Amino acid dipepetide frequency for Candidatus Phytoplasma pini

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.418AlaAla: 1.418 ± 0.125
0.357AlaCys: 0.357 ± 0.052
1.386AlaAsp: 1.386 ± 0.111
1.629AlaGlu: 1.629 ± 0.143
2.002AlaPhe: 2.002 ± 0.141
1.605AlaGly: 1.605 ± 0.13
0.705AlaHis: 0.705 ± 0.079
3.736AlaIle: 3.736 ± 0.176
3.25AlaLys: 3.25 ± 0.21
4.141AlaLeu: 4.141 ± 0.213
0.689AlaMet: 0.689 ± 0.071
1.84AlaAsn: 1.84 ± 0.143
0.6AlaPro: 0.6 ± 0.075
1.386AlaGln: 1.386 ± 0.099
1.321AlaArg: 1.321 ± 0.11
2.139AlaSer: 2.139 ± 0.139
1.75AlaThr: 1.75 ± 0.157
1.718AlaVal: 1.718 ± 0.122
0.138AlaTrp: 0.138 ± 0.032
1.297AlaTyr: 1.297 ± 0.107
0.0AlaXaa: 0.0 ± 0.0
Cys
0.292CysAla: 0.292 ± 0.05
0.194CysCys: 0.194 ± 0.039
0.494CysAsp: 0.494 ± 0.067
0.462CysGlu: 0.462 ± 0.068
1.013CysPhe: 1.013 ± 0.098
0.462CysGly: 0.462 ± 0.067
0.251CysHis: 0.251 ± 0.05
0.867CysIle: 0.867 ± 0.081
0.583CysLys: 0.583 ± 0.071
1.321CysLeu: 1.321 ± 0.107
0.073CysMet: 0.073 ± 0.029
0.413CysAsn: 0.413 ± 0.062
0.243CysPro: 0.243 ± 0.042
0.292CysGln: 0.292 ± 0.05
0.235CysArg: 0.235 ± 0.045
0.786CysSer: 0.786 ± 0.096
0.259CysThr: 0.259 ± 0.05
0.332CysVal: 0.332 ± 0.05
0.081CysTrp: 0.081 ± 0.026
0.421CysTyr: 0.421 ± 0.06
0.0CysXaa: 0.0 ± 0.0
Asp
1.507AspAla: 1.507 ± 0.131
0.502AspCys: 0.502 ± 0.067
2.318AspAsp: 2.318 ± 0.136
2.861AspGlu: 2.861 ± 0.183
3.995AspPhe: 3.995 ± 0.167
1.929AspGly: 1.929 ± 0.153
0.656AspHis: 0.656 ± 0.069
5.811AspIle: 5.811 ± 0.219
4.927AspLys: 4.927 ± 0.218
6.386AspLeu: 6.386 ± 0.222
0.527AspMet: 0.527 ± 0.054
3.46AspAsn: 3.46 ± 0.174
1.118AspPro: 1.118 ± 0.111
1.426AspGln: 1.426 ± 0.091
0.924AspArg: 0.924 ± 0.087
2.869AspSer: 2.869 ± 0.153
1.605AspThr: 1.605 ± 0.111
2.318AspVal: 2.318 ± 0.131
0.259AspTrp: 0.259 ± 0.047
2.375AspTyr: 2.375 ± 0.159
0.0AspXaa: 0.0 ± 0.0
Glu
2.407GluAla: 2.407 ± 0.183
0.324GluCys: 0.324 ± 0.049
2.723GluAsp: 2.723 ± 0.156
5.673GluGlu: 5.673 ± 0.281
2.804GluPhe: 2.804 ± 0.14
2.456GluGly: 2.456 ± 0.159
0.859GluHis: 0.859 ± 0.076
8.461GluIle: 8.461 ± 0.3
9.514GluLys: 9.514 ± 0.351
5.722GluLeu: 5.722 ± 0.274
1.418GluMet: 1.418 ± 0.109
5.859GluAsn: 5.859 ± 0.244
1.191GluPro: 1.191 ± 0.097
2.958GluGln: 2.958 ± 0.173
1.678GluArg: 1.678 ± 0.11
2.682GluSer: 2.682 ± 0.172
2.966GluThr: 2.966 ± 0.174
2.439GluVal: 2.439 ± 0.153
0.276GluTrp: 0.276 ± 0.045
2.431GluTyr: 2.431 ± 0.159
0.0GluXaa: 0.0 ± 0.0
Phe
1.718PheAla: 1.718 ± 0.124
1.005PheCys: 1.005 ± 0.094
3.363PheAsp: 3.363 ± 0.164
3.388PheGlu: 3.388 ± 0.206
6.581PhePhe: 6.581 ± 0.333
2.212PheGly: 2.212 ± 0.149
1.264PheHis: 1.264 ± 0.107
6.929PheIle: 6.929 ± 0.288
5.527PheLys: 5.527 ± 0.212
10.211PheLeu: 10.211 ± 0.372
1.037PheMet: 1.037 ± 0.082
4.214PheAsn: 4.214 ± 0.172
1.686PhePro: 1.686 ± 0.117
2.958PheGln: 2.958 ± 0.17
1.783PheArg: 1.783 ± 0.124
4.676PheSer: 4.676 ± 0.229
1.856PheThr: 1.856 ± 0.126
3.193PheVal: 3.193 ± 0.172
0.527PheTrp: 0.527 ± 0.063
3.679PheTyr: 3.679 ± 0.196
0.0PheXaa: 0.0 ± 0.0
Gly
1.597GlyAla: 1.597 ± 0.131
0.348GlyCys: 0.348 ± 0.051
1.986GlyAsp: 1.986 ± 0.126
2.212GlyGlu: 2.212 ± 0.15
2.95GlyPhe: 2.95 ± 0.193
2.472GlyGly: 2.472 ± 0.2
1.045GlyHis: 1.045 ± 0.091
4.984GlyIle: 4.984 ± 0.213
4.214GlyLys: 4.214 ± 0.217
3.866GlyLeu: 3.866 ± 0.177
0.754GlyMet: 0.754 ± 0.099
2.456GlyAsn: 2.456 ± 0.146
0.94GlyPro: 0.94 ± 0.1
1.418GlyGln: 1.418 ± 0.099
1.321GlyArg: 1.321 ± 0.119
2.472GlySer: 2.472 ± 0.149
2.018GlyThr: 2.018 ± 0.135
2.553GlyVal: 2.553 ± 0.132
0.259GlyTrp: 0.259 ± 0.04
1.726GlyTyr: 1.726 ± 0.109
0.0GlyXaa: 0.0 ± 0.0
His
0.551HisAla: 0.551 ± 0.064
0.089HisCys: 0.089 ± 0.028
0.875HisAsp: 0.875 ± 0.097
1.062HisGlu: 1.062 ± 0.093
1.216HisPhe: 1.216 ± 0.096
0.737HisGly: 0.737 ± 0.087
0.405HisHis: 0.405 ± 0.065
1.678HisIle: 1.678 ± 0.105
1.54HisLys: 1.54 ± 0.134
2.099HisLeu: 2.099 ± 0.133
0.211HisMet: 0.211 ± 0.04
1.126HisAsn: 1.126 ± 0.104
0.681HisPro: 0.681 ± 0.084
0.737HisGln: 0.737 ± 0.081
0.608HisArg: 0.608 ± 0.07
1.062HisSer: 1.062 ± 0.104
0.648HisThr: 0.648 ± 0.068
0.746HisVal: 0.746 ± 0.08
0.081HisTrp: 0.081 ± 0.025
0.778HisTyr: 0.778 ± 0.076
0.0HisXaa: 0.0 ± 0.0
Ile
4.425IleAla: 4.425 ± 0.188
1.005IleCys: 1.005 ± 0.094
5.94IleAsp: 5.94 ± 0.242
7.107IleGlu: 7.107 ± 0.292
8.38IlePhe: 8.38 ± 0.36
4.401IleGly: 4.401 ± 0.213
1.799IleHis: 1.799 ± 0.12
13.161IleIle: 13.161 ± 0.401
12.651IleLys: 12.651 ± 0.388
13.21IleLeu: 13.21 ± 0.371
1.88IleMet: 1.88 ± 0.11
8.372IleAsn: 8.372 ± 0.28
3.266IlePro: 3.266 ± 0.171
4.482IleGln: 4.482 ± 0.225
2.788IleArg: 2.788 ± 0.16
8.566IleSer: 8.566 ± 0.255
4.457IleThr: 4.457 ± 0.183
5.073IleVal: 5.073 ± 0.212
0.478IleTrp: 0.478 ± 0.067
4.117IleTyr: 4.117 ± 0.199
0.0IleXaa: 0.0 ± 0.0
Lys
3.525LysAla: 3.525 ± 0.152
0.64LysCys: 0.64 ± 0.068
5.778LysAsp: 5.778 ± 0.231
9.903LysGlu: 9.903 ± 0.317
4.781LysPhe: 4.781 ± 0.256
4.311LysGly: 4.311 ± 0.215
1.459LysHis: 1.459 ± 0.126
16.395LysIle: 16.395 ± 0.406
18.202LysLys: 18.202 ± 0.51
8.039LysLeu: 8.039 ± 0.265
2.504LysMet: 2.504 ± 0.139
11.702LysAsn: 11.702 ± 0.309
2.302LysPro: 2.302 ± 0.153
5.13LysGln: 5.13 ± 0.265
3.104LysArg: 3.104 ± 0.175
5.454LysSer: 5.454 ± 0.179
5.551LysThr: 5.551 ± 0.234
4.166LysVal: 4.166 ± 0.202
0.535LysTrp: 0.535 ± 0.066
4.83LysTyr: 4.83 ± 0.221
0.0LysXaa: 0.0 ± 0.0
Leu
3.452LeuAla: 3.452 ± 0.214
1.094LeuCys: 1.094 ± 0.091
5.114LeuAsp: 5.114 ± 0.221
7.958LeuGlu: 7.958 ± 0.257
7.342LeuPhe: 7.342 ± 0.306
5.073LeuGly: 5.073 ± 0.237
1.443LeuHis: 1.443 ± 0.112
11.014LeuIle: 11.014 ± 0.372
13.55LeuLys: 13.55 ± 0.395
10.017LeuLeu: 10.017 ± 0.36
1.637LeuMet: 1.637 ± 0.113
7.853LeuAsn: 7.853 ± 0.273
2.585LeuPro: 2.585 ± 0.144
3.736LeuGln: 3.736 ± 0.209
2.982LeuArg: 2.982 ± 0.146
7.845LeuSer: 7.845 ± 0.328
4.401LeuThr: 4.401 ± 0.22
4.814LeuVal: 4.814 ± 0.207
0.486LeuTrp: 0.486 ± 0.057
3.217LeuTyr: 3.217 ± 0.172
0.0LeuXaa: 0.0 ± 0.0
Met
0.713MetAla: 0.713 ± 0.085
0.089MetCys: 0.089 ± 0.025
0.616MetAsp: 0.616 ± 0.069
0.891MetGlu: 0.891 ± 0.078
1.102MetPhe: 1.102 ± 0.093
0.729MetGly: 0.729 ± 0.069
0.276MetHis: 0.276 ± 0.047
2.026MetIle: 2.026 ± 0.136
2.01MetLys: 2.01 ± 0.127
1.645MetLeu: 1.645 ± 0.098
0.308MetMet: 0.308 ± 0.045
1.613MetAsn: 1.613 ± 0.096
0.527MetPro: 0.527 ± 0.071
0.673MetGln: 0.673 ± 0.078
0.494MetArg: 0.494 ± 0.064
1.045MetSer: 1.045 ± 0.113
0.77MetThr: 0.77 ± 0.079
0.81MetVal: 0.81 ± 0.077
0.049MetTrp: 0.049 ± 0.022
0.421MetTyr: 0.421 ± 0.059
0.0MetXaa: 0.0 ± 0.0
Asn
1.937AsnAla: 1.937 ± 0.137
0.721AsnCys: 0.721 ± 0.063
3.785AsnAsp: 3.785 ± 0.194
4.044AsnGlu: 4.044 ± 0.189
5.616AsnPhe: 5.616 ± 0.248
2.156AsnGly: 2.156 ± 0.152
1.386AsnHis: 1.386 ± 0.106
9.863AsnIle: 9.863 ± 0.296
9.668AsnLys: 9.668 ± 0.276
8.015AsnLeu: 8.015 ± 0.309
1.434AsnMet: 1.434 ± 0.108
6.856AsnAsn: 6.856 ± 0.301
2.01AsnPro: 2.01 ± 0.134
3.379AsnGln: 3.379 ± 0.16
1.629AsnArg: 1.629 ± 0.111
4.384AsnSer: 4.384 ± 0.162
2.456AsnThr: 2.456 ± 0.158
2.999AsnVal: 2.999 ± 0.115
0.373AsnTrp: 0.373 ± 0.074
3.922AsnTyr: 3.922 ± 0.199
0.0AsnXaa: 0.0 ± 0.0
Pro
0.697ProAla: 0.697 ± 0.094
0.259ProCys: 0.259 ± 0.047
0.948ProAsp: 0.948 ± 0.096
1.54ProGlu: 1.54 ± 0.111
1.994ProPhe: 1.994 ± 0.144
1.126ProGly: 1.126 ± 0.103
0.632ProHis: 0.632 ± 0.074
2.618ProIle: 2.618 ± 0.153
2.65ProLys: 2.65 ± 0.158
2.528ProLeu: 2.528 ± 0.169
0.243ProMet: 0.243 ± 0.049
1.637ProAsn: 1.637 ± 0.114
0.567ProPro: 0.567 ± 0.074
0.972ProGln: 0.972 ± 0.081
0.754ProArg: 0.754 ± 0.085
1.686ProSer: 1.686 ± 0.128
1.07ProThr: 1.07 ± 0.096
1.11ProVal: 1.11 ± 0.107
0.219ProTrp: 0.219 ± 0.042
1.28ProTyr: 1.28 ± 0.103
0.0ProXaa: 0.0 ± 0.0
Gln
1.353GlnAla: 1.353 ± 0.106
0.267GlnCys: 0.267 ± 0.043
1.694GlnAsp: 1.694 ± 0.145
3.298GlnGlu: 3.298 ± 0.176
1.621GlnPhe: 1.621 ± 0.112
1.361GlnGly: 1.361 ± 0.083
0.502GlnHis: 0.502 ± 0.075
5.17GlnIle: 5.17 ± 0.226
7.626GlnLys: 7.626 ± 0.329
3.274GlnLeu: 3.274 ± 0.199
0.794GlnMet: 0.794 ± 0.082
4.157GlnAsn: 4.157 ± 0.182
0.648GlnPro: 0.648 ± 0.068
1.88GlnGln: 1.88 ± 0.142
1.183GlnArg: 1.183 ± 0.094
1.572GlnSer: 1.572 ± 0.108
1.823GlnThr: 1.823 ± 0.121
1.329GlnVal: 1.329 ± 0.112
0.146GlnTrp: 0.146 ± 0.037
1.37GlnTyr: 1.37 ± 0.117
0.0GlnXaa: 0.0 ± 0.0
Arg
0.875ArgAla: 0.875 ± 0.083
0.227ArgCys: 0.227 ± 0.041
1.289ArgAsp: 1.289 ± 0.107
1.572ArgGlu: 1.572 ± 0.103
1.653ArgPhe: 1.653 ± 0.115
1.345ArgGly: 1.345 ± 0.119
0.519ArgHis: 0.519 ± 0.073
3.542ArgIle: 3.542 ± 0.19
3.436ArgLys: 3.436 ± 0.173
2.682ArgLeu: 2.682 ± 0.166
0.673ArgMet: 0.673 ± 0.076
2.083ArgAsn: 2.083 ± 0.134
0.721ArgPro: 0.721 ± 0.077
1.135ArgGln: 1.135 ± 0.085
1.11ArgArg: 1.11 ± 0.104
1.483ArgSer: 1.483 ± 0.098
1.216ArgThr: 1.216 ± 0.101
1.208ArgVal: 1.208 ± 0.103
0.097ArgTrp: 0.097 ± 0.026
1.199ArgTyr: 1.199 ± 0.102
0.0ArgXaa: 0.0 ± 0.0
Ser
1.961SerAla: 1.961 ± 0.124
0.697SerCys: 0.697 ± 0.081
2.836SerAsp: 2.836 ± 0.145
3.825SerGlu: 3.825 ± 0.176
5.114SerPhe: 5.114 ± 0.23
3.104SerGly: 3.104 ± 0.158
1.062SerHis: 1.062 ± 0.086
6.038SerIle: 6.038 ± 0.214
6.402SerLys: 6.402 ± 0.219
7.269SerLeu: 7.269 ± 0.272
0.81SerMet: 0.81 ± 0.092
4.028SerAsn: 4.028 ± 0.212
1.572SerPro: 1.572 ± 0.116
2.836SerGln: 2.836 ± 0.154
2.067SerArg: 2.067 ± 0.127
4.708SerSer: 4.708 ± 0.228
2.204SerThr: 2.204 ± 0.141
2.747SerVal: 2.747 ± 0.166
0.219SerTrp: 0.219 ± 0.041
2.642SerTyr: 2.642 ± 0.145
0.0SerXaa: 0.0 ± 0.0
Thr
1.361ThrAla: 1.361 ± 0.133
0.292ThrCys: 0.292 ± 0.049
1.694ThrAsp: 1.694 ± 0.121
2.334ThrGlu: 2.334 ± 0.149
2.237ThrPhe: 2.237 ± 0.145
2.148ThrGly: 2.148 ± 0.159
0.956ThrHis: 0.956 ± 0.085
4.457ThrIle: 4.457 ± 0.195
4.838ThrLys: 4.838 ± 0.207
4.117ThrLeu: 4.117 ± 0.178
0.494ThrMet: 0.494 ± 0.06
2.82ThrAsn: 2.82 ± 0.16
1.386ThrPro: 1.386 ± 0.102
1.75ThrGln: 1.75 ± 0.124
1.329ThrArg: 1.329 ± 0.094
2.601ThrSer: 2.601 ± 0.154
2.107ThrThr: 2.107 ± 0.138
1.694ThrVal: 1.694 ± 0.145
0.186ThrTrp: 0.186 ± 0.039
1.386ThrTyr: 1.386 ± 0.101
0.0ThrXaa: 0.0 ± 0.0
Val
1.84ValAla: 1.84 ± 0.13
0.462ValCys: 0.462 ± 0.061
2.334ValAsp: 2.334 ± 0.123
2.528ValGlu: 2.528 ± 0.142
3.477ValPhe: 3.477 ± 0.166
2.196ValGly: 2.196 ± 0.125
0.673ValHis: 0.673 ± 0.073
4.611ValIle: 4.611 ± 0.199
3.647ValLys: 3.647 ± 0.199
5.268ValLeu: 5.268 ± 0.268
0.713ValMet: 0.713 ± 0.071
2.682ValAsn: 2.682 ± 0.151
1.175ValPro: 1.175 ± 0.114
1.28ValGln: 1.28 ± 0.095
1.175ValArg: 1.175 ± 0.112
3.242ValSer: 3.242 ± 0.161
1.597ValThr: 1.597 ± 0.118
2.764ValVal: 2.764 ± 0.188
0.219ValTrp: 0.219 ± 0.043
1.856ValTyr: 1.856 ± 0.102
0.0ValXaa: 0.0 ± 0.0
Trp
0.105TrpAla: 0.105 ± 0.034
0.065TrpCys: 0.065 ± 0.02
0.243TrpAsp: 0.243 ± 0.042
0.276TrpGlu: 0.276 ± 0.049
0.462TrpPhe: 0.462 ± 0.065
0.276TrpGly: 0.276 ± 0.048
0.13TrpHis: 0.13 ± 0.034
0.462TrpIle: 0.462 ± 0.074
0.559TrpLys: 0.559 ± 0.063
0.486TrpLeu: 0.486 ± 0.057
0.065TrpMet: 0.065 ± 0.022
0.316TrpAsn: 0.316 ± 0.058
0.178TrpPro: 0.178 ± 0.046
0.194TrpGln: 0.194 ± 0.04
0.186TrpArg: 0.186 ± 0.035
0.3TrpSer: 0.3 ± 0.045
0.105TrpThr: 0.105 ± 0.03
0.211TrpVal: 0.211 ± 0.042
0.024TrpTrp: 0.024 ± 0.013
0.251TrpTyr: 0.251 ± 0.045
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.37TyrAla: 1.37 ± 0.09
0.438TyrCys: 0.438 ± 0.056
2.358TyrAsp: 2.358 ± 0.159
2.277TyrGlu: 2.277 ± 0.139
3.469TyrPhe: 3.469 ± 0.174
1.491TyrGly: 1.491 ± 0.092
0.908TyrHis: 0.908 ± 0.087
3.744TyrIle: 3.744 ± 0.183
3.517TyrLys: 3.517 ± 0.166
5.316TyrLeu: 5.316 ± 0.22
0.535TyrMet: 0.535 ± 0.068
3.144TyrAsn: 3.144 ± 0.143
1.135TyrPro: 1.135 ± 0.1
2.447TyrGln: 2.447 ± 0.162
1.394TyrArg: 1.394 ± 0.111
2.569TyrSer: 2.569 ± 0.15
1.329TyrThr: 1.329 ± 0.105
1.515TyrVal: 1.515 ± 0.103
0.243TyrTrp: 0.243 ± 0.047
2.123TyrTyr: 2.123 ± 0.141
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 404 proteins (123395 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski