Amino acid dipepetide frequency for Torque teno midi virus 1 (isolate MD1-073)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.886AlaAla: 9.886 ± 4.378
0.76AlaCys: 0.76 ± 0.461
6.844AlaAsp: 6.844 ± 5.155
6.084AlaGlu: 6.084 ± 3.268
1.521AlaPhe: 1.521 ± 0.72
0.76AlaGly: 0.76 ± 0.796
3.042AlaHis: 3.042 ± 2.043
3.042AlaIle: 3.042 ± 1.846
4.563AlaLys: 4.563 ± 1.376
1.521AlaLeu: 1.521 ± 0.754
0.0AlaMet: 0.0 ± 0.0
0.0AlaAsn: 0.0 ± 0.0
1.521AlaPro: 1.521 ± 0.923
1.521AlaGln: 1.521 ± 1.593
2.281AlaArg: 2.281 ± 0.841
2.281AlaSer: 2.281 ± 1.718
4.563AlaThr: 4.563 ± 0.797
2.281AlaVal: 2.281 ± 1.718
0.76AlaTrp: 0.76 ± 0.461
0.76AlaTyr: 0.76 ± 0.461
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.76CysCys: 0.76 ± 0.461
4.563CysAsp: 4.563 ± 3.437
3.802CysGlu: 3.802 ± 0.991
0.0CysPhe: 0.0 ± 0.0
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.76CysIle: 0.76 ± 0.461
0.76CysLys: 0.76 ± 0.461
3.802CysLeu: 3.802 ± 0.991
0.0CysMet: 0.0 ± 0.0
1.521CysAsn: 1.521 ± 0.754
0.76CysPro: 0.76 ± 0.925
0.76CysGln: 0.76 ± 0.461
3.042CysArg: 3.042 ± 1.325
2.281CysSer: 2.281 ± 0.841
0.0CysThr: 0.0 ± 0.0
0.76CysVal: 0.76 ± 0.461
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
4.563AspAla: 4.563 ± 3.437
2.281AspCys: 2.281 ± 1.718
0.76AspAsp: 0.76 ± 0.461
0.0AspGlu: 0.0 ± 0.0
9.886AspPhe: 9.886 ± 6.466
1.521AspGly: 1.521 ± 0.754
0.0AspHis: 0.0 ± 0.0
0.76AspIle: 0.76 ± 0.461
1.521AspLys: 1.521 ± 0.72
4.563AspLeu: 4.563 ± 0.797
0.0AspMet: 0.0 ± 0.0
1.521AspAsn: 1.521 ± 0.923
1.521AspPro: 1.521 ± 0.923
2.281AspGln: 2.281 ± 0.91
2.281AspArg: 2.281 ± 1.718
9.125AspSer: 9.125 ± 1.595
3.802AspThr: 3.802 ± 0.991
0.76AspVal: 0.76 ± 0.461
0.76AspTrp: 0.76 ± 0.461
3.042AspTyr: 3.042 ± 1.128
0.0AspXaa: 0.0 ± 0.0
Glu
1.521GluAla: 1.521 ± 0.923
0.76GluCys: 0.76 ± 0.925
8.365GluAsp: 8.365 ± 4.961
9.125GluGlu: 9.125 ± 3.974
0.0GluPhe: 0.0 ± 0.0
4.563GluGly: 4.563 ± 0.797
0.0GluHis: 0.0 ± 0.0
3.042GluIle: 3.042 ± 1.325
6.844GluLys: 6.844 ± 3.664
1.521GluLeu: 1.521 ± 0.72
1.521GluMet: 1.521 ± 0.85
2.281GluAsn: 2.281 ± 0.91
0.76GluPro: 0.76 ± 0.461
4.563GluGln: 4.563 ± 1.243
0.76GluArg: 0.76 ± 0.461
2.281GluSer: 2.281 ± 1.384
9.886GluThr: 9.886 ± 3.524
0.76GluVal: 0.76 ± 0.461
0.76GluTrp: 0.76 ± 0.461
2.281GluTyr: 2.281 ± 1.384
0.0GluXaa: 0.0 ± 0.0
Phe
3.042PheAla: 3.042 ± 1.325
0.0PheCys: 0.0 ± 0.0
0.0PheAsp: 0.0 ± 0.0
1.521PheGlu: 1.521 ± 0.72
0.76PhePhe: 0.76 ± 0.461
0.76PheGly: 0.76 ± 0.461
2.281PheHis: 2.281 ± 0.91
1.521PheIle: 1.521 ± 0.923
3.802PheLys: 3.802 ± 2.142
0.0PheLeu: 0.0 ± 0.0
0.0PheMet: 0.0 ± 0.0
0.76PheAsn: 0.76 ± 0.796
4.563PhePro: 4.563 ± 0.797
3.802PheGln: 3.802 ± 0.991
2.281PheArg: 2.281 ± 1.718
0.76PheSer: 0.76 ± 0.461
3.042PheThr: 3.042 ± 2.043
2.281PheVal: 2.281 ± 1.384
3.042PheTrp: 3.042 ± 1.846
5.323PheTyr: 5.323 ± 0.933
0.0PheXaa: 0.0 ± 0.0
Gly
3.802GlyAla: 3.802 ± 1.626
1.521GlyCys: 1.521 ± 0.923
0.0GlyAsp: 0.0 ± 0.0
0.76GlyGlu: 0.76 ± 0.461
2.281GlyPhe: 2.281 ± 0.91
8.365GlyGly: 8.365 ± 1.384
3.042GlyHis: 3.042 ± 1.325
2.281GlyIle: 2.281 ± 1.718
4.563GlyLys: 4.563 ± 1.82
1.521GlyLeu: 1.521 ± 0.72
2.281GlyMet: 2.281 ± 1.97
3.042GlyAsn: 3.042 ± 1.251
1.521GlyPro: 1.521 ± 0.923
0.76GlyGln: 0.76 ± 0.461
4.563GlyArg: 4.563 ± 0.797
0.0GlySer: 0.0 ± 0.0
3.042GlyThr: 3.042 ± 0.704
2.281GlyVal: 2.281 ± 0.841
0.0GlyTrp: 0.0 ± 0.0
2.281GlyTyr: 2.281 ± 1.384
0.0GlyXaa: 0.0 ± 0.0
His
0.76HisAla: 0.76 ± 0.925
0.0HisCys: 0.0 ± 0.0
3.802HisAsp: 3.802 ± 0.991
0.76HisGlu: 0.76 ± 0.461
0.76HisPhe: 0.76 ± 0.461
0.0HisGly: 0.0 ± 0.0
0.0HisHis: 0.0 ± 0.0
0.76HisIle: 0.76 ± 0.461
1.521HisLys: 1.521 ± 0.754
3.802HisLeu: 3.802 ± 2.427
0.76HisMet: 0.76 ± 0.461
0.76HisAsn: 0.76 ± 0.461
3.042HisPro: 3.042 ± 1.438
1.521HisGln: 1.521 ± 0.754
0.0HisArg: 0.0 ± 0.0
0.0HisSer: 0.0 ± 0.0
2.281HisThr: 2.281 ± 1.718
0.0HisVal: 0.0 ± 0.0
0.76HisTrp: 0.76 ± 0.461
2.281HisTyr: 2.281 ± 0.841
0.0HisXaa: 0.0 ± 0.0
Ile
3.802IleAla: 3.802 ± 0.991
0.76IleCys: 0.76 ± 0.461
3.042IleAsp: 3.042 ± 1.846
6.084IleGlu: 6.084 ± 2.649
3.802IlePhe: 3.802 ± 0.991
1.521IleGly: 1.521 ± 0.923
0.76IleHis: 0.76 ± 0.925
3.042IleIle: 3.042 ± 1.251
3.802IleLys: 3.802 ± 2.307
4.563IleLeu: 4.563 ± 0.797
0.76IleMet: 0.76 ± 0.461
2.281IleAsn: 2.281 ± 1.384
0.76IlePro: 0.76 ± 0.461
6.084IleGln: 6.084 ± 1.781
0.0IleArg: 0.0 ± 0.0
1.521IleSer: 1.521 ± 0.923
3.802IleThr: 3.802 ± 1.575
3.802IleVal: 3.802 ± 2.307
1.521IleTrp: 1.521 ± 0.923
0.76IleTyr: 0.76 ± 0.461
0.0IleXaa: 0.0 ± 0.0
Lys
0.0LysAla: 0.0 ± 0.0
0.76LysCys: 0.76 ± 0.461
5.323LysAsp: 5.323 ± 1.505
9.125LysGlu: 9.125 ± 3.958
1.521LysPhe: 1.521 ± 0.923
2.281LysGly: 2.281 ± 0.91
3.042LysHis: 3.042 ± 0.704
4.563LysIle: 4.563 ± 2.077
10.646LysLys: 10.646 ± 3.284
6.084LysLeu: 6.084 ± 2.791
0.0LysMet: 0.0 ± 0.0
4.563LysAsn: 4.563 ± 0.797
6.084LysPro: 6.084 ± 1.54
3.042LysGln: 3.042 ± 1.846
9.125LysArg: 9.125 ± 3.022
2.281LysSer: 2.281 ± 0.91
12.167LysThr: 12.167 ± 3.264
3.042LysVal: 3.042 ± 1.128
1.521LysTrp: 1.521 ± 0.923
5.323LysTyr: 5.323 ± 2.515
0.0LysXaa: 0.0 ± 0.0
Leu
6.844LeuAla: 6.844 ± 2.858
2.281LeuCys: 2.281 ± 1.384
0.76LeuAsp: 0.76 ± 0.461
2.281LeuGlu: 2.281 ± 1.384
0.76LeuPhe: 0.76 ± 0.796
1.521LeuGly: 1.521 ± 0.923
2.281LeuHis: 2.281 ± 0.841
4.563LeuIle: 4.563 ± 1.683
8.365LeuLys: 8.365 ± 2.585
12.167LeuLeu: 12.167 ± 2.456
0.0LeuMet: 0.0 ± 0.0
1.521LeuAsn: 1.521 ± 0.72
5.323LeuPro: 5.323 ± 1.575
4.563LeuGln: 4.563 ± 2.768
2.281LeuArg: 2.281 ± 0.91
9.125LeuSer: 9.125 ± 3.933
4.563LeuThr: 4.563 ± 1.966
1.521LeuVal: 1.521 ± 0.72
1.521LeuTrp: 1.521 ± 0.923
2.281LeuTyr: 2.281 ± 1.384
0.0LeuXaa: 0.0 ± 0.0
Met
2.281MetAla: 2.281 ± 1.718
0.76MetCys: 0.76 ± 0.925
0.0MetAsp: 0.0 ± 0.0
0.0MetGlu: 0.0 ± 0.0
1.521MetPhe: 1.521 ± 0.923
0.0MetGly: 0.0 ± 0.0
0.0MetHis: 0.0 ± 0.0
1.521MetIle: 1.521 ± 0.923
0.76MetLys: 0.76 ± 0.461
1.521MetLeu: 1.521 ± 0.923
0.76MetMet: 0.76 ± 0.925
0.76MetAsn: 0.76 ± 0.461
1.521MetPro: 1.521 ± 0.72
3.042MetGln: 3.042 ± 1.325
0.0MetArg: 0.0 ± 0.0
3.042MetSer: 3.042 ± 2.043
1.521MetThr: 1.521 ± 0.754
0.0MetVal: 0.0 ± 0.0
2.281MetTrp: 2.281 ± 1.718
0.76MetTyr: 0.76 ± 0.461
0.0MetXaa: 0.0 ± 0.0
Asn
0.76AsnAla: 0.76 ± 0.461
2.281AsnCys: 2.281 ± 1.718
0.0AsnAsp: 0.0 ± 0.0
0.76AsnGlu: 0.76 ± 0.461
2.281AsnPhe: 2.281 ± 1.446
3.042AsnGly: 3.042 ± 2.221
0.0AsnHis: 0.0 ± 0.0
5.323AsnIle: 5.323 ± 0.846
4.563AsnLys: 4.563 ± 1.918
5.323AsnLeu: 5.323 ± 1.024
0.76AsnMet: 0.76 ± 0.925
1.521AsnAsn: 1.521 ± 0.923
3.042AsnPro: 3.042 ± 1.846
6.844AsnGln: 6.844 ± 1.739
1.521AsnArg: 1.521 ± 0.72
3.802AsnSer: 3.802 ± 1.779
0.76AsnThr: 0.76 ± 0.461
0.76AsnVal: 0.76 ± 0.925
0.0AsnTrp: 0.0 ± 0.0
2.281AsnTyr: 2.281 ± 1.384
0.0AsnXaa: 0.0 ± 0.0
Pro
3.802ProAla: 3.802 ± 1.651
2.281ProCys: 2.281 ± 1.718
2.281ProAsp: 2.281 ± 1.384
0.0ProGlu: 0.0 ± 0.0
4.563ProPhe: 4.563 ± 1.243
6.084ProGly: 6.084 ± 1.54
0.76ProHis: 0.76 ± 0.461
1.521ProIle: 1.521 ± 0.754
3.802ProLys: 3.802 ± 2.307
4.563ProLeu: 4.563 ± 2.16
0.76ProMet: 0.76 ± 0.796
0.76ProAsn: 0.76 ± 0.461
5.323ProPro: 5.323 ± 1.837
3.042ProGln: 3.042 ± 1.251
5.323ProArg: 5.323 ± 2.207
0.76ProSer: 0.76 ± 0.461
2.281ProThr: 2.281 ± 0.91
1.521ProVal: 1.521 ± 0.923
1.521ProTrp: 1.521 ± 0.72
2.281ProTyr: 2.281 ± 1.384
0.0ProXaa: 0.0 ± 0.0
Gln
3.802GlnAla: 3.802 ± 2.142
1.521GlnCys: 1.521 ± 0.923
0.76GlnAsp: 0.76 ± 0.461
6.084GlnGlu: 6.084 ± 1.977
1.521GlnPhe: 1.521 ± 0.923
1.521GlnGly: 1.521 ± 0.72
1.521GlnHis: 1.521 ± 0.754
1.521GlnIle: 1.521 ± 0.923
6.844GlnLys: 6.844 ± 0.796
5.323GlnLeu: 5.323 ± 2.26
3.042GlnMet: 3.042 ± 1.325
6.084GlnAsn: 6.084 ± 3.416
3.802GlnPro: 3.802 ± 1.575
9.886GlnGln: 9.886 ± 4.265
1.521GlnArg: 1.521 ± 0.923
2.281GlnSer: 2.281 ± 1.623
7.605GlnThr: 7.605 ± 3.009
0.0GlnVal: 0.0 ± 0.0
2.281GlnTrp: 2.281 ± 1.384
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
0.0ArgAla: 0.0 ± 0.0
0.76ArgCys: 0.76 ± 0.925
2.281ArgAsp: 2.281 ± 1.718
2.281ArgGlu: 2.281 ± 1.718
3.042ArgPhe: 3.042 ± 1.44
1.521ArgGly: 1.521 ± 0.923
0.76ArgHis: 0.76 ± 0.461
1.521ArgIle: 1.521 ± 0.72
10.646ArgLys: 10.646 ± 3.744
2.281ArgLeu: 2.281 ± 0.91
2.281ArgMet: 2.281 ± 1.242
3.042ArgAsn: 3.042 ± 1.128
2.281ArgPro: 2.281 ± 1.446
2.281ArgGln: 2.281 ± 1.384
13.688ArgArg: 13.688 ± 6.523
2.281ArgSer: 2.281 ± 1.623
6.844ArgThr: 6.844 ± 2.858
0.0ArgVal: 0.0 ± 0.0
0.0ArgTrp: 0.0 ± 0.0
6.084ArgTyr: 6.084 ± 0.793
0.0ArgXaa: 0.0 ± 0.0
Ser
3.042SerAla: 3.042 ± 2.205
0.0SerCys: 0.0 ± 0.0
2.281SerAsp: 2.281 ± 1.384
2.281SerGlu: 2.281 ± 0.91
1.521SerPhe: 1.521 ± 0.923
7.605SerGly: 7.605 ± 4.749
2.281SerHis: 2.281 ± 1.718
4.563SerIle: 4.563 ± 0.797
3.042SerLys: 3.042 ± 1.128
4.563SerLeu: 4.563 ± 1.181
2.281SerMet: 2.281 ± 1.41
1.521SerAsn: 1.521 ± 0.754
2.281SerPro: 2.281 ± 1.446
1.521SerGln: 1.521 ± 0.754
1.521SerArg: 1.521 ± 1.849
11.407SerSer: 11.407 ± 12.679
6.844SerThr: 6.844 ± 1.969
1.521SerVal: 1.521 ± 0.923
2.281SerTrp: 2.281 ± 1.718
0.0SerTyr: 0.0 ± 0.0
0.0SerXaa: 0.0 ± 0.0
Thr
0.76ThrAla: 0.76 ± 0.461
3.042ThrCys: 3.042 ± 1.325
4.563ThrAsp: 4.563 ± 1.376
7.605ThrGlu: 7.605 ± 1.183
0.76ThrPhe: 0.76 ± 0.461
1.521ThrGly: 1.521 ± 0.754
2.281ThrHis: 2.281 ± 0.841
8.365ThrIle: 8.365 ± 1.739
8.365ThrLys: 8.365 ± 0.822
3.042ThrLeu: 3.042 ± 0.704
0.76ThrMet: 0.76 ± 0.461
7.605ThrAsn: 7.605 ± 3.178
4.563ThrPro: 4.563 ± 1.243
5.323ThrGln: 5.323 ± 2.373
7.605ThrArg: 7.605 ± 3.253
4.563ThrSer: 4.563 ± 2.674
6.844ThrThr: 6.844 ± 3.284
0.76ThrVal: 0.76 ± 0.461
0.76ThrTrp: 0.76 ± 0.461
2.281ThrTyr: 2.281 ± 1.384
0.0ThrXaa: 0.0 ± 0.0
Val
3.802ValAla: 3.802 ± 1.779
0.0ValCys: 0.0 ± 0.0
0.76ValAsp: 0.76 ± 0.461
0.76ValGlu: 0.76 ± 0.461
0.0ValPhe: 0.0 ± 0.0
0.0ValGly: 0.0 ± 0.0
0.76ValHis: 0.76 ± 0.925
1.521ValIle: 1.521 ± 0.923
1.521ValLys: 1.521 ± 0.923
3.802ValLeu: 3.802 ± 2.307
0.76ValMet: 0.76 ± 0.461
1.521ValAsn: 1.521 ± 0.72
2.281ValPro: 2.281 ± 1.384
1.521ValGln: 1.521 ± 0.923
1.521ValArg: 1.521 ± 0.923
1.521ValSer: 1.521 ± 0.754
0.0ValThr: 0.0 ± 0.0
0.76ValVal: 0.76 ± 0.461
0.0ValTrp: 0.0 ± 0.0
0.76ValTyr: 0.76 ± 0.461
0.0ValXaa: 0.0 ± 0.0
Trp
0.76TrpAla: 0.76 ± 0.461
2.281TrpCys: 2.281 ± 1.718
1.521TrpAsp: 1.521 ± 0.923
0.76TrpGlu: 0.76 ± 0.461
1.521TrpPhe: 1.521 ± 0.923
4.563TrpGly: 4.563 ± 2.768
0.0TrpHis: 0.0 ± 0.0
0.76TrpIle: 0.76 ± 0.461
0.76TrpLys: 0.76 ± 0.461
1.521TrpLeu: 1.521 ± 0.72
2.281TrpMet: 2.281 ± 1.718
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
1.521TrpGln: 1.521 ± 0.923
0.0TrpArg: 0.0 ± 0.0
0.0TrpSer: 0.0 ± 0.0
0.76TrpThr: 0.76 ± 0.461
0.0TrpVal: 0.0 ± 0.0
0.76TrpTrp: 0.76 ± 0.461
0.76TrpTyr: 0.76 ± 0.461
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.76TyrAla: 0.76 ± 0.461
0.76TyrCys: 0.76 ± 0.461
3.042TyrAsp: 3.042 ± 1.846
1.521TyrGlu: 1.521 ± 0.923
1.521TyrPhe: 1.521 ± 0.923
1.521TyrGly: 1.521 ± 0.923
0.76TyrHis: 0.76 ± 0.461
1.521TyrIle: 1.521 ± 0.923
3.802TyrLys: 3.802 ± 1.779
3.042TyrLeu: 3.042 ± 1.846
2.281TyrMet: 2.281 ± 0.91
4.563TyrAsn: 4.563 ± 0.797
2.281TyrPro: 2.281 ± 0.91
3.042TyrGln: 3.042 ± 1.508
4.563TyrArg: 4.563 ± 2.768
3.042TyrSer: 3.042 ± 1.846
0.76TyrThr: 0.76 ± 0.461
0.76TyrVal: 0.76 ± 0.461
0.0TyrTrp: 0.0 ± 0.0
2.281TyrTyr: 2.281 ± 0.841
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (1316 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski