.632 ± 0.022	1.044IleIle: 1.044 ± 0.036	0.741IleLys: 0.741 ± 0.032	2.55IleLeu: 2.55 ± 0.05	0.453IleMet: 0.453 ± 0.019	0.708IleAsn: 0.708 ± 0.026	1.84IlePro: 1.84 ± 0.042	0.764IleGln: 0.764 ± 0.022	2.161IleArg: 2.161 ± 0.044	1.759IleSer: 1.759 ± 0.042	2.133IleThr: 2.133 ± 0.05	3.191IleVal: 3.191 ± 0.058	0.401IleTrp: 0.401 ± 0.02	0.588IleTyr: 0.588 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	3.114LysAla: 3.114 ± 0.063	0.1LysCys: 0.1 ± 0.01	1.378LysAsp: 1.378 ± 0.039	1.005LysGlu: 1.005 ± 0.034	0.519LysPhe: 0.519 ± 0.024	1.976LysGly: 1.976 ± 0.044	0.402LysHis: 0.402 ± 0.017	0.772LysIle: 0.772 ± 0.029	0.78LysLys: 0.78 ± 0.044	1.681LysLeu: 1.681 ± 0.044	0.376LysMet: 0.376 ± 0.017	0.509LysAsn: 0.509 ± 0.021	1.304LysPro: 1.304 ± 0.042	0.654LysGln: 0.654 ± 0.023	1.342LysArg: 1.342 ± 0.04	1.211LysSer: 1.211 ± 0.037	1.352LysThr: 1.352 ± 0.038	2.157LysVal: 2.157 ± 0.043	0.236LysTrp: 0.236 ± 0.016	0.455LysTyr: 0.455 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	15.098LeuAla: 15.098 ± 0.147	0.672LeuCys: 0.672 ± 0.025	6.803LeuAsp: 6.803 ± 0.086	4.965LeuGlu: 4.965 ± 0.075	2.407LeuPhe: 2.407 ± 0.056	9.717LeuGly: 9.717 ± 0.12	2.008LeuHis: 2.008 ± 0.04	2.777LeuIle: 2.777 ± 0.053	1.889LeuLys: 1.889 ± 0.045	10.261LeuLeu: 10.261 ± 0.136	1.621LeuMet: 1.621 ± 0.04	1.55LeuAsn: 1.55 ± 0.037	5.74LeuPro: 5.74 ± 0.07	2.348LeuGln: 2.348 ± 0.043	7.672LeuArg: 7.672 ± 0.104	5.394LeuSer: 5.394 ± 0.071	6.428LeuThr: 6.428 ± 0.077	10.441LeuVal: 10.441 ± 0.119	1.272LeuTrp: 1.272 ± 0.033	1.515LeuTyr: 1.515 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	2.422MetAla: 2.422 ± 0.047	0.129MetCys: 0.129 ± 0.011	0.898MetAsp: 0.898 ± 0.028	0.733MetGlu: 0.733 ± 0.024	0.448MetPhe: 0.448 ± 0.021	1.437MetGly: 1.437 ± 0.036	0.328MetHis: 0.328 ± 0.017	0.586MetIle: 0.586 ± 0.023	0.44MetLys: 0.44 ± 0.02	1.706MetLeu: 1.706 ± 0.039	0.301MetMet: 0.301 ± 0.018	0.394MetAsn: 0.394 ± 0.019	1.097MetPro: 1.097 ± 0.03	0.453MetGln: 0.453 ± 0.021	1.35MetArg: 1.35 ± 0.034	1.514MetSer: 1.514 ± 0.036	1.668MetThr: 1.668 ± 0.036	1.563MetVal: 1.563 ± 0.038	0.185MetTrp: 0.185 ± 0.013	0.254MetTyr: 0.254 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.212AsnAla: 2.212 ± 0.048	0.138AsnCys: 0.138 ± 0.011	1.035AsnAsp: 1.035 ± 0.038	0.775AsnGlu: 0.775 ± 0.024	0.464AsnPhe: 0.464 ± 0.022	1.784AsnGly: 1.784 ± 0.055	0.387AsnHis: 0.387 ± 0.019	0.659AsnIle: 0.659 ± 0.027	0.359AsnLys: 0.359 ± 0.018	1.773AsnLeu: 1.773 ± 0.041	0.246AsnMet: 0.246 ± 0.016	0.443AsnAsn: 0.443 ± 0.022	1.438AsnPro: 1.438 ± 0.042	0.543AsnGln: 0.543 ± 0.022	1.19AsnArg: 1.19 ± 0.036	0.912AsnSer: 0.912 ± 0.028	1.038AsnThr: 1.038 ± 0.037	1.451AsnVal: 1.451 ± 0.041	0.288AsnTrp: 0.288 ± 0.015	0.394AsnTyr: 0.394 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	7.642ProAla: 7.642 ± 0.103	0.285ProCys: 0.285 ± 0.017	4.389ProAsp: 4.389 ± 0.069	3.557ProGlu: 3.557 ± 0.06	1.478ProPhe: 1.478 ± 0.039	5.891ProGly: 5.891 ± 0.081	1.275ProHis: 1.275 ± 0.035	1.495ProIle: 1.495 ± 0.039	1.126ProLys: 1.126 ± 0.035	4.724ProLeu: 4.724 ± 0.066	1.056ProMet: 1.056 ± 0.026	0.872ProAsn: 0.872 ± 0.028	2.947ProPro: 2.947 ± 0.075	1.683ProGln: 1.683 ± 0.043	3.666ProArg: 3.666 ± 0.056	3.49ProSer: 3.49 ± 0.058	4.038ProThr: 4.038 ± 0.078	5.376ProVal: 5.376 ± 0.075	0.965ProTrp: 0.965 ± 0.029	0.995ProTyr: 0.995 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	3.741GlnAla: 3.741 ± 0.061	0.158GlnCys: 0.158 ± 0.01	1.428GlnAsp: 1.428 ± 0.035	1.348GlnGlu: 1.348 ± 0.037	0.786GlnPhe: 0.786 ± 0.027	2.356GlnGly: 2.356 ± 0.051	0.708GlnHis: 0.708 ± 0.023	1.049GlnIle: 1.049 ± 0.032	0.592GlnLys: 0.592 ± 0.024	3.146GlnLeu: 3.146 ± 0.055	0.508GlnMet: 0.508 ± 0.022	0.511GlnAsn: 0.511 ± 0.023	1.856GlnPro: 1.856 ± 0.039	1.174GlnGln: 1.174 ± 0.041	2.67GlnArg: 2.67 ± 0.05	1.493GlnSer: 1.493 ± 0.042	1.574GlnThr: 1.574 ± 0.035	2.964GlnVal: 2.964 ± 0.051	0.521GlnTrp: 0.521 ± 0.023	0.491GlnTyr: 0.491 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	9.036ArgAla: 9.036 ± 0.113	0.462ArgCys: 0.462 ± 0.022	4.451ArgAsp: 4.451 ± 0.067	4.378ArgGlu: 4.378 ± 0.07	2.189ArgPhe: 2.189 ± 0.047	5.754ArgGly: 5.754 ± 0.078	1.898ArgHis: 1.898 ± 0.043	2.84ArgIle: 2.84 ± 0.048	1.476ArgLys: 1.476 ± 0.039	7.783ArgLeu: 7.783 ± 0.09	1.682ArgMet: 1.682 ± 0.035	1.207ArgAsn: 1.207 ± 0.031	4.199ArgPro: 4.199 ± 0.074	2.242ArgGln: 2.242 ± 0.049	6.867ArgArg: 6.867 ± 0.101	4.3ArgSer: 4.3 ± 0.066	4.619ArgThr: 4.619 ± 0.065	6.154ArgVal: 6.154 ± 0.069	1.422ArgTrp: 1.422 ± 0.031	1.539ArgTyr: 1.539 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	7.155SerAla: 7.155 ± 0.092	0.334SerCys: 0.334 ± 0.018	3.211SerAsp: 3.211 ± 0.052	2.49SerGlu: 2.49 ± 0.056	1.617SerPhe: 1.617 ± 0.043	5.958SerGly: 5.958 ± 0.079	1.128SerHis: 1.128 ± 0.031	1.922SerIle: 1.922 ± 0.049	1.13SerLys: 1.13 ± 0.038	5.232SerLeu: 5.232 ± 0.069	1.283SerMet: 1.283 ± 0.033	1.03SerAsn: 1.03 ± 0.031	3.257SerPro: 3.257 ± 0.06	1.491SerGln: 1.491 ± 0.035	3.982SerArg: 3.982 ± 0.06	3.557SerSer: 3.557 ± 0.078	4.03SerThr: 4.03 ± 0.071	4.753SerVal: 4.753 ± 0.072	0.975SerTrp: 0.975 ± 0.03	1.099SerTyr: 1.099 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	8.262ThrAla: 8.262 ± 0.113	0.444ThrCys: 0.444 ± 0.02	3.725ThrAsp: 3.725 ± 0.059	2.959ThrGlu: 2.959 ± 0.047	1.838ThrPhe: 1.838 ± 0.049	6.269ThrGly: 6.269 ± 0.079	1.304ThrHis: 1.304 ± 0.029	2.315ThrIle: 2.315 ± 0.048	1.402ThrLys: 1.402 ± 0.04	5.879ThrLeu: 5.879 ± 0.078	1.117ThrMet: 1.117 ± 0.032	1.164ThrAsn: 1.164 ± 0.034	4.229ThrPro: 4.229 ± 0.074	1.586ThrGln: 1.586 ± 0.036	4.068ThrArg: 4.068 ± 0.071	3.852ThrSer: 3.852 ± 0.063	5.013ThrThr: 5.013 ± 0.113	6.341ThrVal: 6.341 ± 0.079	1.024ThrTrp: 1.024 ± 0.032	1.301ThrTyr: 1.301 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	12.773ValAla: 12.773 ± 0.126	0.664ValCys: 0.664 ± 0.023	6.207ValAsp: 6.207 ± 0.069	5.354ValGlu: 5.354 ± 0.08	2.469ValPhe: 2.469 ± 0.048	8.051ValGly: 8.051 ± 0.097	1.904ValHis: 1.904 ± 0.042	3.143ValIle: 3.143 ± 0.055	1.861ValLys: 1.861 ± 0.047	9.85ValLeu: 9.85 ± 0.118	1.559ValMet: 1.559 ± 0.038	1.748ValAsn: 1.748 ± 0.041	5.015ValPro: 5.015 ± 0.072	2.434ValGln: 2.434 ± 0.042	6.714ValArg: 6.714 ± 0.08	5.043ValSer: 5.043 ± 0.072	6.337ValThr: 6.337 ± 0.094	10.693ValVal: 10.693 ± 0.123	1.229ValTrp: 1.229 ± 0.035	1.447ValTyr: 1.447 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.784TrpAla: 1.784 ± 0.038	0.136TrpCys: 0.136 ± 0.011	0.871TrpAsp: 0.871 ± 0.027	0.666TrpGlu: 0.666 ± 0.021	0.558TrpPhe: 0.558 ± 0.02	1.17TrpGly: 1.17 ± 0.035	0.4TrpHis: 0.4 ± 0.018	0.467TrpIle: 0.467 ± 0.019	0.327TrpLys: 0.327 ± 0.02	1.802TrpLeu: 1.802 ± 0.042	0.289TrpMet: 0.289 ± 0.015	0.349TrpAsn: 0.349 ± 0.017	0.833TrpPro: 0.833 ± 0.023	0.553TrpGln: 0.553 ± 0.02	1.272TrpArg: 1.272 ± 0.037	1.041TrpSer: 1.041 ± 0.031	1.01TrpThr: 1.01 ± 0.032	1.455TrpVal: 1.455 ± 0.045	0.421TrpTrp: 0.421 ± 0.024	0.28TrpTyr: 0.28 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.863TyrAla: 2.863 ± 0.044	0.123TyrCys: 0.123 ± 0.01	1.344TyrAsp: 1.344 ± 0.038	0.924TyrGlu: 0.924 ± 0.026	0.587TyrPhe: 0.587 ± 0.023	1.824TyrGly: 1.824 ± 0.038	0.337TyrHis: 0.337 ± 0.018	0.471TyrIle: 0.471 ± 0.024	0.348TyrLys: 0.348 ± 0.019	2.061TyrLeu: 2.061 ± 0.045	0.184TyrMet: 0.184 ± 0.013	0.392TyrAsn: 0.392 ± 0.02	1.013TyrPro: 1.013 ± 0.032	0.554TyrGln: 0.554 ± 0.021	1.461TyrArg: 1.461 ± 0.035	0.952TyrSer: 0.952 ± 0.033	1.017TyrThr: 1.017 ± 0.033	1.614TyrVal: 1.614 ± 0.039	0.294TyrTrp: 0.294 ± 0.018	0.441TyrTyr: 0.441 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3628 proteins (1185105 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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