Amino acid dipepetide frequency for Bat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.239AlaAla: 4.239 ± 1.276
2.119AlaCys: 2.119 ± 0.235
2.195AlaAsp: 2.195 ± 1.035
2.119AlaGlu: 2.119 ± 0.187
4.617AlaPhe: 4.617 ± 0.345
3.86AlaGly: 3.86 ± 0.764
0.606AlaHis: 0.606 ± 0.192
3.86AlaIle: 3.86 ± 0.161
4.844AlaLys: 4.844 ± 0.794
6.131AlaLeu: 6.131 ± 0.526
1.892AlaMet: 1.892 ± 0.341
4.39AlaAsn: 4.39 ± 0.557
1.665AlaPro: 1.665 ± 0.488
1.514AlaGln: 1.514 ± 0.511
1.589AlaArg: 1.589 ± 0.33
4.768AlaSer: 4.768 ± 0.463
4.617AlaThr: 4.617 ± 0.4
5.374AlaVal: 5.374 ± 0.323
0.378AlaTrp: 0.378 ± 0.195
1.817AlaTyr: 1.817 ± 0.301
0.0AlaXaa: 0.0 ± 0.0
Cys
1.741CysAla: 1.741 ± 0.308
1.06CysCys: 1.06 ± 0.383
2.498CysAsp: 2.498 ± 0.684
0.908CysGlu: 0.908 ± 0.193
2.119CysPhe: 2.119 ± 0.175
2.346CysGly: 2.346 ± 0.275
0.303CysHis: 0.303 ± 0.175
1.514CysIle: 1.514 ± 0.411
2.346CysLys: 2.346 ± 0.477
1.741CysLeu: 1.741 ± 0.202
0.151CysMet: 0.151 ± 0.053
1.741CysAsn: 1.741 ± 0.288
0.606CysPro: 0.606 ± 0.111
0.303CysGln: 0.303 ± 0.232
1.135CysArg: 1.135 ± 0.265
1.892CysSer: 1.892 ± 0.379
3.406CysThr: 3.406 ± 0.559
3.86CysVal: 3.86 ± 0.643
0.606CysTrp: 0.606 ± 0.192
2.498CysTyr: 2.498 ± 0.826
0.0CysXaa: 0.0 ± 0.0
Asp
3.633AspAla: 3.633 ± 0.575
1.817AspCys: 1.817 ± 0.525
2.649AspAsp: 2.649 ± 0.53
3.179AspGlu: 3.179 ± 0.342
3.633AspPhe: 3.633 ± 1.05
5.828AspGly: 5.828 ± 0.645
0.984AspHis: 0.984 ± 0.162
2.271AspIle: 2.271 ± 0.614
3.103AspLys: 3.103 ± 0.418
4.087AspLeu: 4.087 ± 0.469
1.514AspMet: 1.514 ± 0.375
2.195AspAsn: 2.195 ± 0.508
1.968AspPro: 1.968 ± 0.29
1.665AspGln: 1.665 ± 0.194
3.255AspArg: 3.255 ± 0.364
3.709AspSer: 3.709 ± 0.399
2.952AspThr: 2.952 ± 0.401
5.147AspVal: 5.147 ± 0.837
1.06AspTrp: 1.06 ± 0.236
2.876AspTyr: 2.876 ± 0.612
0.0AspXaa: 0.0 ± 0.0
Glu
2.573GluAla: 2.573 ± 0.304
1.06GluCys: 1.06 ± 0.236
3.179GluAsp: 3.179 ± 0.263
2.876GluGlu: 2.876 ± 0.496
2.8GluPhe: 2.8 ± 0.607
2.876GluGly: 2.876 ± 0.388
1.06GluHis: 1.06 ± 0.323
1.135GluIle: 1.135 ± 0.733
1.968GluLys: 1.968 ± 0.354
3.709GluLeu: 3.709 ± 0.622
1.135GluMet: 1.135 ± 0.369
1.589GluAsn: 1.589 ± 0.271
1.589GluPro: 1.589 ± 0.266
1.06GluGln: 1.06 ± 0.235
0.757GluArg: 0.757 ± 0.156
2.271GluSer: 2.271 ± 0.262
1.438GluThr: 1.438 ± 0.263
3.482GluVal: 3.482 ± 0.328
0.833GluTrp: 0.833 ± 0.346
0.984GluTyr: 0.984 ± 0.346
0.0GluXaa: 0.0 ± 0.0
Phe
2.952PheAla: 2.952 ± 0.21
2.044PheCys: 2.044 ± 0.249
4.012PheAsp: 4.012 ± 0.42
1.892PheGlu: 1.892 ± 0.24
2.573PhePhe: 2.573 ± 0.41
3.709PheGly: 3.709 ± 0.538
0.53PheHis: 0.53 ± 0.169
2.876PheIle: 2.876 ± 0.566
3.255PheLys: 3.255 ± 0.583
5.45PheLeu: 5.45 ± 0.919
1.362PheMet: 1.362 ± 0.331
3.936PheAsn: 3.936 ± 0.47
1.135PhePro: 1.135 ± 0.269
1.362PheGln: 1.362 ± 0.279
1.589PheArg: 1.589 ± 0.138
3.936PheSer: 3.936 ± 0.318
3.557PheThr: 3.557 ± 0.603
6.585PheVal: 6.585 ± 0.642
0.908PheTrp: 0.908 ± 0.139
2.346PheTyr: 2.346 ± 0.226
0.0PheXaa: 0.0 ± 0.0
Gly
4.087GlyAla: 4.087 ± 0.471
2.498GlyCys: 2.498 ± 0.452
4.995GlyAsp: 4.995 ± 0.514
1.211GlyGlu: 1.211 ± 0.216
4.087GlyPhe: 4.087 ± 0.769
4.617GlyGly: 4.617 ± 0.443
1.06GlyHis: 1.06 ± 0.25
2.8GlyIle: 2.8 ± 0.477
3.255GlyLys: 3.255 ± 0.532
5.45GlyLeu: 5.45 ± 0.391
1.287GlyMet: 1.287 ± 0.171
3.557GlyAsn: 3.557 ± 0.393
1.589GlyPro: 1.589 ± 0.274
0.984GlyGln: 0.984 ± 0.245
2.422GlyArg: 2.422 ± 0.671
5.904GlySer: 5.904 ± 0.855
4.314GlyThr: 4.314 ± 0.247
9.84GlyVal: 9.84 ± 0.602
0.606GlyTrp: 0.606 ± 0.201
2.952GlyTyr: 2.952 ± 0.391
0.0GlyXaa: 0.0 ± 0.0
His
1.741HisAla: 1.741 ± 0.312
0.454HisCys: 0.454 ± 0.124
0.833HisAsp: 0.833 ± 0.27
0.681HisGlu: 0.681 ± 0.361
0.681HisPhe: 0.681 ± 0.221
0.908HisGly: 0.908 ± 0.27
0.378HisHis: 0.378 ± 0.163
0.908HisIle: 0.908 ± 0.15
0.984HisLys: 0.984 ± 0.396
1.968HisLeu: 1.968 ± 0.3
0.303HisMet: 0.303 ± 0.067
1.06HisAsn: 1.06 ± 0.337
0.53HisPro: 0.53 ± 0.169
0.076HisGln: 0.076 ± 0.051
0.757HisArg: 0.757 ± 0.177
1.135HisSer: 1.135 ± 0.304
2.195HisThr: 2.195 ± 0.27
1.892HisVal: 1.892 ± 0.31
0.227HisTrp: 0.227 ± 0.075
0.908HisTyr: 0.908 ± 0.344
0.0HisXaa: 0.0 ± 0.0
Ile
2.119IleAla: 2.119 ± 0.38
1.589IleCys: 1.589 ± 0.322
1.817IleAsp: 1.817 ± 0.194
1.817IleGlu: 1.817 ± 0.333
3.028IlePhe: 3.028 ± 0.307
2.8IleGly: 2.8 ± 0.278
0.378IleHis: 0.378 ± 0.253
2.952IleIle: 2.952 ± 0.405
3.255IleLys: 3.255 ± 0.774
4.314IleLeu: 4.314 ± 1.323
0.757IleMet: 0.757 ± 0.195
2.725IleAsn: 2.725 ± 0.217
2.271IlePro: 2.271 ± 0.403
2.119IleGln: 2.119 ± 0.622
1.514IleArg: 1.514 ± 0.229
4.012IleSer: 4.012 ± 0.509
4.617IleThr: 4.617 ± 0.508
4.617IleVal: 4.617 ± 0.51
0.53IleTrp: 0.53 ± 0.169
1.362IleTyr: 1.362 ± 0.67
0.0IleXaa: 0.0 ± 0.0
Lys
3.709LysAla: 3.709 ± 0.579
1.741LysCys: 1.741 ± 0.434
3.406LysAsp: 3.406 ± 0.683
1.741LysGlu: 1.741 ± 0.391
3.784LysPhe: 3.784 ± 0.371
3.86LysGly: 3.86 ± 0.467
1.968LysHis: 1.968 ± 0.492
2.498LysIle: 2.498 ± 0.524
2.498LysLys: 2.498 ± 0.392
6.055LysLeu: 6.055 ± 1.124
0.908LysMet: 0.908 ± 0.295
2.346LysAsn: 2.346 ± 0.633
4.541LysPro: 4.541 ± 0.88
1.589LysGln: 1.589 ± 0.322
2.119LysArg: 2.119 ± 0.263
3.103LysSer: 3.103 ± 0.525
2.346LysThr: 2.346 ± 0.254
6.131LysVal: 6.131 ± 0.912
0.53LysTrp: 0.53 ± 0.251
2.876LysTyr: 2.876 ± 0.351
0.0LysXaa: 0.0 ± 0.0
Leu
6.585LeuAla: 6.585 ± 0.544
3.86LeuCys: 3.86 ± 0.846
4.92LeuAsp: 4.92 ± 0.864
3.633LeuGlu: 3.633 ± 0.403
5.223LeuPhe: 5.223 ± 0.684
5.601LeuGly: 5.601 ± 0.756
1.817LeuHis: 1.817 ± 0.188
3.784LeuIle: 3.784 ± 0.502
7.039LeuLys: 7.039 ± 1.728
8.856LeuLeu: 8.856 ± 1.269
1.287LeuMet: 1.287 ± 0.404
4.693LeuAsn: 4.693 ± 0.591
4.39LeuPro: 4.39 ± 0.916
4.541LeuGln: 4.541 ± 0.613
3.103LeuArg: 3.103 ± 0.344
6.509LeuSer: 6.509 ± 0.365
5.374LeuThr: 5.374 ± 0.74
6.736LeuVal: 6.736 ± 1.408
1.06LeuTrp: 1.06 ± 0.946
4.617LeuTyr: 4.617 ± 0.512
0.0LeuXaa: 0.0 ± 0.0
Met
1.438MetAla: 1.438 ± 0.628
0.606MetCys: 0.606 ± 0.311
1.287MetAsp: 1.287 ± 0.315
0.227MetGlu: 0.227 ± 0.107
1.665MetPhe: 1.665 ± 0.306
1.06MetGly: 1.06 ± 0.235
0.833MetHis: 0.833 ± 0.271
0.454MetIle: 0.454 ± 0.259
0.681MetLys: 0.681 ± 0.161
2.573MetLeu: 2.573 ± 0.312
0.227MetMet: 0.227 ± 0.152
0.757MetAsn: 0.757 ± 0.193
0.378MetPro: 0.378 ± 0.163
0.454MetGln: 0.454 ± 0.075
1.06MetArg: 1.06 ± 0.229
1.741MetSer: 1.741 ± 0.306
0.984MetThr: 0.984 ± 0.27
1.438MetVal: 1.438 ± 0.264
0.151MetTrp: 0.151 ± 0.053
1.362MetTyr: 1.362 ± 0.161
0.0MetXaa: 0.0 ± 0.0
Asn
3.936AsnAla: 3.936 ± 0.347
2.573AsnCys: 2.573 ± 0.614
2.573AsnAsp: 2.573 ± 0.296
1.589AsnGlu: 1.589 ± 0.138
2.044AsnPhe: 2.044 ± 0.445
5.298AsnGly: 5.298 ± 0.671
1.287AsnHis: 1.287 ± 0.307
3.255AsnIle: 3.255 ± 0.316
2.044AsnLys: 2.044 ± 0.382
4.541AsnLeu: 4.541 ± 0.512
1.438AsnMet: 1.438 ± 0.101
3.633AsnAsn: 3.633 ± 1.273
1.514AsnPro: 1.514 ± 0.37
2.044AsnGln: 2.044 ± 0.432
1.514AsnArg: 1.514 ± 0.346
4.617AsnSer: 4.617 ± 0.953
3.028AsnThr: 3.028 ± 0.646
7.115AsnVal: 7.115 ± 0.566
0.303AsnTrp: 0.303 ± 0.684
2.271AsnTyr: 2.271 ± 0.288
0.0AsnXaa: 0.0 ± 0.0
Pro
1.589ProAla: 1.589 ± 0.133
0.757ProCys: 0.757 ± 0.157
1.892ProAsp: 1.892 ± 0.341
1.892ProGlu: 1.892 ± 0.156
1.741ProPhe: 1.741 ± 0.178
3.028ProGly: 3.028 ± 0.421
0.681ProHis: 0.681 ± 0.155
2.346ProIle: 2.346 ± 0.278
2.195ProLys: 2.195 ± 1.189
4.239ProLeu: 4.239 ± 0.596
0.454ProMet: 0.454 ± 0.075
1.741ProAsn: 1.741 ± 0.571
1.438ProPro: 1.438 ± 0.268
0.833ProGln: 0.833 ± 0.414
1.211ProArg: 1.211 ± 0.487
2.573ProSer: 2.573 ± 0.257
2.271ProThr: 2.271 ± 0.98
4.466ProVal: 4.466 ± 0.809
0.454ProTrp: 0.454 ± 0.075
0.606ProTyr: 0.606 ± 0.307
0.0ProXaa: 0.0 ± 0.0
Gln
2.195GlnAla: 2.195 ± 0.231
0.378GlnCys: 0.378 ± 0.119
2.044GlnAsp: 2.044 ± 0.385
0.681GlnGlu: 0.681 ± 0.149
1.287GlnPhe: 1.287 ± 0.232
1.892GlnGly: 1.892 ± 0.508
0.681GlnHis: 0.681 ± 0.223
1.211GlnIle: 1.211 ± 0.138
1.211GlnLys: 1.211 ± 0.299
4.541GlnLeu: 4.541 ± 0.853
0.606GlnMet: 0.606 ± 0.133
1.287GlnAsn: 1.287 ± 0.385
1.362GlnPro: 1.362 ± 0.7
1.06GlnGln: 1.06 ± 0.362
1.438GlnArg: 1.438 ± 0.686
2.8GlnSer: 2.8 ± 0.712
1.741GlnThr: 1.741 ± 0.374
2.119GlnVal: 2.119 ± 0.806
0.378GlnTrp: 0.378 ± 0.161
1.362GlnTyr: 1.362 ± 0.287
0.0GlnXaa: 0.0 ± 0.0
Arg
2.573ArgAla: 2.573 ± 0.586
1.438ArgCys: 1.438 ± 0.264
1.287ArgAsp: 1.287 ± 0.104
1.06ArgGlu: 1.06 ± 0.182
1.817ArgPhe: 1.817 ± 0.384
2.271ArgGly: 2.271 ± 1.487
1.06ArgHis: 1.06 ± 0.153
1.741ArgIle: 1.741 ± 0.261
2.044ArgLys: 2.044 ± 0.407
4.087ArgLeu: 4.087 ± 0.589
0.757ArgMet: 0.757 ± 0.224
1.892ArgAsn: 1.892 ± 0.679
1.06ArgPro: 1.06 ± 0.2
0.757ArgGln: 0.757 ± 0.211
1.589ArgArg: 1.589 ± 0.409
1.817ArgSer: 1.817 ± 1.524
2.271ArgThr: 2.271 ± 0.729
3.33ArgVal: 3.33 ± 0.543
0.454ArgTrp: 0.454 ± 0.2
1.287ArgTyr: 1.287 ± 0.212
0.0ArgXaa: 0.0 ± 0.0
Ser
4.995SerAla: 4.995 ± 0.72
1.589SerCys: 1.589 ± 0.19
5.071SerAsp: 5.071 ± 0.892
2.725SerGlu: 2.725 ± 0.36
3.784SerPhe: 3.784 ± 0.631
4.995SerGly: 4.995 ± 0.425
0.984SerHis: 0.984 ± 0.253
3.028SerIle: 3.028 ± 0.722
3.406SerLys: 3.406 ± 0.48
6.358SerLeu: 6.358 ± 1.15
1.514SerMet: 1.514 ± 0.194
5.45SerAsn: 5.45 ± 0.407
1.741SerPro: 1.741 ± 0.412
2.195SerGln: 2.195 ± 0.775
2.498SerArg: 2.498 ± 2.492
4.995SerSer: 4.995 ± 0.758
4.314SerThr: 4.314 ± 0.413
6.661SerVal: 6.661 ± 0.408
0.757SerTrp: 0.757 ± 0.537
4.39SerTyr: 4.39 ± 0.529
0.0SerXaa: 0.0 ± 0.0
Thr
2.8ThrAla: 2.8 ± 0.427
1.665ThrCys: 1.665 ± 0.258
3.103ThrAsp: 3.103 ± 0.549
2.119ThrGlu: 2.119 ± 0.174
3.709ThrPhe: 3.709 ± 0.575
3.557ThrGly: 3.557 ± 1.027
0.908ThrHis: 0.908 ± 0.278
4.541ThrIle: 4.541 ± 0.539
3.936ThrLys: 3.936 ± 0.464
6.736ThrLeu: 6.736 ± 0.632
1.362ThrMet: 1.362 ± 0.379
3.86ThrAsn: 3.86 ± 0.675
2.725ThrPro: 2.725 ± 0.865
2.346ThrGln: 2.346 ± 0.409
2.422ThrArg: 2.422 ± 0.299
5.298ThrSer: 5.298 ± 0.902
2.876ThrThr: 2.876 ± 0.576
4.92ThrVal: 4.92 ± 0.626
0.227ThrTrp: 0.227 ± 0.107
3.179ThrTyr: 3.179 ± 0.482
0.0ThrXaa: 0.0 ± 0.0
Val
6.509ValAla: 6.509 ± 0.661
3.33ValCys: 3.33 ± 0.302
6.434ValAsp: 6.434 ± 0.934
5.374ValGlu: 5.374 ± 1.469
4.693ValPhe: 4.693 ± 0.082
5.677ValGly: 5.677 ± 0.398
1.741ValHis: 1.741 ± 0.301
4.617ValIle: 4.617 ± 0.677
5.979ValLys: 5.979 ± 0.68
8.174ValLeu: 8.174 ± 0.912
1.665ValMet: 1.665 ± 0.321
6.055ValAsn: 6.055 ± 1.065
4.541ValPro: 4.541 ± 0.82
4.087ValGln: 4.087 ± 0.689
2.952ValArg: 2.952 ± 0.639
6.509ValSer: 6.509 ± 0.814
6.358ValThr: 6.358 ± 1.014
12.262ValVal: 12.262 ± 1.969
0.908ValTrp: 0.908 ± 0.15
2.876ValTyr: 2.876 ± 0.819
0.0ValXaa: 0.0 ± 0.0
Trp
0.53TrpAla: 0.53 ± 0.41
0.227TrpCys: 0.227 ± 0.107
0.908TrpAsp: 0.908 ± 0.139
0.606TrpGlu: 0.606 ± 0.111
0.454TrpPhe: 0.454 ± 0.075
0.303TrpGly: 0.303 ± 0.117
0.53TrpHis: 0.53 ± 0.18
0.908TrpIle: 0.908 ± 0.212
0.53TrpLys: 0.53 ± 0.094
1.589TrpLeu: 1.589 ± 0.308
0.076TrpMet: 0.076 ± 0.051
0.454TrpAsn: 0.454 ± 0.474
0.53TrpPro: 0.53 ± 0.274
0.378TrpGln: 0.378 ± 0.119
0.606TrpArg: 0.606 ± 0.697
0.681TrpSer: 0.681 ± 0.179
0.681TrpThr: 0.681 ± 0.126
0.833TrpVal: 0.833 ± 0.503
0.378TrpTrp: 0.378 ± 0.195
0.227TrpTyr: 0.227 ± 0.107
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.649TyrAla: 2.649 ± 0.521
1.968TyrCys: 1.968 ± 0.431
2.422TyrAsp: 2.422 ± 0.752
2.044TyrGlu: 2.044 ± 0.56
2.271TyrPhe: 2.271 ± 0.366
3.028TyrGly: 3.028 ± 0.352
0.833TyrHis: 0.833 ± 0.207
1.892TyrIle: 1.892 ± 0.214
3.179TyrLys: 3.179 ± 0.995
3.028TyrLeu: 3.028 ± 0.423
0.606TyrMet: 0.606 ± 0.168
3.255TyrAsn: 3.255 ± 0.381
0.833TyrPro: 0.833 ± 0.363
0.984TyrGln: 0.984 ± 0.396
1.06TyrArg: 1.06 ± 0.379
3.179TyrSer: 3.179 ± 0.434
2.952TyrThr: 2.952 ± 0.181
3.936TyrVal: 3.936 ± 0.604
0.681TyrTrp: 0.681 ± 0.155
2.649TyrTyr: 2.649 ± 0.344
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (13213 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski