Amino acid dipepetide frequency for Corynebacterium otitidis ATCC 51513

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.968AlaAla: 21.968 ± 0.381	0.813AlaCys: 0.813 ± 0.039	7.491AlaAsp: 7.491 ± 0.119	9.975AlaGlu: 9.975 ± 0.17	3.24AlaPhe: 3.24 ± 0.079	14.092AlaGly: 14.092 ± 0.164	2.096AlaHis: 2.096 ± 0.06	5.215AlaIle: 5.215 ± 0.102	3.4AlaLys: 3.4 ± 0.095	13.518AlaLeu: 13.518 ± 0.224	2.289AlaMet: 2.289 ± 0.06	2.363AlaAsn: 2.363 ± 0.063	6.644AlaPro: 6.644 ± 0.137	3.222AlaGln: 3.222 ± 0.077	9.972AlaArg: 9.972 ± 0.144	5.818AlaSer: 5.818 ± 0.09	6.788AlaThr: 6.788 ± 0.119	10.368AlaVal: 10.368 ± 0.16	1.624AlaTrp: 1.624 ± 0.057	2.255AlaTyr: 2.255 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	0.721CysAla: 0.721 ± 0.034	0.059CysCys: 0.059 ± 0.009	0.333CysAsp: 0.333 ± 0.025	0.349CysGlu: 0.349 ± 0.022	0.187CysPhe: 0.187 ± 0.017	0.642CysGly: 0.642 ± 0.031	0.144CysHis: 0.144 ± 0.016	0.187CysIle: 0.187 ± 0.019	0.079CysLys: 0.079 ± 0.012	0.536CysLeu: 0.536 ± 0.031	0.09CysMet: 0.09 ± 0.013	0.111CysAsn: 0.111 ± 0.013	0.377CysPro: 0.377 ± 0.024	0.149CysGln: 0.149 ± 0.016	0.447CysArg: 0.447 ± 0.028	0.351CysSer: 0.351 ± 0.023	0.316CysThr: 0.316 ± 0.021	0.406CysVal: 0.406 ± 0.025	0.079CysTrp: 0.079 ± 0.012	0.147CysTyr: 0.147 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	7.628AspAla: 7.628 ± 0.128	0.32AspCys: 0.32 ± 0.024	4.159AspAsp: 4.159 ± 0.094	6.545AspGlu: 6.545 ± 0.121	1.816AspPhe: 1.816 ± 0.054	5.59AspGly: 5.59 ± 0.107	1.136AspHis: 1.136 ± 0.049	2.368AspIle: 2.368 ± 0.065	1.611AspLys: 1.611 ± 0.067	5.588AspLeu: 5.588 ± 0.111	0.919AspMet: 0.919 ± 0.038	1.485AspAsn: 1.485 ± 0.053	4.107AspPro: 4.107 ± 0.101	1.49AspGln: 1.49 ± 0.048	4.279AspArg: 4.279 ± 0.097	3.138AspSer: 3.138 ± 0.079	2.82AspThr: 2.82 ± 0.068	4.949AspVal: 4.949 ± 0.098	0.801AspTrp: 0.801 ± 0.039	1.56AspTyr: 1.56 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	9.284GluAla: 9.284 ± 0.161	0.334GluCys: 0.334 ± 0.023	4.615GluAsp: 4.615 ± 0.11	6.306GluGlu: 6.306 ± 0.12	2.085GluPhe: 2.085 ± 0.066	5.973GluGly: 5.973 ± 0.122	1.617GluHis: 1.617 ± 0.062	3.333GluIle: 3.333 ± 0.076	2.291GluLys: 2.291 ± 0.068	7.892GluLeu: 7.892 ± 0.129	1.011GluMet: 1.011 ± 0.046	1.74GluAsn: 1.74 ± 0.06	4.739GluPro: 4.739 ± 0.122	2.452GluGln: 2.452 ± 0.07	6.707GluArg: 6.707 ± 0.14	3.138GluSer: 3.138 ± 0.069	3.514GluThr: 3.514 ± 0.077	5.31GluVal: 5.31 ± 0.102	0.811GluTrp: 0.811 ± 0.038	1.065GluTyr: 1.065 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.61PheAla: 3.61 ± 0.076	0.211PheCys: 0.211 ± 0.019	2.137PheAsp: 2.137 ± 0.064	1.822PheGlu: 1.822 ± 0.061	1.119PhePhe: 1.119 ± 0.055	3.145PheGly: 3.145 ± 0.09	0.585PheHis: 0.585 ± 0.032	1.15PheIle: 1.15 ± 0.047	0.611PheLys: 0.611 ± 0.033	2.855PheLeu: 2.855 ± 0.081	0.408PheMet: 0.408 ± 0.028	0.752PheAsn: 0.752 ± 0.039	1.367PhePro: 1.367 ± 0.049	0.778PheGln: 0.778 ± 0.031	1.734PheArg: 1.734 ± 0.055	1.98PheSer: 1.98 ± 0.06	1.681PheThr: 1.681 ± 0.056	2.576PheVal: 2.576 ± 0.074	0.365PheTrp: 0.365 ± 0.027	0.734PheTyr: 0.734 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	11.006GlyAla: 11.006 ± 0.163	0.664GlyCys: 0.664 ± 0.039	5.442GlyAsp: 5.442 ± 0.111	8.064GlyGlu: 8.064 ± 0.126	3.128GlyPhe: 3.128 ± 0.077	8.959GlyGly: 8.959 ± 0.165	1.801GlyHis: 1.801 ± 0.062	4.259GlyIle: 4.259 ± 0.086	2.615GlyLys: 2.615 ± 0.079	9.864GlyLeu: 9.864 ± 0.171	1.87GlyMet: 1.87 ± 0.06	1.978GlyAsn: 1.978 ± 0.061	4.335GlyPro: 4.335 ± 0.09	2.655GlyGln: 2.655 ± 0.074	7.188GlyArg: 7.188 ± 0.133	5.197GlySer: 5.197 ± 0.094	4.541GlyThr: 4.541 ± 0.081	7.723GlyVal: 7.723 ± 0.119	1.449GlyTrp: 1.449 ± 0.044	2.078GlyTyr: 2.078 ± 0.067	0.0GlyXaa: 0.0 ± 0.0
His	2.068HisAla: 2.068 ± 0.067	0.123HisCys: 0.123 ± 0.015	1.2HisAsp: 1.2 ± 0.047	1.27HisGlu: 1.27 ± 0.049	0.492HisPhe: 0.492 ± 0.031	1.642HisGly: 1.642 ± 0.057	0.431HisHis: 0.431 ± 0.029	0.618HisIle: 0.618 ± 0.037	0.333HisLys: 0.333 ± 0.022	1.806HisLeu: 1.806 ± 0.057	0.298HisMet: 0.298 ± 0.025	0.505HisAsn: 0.505 ± 0.031	1.444HisPro: 1.444 ± 0.044	0.521HisGln: 0.521 ± 0.031	1.495HisArg: 1.495 ± 0.045	0.905HisSer: 0.905 ± 0.038	0.95HisThr: 0.95 ± 0.036	1.542HisVal: 1.542 ± 0.05	0.252HisTrp: 0.252 ± 0.022	0.434HisTyr: 0.434 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.99IleAla: 5.99 ± 0.107	0.238IleCys: 0.238 ± 0.02	3.4IleAsp: 3.4 ± 0.074	2.856IleGlu: 2.856 ± 0.076	1.167IlePhe: 1.167 ± 0.052	4.031IleGly: 4.031 ± 0.1	0.667IleHis: 0.667 ± 0.037	1.662IleIle: 1.662 ± 0.067	1.023IleLys: 1.023 ± 0.043	3.412IleLeu: 3.412 ± 0.081	0.623IleMet: 0.623 ± 0.036	1.093IleAsn: 1.093 ± 0.053	2.107IlePro: 2.107 ± 0.062	0.872IleGln: 0.872 ± 0.038	2.257IleArg: 2.257 ± 0.06	2.221IleSer: 2.221 ± 0.061	2.466IleThr: 2.466 ± 0.064	4.056IleVal: 4.056 ± 0.084	0.365IleTrp: 0.365 ± 0.025	0.752IleTyr: 0.752 ± 0.04	0.0IleXaa: 0.0 ± 0.0
Lys	3.056LysAla: 3.056 ± 0.087	0.08LysCys: 0.08 ± 0.011	1.822LysAsp: 1.822 ± 0.068	2.045LysGlu: 2.045 ± 0.075	0.538LysPhe: 0.538 ± 0.032	1.953LysGly: 1.953 ± 0.072	0.497LysHis: 0.497 ± 0.031	1.114LysIle: 1.114 ± 0.048	1.481LysLys: 1.481 ± 0.091	2.339LysLeu: 2.339 ± 0.067	0.454LysMet: 0.454 ± 0.027	0.954LysAsn: 0.954 ± 0.039	1.662LysPro: 1.662 ± 0.064	0.772LysGln: 0.772 ± 0.039	2.153LysArg: 2.153 ± 0.072	1.208LysSer: 1.208 ± 0.05	1.427LysThr: 1.427 ± 0.05	1.988LysVal: 1.988 ± 0.069	0.277LysTrp: 0.277 ± 0.021	0.451LysTyr: 0.451 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	14.423LeuAla: 14.423 ± 0.199	0.515LeuCys: 0.515 ± 0.033	6.534LeuAsp: 6.534 ± 0.116	6.234LeuGlu: 6.234 ± 0.115	2.714LeuPhe: 2.714 ± 0.079	9.613LeuGly: 9.613 ± 0.17	1.586LeuHis: 1.586 ± 0.05	4.13LeuIle: 4.13 ± 0.101	2.81LeuLys: 2.81 ± 0.079	8.923LeuLeu: 8.923 ± 0.168	1.386LeuMet: 1.386 ± 0.052	2.148LeuAsn: 2.148 ± 0.062	5.65LeuPro: 5.65 ± 0.114	2.062LeuGln: 2.062 ± 0.067	6.634LeuArg: 6.634 ± 0.118	6.031LeuSer: 6.031 ± 0.101	5.269LeuThr: 5.269 ± 0.111	8.854LeuVal: 8.854 ± 0.133	1.078LeuTrp: 1.078 ± 0.05	1.74LeuTyr: 1.74 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	2.461MetAla: 2.461 ± 0.068	0.085MetCys: 0.085 ± 0.011	0.729MetAsp: 0.729 ± 0.037	0.664MetGlu: 0.664 ± 0.033	0.485MetPhe: 0.485 ± 0.033	1.314MetGly: 1.314 ± 0.051	0.27MetHis: 0.27 ± 0.021	0.782MetIle: 0.782 ± 0.043	0.374MetLys: 0.374 ± 0.023	1.616MetLeu: 1.616 ± 0.054	0.285MetMet: 0.285 ± 0.024	0.323MetAsn: 0.323 ± 0.023	0.949MetPro: 0.949 ± 0.041	0.395MetGln: 0.395 ± 0.027	1.277MetArg: 1.277 ± 0.059	1.282MetSer: 1.282 ± 0.045	1.372MetThr: 1.372 ± 0.049	1.206MetVal: 1.206 ± 0.05	0.172MetTrp: 0.172 ± 0.017	0.267MetTyr: 0.267 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	2.535AsnAla: 2.535 ± 0.065	0.138AsnCys: 0.138 ± 0.015	1.434AsnAsp: 1.434 ± 0.052	1.483AsnGlu: 1.483 ± 0.055	0.695AsnPhe: 0.695 ± 0.034	1.842AsnGly: 1.842 ± 0.064	0.459AsnHis: 0.459 ± 0.027	0.949AsnIle: 0.949 ± 0.044	0.623AsnLys: 0.623 ± 0.034	2.14AsnLeu: 2.14 ± 0.061	0.38AsnMet: 0.38 ± 0.026	0.641AsnAsn: 0.641 ± 0.04	1.765AsnPro: 1.765 ± 0.066	0.693AsnGln: 0.693 ± 0.033	1.534AsnArg: 1.534 ± 0.046	1.185AsnSer: 1.185 ± 0.045	1.15AsnThr: 1.15 ± 0.047	1.56AsnVal: 1.56 ± 0.054	0.308AsnTrp: 0.308 ± 0.021	0.564AsnTyr: 0.564 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	7.933ProAla: 7.933 ± 0.153	0.218ProCys: 0.218 ± 0.02	3.622ProAsp: 3.622 ± 0.092	5.637ProGlu: 5.637 ± 0.135	1.495ProPhe: 1.495 ± 0.047	6.385ProGly: 6.385 ± 0.125	0.993ProHis: 0.993 ± 0.038	1.904ProIle: 1.904 ± 0.055	1.586ProLys: 1.586 ± 0.056	4.543ProLeu: 4.543 ± 0.085	0.841ProMet: 0.841 ± 0.037	1.168ProAsn: 1.168 ± 0.043	2.299ProPro: 2.299 ± 0.074	1.46ProGln: 1.46 ± 0.06	3.717ProArg: 3.717 ± 0.073	2.72ProSer: 2.72 ± 0.077	3.068ProThr: 3.068 ± 0.069	4.764ProVal: 4.764 ± 0.092	0.664ProTrp: 0.664 ± 0.034	0.921ProTyr: 0.921 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	3.489GlnAla: 3.489 ± 0.085	0.128GlnCys: 0.128 ± 0.015	1.395GlnAsp: 1.395 ± 0.047	1.506GlnGlu: 1.506 ± 0.058	0.77GlnPhe: 0.77 ± 0.034	1.996GlnGly: 1.996 ± 0.062	0.436GlnHis: 0.436 ± 0.03	1.227GlnIle: 1.227 ± 0.046	0.718GlnLys: 0.718 ± 0.042	2.996GlnLeu: 2.996 ± 0.08	0.472GlnMet: 0.472 ± 0.026	0.578GlnAsn: 0.578 ± 0.028	1.632GlnPro: 1.632 ± 0.066	1.029GlnGln: 1.029 ± 0.052	2.355GlnArg: 2.355 ± 0.059	1.245GlnSer: 1.245 ± 0.04	1.131GlnThr: 1.131 ± 0.042	2.15GlnVal: 2.15 ± 0.062	0.4GlnTrp: 0.4 ± 0.027	0.483GlnTyr: 0.483 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	9.103ArgAla: 9.103 ± 0.155	0.374ArgCys: 0.374 ± 0.026	4.313ArgAsp: 4.313 ± 0.088	5.378ArgGlu: 5.378 ± 0.107	2.234ArgPhe: 2.234 ± 0.06	6.558ArgGly: 6.558 ± 0.113	1.568ArgHis: 1.568 ± 0.05	2.968ArgIle: 2.968 ± 0.072	1.667ArgLys: 1.667 ± 0.056	8.092ArgLeu: 8.092 ± 0.143	1.381ArgMet: 1.381 ± 0.046	1.349ArgAsn: 1.349 ± 0.045	4.289ArgPro: 4.289 ± 0.094	2.121ArgGln: 2.121 ± 0.067	7.668ArgArg: 7.668 ± 0.146	3.841ArgSer: 3.841 ± 0.088	3.302ArgThr: 3.302 ± 0.073	5.639ArgVal: 5.639 ± 0.117	1.008ArgTrp: 1.008 ± 0.042	1.655ArgTyr: 1.655 ± 0.057	0.0ArgXaa: 0.0 ± 0.0
Ser	6.154SerAla: 6.154 ± 0.113	0.29SerCys: 0.29 ± 0.024	2.847SerAsp: 2.847 ± 0.071	3.237SerGlu: 3.237 ± 0.073	1.95SerPhe: 1.95 ± 0.061	6.024SerGly: 6.024 ± 0.093	1.044SerHis: 1.044 ± 0.039	2.137SerIle: 2.137 ± 0.059	1.326SerLys: 1.326 ± 0.05	5.18SerLeu: 5.18 ± 0.091	1.052SerMet: 1.052 ± 0.041	1.186SerAsn: 1.186 ± 0.05	3.153SerPro: 3.153 ± 0.072	1.483SerGln: 1.483 ± 0.052	3.751SerArg: 3.751 ± 0.091	3.246SerSer: 3.246 ± 0.076	2.93SerThr: 2.93 ± 0.081	3.93SerVal: 3.93 ± 0.085	0.855SerTrp: 0.855 ± 0.041	1.218SerTyr: 1.218 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	6.334ThrAla: 6.334 ± 0.105	0.3ThrCys: 0.3 ± 0.018	3.132ThrAsp: 3.132 ± 0.068	3.022ThrGlu: 3.022 ± 0.076	1.668ThrPhe: 1.668 ± 0.058	5.265ThrGly: 5.265 ± 0.098	0.959ThrHis: 0.959 ± 0.045	2.594ThrIle: 2.594 ± 0.066	1.342ThrLys: 1.342 ± 0.055	4.998ThrLeu: 4.998 ± 0.087	0.852ThrMet: 0.852 ± 0.037	1.175ThrAsn: 1.175 ± 0.051	3.358ThrPro: 3.358 ± 0.079	1.288ThrGln: 1.288 ± 0.045	3.219ThrArg: 3.219 ± 0.071	2.897ThrSer: 2.897 ± 0.071	3.45ThrThr: 3.45 ± 0.092	5.02ThrVal: 5.02 ± 0.092	0.703ThrTrp: 0.703 ± 0.033	1.029ThrTyr: 1.029 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	11.911ValAla: 11.911 ± 0.149	0.58ValCys: 0.58 ± 0.032	5.857ValAsp: 5.857 ± 0.109	5.932ValGlu: 5.932 ± 0.1	2.658ValPhe: 2.658 ± 0.069	7.037ValGly: 7.037 ± 0.133	1.398ValHis: 1.398 ± 0.048	3.543ValIle: 3.543 ± 0.086	1.737ValLys: 1.737 ± 0.064	7.987ValLeu: 7.987 ± 0.129	1.275ValMet: 1.275 ± 0.052	1.699ValAsn: 1.699 ± 0.06	4.29ValPro: 4.29 ± 0.086	1.537ValGln: 1.537 ± 0.056	5.038ValArg: 5.038 ± 0.097	4.798ValSer: 4.798 ± 0.084	4.8ValThr: 4.8 ± 0.082	8.61ValVal: 8.61 ± 0.142	0.919ValTrp: 0.919 ± 0.039	1.524ValTyr: 1.524 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	1.404TrpAla: 1.404 ± 0.05	0.097TrpCys: 0.097 ± 0.013	0.641TrpAsp: 0.641 ± 0.032	0.644TrpGlu: 0.644 ± 0.032	0.508TrpPhe: 0.508 ± 0.03	0.972TrpGly: 0.972 ± 0.044	0.262TrpHis: 0.262 ± 0.022	0.472TrpIle: 0.472 ± 0.029	0.257TrpLys: 0.257 ± 0.019	1.775TrpLeu: 1.775 ± 0.059	0.185TrpMet: 0.185 ± 0.02	0.311TrpAsn: 0.311 ± 0.023	0.608TrpPro: 0.608 ± 0.034	0.459TrpGln: 0.459 ± 0.027	1.272TrpArg: 1.272 ± 0.049	0.685TrpSer: 0.685 ± 0.029	0.569TrpThr: 0.569 ± 0.03	1.029TrpVal: 1.029 ± 0.042	0.28TrpTrp: 0.28 ± 0.024	0.264TrpTyr: 0.264 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.071TyrAla: 2.071 ± 0.066	0.146TyrCys: 0.146 ± 0.014	1.209TyrAsp: 1.209 ± 0.046	1.247TyrGlu: 1.247 ± 0.053	0.675TyrPhe: 0.675 ± 0.035	1.781TyrGly: 1.781 ± 0.055	0.379TyrHis: 0.379 ± 0.026	0.646TyrIle: 0.646 ± 0.032	0.387TyrLys: 0.387 ± 0.026	2.275TyrLeu: 2.275 ± 0.063	0.233TyrMet: 0.233 ± 0.02	0.516TyrAsn: 0.516 ± 0.033	1.164TyrPro: 1.164 ± 0.047	0.7TyrGln: 0.7 ± 0.034	1.814TyrArg: 1.814 ± 0.062	1.108TyrSer: 1.108 ± 0.039	1.06TyrThr: 1.06 ± 0.041	1.45TyrVal: 1.45 ± 0.054	0.282TyrTrp: 0.282 ± 0.021	0.452TyrTyr: 0.452 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1846 proteins (610217 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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