Amino acid dipepetide frequency for Citrobacter koseri (Citrobacter diversus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.152AlaAla: 10.152 ± 0.105	1.205AlaCys: 1.205 ± 0.035	4.978AlaAsp: 4.978 ± 0.067	5.575AlaGlu: 5.575 ± 0.071	3.64AlaPhe: 3.64 ± 0.053	7.788AlaGly: 7.788 ± 0.095	1.95AlaHis: 1.95 ± 0.04	5.998AlaIle: 5.998 ± 0.069	3.781AlaLys: 3.781 ± 0.061	11.853AlaLeu: 11.853 ± 0.108	3.043AlaMet: 3.043 ± 0.051	3.093AlaAsn: 3.093 ± 0.051	3.688AlaPro: 3.688 ± 0.061	4.603AlaGln: 4.603 ± 0.075	5.841AlaArg: 5.841 ± 0.071	5.65AlaSer: 5.65 ± 0.07	4.877AlaThr: 4.877 ± 0.068	6.825AlaVal: 6.825 ± 0.072	1.695AlaTrp: 1.695 ± 0.041	1.927AlaTyr: 1.927 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	1.126CysAla: 1.126 ± 0.035	0.24CysCys: 0.24 ± 0.015	0.622CysAsp: 0.622 ± 0.021	0.601CysGlu: 0.601 ± 0.025	0.456CysPhe: 0.456 ± 0.018	1.12CysGly: 1.12 ± 0.03	0.368CysHis: 0.368 ± 0.017	0.585CysIle: 0.585 ± 0.023	0.33CysLys: 0.33 ± 0.013	1.075CysLeu: 1.075 ± 0.028	0.316CysMet: 0.316 ± 0.017	0.357CysAsn: 0.357 ± 0.017	0.555CysPro: 0.555 ± 0.022	0.504CysGln: 0.504 ± 0.021	0.781CysArg: 0.781 ± 0.024	0.746CysSer: 0.746 ± 0.024	0.538CysThr: 0.538 ± 0.017	0.801CysVal: 0.801 ± 0.027	0.242CysTrp: 0.242 ± 0.015	0.329CysTyr: 0.329 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	5.45AspAla: 5.45 ± 0.07	0.521AspCys: 0.521 ± 0.021	3.061AspAsp: 3.061 ± 0.062	3.568AspGlu: 3.568 ± 0.051	2.041AspPhe: 2.041 ± 0.039	3.772AspGly: 3.772 ± 0.057	0.981AspHis: 0.981 ± 0.023	3.455AspIle: 3.455 ± 0.052	2.474AspLys: 2.474 ± 0.052	4.546AspLeu: 4.546 ± 0.067	1.37AspMet: 1.37 ± 0.036	2.17AspAsn: 2.17 ± 0.045	2.214AspPro: 2.214 ± 0.037	1.508AspGln: 1.508 ± 0.032	2.66AspArg: 2.66 ± 0.046	2.755AspSer: 2.755 ± 0.053	2.53AspThr: 2.53 ± 0.043	3.934AspVal: 3.934 ± 0.052	0.817AspTrp: 0.817 ± 0.026	1.848AspTyr: 1.848 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	5.151GluAla: 5.151 ± 0.067	0.504GluCys: 0.504 ± 0.02	2.311GluAsp: 2.311 ± 0.044	3.396GluGlu: 3.396 ± 0.062	1.745GluPhe: 1.745 ± 0.041	3.663GluGly: 3.663 ± 0.054	1.418GluHis: 1.418 ± 0.035	3.242GluIle: 3.242 ± 0.053	3.296GluLys: 3.296 ± 0.052	5.725GluLeu: 5.725 ± 0.069	1.817GluMet: 1.817 ± 0.04	2.432GluAsn: 2.432 ± 0.043	2.063GluPro: 2.063 ± 0.044	3.37GluGln: 3.37 ± 0.055	3.647GluArg: 3.647 ± 0.062	2.908GluSer: 2.908 ± 0.048	3.033GluThr: 3.033 ± 0.046	3.554GluVal: 3.554 ± 0.061	0.775GluTrp: 0.775 ± 0.023	1.462GluTyr: 1.462 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	3.753PheAla: 3.753 ± 0.057	0.599PheCys: 0.599 ± 0.022	2.291PheAsp: 2.291 ± 0.044	1.69PheGlu: 1.69 ± 0.035	1.667PhePhe: 1.667 ± 0.045	3.157PheGly: 3.157 ± 0.056	0.787PheHis: 0.787 ± 0.021	2.516PheIle: 2.516 ± 0.05	1.202PheLys: 1.202 ± 0.029	3.339PheLeu: 3.339 ± 0.06	1.033PheMet: 1.033 ± 0.03	1.711PheAsn: 1.711 ± 0.038	1.547PhePro: 1.547 ± 0.031	1.105PheGln: 1.105 ± 0.026	1.968PheArg: 1.968 ± 0.037	3.14PheSer: 3.14 ± 0.052	2.466PheThr: 2.466 ± 0.044	2.528PheVal: 2.528 ± 0.046	0.625PheTrp: 0.625 ± 0.024	1.145PheTyr: 1.145 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	6.426GlyAla: 6.426 ± 0.085	1.117GlyCys: 1.117 ± 0.03	3.776GlyAsp: 3.776 ± 0.062	4.552GlyGlu: 4.552 ± 0.067	3.215GlyPhe: 3.215 ± 0.053	5.49GlyGly: 5.49 ± 0.077	1.692GlyHis: 1.692 ± 0.037	5.102GlyIle: 5.102 ± 0.068	3.968GlyLys: 3.968 ± 0.059	7.424GlyLeu: 7.424 ± 0.071	2.488GlyMet: 2.488 ± 0.044	2.786GlyAsn: 2.786 ± 0.051	1.978GlyPro: 1.978 ± 0.037	2.905GlyGln: 2.905 ± 0.046	3.986GlyArg: 3.986 ± 0.061	4.161GlySer: 4.161 ± 0.062	3.772GlyThr: 3.772 ± 0.054	5.868GlyVal: 5.868 ± 0.062	1.337GlyTrp: 1.337 ± 0.035	2.635GlyTyr: 2.635 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	2.046HisAla: 2.046 ± 0.044	0.351HisCys: 0.351 ± 0.017	1.243HisAsp: 1.243 ± 0.033	1.081HisGlu: 1.081 ± 0.032	1.075HisPhe: 1.075 ± 0.027	1.725HisGly: 1.725 ± 0.033	0.804HisHis: 0.804 ± 0.03	1.358HisIle: 1.358 ± 0.036	0.717HisLys: 0.717 ± 0.025	2.288HisLeu: 2.288 ± 0.041	0.579HisMet: 0.579 ± 0.02	0.857HisAsn: 0.857 ± 0.025	1.345HisPro: 1.345 ± 0.036	1.143HisGln: 1.143 ± 0.034	1.33HisArg: 1.33 ± 0.036	1.226HisSer: 1.226 ± 0.031	1.099HisThr: 1.099 ± 0.029	1.304HisVal: 1.304 ± 0.033	0.42HisTrp: 0.42 ± 0.02	0.927HisTyr: 0.927 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.51IleAla: 6.51 ± 0.077	0.736IleCys: 0.736 ± 0.022	3.434IleAsp: 3.434 ± 0.051	3.228IleGlu: 3.228 ± 0.055	2.102IlePhe: 2.102 ± 0.045	4.598IleGly: 4.598 ± 0.067	1.212IleHis: 1.212 ± 0.03	3.408IleIle: 3.408 ± 0.056	2.268IleLys: 2.268 ± 0.049	5.123IleLeu: 5.123 ± 0.078	1.298IleMet: 1.298 ± 0.032	2.641IleAsn: 2.641 ± 0.047	2.824IlePro: 2.824 ± 0.056	1.855IleGln: 1.855 ± 0.034	3.088IleArg: 3.088 ± 0.051	3.795IleSer: 3.795 ± 0.045	3.576IleThr: 3.576 ± 0.046	4.015IleVal: 4.015 ± 0.059	0.76IleTrp: 0.76 ± 0.026	1.521IleTyr: 1.521 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.127LysAla: 4.127 ± 0.063	0.296LysCys: 0.296 ± 0.018	2.006LysAsp: 2.006 ± 0.044	2.428LysGlu: 2.428 ± 0.046	1.11LysPhe: 1.11 ± 0.031	2.962LysGly: 2.962 ± 0.052	0.868LysHis: 0.868 ± 0.025	2.259LysIle: 2.259 ± 0.048	2.14LysLys: 2.14 ± 0.047	4.097LysLeu: 4.097 ± 0.061	1.274LysMet: 1.274 ± 0.03	1.779LysAsn: 1.779 ± 0.04	2.144LysPro: 2.144 ± 0.043	1.868LysGln: 1.868 ± 0.034	2.625LysArg: 2.625 ± 0.042	2.258LysSer: 2.258 ± 0.044	2.616LysThr: 2.616 ± 0.051	2.866LysVal: 2.866 ± 0.053	0.42LysTrp: 0.42 ± 0.021	1.139LysTyr: 1.139 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	11.448LeuAla: 11.448 ± 0.108	1.304LeuCys: 1.304 ± 0.025	5.295LeuAsp: 5.295 ± 0.062	5.426LeuGlu: 5.426 ± 0.068	4.284LeuPhe: 4.284 ± 0.062	7.145LeuGly: 7.145 ± 0.08	2.305LeuHis: 2.305 ± 0.044	5.813LeuIle: 5.813 ± 0.083	4.432LeuLys: 4.432 ± 0.069	11.879LeuLeu: 11.879 ± 0.14	3.061LeuMet: 3.061 ± 0.056	4.268LeuAsn: 4.268 ± 0.062	5.7LeuPro: 5.7 ± 0.06	3.998LeuGln: 3.998 ± 0.053	6.268LeuArg: 6.268 ± 0.084	7.257LeuSer: 7.257 ± 0.078	6.411LeuThr: 6.411 ± 0.076	6.98LeuVal: 6.98 ± 0.077	1.451LeuTrp: 1.451 ± 0.035	2.559LeuTyr: 2.559 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	2.99MetAla: 2.99 ± 0.055	0.231MetCys: 0.231 ± 0.012	1.256MetAsp: 1.256 ± 0.031	1.242MetGlu: 1.242 ± 0.031	0.916MetPhe: 0.916 ± 0.027	1.996MetGly: 1.996 ± 0.042	0.513MetHis: 0.513 ± 0.021	1.572MetIle: 1.572 ± 0.034	1.468MetLys: 1.468 ± 0.034	3.316MetLeu: 3.316 ± 0.053	0.95MetMet: 0.95 ± 0.029	1.177MetAsn: 1.177 ± 0.029	1.474MetPro: 1.474 ± 0.032	1.258MetGln: 1.258 ± 0.031	1.584MetArg: 1.584 ± 0.034	1.882MetSer: 1.882 ± 0.039	1.861MetThr: 1.861 ± 0.038	1.984MetVal: 1.984 ± 0.042	0.273MetTrp: 0.273 ± 0.015	0.552MetTyr: 0.552 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.74AsnAla: 3.74 ± 0.05	0.354AsnCys: 0.354 ± 0.018	2.063AsnAsp: 2.063 ± 0.043	1.872AsnGlu: 1.872 ± 0.037	1.288AsnPhe: 1.288 ± 0.033	3.082AsnGly: 3.082 ± 0.052	0.856AsnHis: 0.856 ± 0.023	2.368AsnIle: 2.368 ± 0.047	1.494AsnLys: 1.494 ± 0.039	3.55AsnLeu: 3.55 ± 0.049	0.964AsnMet: 0.964 ± 0.028	1.569AsnAsn: 1.569 ± 0.04	2.08AsnPro: 2.08 ± 0.038	1.526AsnGln: 1.526 ± 0.035	2.067AsnArg: 2.067 ± 0.041	1.983AsnSer: 1.983 ± 0.042	2.109AsnThr: 2.109 ± 0.043	2.696AsnVal: 2.696 ± 0.048	0.585AsnTrp: 0.585 ± 0.024	1.174AsnTyr: 1.174 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	4.597ProAla: 4.597 ± 0.067	0.437ProCys: 0.437 ± 0.018	2.784ProAsp: 2.784 ± 0.045	3.382ProGlu: 3.382 ± 0.058	1.897ProPhe: 1.897 ± 0.037	3.583ProGly: 3.583 ± 0.056	1.075ProHis: 1.075 ± 0.027	1.752ProIle: 1.752 ± 0.038	1.448ProLys: 1.448 ± 0.036	5.139ProLeu: 5.139 ± 0.074	1.132ProMet: 1.132 ± 0.027	1.239ProAsn: 1.239 ± 0.031	1.67ProPro: 1.67 ± 0.043	2.226ProGln: 2.226 ± 0.046	2.091ProArg: 2.091 ± 0.042	2.201ProSer: 2.201 ± 0.042	2.112ProThr: 2.112 ± 0.041	4.081ProVal: 4.081 ± 0.061	0.763ProTrp: 0.763 ± 0.023	1.178ProTyr: 1.178 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	4.495GlnAla: 4.495 ± 0.068	0.385GlnCys: 0.385 ± 0.019	1.803GlnAsp: 1.803 ± 0.039	2.239GlnGlu: 2.239 ± 0.045	1.479GlnPhe: 1.479 ± 0.035	3.053GlnGly: 3.053 ± 0.049	1.228GlnHis: 1.228 ± 0.032	2.259GlnIle: 2.259 ± 0.044	1.79GlnLys: 1.79 ± 0.039	4.855GlnLeu: 4.855 ± 0.062	1.202GlnMet: 1.202 ± 0.025	1.497GlnAsn: 1.497 ± 0.04	2.185GlnPro: 2.185 ± 0.051	3.194GlnGln: 3.194 ± 0.073	3.083GlnArg: 3.083 ± 0.055	2.259GlnSer: 2.259 ± 0.046	2.312GlnThr: 2.312 ± 0.043	2.948GlnVal: 2.948 ± 0.045	0.705GlnTrp: 0.705 ± 0.023	1.184GlnTyr: 1.184 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	4.756ArgAla: 4.756 ± 0.054	0.755ArgCys: 0.755 ± 0.024	3.111ArgAsp: 3.111 ± 0.052	3.854ArgGlu: 3.854 ± 0.058	2.601ArgPhe: 2.601 ± 0.043	3.482ArgGly: 3.482 ± 0.058	1.721ArgHis: 1.721 ± 0.038	3.489ArgIle: 3.489 ± 0.047	2.403ArgLys: 2.403 ± 0.044	6.445ArgLeu: 6.445 ± 0.083	1.796ArgMet: 1.796 ± 0.035	2.146ArgAsn: 2.146 ± 0.04	2.265ArgPro: 2.265 ± 0.047	3.201ArgGln: 3.201 ± 0.05	3.919ArgArg: 3.919 ± 0.063	2.906ArgSer: 2.906 ± 0.046	2.692ArgThr: 2.692 ± 0.045	3.867ArgVal: 3.867 ± 0.055	1.051ArgTrp: 1.051 ± 0.032	2.233ArgTyr: 2.233 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	5.767SerAla: 5.767 ± 0.072	0.646SerCys: 0.646 ± 0.024	3.085SerAsp: 3.085 ± 0.048	2.944SerGlu: 2.944 ± 0.048	2.227SerPhe: 2.227 ± 0.038	5.397SerGly: 5.397 ± 0.069	1.428SerHis: 1.428 ± 0.031	3.071SerIle: 3.071 ± 0.057	1.998SerLys: 1.998 ± 0.038	6.624SerLeu: 6.624 ± 0.074	1.555SerMet: 1.555 ± 0.031	1.816SerAsn: 1.816 ± 0.039	2.683SerPro: 2.683 ± 0.048	2.5SerGln: 2.5 ± 0.044	3.552SerArg: 3.552 ± 0.059	3.656SerSer: 3.656 ± 0.061	3.005SerThr: 3.005 ± 0.045	4.303SerVal: 4.303 ± 0.056	0.975SerTrp: 0.975 ± 0.029	1.598SerTyr: 1.598 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	5.025ThrAla: 5.025 ± 0.058	0.576ThrCys: 0.576 ± 0.021	2.647ThrAsp: 2.647 ± 0.048	2.711ThrGlu: 2.711 ± 0.048	2.089ThrPhe: 2.089 ± 0.039	4.752ThrGly: 4.752 ± 0.063	1.258ThrHis: 1.258 ± 0.029	2.92ThrIle: 2.92 ± 0.049	1.495ThrLys: 1.495 ± 0.036	7.517ThrLeu: 7.517 ± 0.084	1.21ThrMet: 1.21 ± 0.033	1.572ThrAsn: 1.572 ± 0.038	3.258ThrPro: 3.258 ± 0.053	2.23ThrGln: 2.23 ± 0.042	3.222ThrArg: 3.222 ± 0.051	2.951ThrSer: 2.951 ± 0.047	3.017ThrThr: 3.017 ± 0.048	3.939ThrVal: 3.939 ± 0.053	0.862ThrTrp: 0.862 ± 0.027	1.142ThrTyr: 1.142 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	7.054ValAla: 7.054 ± 0.084	0.853ValCys: 0.853 ± 0.026	3.733ValAsp: 3.733 ± 0.064	3.906ValGlu: 3.906 ± 0.056	2.582ValPhe: 2.582 ± 0.049	4.779ValGly: 4.779 ± 0.067	1.278ValHis: 1.278 ± 0.033	4.646ValIle: 4.646 ± 0.072	3.093ValLys: 3.093 ± 0.052	7.231ValLeu: 7.231 ± 0.084	2.307ValMet: 2.307 ± 0.045	2.799ValAsn: 2.799 ± 0.05	3.062ValPro: 3.062 ± 0.046	2.412ValGln: 2.412 ± 0.049	3.808ValArg: 3.808 ± 0.056	4.482ValSer: 4.482 ± 0.055	4.277ValThr: 4.277 ± 0.06	5.516ValVal: 5.516 ± 0.079	1.057ValTrp: 1.057 ± 0.033	1.731ValTyr: 1.731 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.021TrpAla: 1.021 ± 0.029	0.212TrpCys: 0.212 ± 0.012	0.645TrpAsp: 0.645 ± 0.025	0.613TrpGlu: 0.613 ± 0.021	0.712TrpPhe: 0.712 ± 0.024	0.939TrpGly: 0.939 ± 0.027	0.459TrpHis: 0.459 ± 0.018	0.739TrpIle: 0.739 ± 0.028	0.551TrpLys: 0.551 ± 0.023	2.311TrpLeu: 2.311 ± 0.051	0.498TrpMet: 0.498 ± 0.02	0.502TrpAsn: 0.502 ± 0.017	0.72TrpPro: 0.72 ± 0.022	1.195TrpGln: 1.195 ± 0.034	1.283TrpArg: 1.283 ± 0.033	0.866TrpSer: 0.866 ± 0.028	0.616TrpThr: 0.616 ± 0.021	0.948TrpVal: 0.948 ± 0.031	0.256TrpTrp: 0.256 ± 0.014	0.446TrpTyr: 0.446 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.528TyrAla: 2.528 ± 0.044	0.373TyrCys: 0.373 ± 0.017	1.529TyrAsp: 1.529 ± 0.034	1.201TyrGlu: 1.201 ± 0.036	1.144TyrPhe: 1.144 ± 0.03	2.195TyrGly: 2.195 ± 0.043	0.715TyrHis: 0.715 ± 0.023	1.44TyrIle: 1.44 ± 0.034	0.931TyrLys: 0.931 ± 0.029	2.947TyrLeu: 2.947 ± 0.049	0.605TyrMet: 0.605 ± 0.022	1.009TyrAsn: 1.009 ± 0.028	1.332TyrPro: 1.332 ± 0.03	1.555TyrGln: 1.555 ± 0.035	1.89TyrArg: 1.89 ± 0.041	1.747TyrSer: 1.747 ± 0.036	1.474TyrThr: 1.474 ± 0.034	1.65TyrVal: 1.65 ± 0.037	0.466TyrTrp: 0.466 ± 0.018	0.904TyrTyr: 0.904 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5320 proteins (1346380 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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