Amino acid dipepetide frequency for Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIMB 9529 / HD100)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.237AlaAla: 8.237 ± 0.129
0.922AlaCys: 0.922 ± 0.029
4.409AlaAsp: 4.409 ± 0.07
5.449AlaGlu: 5.449 ± 0.083
3.497AlaPhe: 3.497 ± 0.057
6.525AlaGly: 6.525 ± 0.107
1.596AlaHis: 1.596 ± 0.035
4.234AlaIle: 4.234 ± 0.071
5.277AlaLys: 5.277 ± 0.083
8.93AlaLeu: 8.93 ± 0.108
2.202AlaMet: 2.202 ± 0.045
3.039AlaAsn: 3.039 ± 0.058
3.568AlaPro: 3.568 ± 0.082
3.913AlaGln: 3.913 ± 0.071
3.945AlaArg: 3.945 ± 0.071
5.479AlaSer: 5.479 ± 0.078
4.516AlaThr: 4.516 ± 0.103
5.8AlaVal: 5.8 ± 0.084
0.93AlaTrp: 0.93 ± 0.033
2.327AlaTyr: 2.327 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
0.849CysAla: 0.849 ± 0.032
0.072CysCys: 0.072 ± 0.008
0.527CysAsp: 0.527 ± 0.025
0.609CysGlu: 0.609 ± 0.025
0.409CysPhe: 0.409 ± 0.019
0.762CysGly: 0.762 ± 0.03
0.264CysHis: 0.264 ± 0.017
0.413CysIle: 0.413 ± 0.018
0.466CysLys: 0.466 ± 0.024
0.898CysLeu: 0.898 ± 0.028
0.228CysMet: 0.228 ± 0.014
0.309CysAsn: 0.309 ± 0.016
0.481CysPro: 0.481 ± 0.024
0.377CysGln: 0.377 ± 0.018
0.504CysArg: 0.504 ± 0.021
0.754CysSer: 0.754 ± 0.029
0.551CysThr: 0.551 ± 0.024
0.684CysVal: 0.684 ± 0.022
0.151CysTrp: 0.151 ± 0.024
0.29CysTyr: 0.29 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
3.694AspAla: 3.694 ± 0.058
0.494AspCys: 0.494 ± 0.02
2.219AspAsp: 2.219 ± 0.049
3.197AspGlu: 3.197 ± 0.055
2.836AspPhe: 2.836 ± 0.056
3.793AspGly: 3.793 ± 0.071
0.993AspHis: 0.993 ± 0.028
3.168AspIle: 3.168 ± 0.054
3.041AspLys: 3.041 ± 0.05
5.816AspLeu: 5.816 ± 0.075
1.245AspMet: 1.245 ± 0.036
1.772AspAsn: 1.772 ± 0.045
2.458AspPro: 2.458 ± 0.041
2.056AspGln: 2.056 ± 0.044
2.6AspArg: 2.6 ± 0.049
3.345AspSer: 3.345 ± 0.058
2.323AspThr: 2.323 ± 0.048
3.748AspVal: 3.748 ± 0.065
0.681AspTrp: 0.681 ± 0.026
1.841AspTyr: 1.841 ± 0.042
0.0AspXaa: 0.0 ± 0.0
Glu
5.503GluAla: 5.503 ± 0.079
0.43GluCys: 0.43 ± 0.021
3.115GluAsp: 3.115 ± 0.063
4.234GluGlu: 4.234 ± 0.072
2.693GluPhe: 2.693 ± 0.051
3.88GluGly: 3.88 ± 0.063
1.089GluHis: 1.089 ± 0.03
4.342GluIle: 4.342 ± 0.066
5.176GluLys: 5.176 ± 0.083
5.949GluLeu: 5.949 ± 0.077
1.884GluMet: 1.884 ± 0.042
2.809GluAsn: 2.809 ± 0.046
1.854GluPro: 1.854 ± 0.047
2.399GluGln: 2.399 ± 0.05
3.16GluArg: 3.16 ± 0.054
3.906GluSer: 3.906 ± 0.061
3.146GluThr: 3.146 ± 0.054
4.839GluVal: 4.839 ± 0.071
0.697GluTrp: 0.697 ± 0.026
1.789GluTyr: 1.789 ± 0.041
0.0GluXaa: 0.0 ± 0.0
Phe
3.884PheAla: 3.884 ± 0.063
0.518PheCys: 0.518 ± 0.021
2.566PheAsp: 2.566 ± 0.052
2.74PheGlu: 2.74 ± 0.054
2.173PhePhe: 2.173 ± 0.054
3.061PheGly: 3.061 ± 0.059
0.909PheHis: 0.909 ± 0.03
2.354PheIle: 2.354 ± 0.051
2.78PheLys: 2.78 ± 0.049
4.325PheLeu: 4.325 ± 0.07
1.237PheMet: 1.237 ± 0.031
1.954PheAsn: 1.954 ± 0.047
1.727PhePro: 1.727 ± 0.043
1.532PheGln: 1.532 ± 0.035
1.912PheArg: 1.912 ± 0.044
3.252PheSer: 3.252 ± 0.058
2.406PheThr: 2.406 ± 0.046
3.428PheVal: 3.428 ± 0.055
0.581PheTrp: 0.581 ± 0.025
1.5PheTyr: 1.5 ± 0.037
0.0PheXaa: 0.0 ± 0.0
Gly
5.93GlyAla: 5.93 ± 0.092
0.75GlyCys: 0.75 ± 0.025
3.636GlyAsp: 3.636 ± 0.063
3.981GlyGlu: 3.981 ± 0.066
3.381GlyPhe: 3.381 ± 0.065
5.807GlyGly: 5.807 ± 0.123
1.511GlyHis: 1.511 ± 0.043
4.08GlyIle: 4.08 ± 0.066
4.541GlyLys: 4.541 ± 0.067
7.096GlyLeu: 7.096 ± 0.081
1.929GlyMet: 1.929 ± 0.057
2.833GlyAsn: 2.833 ± 0.086
2.385GlyPro: 2.385 ± 0.047
2.682GlyGln: 2.682 ± 0.047
3.244GlyArg: 3.244 ± 0.054
5.105GlySer: 5.105 ± 0.093
4.774GlyThr: 4.774 ± 0.135
5.21GlyVal: 5.21 ± 0.088
0.857GlyTrp: 0.857 ± 0.028
2.421GlyTyr: 2.421 ± 0.06
0.0GlyXaa: 0.0 ± 0.0
His
1.328HisAla: 1.328 ± 0.04
0.247HisCys: 0.247 ± 0.015
0.942HisAsp: 0.942 ± 0.03
1.128HisGlu: 1.128 ± 0.038
1.056HisPhe: 1.056 ± 0.027
1.333HisGly: 1.333 ± 0.037
0.508HisHis: 0.508 ± 0.024
1.028HisIle: 1.028 ± 0.032
1.035HisLys: 1.035 ± 0.031
2.075HisLeu: 2.075 ± 0.044
0.507HisMet: 0.507 ± 0.021
0.679HisAsn: 0.679 ± 0.026
1.152HisPro: 1.152 ± 0.033
0.725HisGln: 0.725 ± 0.028
0.974HisArg: 0.974 ± 0.027
1.248HisSer: 1.248 ± 0.033
0.88HisThr: 0.88 ± 0.029
1.17HisVal: 1.17 ± 0.033
0.311HisTrp: 0.311 ± 0.015
0.667HisTyr: 0.667 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
4.552IleAla: 4.552 ± 0.071
0.596IleCys: 0.596 ± 0.025
2.936IleAsp: 2.936 ± 0.054
3.923IleGlu: 3.923 ± 0.071
2.446IlePhe: 2.446 ± 0.051
3.653IleGly: 3.653 ± 0.062
1.152IleHis: 1.152 ± 0.031
2.73IleIle: 2.73 ± 0.048
3.349IleLys: 3.349 ± 0.058
5.554IleLeu: 5.554 ± 0.09
1.197IleMet: 1.197 ± 0.036
2.311IleAsn: 2.311 ± 0.048
2.754IlePro: 2.754 ± 0.055
2.382IleGln: 2.382 ± 0.047
2.892IleArg: 2.892 ± 0.047
4.324IleSer: 4.324 ± 0.055
3.193IleThr: 3.193 ± 0.061
3.753IleVal: 3.753 ± 0.059
0.571IleTrp: 0.571 ± 0.019
1.766IleTyr: 1.766 ± 0.04
0.0IleXaa: 0.0 ± 0.0
Lys
5.867LysAla: 5.867 ± 0.085
0.434LysCys: 0.434 ± 0.024
3.985LysAsp: 3.985 ± 0.065
4.431LysGlu: 4.431 ± 0.065
2.375LysPhe: 2.375 ± 0.048
4.147LysGly: 4.147 ± 0.068
1.09LysHis: 1.09 ± 0.034
4.237LysIle: 4.237 ± 0.061
5.461LysLys: 5.461 ± 0.089
5.246LysLeu: 5.246 ± 0.067
2.083LysMet: 2.083 ± 0.045
3.339LysAsn: 3.339 ± 0.058
2.469LysPro: 2.469 ± 0.049
2.045LysGln: 2.045 ± 0.046
2.615LysArg: 2.615 ± 0.051
4.31LysSer: 4.31 ± 0.068
3.959LysThr: 3.959 ± 0.063
4.702LysVal: 4.702 ± 0.068
0.705LysTrp: 0.705 ± 0.023
1.904LysTyr: 1.904 ± 0.041
0.0LysXaa: 0.0 ± 0.0
Leu
8.108LeuAla: 8.108 ± 0.098
0.933LeuCys: 0.933 ± 0.027
4.724LeuAsp: 4.724 ± 0.067
6.013LeuGlu: 6.013 ± 0.091
4.136LeuPhe: 4.136 ± 0.07
6.989LeuGly: 6.989 ± 0.088
1.772LeuHis: 1.772 ± 0.039
5.48LeuIle: 5.48 ± 0.07
7.277LeuLys: 7.277 ± 0.087
9.224LeuLeu: 9.224 ± 0.117
2.697LeuMet: 2.697 ± 0.047
4.404LeuAsn: 4.404 ± 0.065
4.274LeuPro: 4.274 ± 0.062
3.778LeuGln: 3.778 ± 0.069
4.952LeuArg: 4.952 ± 0.068
7.443LeuSer: 7.443 ± 0.068
5.572LeuThr: 5.572 ± 0.068
6.443LeuVal: 6.443 ± 0.077
1.066LeuTrp: 1.066 ± 0.029
2.498LeuTyr: 2.498 ± 0.045
0.0LeuXaa: 0.0 ± 0.0
Met
2.496MetAla: 2.496 ± 0.048
0.194MetCys: 0.194 ± 0.013
1.381MetAsp: 1.381 ± 0.038
1.524MetGlu: 1.524 ± 0.033
0.874MetPhe: 0.874 ± 0.026
2.13MetGly: 2.13 ± 0.062
0.386MetHis: 0.386 ± 0.018
1.579MetIle: 1.579 ± 0.04
2.563MetLys: 2.563 ± 0.047
2.002MetLeu: 2.002 ± 0.045
0.844MetMet: 0.844 ± 0.038
1.407MetAsn: 1.407 ± 0.035
1.065MetPro: 1.065 ± 0.034
0.998MetGln: 0.998 ± 0.03
1.293MetArg: 1.293 ± 0.033
1.923MetSer: 1.923 ± 0.038
1.781MetThr: 1.781 ± 0.04
1.676MetVal: 1.676 ± 0.033
0.228MetTrp: 0.228 ± 0.012
0.545MetTyr: 0.545 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
3.049AsnAla: 3.049 ± 0.064
0.436AsnCys: 0.436 ± 0.022
1.87AsnAsp: 1.87 ± 0.045
2.328AsnGlu: 2.328 ± 0.046
2.011AsnPhe: 2.011 ± 0.044
3.075AsnGly: 3.075 ± 0.09
0.742AsnHis: 0.742 ± 0.027
2.419AsnIle: 2.419 ± 0.047
2.486AsnLys: 2.486 ± 0.045
4.223AsnLeu: 4.223 ± 0.062
1.064AsnMet: 1.064 ± 0.031
1.776AsnAsn: 1.776 ± 0.082
2.432AsnPro: 2.432 ± 0.046
1.693AsnGln: 1.693 ± 0.04
1.911AsnArg: 1.911 ± 0.038
2.928AsnSer: 2.928 ± 0.065
2.228AsnThr: 2.228 ± 0.051
2.633AsnVal: 2.633 ± 0.056
0.592AsnTrp: 0.592 ± 0.023
1.495AsnTyr: 1.495 ± 0.039
0.0AsnXaa: 0.0 ± 0.0
Pro
4.128ProAla: 4.128 ± 0.081
0.308ProCys: 0.308 ± 0.018
2.187ProAsp: 2.187 ± 0.043
3.356ProGlu: 3.356 ± 0.052
1.884ProPhe: 1.884 ± 0.042
2.956ProGly: 2.956 ± 0.045
0.868ProHis: 0.868 ± 0.028
1.814ProIle: 1.814 ± 0.046
2.347ProLys: 2.347 ± 0.058
3.835ProLeu: 3.835 ± 0.058
1.136ProMet: 1.136 ± 0.031
1.569ProAsn: 1.569 ± 0.04
1.543ProPro: 1.543 ± 0.047
1.903ProGln: 1.903 ± 0.046
1.739ProArg: 1.739 ± 0.041
2.684ProSer: 2.684 ± 0.055
2.405ProThr: 2.405 ± 0.053
3.435ProVal: 3.435 ± 0.058
0.564ProTrp: 0.564 ± 0.022
1.319ProTyr: 1.319 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
3.471GlnAla: 3.471 ± 0.065
0.3GlnCys: 0.3 ± 0.016
2.047GlnAsp: 2.047 ± 0.04
2.521GlnGlu: 2.521 ± 0.049
1.661GlnPhe: 1.661 ± 0.035
2.8GlnGly: 2.8 ± 0.054
0.636GlnHis: 0.636 ± 0.024
2.586GlnIle: 2.586 ± 0.051
3.045GlnLys: 3.045 ± 0.061
3.274GlnLeu: 3.274 ± 0.054
1.287GlnMet: 1.287 ± 0.036
1.858GlnAsn: 1.858 ± 0.042
1.29GlnPro: 1.29 ± 0.035
1.596GlnGln: 1.596 ± 0.055
1.953GlnArg: 1.953 ± 0.045
2.554GlnSer: 2.554 ± 0.055
2.021GlnThr: 2.021 ± 0.04
2.887GlnVal: 2.887 ± 0.047
0.574GlnTrp: 0.574 ± 0.022
1.14GlnTyr: 1.14 ± 0.032
0.0GlnXaa: 0.0 ± 0.0
Arg
3.601ArgAla: 3.601 ± 0.066
0.388ArgCys: 0.388 ± 0.019
2.576ArgAsp: 2.576 ± 0.049
3.26ArgGlu: 3.26 ± 0.056
2.271ArgPhe: 2.271 ± 0.049
3.049ArgGly: 3.049 ± 0.062
0.951ArgHis: 0.951 ± 0.03
3.069ArgIle: 3.069 ± 0.052
2.942ArgLys: 2.942 ± 0.055
4.875ArgLeu: 4.875 ± 0.073
1.479ArgMet: 1.479 ± 0.033
1.905ArgAsn: 1.905 ± 0.039
1.943ArgPro: 1.943 ± 0.038
1.895ArgGln: 1.895 ± 0.041
2.505ArgArg: 2.505 ± 0.053
2.989ArgSer: 2.989 ± 0.056
2.415ArgThr: 2.415 ± 0.044
3.303ArgVal: 3.303 ± 0.048
0.651ArgTrp: 0.651 ± 0.022
1.615ArgTyr: 1.615 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
5.885SerAla: 5.885 ± 0.075
0.77SerCys: 0.77 ± 0.03
3.235SerAsp: 3.235 ± 0.056
4.125SerGlu: 4.125 ± 0.059
3.525SerPhe: 3.525 ± 0.057
5.535SerGly: 5.535 ± 0.103
1.342SerHis: 1.342 ± 0.03
3.477SerIle: 3.477 ± 0.049
3.796SerLys: 3.796 ± 0.059
7.605SerLeu: 7.605 ± 0.089
1.738SerMet: 1.738 ± 0.041
2.34SerAsn: 2.34 ± 0.053
2.951SerPro: 2.951 ± 0.049
2.893SerGln: 2.893 ± 0.045
3.292SerArg: 3.292 ± 0.056
5.087SerSer: 5.087 ± 0.081
3.692SerThr: 3.692 ± 0.072
4.88SerVal: 4.88 ± 0.061
0.936SerTrp: 0.936 ± 0.032
2.245SerTyr: 2.245 ± 0.043
0.0SerXaa: 0.0 ± 0.0
Thr
5.038ThrAla: 5.038 ± 0.106
0.607ThrCys: 0.607 ± 0.028
2.835ThrAsp: 2.835 ± 0.057
3.222ThrGlu: 3.222 ± 0.056
2.324ThrPhe: 2.324 ± 0.05
4.43ThrGly: 4.43 ± 0.101
1.093ThrHis: 1.093 ± 0.03
2.723ThrIle: 2.723 ± 0.05
2.919ThrLys: 2.919 ± 0.052
5.741ThrLeu: 5.741 ± 0.076
1.192ThrMet: 1.192 ± 0.035
2.146ThrAsn: 2.146 ± 0.058
2.99ThrPro: 2.99 ± 0.054
2.14ThrGln: 2.14 ± 0.047
2.411ThrArg: 2.411 ± 0.046
3.862ThrSer: 3.862 ± 0.083
3.305ThrThr: 3.305 ± 0.086
4.229ThrVal: 4.229 ± 0.075
0.655ThrTrp: 0.655 ± 0.025
1.802ThrTyr: 1.802 ± 0.046
0.0ThrXaa: 0.0 ± 0.0
Val
6.082ValAla: 6.082 ± 0.086
0.702ValCys: 0.702 ± 0.025
3.784ValAsp: 3.784 ± 0.06
4.403ValGlu: 4.403 ± 0.077
3.191ValPhe: 3.191 ± 0.059
5.086ValGly: 5.086 ± 0.082
1.249ValHis: 1.249 ± 0.032
4.135ValIle: 4.135 ± 0.056
4.34ValLys: 4.34 ± 0.072
7.001ValLeu: 7.001 ± 0.085
1.798ValMet: 1.798 ± 0.034
2.917ValAsn: 2.917 ± 0.054
2.958ValPro: 2.958 ± 0.054
2.693ValGln: 2.693 ± 0.043
3.485ValArg: 3.485 ± 0.059
4.984ValSer: 4.984 ± 0.069
4.278ValThr: 4.278 ± 0.087
5.354ValVal: 5.354 ± 0.079
0.694ValTrp: 0.694 ± 0.026
1.947ValTyr: 1.947 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
0.999TrpAla: 0.999 ± 0.028
0.104TrpCys: 0.104 ± 0.01
0.645TrpAsp: 0.645 ± 0.025
0.643TrpGlu: 0.643 ± 0.025
0.459TrpPhe: 0.459 ± 0.022
1.009TrpGly: 1.009 ± 0.038
0.214TrpHis: 0.214 ± 0.014
0.717TrpIle: 0.717 ± 0.028
0.812TrpLys: 0.812 ± 0.03
1.075TrpLeu: 1.075 ± 0.03
0.389TrpMet: 0.389 ± 0.018
0.662TrpAsn: 0.662 ± 0.022
0.413TrpPro: 0.413 ± 0.021
0.481TrpGln: 0.481 ± 0.019
0.542TrpArg: 0.542 ± 0.02
0.9TrpSer: 0.9 ± 0.028
0.671TrpThr: 0.671 ± 0.023
0.854TrpVal: 0.854 ± 0.031
0.157TrpTrp: 0.157 ± 0.013
0.329TrpTyr: 0.329 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.095TyrAla: 2.095 ± 0.041
0.394TyrCys: 0.394 ± 0.024
1.699TyrAsp: 1.699 ± 0.04
1.809TyrGlu: 1.809 ± 0.042
1.639TyrPhe: 1.639 ± 0.039
2.135TyrGly: 2.135 ± 0.046
0.631TyrHis: 0.631 ± 0.022
1.447TyrIle: 1.447 ± 0.04
1.751TyrLys: 1.751 ± 0.044
3.037TyrLeu: 3.037 ± 0.056
0.751TyrMet: 0.751 ± 0.027
1.362TyrAsn: 1.362 ± 0.041
1.274TyrPro: 1.274 ± 0.039
1.321TyrGln: 1.321 ± 0.034
1.752TyrArg: 1.752 ± 0.039
2.272TyrSer: 2.272 ± 0.05
1.548TyrThr: 1.548 ± 0.041
2.05TyrVal: 2.05 ± 0.044
0.473TyrTrp: 0.473 ± 0.018
1.135TyrTyr: 1.135 ± 0.04
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3583 proteins (1168751 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski