Amino acid dipepetide frequency for Weissella ceti

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.987AlaAla: 7.987 ± 0.188
0.171AlaCys: 0.171 ± 0.023
6.042AlaAsp: 6.042 ± 0.141
6.381AlaGlu: 6.381 ± 0.163
3.54AlaPhe: 3.54 ± 0.105
6.545AlaGly: 6.545 ± 0.167
1.623AlaHis: 1.623 ± 0.055
6.097AlaIle: 6.097 ± 0.129
5.115AlaLys: 5.115 ± 0.134
8.808AlaLeu: 8.808 ± 0.179
2.932AlaMet: 2.932 ± 0.087
3.741AlaAsn: 3.741 ± 0.107
2.781AlaPro: 2.781 ± 0.101
3.939AlaGln: 3.939 ± 0.135
3.462AlaArg: 3.462 ± 0.129
4.271AlaSer: 4.271 ± 0.116
5.394AlaThr: 5.394 ± 0.132
6.379AlaVal: 6.379 ± 0.141
0.907AlaTrp: 0.907 ± 0.047
2.816AlaTyr: 2.816 ± 0.094
0.0AlaXaa: 0.0 ± 0.0
Cys
0.126CysAla: 0.126 ± 0.023
0.023CysCys: 0.023 ± 0.01
0.126CysAsp: 0.126 ± 0.022
0.113CysGlu: 0.113 ± 0.019
0.106CysPhe: 0.106 ± 0.019
0.178CysGly: 0.178 ± 0.026
0.053CysHis: 0.053 ± 0.012
0.136CysIle: 0.136 ± 0.017
0.053CysLys: 0.053 ± 0.011
0.256CysLeu: 0.256 ± 0.027
0.05CysMet: 0.05 ± 0.01
0.065CysAsn: 0.065 ± 0.013
0.068CysPro: 0.068 ± 0.015
0.07CysGln: 0.07 ± 0.014
0.078CysArg: 0.078 ± 0.016
0.103CysSer: 0.103 ± 0.017
0.131CysThr: 0.131 ± 0.017
0.173CysVal: 0.173 ± 0.022
0.043CysTrp: 0.043 ± 0.011
0.055CysTyr: 0.055 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
5.899AspAla: 5.899 ± 0.186
0.075AspCys: 0.075 ± 0.016
3.839AspAsp: 3.839 ± 0.119
4.902AspGlu: 4.902 ± 0.163
2.779AspPhe: 2.779 ± 0.076
4.299AspGly: 4.299 ± 0.142
1.06AspHis: 1.06 ± 0.052
4.223AspIle: 4.223 ± 0.123
3.492AspLys: 3.492 ± 0.136
5.814AspLeu: 5.814 ± 0.139
2.08AspMet: 2.08 ± 0.07
2.384AspAsn: 2.384 ± 0.089
2.058AspPro: 2.058 ± 0.084
2.223AspGln: 2.223 ± 0.082
2.419AspArg: 2.419 ± 0.095
2.46AspSer: 2.46 ± 0.084
3.434AspThr: 3.434 ± 0.111
5.53AspVal: 5.53 ± 0.169
0.739AspTrp: 0.739 ± 0.044
2.367AspTyr: 2.367 ± 0.084
0.0AspXaa: 0.0 ± 0.0
Glu
5.881GluAla: 5.881 ± 0.18
0.083GluCys: 0.083 ± 0.016
3.578GluAsp: 3.578 ± 0.139
4.706GluGlu: 4.706 ± 0.209
2.372GluPhe: 2.372 ± 0.09
3.354GluGly: 3.354 ± 0.104
1.392GluHis: 1.392 ± 0.072
4.55GluIle: 4.55 ± 0.124
4.168GluLys: 4.168 ± 0.135
6.587GluLeu: 6.587 ± 0.166
2.281GluMet: 2.281 ± 0.079
3.336GluAsn: 3.336 ± 0.116
2.173GluPro: 2.173 ± 0.093
3.256GluGln: 3.256 ± 0.109
3.344GluArg: 3.344 ± 0.105
3.01GluSer: 3.01 ± 0.109
4.309GluThr: 4.309 ± 0.129
4.763GluVal: 4.763 ± 0.139
0.661GluTrp: 0.661 ± 0.045
1.839GluTyr: 1.839 ± 0.084
0.0GluXaa: 0.0 ± 0.0
Phe
3.485PheAla: 3.485 ± 0.099
0.083PheCys: 0.083 ± 0.015
3.058PheAsp: 3.058 ± 0.091
2.565PheGlu: 2.565 ± 0.091
1.791PhePhe: 1.791 ± 0.062
3.58PheGly: 3.58 ± 0.099
0.613PheHis: 0.613 ± 0.041
2.761PheIle: 2.761 ± 0.091
2.228PheLys: 2.228 ± 0.069
3.392PheLeu: 3.392 ± 0.114
1.394PheMet: 1.394 ± 0.067
2.063PheAsn: 2.063 ± 0.068
1.339PhePro: 1.339 ± 0.058
1.334PheGln: 1.334 ± 0.056
1.241PheArg: 1.241 ± 0.054
2.691PheSer: 2.691 ± 0.081
2.485PheThr: 2.485 ± 0.079
3.324PheVal: 3.324 ± 0.095
0.495PheTrp: 0.495 ± 0.039
1.372PheTyr: 1.372 ± 0.064
0.0PheXaa: 0.0 ± 0.0
Gly
5.603GlyAla: 5.603 ± 0.141
0.106GlyCys: 0.106 ± 0.015
4.088GlyAsp: 4.088 ± 0.123
4.045GlyGlu: 4.045 ± 0.121
3.231GlyPhe: 3.231 ± 0.089
4.67GlyGly: 4.67 ± 0.154
1.43GlyHis: 1.43 ± 0.052
5.268GlyIle: 5.268 ± 0.124
3.997GlyLys: 3.997 ± 0.181
6.992GlyLeu: 6.992 ± 0.142
2.467GlyMet: 2.467 ± 0.087
2.731GlyAsn: 2.731 ± 0.107
1.759GlyPro: 1.759 ± 0.068
2.904GlyGln: 2.904 ± 0.091
3.053GlyArg: 3.053 ± 0.096
3.791GlySer: 3.791 ± 0.096
4.296GlyThr: 4.296 ± 0.11
5.462GlyVal: 5.462 ± 0.118
0.774GlyTrp: 0.774 ± 0.043
2.59GlyTyr: 2.59 ± 0.1
0.0GlyXaa: 0.0 ± 0.0
His
1.681HisAla: 1.681 ± 0.063
0.04HisCys: 0.04 ± 0.011
1.342HisAsp: 1.342 ± 0.06
1.251HisGlu: 1.251 ± 0.06
0.852HisPhe: 0.852 ± 0.054
1.337HisGly: 1.337 ± 0.065
0.427HisHis: 0.427 ± 0.032
1.123HisIle: 1.123 ± 0.048
0.804HisLys: 0.804 ± 0.048
1.701HisLeu: 1.701 ± 0.069
0.575HisMet: 0.575 ± 0.039
0.804HisAsn: 0.804 ± 0.059
0.847HisPro: 0.847 ± 0.045
0.827HisGln: 0.827 ± 0.05
0.867HisArg: 0.867 ± 0.05
0.784HisSer: 0.784 ± 0.046
0.96HisThr: 0.96 ± 0.054
1.51HisVal: 1.51 ± 0.059
0.188HisTrp: 0.188 ± 0.021
0.666HisTyr: 0.666 ± 0.042
0.0HisXaa: 0.0 ± 0.0
Ile
6.326IleAla: 6.326 ± 0.136
0.188IleCys: 0.188 ± 0.026
4.291IleAsp: 4.291 ± 0.119
4.123IleGlu: 4.123 ± 0.125
2.686IlePhe: 2.686 ± 0.094
5.095IleGly: 5.095 ± 0.136
1.136IleHis: 1.136 ± 0.066
4.183IleIle: 4.183 ± 0.119
3.46IleLys: 3.46 ± 0.111
5.919IleLeu: 5.919 ± 0.139
1.854IleMet: 1.854 ± 0.071
3.075IleAsn: 3.075 ± 0.088
2.623IlePro: 2.623 ± 0.151
2.505IleGln: 2.505 ± 0.087
2.445IleArg: 2.445 ± 0.09
3.987IleSer: 3.987 ± 0.094
4.213IleThr: 4.213 ± 0.111
5.384IleVal: 5.384 ± 0.125
0.701IleTrp: 0.701 ± 0.047
1.965IleTyr: 1.965 ± 0.086
0.0IleXaa: 0.0 ± 0.0
Lys
4.588LysAla: 4.588 ± 0.122
0.068LysCys: 0.068 ± 0.016
3.156LysAsp: 3.156 ± 0.112
3.52LysGlu: 3.52 ± 0.121
1.739LysPhe: 1.739 ± 0.062
3.1LysGly: 3.1 ± 0.125
0.935LysHis: 0.935 ± 0.048
3.387LysIle: 3.387 ± 0.088
3.957LysLys: 3.957 ± 0.174
4.771LysLeu: 4.771 ± 0.104
2.183LysMet: 2.183 ± 0.081
2.781LysAsn: 2.781 ± 0.092
2.213LysPro: 2.213 ± 0.143
2.728LysGln: 2.728 ± 0.081
2.733LysArg: 2.733 ± 0.085
3.118LysSer: 3.118 ± 0.103
3.736LysThr: 3.736 ± 0.116
3.736LysVal: 3.736 ± 0.119
0.563LysTrp: 0.563 ± 0.041
1.862LysTyr: 1.862 ± 0.068
0.0LysXaa: 0.0 ± 0.0
Leu
9.296LeuAla: 9.296 ± 0.2
0.236LeuCys: 0.236 ± 0.031
5.846LeuAsp: 5.846 ± 0.151
5.379LeuGlu: 5.379 ± 0.145
3.799LeuPhe: 3.799 ± 0.109
6.703LeuGly: 6.703 ± 0.146
1.588LeuHis: 1.588 ± 0.062
6.128LeuIle: 6.128 ± 0.148
4.794LeuLys: 4.794 ± 0.125
8.791LeuLeu: 8.791 ± 0.183
2.939LeuMet: 2.939 ± 0.083
4.409LeuAsn: 4.409 ± 0.117
4.176LeuPro: 4.176 ± 0.135
3.751LeuGln: 3.751 ± 0.109
3.922LeuArg: 3.922 ± 0.109
5.912LeuSer: 5.912 ± 0.122
6.929LeuThr: 6.929 ± 0.156
7.165LeuVal: 7.165 ± 0.145
0.914LeuTrp: 0.914 ± 0.056
2.369LeuTyr: 2.369 ± 0.087
0.0LeuXaa: 0.0 ± 0.0
Met
3.198MetAla: 3.198 ± 0.093
0.068MetCys: 0.068 ± 0.011
1.769MetAsp: 1.769 ± 0.071
1.404MetGlu: 1.404 ± 0.061
1.218MetPhe: 1.218 ± 0.061
2.095MetGly: 2.095 ± 0.085
0.565MetHis: 0.565 ± 0.04
2.231MetIle: 2.231 ± 0.078
1.711MetLys: 1.711 ± 0.064
2.927MetLeu: 2.927 ± 0.093
1.191MetMet: 1.191 ± 0.062
1.686MetAsn: 1.686 ± 0.07
1.51MetPro: 1.51 ± 0.078
1.55MetGln: 1.55 ± 0.07
1.342MetArg: 1.342 ± 0.059
1.862MetSer: 1.862 ± 0.074
2.568MetThr: 2.568 ± 0.069
2.294MetVal: 2.294 ± 0.078
0.266MetTrp: 0.266 ± 0.027
0.862MetTyr: 0.862 ± 0.047
0.0MetXaa: 0.0 ± 0.0
Asn
4.05AsnAla: 4.05 ± 0.128
0.078AsnCys: 0.078 ± 0.013
2.907AsnAsp: 2.907 ± 0.083
2.932AsnGlu: 2.932 ± 0.099
1.663AsnPhe: 1.663 ± 0.071
3.402AsnGly: 3.402 ± 0.101
0.925AsnHis: 0.925 ± 0.056
2.794AsnIle: 2.794 ± 0.091
2.537AsnLys: 2.537 ± 0.105
3.927AsnLeu: 3.927 ± 0.094
1.48AsnMet: 1.48 ± 0.058
2.105AsnAsn: 2.105 ± 0.093
2.085AsnPro: 2.085 ± 0.071
2.143AsnGln: 2.143 ± 0.084
1.761AsnArg: 1.761 ± 0.069
1.746AsnSer: 1.746 ± 0.072
2.326AsnThr: 2.326 ± 0.08
3.61AsnVal: 3.61 ± 0.098
0.611AsnTrp: 0.611 ± 0.037
1.553AsnTyr: 1.553 ± 0.071
0.0AsnXaa: 0.0 ± 0.0
Pro
3.191ProAla: 3.191 ± 0.101
0.058ProCys: 0.058 ± 0.013
2.58ProAsp: 2.58 ± 0.151
3.505ProGlu: 3.505 ± 0.151
1.636ProPhe: 1.636 ± 0.071
2.412ProGly: 2.412 ± 0.131
0.678ProHis: 0.678 ± 0.042
2.387ProIle: 2.387 ± 0.092
2.231ProLys: 2.231 ± 0.135
3.125ProLeu: 3.125 ± 0.092
1.045ProMet: 1.045 ± 0.05
1.844ProAsn: 1.844 ± 0.079
0.487ProPro: 0.487 ± 0.041
1.455ProGln: 1.455 ± 0.059
1.251ProArg: 1.251 ± 0.056
1.759ProSer: 1.759 ± 0.062
2.575ProThr: 2.575 ± 0.079
3.163ProVal: 3.163 ± 0.13
0.354ProTrp: 0.354 ± 0.028
1.299ProTyr: 1.299 ± 0.065
0.0ProXaa: 0.0 ± 0.0
Gln
4.299GlnAla: 4.299 ± 0.12
0.063GlnCys: 0.063 ± 0.013
1.982GlnAsp: 1.982 ± 0.092
2.706GlnGlu: 2.706 ± 0.108
1.59GlnPhe: 1.59 ± 0.072
2.63GlnGly: 2.63 ± 0.064
0.839GlnHis: 0.839 ± 0.049
2.683GlnIle: 2.683 ± 0.069
2.399GlnLys: 2.399 ± 0.084
4.409GlnLeu: 4.409 ± 0.122
1.417GlnMet: 1.417 ± 0.071
2.035GlnAsn: 2.035 ± 0.077
1.721GlnPro: 1.721 ± 0.079
2.281GlnGln: 2.281 ± 0.109
2.186GlnArg: 2.186 ± 0.091
2.058GlnSer: 2.058 ± 0.067
2.927GlnThr: 2.927 ± 0.086
3.068GlnVal: 3.068 ± 0.078
0.412GlnTrp: 0.412 ± 0.035
1.432GlnTyr: 1.432 ± 0.055
0.0GlnXaa: 0.0 ± 0.0
Arg
3.316ArgAla: 3.316 ± 0.109
0.07ArgCys: 0.07 ± 0.013
2.656ArgAsp: 2.656 ± 0.096
3.181ArgGlu: 3.181 ± 0.11
1.887ArgPhe: 1.887 ± 0.078
2.666ArgGly: 2.666 ± 0.086
0.925ArgHis: 0.925 ± 0.054
2.63ArgIle: 2.63 ± 0.092
2.158ArgLys: 2.158 ± 0.084
4.311ArgLeu: 4.311 ± 0.118
1.301ArgMet: 1.301 ± 0.057
1.713ArgAsn: 1.713 ± 0.08
1.575ArgPro: 1.575 ± 0.086
2.148ArgGln: 2.148 ± 0.082
2.171ArgArg: 2.171 ± 0.096
1.919ArgSer: 1.919 ± 0.067
2.223ArgThr: 2.223 ± 0.079
3.233ArgVal: 3.233 ± 0.1
0.492ArgTrp: 0.492 ± 0.038
1.615ArgTyr: 1.615 ± 0.073
0.0ArgXaa: 0.0 ± 0.0
Ser
4.326SerAla: 4.326 ± 0.108
0.121SerCys: 0.121 ± 0.019
3.439SerAsp: 3.439 ± 0.089
3.472SerGlu: 3.472 ± 0.113
2.51SerPhe: 2.51 ± 0.087
4.125SerGly: 4.125 ± 0.094
0.992SerHis: 0.992 ± 0.052
3.434SerIle: 3.434 ± 0.094
2.759SerLys: 2.759 ± 0.096
4.964SerLeu: 4.964 ± 0.112
1.578SerMet: 1.578 ± 0.061
2.183SerAsn: 2.183 ± 0.077
1.625SerPro: 1.625 ± 0.07
2.09SerGln: 2.09 ± 0.07
2.321SerArg: 2.321 ± 0.075
2.718SerSer: 2.718 ± 0.105
3.032SerThr: 3.032 ± 0.095
4.306SerVal: 4.306 ± 0.108
0.636SerTrp: 0.636 ± 0.043
1.686SerTyr: 1.686 ± 0.068
0.0SerXaa: 0.0 ± 0.0
Thr
5.145ThrAla: 5.145 ± 0.133
0.136ThrCys: 0.136 ± 0.017
3.879ThrAsp: 3.879 ± 0.11
4.085ThrGlu: 4.085 ± 0.131
2.681ThrPhe: 2.681 ± 0.086
4.766ThrGly: 4.766 ± 0.113
1.181ThrHis: 1.181 ± 0.058
4.407ThrIle: 4.407 ± 0.125
3.324ThrLys: 3.324 ± 0.092
6.296ThrLeu: 6.296 ± 0.164
1.844ThrMet: 1.844 ± 0.067
2.771ThrAsn: 2.771 ± 0.1
3.06ThrPro: 3.06 ± 0.106
2.683ThrGln: 2.683 ± 0.097
2.246ThrArg: 2.246 ± 0.073
3.351ThrSer: 3.351 ± 0.098
4.191ThrThr: 4.191 ± 0.127
4.972ThrVal: 4.972 ± 0.12
0.648ThrTrp: 0.648 ± 0.041
2.13ThrTyr: 2.13 ± 0.079
0.0ThrXaa: 0.0 ± 0.0
Val
7.065ValAla: 7.065 ± 0.169
0.198ValCys: 0.198 ± 0.025
4.874ValAsp: 4.874 ± 0.115
4.854ValGlu: 4.854 ± 0.131
3.047ValPhe: 3.047 ± 0.102
5.361ValGly: 5.361 ± 0.118
1.314ValHis: 1.314 ± 0.066
5.248ValIle: 5.248 ± 0.119
3.859ValLys: 3.859 ± 0.111
7.359ValLeu: 7.359 ± 0.126
2.424ValMet: 2.424 ± 0.088
3.284ValAsn: 3.284 ± 0.102
3.372ValPro: 3.372 ± 0.112
2.919ValGln: 2.919 ± 0.085
3.06ValArg: 3.06 ± 0.114
4.64ValSer: 4.64 ± 0.107
5.376ValThr: 5.376 ± 0.131
6.309ValVal: 6.309 ± 0.155
0.811ValTrp: 0.811 ± 0.058
2.218ValTyr: 2.218 ± 0.08
0.0ValXaa: 0.0 ± 0.0
Trp
0.766TrpAla: 0.766 ± 0.046
0.045TrpCys: 0.045 ± 0.011
0.53TrpAsp: 0.53 ± 0.04
0.502TrpGlu: 0.502 ± 0.034
0.616TrpPhe: 0.616 ± 0.049
0.688TrpGly: 0.688 ± 0.045
0.264TrpHis: 0.264 ± 0.032
0.681TrpIle: 0.681 ± 0.045
0.332TrpLys: 0.332 ± 0.027
1.389TrpLeu: 1.389 ± 0.071
0.334TrpMet: 0.334 ± 0.029
0.404TrpAsn: 0.404 ± 0.033
0.294TrpPro: 0.294 ± 0.027
0.734TrpGln: 0.734 ± 0.047
0.641TrpArg: 0.641 ± 0.041
0.661TrpSer: 0.661 ± 0.048
0.616TrpThr: 0.616 ± 0.044
0.766TrpVal: 0.766 ± 0.048
0.178TrpTrp: 0.178 ± 0.021
0.344TrpTyr: 0.344 ± 0.034
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.706TyrAla: 2.706 ± 0.088
0.095TyrCys: 0.095 ± 0.019
2.098TyrAsp: 2.098 ± 0.082
2.017TyrGlu: 2.017 ± 0.074
1.553TyrPhe: 1.553 ± 0.069
2.249TyrGly: 2.249 ± 0.071
0.646TyrHis: 0.646 ± 0.044
1.806TyrIle: 1.806 ± 0.07
1.495TyrLys: 1.495 ± 0.073
3.306TyrLeu: 3.306 ± 0.102
0.942TyrMet: 0.942 ± 0.046
1.218TyrAsn: 1.218 ± 0.067
1.269TyrPro: 1.269 ± 0.06
1.595TyrGln: 1.595 ± 0.068
1.651TyrArg: 1.651 ± 0.073
1.48TyrSer: 1.48 ± 0.065
2.075TyrThr: 2.075 ± 0.081
2.447TyrVal: 2.447 ± 0.095
0.392TyrTrp: 0.392 ± 0.032
1.284TyrTyr: 1.284 ± 0.065
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1338 proteins (398033 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski