Amino acid dipepetide frequency for Zavarzinia compransoris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
24.015AlaAla: 24.015 ± 0.262
1.15AlaCys: 1.15 ± 0.03
7.772AlaAsp: 7.772 ± 0.076
8.462AlaGlu: 8.462 ± 0.099
4.731AlaPhe: 4.731 ± 0.067
14.684AlaGly: 14.684 ± 0.152
2.198AlaHis: 2.198 ± 0.049
6.193AlaIle: 6.193 ± 0.066
3.602AlaLys: 3.602 ± 0.069
15.936AlaLeu: 15.936 ± 0.158
3.228AlaMet: 3.228 ± 0.056
2.569AlaAsn: 2.569 ± 0.049
6.975AlaPro: 6.975 ± 0.106
3.537AlaGln: 3.537 ± 0.053
10.882AlaArg: 10.882 ± 0.126
5.233AlaSer: 5.233 ± 0.083
6.373AlaThr: 6.373 ± 0.097
10.457AlaVal: 10.457 ± 0.092
1.654AlaTrp: 1.654 ± 0.036
2.712AlaTyr: 2.712 ± 0.053
0.0AlaXaa: 0.0 ± 0.0
Cys
0.911CysAla: 0.911 ± 0.028
0.122CysCys: 0.122 ± 0.01
0.452CysAsp: 0.452 ± 0.018
0.344CysGlu: 0.344 ± 0.018
0.298CysPhe: 0.298 ± 0.017
0.866CysGly: 0.866 ± 0.027
0.216CysHis: 0.216 ± 0.013
0.356CysIle: 0.356 ± 0.015
0.172CysLys: 0.172 ± 0.01
0.82CysLeu: 0.82 ± 0.027
0.138CysMet: 0.138 ± 0.009
0.169CysAsn: 0.169 ± 0.011
0.481CysPro: 0.481 ± 0.02
0.196CysGln: 0.196 ± 0.011
0.726CysArg: 0.726 ± 0.023
0.36CysSer: 0.36 ± 0.017
0.393CysThr: 0.393 ± 0.017
0.475CysVal: 0.475 ± 0.017
0.126CysTrp: 0.126 ± 0.01
0.185CysTyr: 0.185 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
6.758AspAla: 6.758 ± 0.079
0.423AspCys: 0.423 ± 0.019
3.273AspAsp: 3.273 ± 0.054
3.267AspGlu: 3.267 ± 0.048
2.327AspPhe: 2.327 ± 0.043
5.886AspGly: 5.886 ± 0.073
1.33AspHis: 1.33 ± 0.033
2.801AspIle: 2.801 ± 0.045
1.479AspLys: 1.479 ± 0.036
7.021AspLeu: 7.021 ± 0.081
1.101AspMet: 1.101 ± 0.027
1.156AspAsn: 1.156 ± 0.033
3.696AspPro: 3.696 ± 0.057
1.655AspGln: 1.655 ± 0.035
4.798AspArg: 4.798 ± 0.07
2.047AspSer: 2.047 ± 0.042
2.335AspThr: 2.335 ± 0.047
3.832AspVal: 3.832 ± 0.054
1.005AspTrp: 1.005 ± 0.028
1.61AspTyr: 1.61 ± 0.035
0.0AspXaa: 0.0 ± 0.0
Glu
8.424GluAla: 8.424 ± 0.095
0.296GluCys: 0.296 ± 0.017
2.671GluAsp: 2.671 ± 0.049
2.526GluGlu: 2.526 ± 0.056
1.593GluPhe: 1.593 ± 0.038
4.446GluGly: 4.446 ± 0.055
0.989GluHis: 0.989 ± 0.026
3.343GluIle: 3.343 ± 0.053
1.8GluLys: 1.8 ± 0.044
4.508GluLeu: 4.508 ± 0.064
1.263GluMet: 1.263 ± 0.033
1.275GluAsn: 1.275 ± 0.034
2.398GluPro: 2.398 ± 0.044
1.787GluGln: 1.787 ± 0.042
4.739GluArg: 4.739 ± 0.074
1.805GluSer: 1.805 ± 0.038
3.501GluThr: 3.501 ± 0.053
3.93GluVal: 3.93 ± 0.065
0.555GluTrp: 0.555 ± 0.022
0.855GluTyr: 0.855 ± 0.027
0.001GluXaa: 0.001 ± 0.001
Phe
4.866PheAla: 4.866 ± 0.066
0.401PheCys: 0.401 ± 0.017
2.659PheAsp: 2.659 ± 0.043
2.046PheGlu: 2.046 ± 0.041
1.319PhePhe: 1.319 ± 0.038
3.864PheGly: 3.864 ± 0.06
0.73PheHis: 0.73 ± 0.022
1.585PheIle: 1.585 ± 0.035
0.929PheLys: 0.929 ± 0.026
3.47PheLeu: 3.47 ± 0.054
0.783PheMet: 0.783 ± 0.025
0.95PheAsn: 0.95 ± 0.028
1.575PhePro: 1.575 ± 0.039
0.942PheGln: 0.942 ± 0.024
2.382PheArg: 2.382 ± 0.041
1.807PheSer: 1.807 ± 0.038
2.016PheThr: 2.016 ± 0.045
2.655PheVal: 2.655 ± 0.043
0.517PheTrp: 0.517 ± 0.019
0.865PheTyr: 0.865 ± 0.025
0.0PheXaa: 0.0 ± 0.0
Gly
11.405GlyAla: 11.405 ± 0.126
0.803GlyCys: 0.803 ± 0.026
5.143GlyAsp: 5.143 ± 0.076
4.855GlyGlu: 4.855 ± 0.059
3.903GlyPhe: 3.903 ± 0.053
8.817GlyGly: 8.817 ± 0.158
2.031GlyHis: 2.031 ± 0.045
4.932GlyIle: 4.932 ± 0.058
2.938GlyLys: 2.938 ± 0.054
10.834GlyLeu: 10.834 ± 0.12
1.997GlyMet: 1.997 ± 0.04
2.211GlyAsn: 2.211 ± 0.055
4.476GlyPro: 4.476 ± 0.06
3.015GlyGln: 3.015 ± 0.052
7.849GlyArg: 7.849 ± 0.088
4.16GlySer: 4.16 ± 0.082
5.161GlyThr: 5.161 ± 0.113
6.244GlyVal: 6.244 ± 0.078
1.351GlyTrp: 1.351 ± 0.035
2.198GlyTyr: 2.198 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
2.277HisAla: 2.277 ± 0.049
0.228HisCys: 0.228 ± 0.013
1.243HisAsp: 1.243 ± 0.033
0.871HisGlu: 0.871 ± 0.029
0.875HisPhe: 0.875 ± 0.024
2.014HisGly: 2.014 ± 0.043
0.589HisHis: 0.589 ± 0.02
0.799HisIle: 0.799 ± 0.026
0.392HisLys: 0.392 ± 0.017
2.275HisLeu: 2.275 ± 0.043
0.42HisMet: 0.42 ± 0.017
0.394HisAsn: 0.394 ± 0.018
1.304HisPro: 1.304 ± 0.027
0.556HisGln: 0.556 ± 0.02
1.619HisArg: 1.619 ± 0.037
0.705HisSer: 0.705 ± 0.024
0.643HisThr: 0.643 ± 0.024
1.481HisVal: 1.481 ± 0.034
0.377HisTrp: 0.377 ± 0.016
0.577HisTyr: 0.577 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
7.602IleAla: 7.602 ± 0.068
0.388IleCys: 0.388 ± 0.014
3.592IleAsp: 3.592 ± 0.05
3.611IleGlu: 3.611 ± 0.058
1.396IlePhe: 1.396 ± 0.031
5.024IleGly: 5.024 ± 0.072
0.881IleHis: 0.881 ± 0.025
1.645IleIle: 1.645 ± 0.04
1.041IleLys: 1.041 ± 0.027
4.208IleLeu: 4.208 ± 0.059
0.825IleMet: 0.825 ± 0.024
1.134IleAsn: 1.134 ± 0.031
2.048IlePro: 2.048 ± 0.037
1.096IleGln: 1.096 ± 0.03
3.277IleArg: 3.277 ± 0.051
2.162IleSer: 2.162 ± 0.048
2.472IleThr: 2.472 ± 0.056
3.894IleVal: 3.894 ± 0.057
0.46IleTrp: 0.46 ± 0.021
0.941IleTyr: 0.941 ± 0.028
0.0IleXaa: 0.0 ± 0.0
Lys
4.196LysAla: 4.196 ± 0.068
0.131LysCys: 0.131 ± 0.01
1.389LysAsp: 1.389 ± 0.036
1.116LysGlu: 1.116 ± 0.036
0.745LysPhe: 0.745 ± 0.022
2.447LysGly: 2.447 ± 0.043
0.412LysHis: 0.412 ± 0.019
1.344LysIle: 1.344 ± 0.036
0.894LysLys: 0.894 ± 0.037
2.728LysLeu: 2.728 ± 0.053
0.561LysMet: 0.561 ± 0.021
0.563LysAsn: 0.563 ± 0.02
1.838LysPro: 1.838 ± 0.043
0.711LysGln: 0.711 ± 0.028
2.0LysArg: 2.0 ± 0.042
1.267LysSer: 1.267 ± 0.034
1.58LysThr: 1.58 ± 0.038
2.381LysVal: 2.381 ± 0.047
0.302LysTrp: 0.302 ± 0.015
0.524LysTyr: 0.524 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
16.811LeuAla: 16.811 ± 0.143
0.839LeuCys: 0.839 ± 0.026
6.935LeuAsp: 6.935 ± 0.075
4.791LeuGlu: 4.791 ± 0.067
3.712LeuPhe: 3.712 ± 0.056
9.801LeuGly: 9.801 ± 0.096
1.999LeuHis: 1.999 ± 0.039
4.891LeuIle: 4.891 ± 0.054
3.241LeuLys: 3.241 ± 0.059
10.07LeuLeu: 10.07 ± 0.112
2.102LeuMet: 2.102 ± 0.044
2.397LeuAsn: 2.397 ± 0.042
6.41LeuPro: 6.41 ± 0.083
2.374LeuGln: 2.374 ± 0.04
7.599LeuArg: 7.599 ± 0.096
5.85LeuSer: 5.85 ± 0.077
5.582LeuThr: 5.582 ± 0.084
8.126LeuVal: 8.126 ± 0.08
1.286LeuTrp: 1.286 ± 0.028
2.155LeuTyr: 2.155 ± 0.043
0.001LeuXaa: 0.001 ± 0.001
Met
3.14MetAla: 3.14 ± 0.047
0.135MetCys: 0.135 ± 0.009
0.952MetAsp: 0.952 ± 0.029
0.843MetGlu: 0.843 ± 0.026
0.584MetPhe: 0.584 ± 0.02
1.601MetGly: 1.601 ± 0.038
0.351MetHis: 0.351 ± 0.016
1.114MetIle: 1.114 ± 0.03
0.705MetLys: 0.705 ± 0.023
2.028MetLeu: 2.028 ± 0.043
0.527MetMet: 0.527 ± 0.021
0.6MetAsn: 0.6 ± 0.018
1.42MetPro: 1.42 ± 0.033
0.591MetGln: 0.591 ± 0.021
1.563MetArg: 1.563 ± 0.039
1.301MetSer: 1.301 ± 0.033
1.626MetThr: 1.626 ± 0.035
1.627MetVal: 1.627 ± 0.037
0.157MetTrp: 0.157 ± 0.009
0.242MetTyr: 0.242 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
2.784AsnAla: 2.784 ± 0.048
0.193AsnCys: 0.193 ± 0.012
1.247AsnAsp: 1.247 ± 0.036
0.987AsnGlu: 0.987 ± 0.026
0.834AsnPhe: 0.834 ± 0.028
2.129AsnGly: 2.129 ± 0.042
0.435AsnHis: 0.435 ± 0.021
1.152AsnIle: 1.152 ± 0.027
0.531AsnLys: 0.531 ± 0.019
2.444AsnLeu: 2.444 ± 0.043
0.484AsnMet: 0.484 ± 0.017
0.614AsnAsn: 0.614 ± 0.022
1.682AsnPro: 1.682 ± 0.044
0.634AsnGln: 0.634 ± 0.023
1.702AsnArg: 1.702 ± 0.04
0.907AsnSer: 0.907 ± 0.027
1.088AsnThr: 1.088 ± 0.029
1.636AsnVal: 1.636 ± 0.041
0.339AsnTrp: 0.339 ± 0.014
0.622AsnTyr: 0.622 ± 0.029
0.0AsnXaa: 0.0 ± 0.0
Pro
8.961ProAla: 8.961 ± 0.121
0.342ProCys: 0.342 ± 0.015
3.669ProAsp: 3.669 ± 0.053
3.539ProGlu: 3.539 ± 0.058
2.061ProPhe: 2.061 ± 0.039
5.716ProGly: 5.716 ± 0.072
1.002ProHis: 1.002 ± 0.026
1.951ProIle: 1.951 ± 0.036
1.447ProLys: 1.447 ± 0.036
5.473ProLeu: 5.473 ± 0.065
1.124ProMet: 1.124 ± 0.028
1.066ProAsn: 1.066 ± 0.032
3.377ProPro: 3.377 ± 0.083
1.371ProGln: 1.371 ± 0.03
3.518ProArg: 3.518 ± 0.058
2.297ProSer: 2.297 ± 0.038
2.257ProThr: 2.257 ± 0.05
4.822ProVal: 4.822 ± 0.07
0.779ProTrp: 0.779 ± 0.024
1.125ProTyr: 1.125 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
4.205GlnAla: 4.205 ± 0.061
0.191GlnCys: 0.191 ± 0.012
1.347GlnAsp: 1.347 ± 0.029
1.163GlnGlu: 1.163 ± 0.033
0.971GlnPhe: 0.971 ± 0.031
2.623GlnGly: 2.623 ± 0.043
0.531GlnHis: 0.531 ± 0.017
1.471GlnIle: 1.471 ± 0.033
0.749GlnLys: 0.749 ± 0.025
2.518GlnLeu: 2.518 ± 0.043
0.639GlnMet: 0.639 ± 0.022
0.635GlnAsn: 0.635 ± 0.024
1.566GlnPro: 1.566 ± 0.036
0.914GlnGln: 0.914 ± 0.032
2.145GlnArg: 2.145 ± 0.04
1.367GlnSer: 1.367 ± 0.037
1.17GlnThr: 1.17 ± 0.031
2.287GlnVal: 2.287 ± 0.042
0.371GlnTrp: 0.371 ± 0.016
0.544GlnTyr: 0.544 ± 0.018
0.0GlnXaa: 0.0 ± 0.0
Arg
9.321ArgAla: 9.321 ± 0.1
0.54ArgCys: 0.54 ± 0.021
4.413ArgAsp: 4.413 ± 0.054
3.774ArgGlu: 3.774 ± 0.063
3.168ArgPhe: 3.168 ± 0.043
5.533ArgGly: 5.533 ± 0.074
2.116ArgHis: 2.116 ± 0.046
3.917ArgIle: 3.917 ± 0.047
1.903ArgLys: 1.903 ± 0.04
10.065ArgLeu: 10.065 ± 0.126
1.642ArgMet: 1.642 ± 0.032
1.727ArgAsn: 1.727 ± 0.037
4.511ArgPro: 4.511 ± 0.069
2.676ArgGln: 2.676 ± 0.044
7.182ArgArg: 7.182 ± 0.086
3.076ArgSer: 3.076 ± 0.051
3.039ArgThr: 3.039 ± 0.05
4.885ArgVal: 4.885 ± 0.067
1.0ArgTrp: 1.0 ± 0.031
1.761ArgTyr: 1.761 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
5.34SerAla: 5.34 ± 0.076
0.354SerCys: 0.354 ± 0.016
2.215SerAsp: 2.215 ± 0.04
1.873SerGlu: 1.873 ± 0.036
2.024SerPhe: 2.024 ± 0.039
4.592SerGly: 4.592 ± 0.087
0.898SerHis: 0.898 ± 0.026
2.218SerIle: 2.218 ± 0.042
1.122SerLys: 1.122 ± 0.031
5.161SerLeu: 5.161 ± 0.062
0.964SerMet: 0.964 ± 0.027
1.012SerAsn: 1.012 ± 0.03
2.723SerPro: 2.723 ± 0.049
1.067SerGln: 1.067 ± 0.032
3.247SerArg: 3.247 ± 0.049
2.086SerSer: 2.086 ± 0.051
2.313SerThr: 2.313 ± 0.051
3.179SerVal: 3.179 ± 0.056
0.606SerTrp: 0.606 ± 0.022
1.045SerTyr: 1.045 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
6.88ThrAla: 6.88 ± 0.106
0.392ThrCys: 0.392 ± 0.019
2.59ThrAsp: 2.59 ± 0.051
2.457ThrGlu: 2.457 ± 0.046
1.749ThrPhe: 1.749 ± 0.041
5.459ThrGly: 5.459 ± 0.145
0.815ThrHis: 0.815 ± 0.023
2.629ThrIle: 2.629 ± 0.053
1.132ThrLys: 1.132 ± 0.031
5.694ThrLeu: 5.694 ± 0.076
0.991ThrMet: 0.991 ± 0.026
1.043ThrAsn: 1.043 ± 0.028
3.233ThrPro: 3.233 ± 0.051
1.064ThrGln: 1.064 ± 0.026
3.302ThrArg: 3.302 ± 0.044
2.203ThrSer: 2.203 ± 0.045
2.565ThrThr: 2.565 ± 0.068
4.676ThrVal: 4.676 ± 0.076
0.622ThrTrp: 0.622 ± 0.02
1.175ThrTyr: 1.175 ± 0.031
0.0ThrXaa: 0.0 ± 0.0
Val
10.484ValAla: 10.484 ± 0.099
0.538ValCys: 0.538 ± 0.02
4.152ValAsp: 4.152 ± 0.05
4.609ValGlu: 4.609 ± 0.063
2.67ValPhe: 2.67 ± 0.053
5.745ValGly: 5.745 ± 0.086
1.341ValHis: 1.341 ± 0.032
3.953ValIle: 3.953 ± 0.057
2.192ValLys: 2.192 ± 0.045
7.89ValLeu: 7.89 ± 0.082
1.651ValMet: 1.651 ± 0.037
1.932ValAsn: 1.932 ± 0.041
4.404ValPro: 4.404 ± 0.062
1.939ValGln: 1.939 ± 0.039
4.643ValArg: 4.643 ± 0.066
3.729ValSer: 3.729 ± 0.063
4.837ValThr: 4.837 ± 0.08
6.203ValVal: 6.203 ± 0.076
0.788ValTrp: 0.788 ± 0.025
1.389ValTyr: 1.389 ± 0.034
0.0ValXaa: 0.0 ± 0.0
Trp
1.409TrpAla: 1.409 ± 0.032
0.138TrpCys: 0.138 ± 0.009
0.599TrpAsp: 0.599 ± 0.022
0.466TrpGlu: 0.466 ± 0.023
0.48TrpPhe: 0.48 ± 0.02
0.959TrpGly: 0.959 ± 0.025
0.304TrpHis: 0.304 ± 0.016
0.561TrpIle: 0.561 ± 0.022
0.354TrpLys: 0.354 ± 0.015
1.611TrpLeu: 1.611 ± 0.035
0.274TrpMet: 0.274 ± 0.012
0.431TrpAsn: 0.431 ± 0.02
0.712TrpPro: 0.712 ± 0.021
0.597TrpGln: 0.597 ± 0.023
1.228TrpArg: 1.228 ± 0.031
0.751TrpSer: 0.751 ± 0.024
0.718TrpThr: 0.718 ± 0.02
0.774TrpVal: 0.774 ± 0.025
0.22TrpTrp: 0.22 ± 0.013
0.291TrpTyr: 0.291 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.574TyrAla: 2.574 ± 0.054
0.202TyrCys: 0.202 ± 0.011
1.484TyrAsp: 1.484 ± 0.041
1.107TyrGlu: 1.107 ± 0.03
0.92TyrPhe: 0.92 ± 0.028
2.117TyrGly: 2.117 ± 0.042
0.475TyrHis: 0.475 ± 0.018
0.84TyrIle: 0.84 ± 0.026
0.506TyrLys: 0.506 ± 0.021
2.218TyrLeu: 2.218 ± 0.041
0.394TyrMet: 0.394 ± 0.018
0.567TyrAsn: 0.567 ± 0.024
1.07TyrPro: 1.07 ± 0.029
0.684TyrGln: 0.684 ± 0.023
1.846TyrArg: 1.846 ± 0.038
0.928TyrSer: 0.928 ± 0.033
1.0TyrThr: 1.0 ± 0.039
1.523TyrVal: 1.523 ± 0.031
0.361TyrTrp: 0.361 ± 0.017
0.604TyrTyr: 0.604 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.001XaaAla: 0.001 ± 0.001
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.001XaaGln: 0.001 ± 0.001
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4405 proteins (1447416 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski