Amino acid dipepetide frequency for Cutibacterium acnes JCM 18916

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.686AlaAla: 12.686 ± 0.159	1.355AlaCys: 1.355 ± 0.05	6.51AlaAsp: 6.51 ± 0.099	5.917AlaGlu: 5.917 ± 0.104	2.8AlaPhe: 2.8 ± 0.066	9.554AlaGly: 9.554 ± 0.134	2.593AlaHis: 2.593 ± 0.057	5.45AlaIle: 5.45 ± 0.11	3.298AlaLys: 3.298 ± 0.091	9.854AlaLeu: 9.854 ± 0.135	3.243AlaMet: 3.243 ± 0.076	2.462AlaAsn: 2.462 ± 0.063	4.95AlaPro: 4.95 ± 0.089	3.363AlaGln: 3.363 ± 0.077	7.449AlaArg: 7.449 ± 0.109	6.962AlaSer: 6.962 ± 0.103	6.786AlaThr: 6.786 ± 0.095	9.044AlaVal: 9.044 ± 0.119	1.785AlaTrp: 1.785 ± 0.052	1.787AlaTyr: 1.787 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.301CysAla: 1.301 ± 0.047	0.363CysCys: 0.363 ± 0.026	0.702CysAsp: 0.702 ± 0.034	0.527CysGlu: 0.527 ± 0.025	0.346CysPhe: 0.346 ± 0.021	1.333CysGly: 1.333 ± 0.045	0.366CysHis: 0.366 ± 0.025	0.405CysIle: 0.405 ± 0.029	0.205CysLys: 0.205 ± 0.017	1.146CysLeu: 1.146 ± 0.043	0.32CysMet: 0.32 ± 0.021	0.221CysAsn: 0.221 ± 0.017	0.81CysPro: 0.81 ± 0.035	0.467CysGln: 0.467 ± 0.028	1.149CysArg: 1.149 ± 0.041	0.962CysSer: 0.962 ± 0.039	0.656CysThr: 0.656 ± 0.031	0.902CysVal: 0.902 ± 0.038	0.31CysTrp: 0.31 ± 0.021	0.244CysTyr: 0.244 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	6.401AspAla: 6.401 ± 0.102	0.493AspCys: 0.493 ± 0.024	4.434AspAsp: 4.434 ± 0.1	4.12AspGlu: 4.12 ± 0.087	1.548AspPhe: 1.548 ± 0.045	5.267AspGly: 5.267 ± 0.089	1.699AspHis: 1.699 ± 0.045	2.662AspIle: 2.662 ± 0.063	1.62AspLys: 1.62 ± 0.052	6.069AspLeu: 6.069 ± 0.111	1.234AspMet: 1.234 ± 0.041	1.3AspAsn: 1.3 ± 0.044	3.877AspPro: 3.877 ± 0.079	1.837AspGln: 1.837 ± 0.05	4.084AspArg: 4.084 ± 0.073	3.09AspSer: 3.09 ± 0.065	2.827AspThr: 2.827 ± 0.061	5.23AspVal: 5.23 ± 0.083	0.823AspTrp: 0.823 ± 0.038	1.228AspTyr: 1.228 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	5.724GluAla: 5.724 ± 0.089	0.44GluCys: 0.44 ± 0.024	2.636GluAsp: 2.636 ± 0.062	2.943GluGlu: 2.943 ± 0.08	1.458GluPhe: 1.458 ± 0.043	3.582GluGly: 3.582 ± 0.08	1.336GluHis: 1.336 ± 0.051	2.634GluIle: 2.634 ± 0.055	1.706GluLys: 1.706 ± 0.055	5.243GluLeu: 5.243 ± 0.093	1.227GluMet: 1.227 ± 0.037	1.242GluAsn: 1.242 ± 0.041	2.698GluPro: 2.698 ± 0.061	1.754GluGln: 1.754 ± 0.053	3.532GluArg: 3.532 ± 0.074	2.784GluSer: 2.784 ± 0.064	2.607GluThr: 2.607 ± 0.056	4.553GluVal: 4.553 ± 0.078	0.773GluTrp: 0.773 ± 0.032	1.063GluTyr: 1.063 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	2.991PheAla: 2.991 ± 0.069	0.455PheCys: 0.455 ± 0.024	2.028PheAsp: 2.028 ± 0.066	1.215PheGlu: 1.215 ± 0.041	1.245PhePhe: 1.245 ± 0.048	2.787PheGly: 2.787 ± 0.062	0.678PheHis: 0.678 ± 0.03	1.357PheIle: 1.357 ± 0.051	0.629PheLys: 0.629 ± 0.031	2.682PheLeu: 2.682 ± 0.066	0.695PheMet: 0.695 ± 0.03	0.813PheAsn: 0.813 ± 0.036	1.36PhePro: 1.36 ± 0.041	0.74PheGln: 0.74 ± 0.032	1.669PheArg: 1.669 ± 0.051	1.978PheSer: 1.978 ± 0.048	1.833PheThr: 1.833 ± 0.052	2.397PheVal: 2.397 ± 0.066	0.491PheTrp: 0.491 ± 0.027	0.573PheTyr: 0.573 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	7.988GlyAla: 7.988 ± 0.118	1.165GlyCys: 1.165 ± 0.042	4.337GlyAsp: 4.337 ± 0.075	3.881GlyGlu: 3.881 ± 0.084	2.835GlyPhe: 2.835 ± 0.07	6.369GlyGly: 6.369 ± 0.107	2.43GlyHis: 2.43 ± 0.066	4.543GlyIle: 4.543 ± 0.09	2.841GlyLys: 2.841 ± 0.069	8.1GlyLeu: 8.1 ± 0.12	2.512GlyMet: 2.512 ± 0.062	2.053GlyAsn: 2.053 ± 0.061	3.914GlyPro: 3.914 ± 0.088	2.824GlyGln: 2.824 ± 0.069	6.225GlyArg: 6.225 ± 0.092	5.555GlySer: 5.555 ± 0.089	5.04GlyThr: 5.04 ± 0.092	7.171GlyVal: 7.171 ± 0.109	1.775GlyTrp: 1.775 ± 0.042	2.04GlyTyr: 2.04 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.288HisAla: 2.288 ± 0.055	0.312HisCys: 0.312 ± 0.021	1.768HisAsp: 1.768 ± 0.051	1.31HisGlu: 1.31 ± 0.043	0.644HisPhe: 0.644 ± 0.031	2.275HisGly: 2.275 ± 0.056	0.938HisHis: 0.938 ± 0.035	1.057HisIle: 1.057 ± 0.042	0.537HisLys: 0.537 ± 0.032	2.357HisLeu: 2.357 ± 0.058	0.557HisMet: 0.557 ± 0.026	0.645HisAsn: 0.645 ± 0.028	1.833HisPro: 1.833 ± 0.056	0.872HisGln: 0.872 ± 0.037	2.218HisArg: 2.218 ± 0.06	1.366HisSer: 1.366 ± 0.038	1.334HisThr: 1.334 ± 0.039	1.989HisVal: 1.989 ± 0.053	0.375HisTrp: 0.375 ± 0.024	0.497HisTyr: 0.497 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.625IleAla: 5.625 ± 0.098	0.661IleCys: 0.661 ± 0.027	3.519IleAsp: 3.519 ± 0.075	2.468IleGlu: 2.468 ± 0.067	1.355IlePhe: 1.355 ± 0.049	4.589IleGly: 4.589 ± 0.087	1.046IleHis: 1.046 ± 0.04	2.501IleIle: 2.501 ± 0.077	1.264IleLys: 1.264 ± 0.049	4.042IleLeu: 4.042 ± 0.08	1.165IleMet: 1.165 ± 0.041	1.299IleAsn: 1.299 ± 0.042	2.659IlePro: 2.659 ± 0.062	1.031IleGln: 1.031 ± 0.039	2.873IleArg: 2.873 ± 0.07	3.002IleSer: 3.002 ± 0.075	3.2IleThr: 3.2 ± 0.069	4.621IleVal: 4.621 ± 0.08	0.567IleTrp: 0.567 ± 0.029	0.847IleTyr: 0.847 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	3.538LysAla: 3.538 ± 0.082	0.195LysCys: 0.195 ± 0.019	1.543LysAsp: 1.543 ± 0.06	1.392LysGlu: 1.392 ± 0.047	0.682LysPhe: 0.682 ± 0.033	2.034LysGly: 2.034 ± 0.054	0.557LysHis: 0.557 ± 0.03	1.467LysIle: 1.467 ± 0.051	1.469LysLys: 1.469 ± 0.051	2.498LysLeu: 2.498 ± 0.059	0.664LysMet: 0.664 ± 0.029	0.704LysAsn: 0.704 ± 0.033	1.765LysPro: 1.765 ± 0.055	0.822LysGln: 0.822 ± 0.037	1.913LysArg: 1.913 ± 0.053	1.695LysSer: 1.695 ± 0.049	1.744LysThr: 1.744 ± 0.044	2.751LysVal: 2.751 ± 0.074	0.33LysTrp: 0.33 ± 0.021	0.589LysTyr: 0.589 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	11.49LeuAla: 11.49 ± 0.144	1.083LeuCys: 1.083 ± 0.039	6.099LeuAsp: 6.099 ± 0.096	4.154LeuGlu: 4.154 ± 0.08	2.442LeuPhe: 2.442 ± 0.073	7.938LeuGly: 7.938 ± 0.104	1.961LeuHis: 1.961 ± 0.052	4.078LeuIle: 4.078 ± 0.079	2.314LeuLys: 2.314 ± 0.057	8.341LeuLeu: 8.341 ± 0.13	2.221LeuMet: 2.221 ± 0.06	2.143LeuAsn: 2.143 ± 0.058	5.466LeuPro: 5.466 ± 0.095	2.048LeuGln: 2.048 ± 0.054	6.329LeuArg: 6.329 ± 0.113	6.37LeuSer: 6.37 ± 0.099	6.559LeuThr: 6.559 ± 0.091	8.713LeuVal: 8.713 ± 0.128	1.228LeuTrp: 1.228 ± 0.047	1.412LeuTyr: 1.412 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	3.411MetAla: 3.411 ± 0.071	0.306MetCys: 0.306 ± 0.018	1.221MetAsp: 1.221 ± 0.04	0.995MetGlu: 0.995 ± 0.035	0.671MetPhe: 0.671 ± 0.034	2.132MetGly: 2.132 ± 0.058	0.516MetHis: 0.516 ± 0.024	1.296MetIle: 1.296 ± 0.048	0.826MetLys: 0.826 ± 0.036	2.336MetLeu: 2.336 ± 0.061	0.612MetMet: 0.612 ± 0.032	0.702MetAsn: 0.702 ± 0.033	1.54MetPro: 1.54 ± 0.045	0.572MetGln: 0.572 ± 0.028	1.739MetArg: 1.739 ± 0.049	2.212MetSer: 2.212 ± 0.058	2.369MetThr: 2.369 ± 0.069	2.218MetVal: 2.218 ± 0.05	0.452MetTrp: 0.452 ± 0.023	0.395MetTyr: 0.395 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	2.499AsnAla: 2.499 ± 0.067	0.267AsnCys: 0.267 ± 0.021	1.459AsnAsp: 1.459 ± 0.042	1.179AsnGlu: 1.179 ± 0.04	0.723AsnPhe: 0.723 ± 0.033	2.242AsnGly: 2.242 ± 0.056	0.768AsnHis: 0.768 ± 0.035	1.028AsnIle: 1.028 ± 0.043	0.688AsnLys: 0.688 ± 0.036	2.41AsnLeu: 2.41 ± 0.062	0.498AsnMet: 0.498 ± 0.029	0.697AsnAsn: 0.697 ± 0.029	1.887AsnPro: 1.887 ± 0.058	0.853AsnGln: 0.853 ± 0.037	1.58AsnArg: 1.58 ± 0.042	1.438AsnSer: 1.438 ± 0.046	1.418AsnThr: 1.418 ± 0.049	1.81AsnVal: 1.81 ± 0.062	0.366AsnTrp: 0.366 ± 0.024	0.602AsnTyr: 0.602 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	5.695ProAla: 5.695 ± 0.096	0.697ProCys: 0.697 ± 0.029	3.881ProAsp: 3.881 ± 0.078	3.291ProGlu: 3.291 ± 0.084	1.502ProPhe: 1.502 ± 0.047	4.974ProGly: 4.974 ± 0.084	1.501ProHis: 1.501 ± 0.051	2.287ProIle: 2.287 ± 0.059	1.518ProLys: 1.518 ± 0.043	4.44ProLeu: 4.44 ± 0.085	1.449ProMet: 1.449 ± 0.045	1.373ProAsn: 1.373 ± 0.047	2.501ProPro: 2.501 ± 0.066	1.847ProGln: 1.847 ± 0.057	4.13ProArg: 4.13 ± 0.077	4.276ProSer: 4.276 ± 0.078	4.062ProThr: 4.062 ± 0.103	4.575ProVal: 4.575 ± 0.086	1.07ProTrp: 1.07 ± 0.044	1.039ProTyr: 1.039 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	3.669GlnAla: 3.669 ± 0.07	0.296GlnCys: 0.296 ± 0.02	1.31GlnAsp: 1.31 ± 0.036	1.337GlnGlu: 1.337 ± 0.043	0.8GlnPhe: 0.8 ± 0.039	2.163GlnGly: 2.163 ± 0.055	0.656GlnHis: 0.656 ± 0.031	1.698GlnIle: 1.698 ± 0.052	0.745GlnLys: 0.745 ± 0.032	3.085GlnLeu: 3.085 ± 0.064	0.84GlnMet: 0.84 ± 0.034	0.682GlnAsn: 0.682 ± 0.036	1.663GlnPro: 1.663 ± 0.048	1.09GlnGln: 1.09 ± 0.043	2.417GlnArg: 2.417 ± 0.055	1.564GlnSer: 1.564 ± 0.043	1.678GlnThr: 1.678 ± 0.05	2.821GlnVal: 2.821 ± 0.067	0.586GlnTrp: 0.586 ± 0.03	0.631GlnTyr: 0.631 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	6.63ArgAla: 6.63 ± 0.103	1.244ArgCys: 1.244 ± 0.047	3.771ArgAsp: 3.771 ± 0.083	3.472ArgGlu: 3.472 ± 0.08	2.033ArgPhe: 2.033 ± 0.058	5.193ArgGly: 5.193 ± 0.099	2.305ArgHis: 2.305 ± 0.055	3.773ArgIle: 3.773 ± 0.074	1.974ArgLys: 1.974 ± 0.055	6.567ArgLeu: 6.567 ± 0.093	2.343ArgMet: 2.343 ± 0.059	1.827ArgAsn: 1.827 ± 0.047	4.316ArgPro: 4.316 ± 0.089	2.504ArgGln: 2.504 ± 0.065	7.511ArgArg: 7.511 ± 0.146	5.015ArgSer: 5.015 ± 0.087	4.362ArgThr: 4.362 ± 0.092	5.072ArgVal: 5.072 ± 0.09	1.577ArgTrp: 1.577 ± 0.052	1.482ArgTyr: 1.482 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	6.569SerAla: 6.569 ± 0.102	0.892SerCys: 0.892 ± 0.041	3.386SerAsp: 3.386 ± 0.073	2.739SerGlu: 2.739 ± 0.066	1.902SerPhe: 1.902 ± 0.055	6.047SerGly: 6.047 ± 0.102	1.711SerHis: 1.711 ± 0.053	2.726SerIle: 2.726 ± 0.074	1.747SerLys: 1.747 ± 0.053	5.823SerLeu: 5.823 ± 0.093	2.094SerMet: 2.094 ± 0.057	1.442SerAsn: 1.442 ± 0.045	4.059SerPro: 4.059 ± 0.085	2.231SerGln: 2.231 ± 0.06	5.24SerArg: 5.24 ± 0.091	5.84SerSer: 5.84 ± 0.114	4.681SerThr: 4.681 ± 0.096	5.082SerVal: 5.082 ± 0.087	1.455SerTrp: 1.455 ± 0.043	1.23SerTyr: 1.23 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	6.652ThrAla: 6.652 ± 0.102	0.833ThrCys: 0.833 ± 0.041	3.618ThrAsp: 3.618 ± 0.075	2.779ThrGlu: 2.779 ± 0.063	1.945ThrPhe: 1.945 ± 0.053	5.401ThrGly: 5.401 ± 0.092	1.402ThrHis: 1.402 ± 0.046	3.289ThrIle: 3.289 ± 0.074	1.767ThrLys: 1.767 ± 0.05	5.444ThrLeu: 5.444 ± 0.094	1.744ThrMet: 1.744 ± 0.053	1.587ThrAsn: 1.587 ± 0.05	4.217ThrPro: 4.217 ± 0.093	1.533ThrGln: 1.533 ± 0.049	4.181ThrArg: 4.181 ± 0.084	4.752ThrSer: 4.752 ± 0.078	4.838ThrThr: 4.838 ± 0.105	5.879ThrVal: 5.879 ± 0.104	1.25ThrTrp: 1.25 ± 0.036	1.156ThrTyr: 1.156 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	9.437ValAla: 9.437 ± 0.13	1.105ValCys: 1.105 ± 0.046	5.565ValAsp: 5.565 ± 0.095	4.724ValGlu: 4.724 ± 0.084	2.392ValPhe: 2.392 ± 0.067	6.813ValGly: 6.813 ± 0.108	1.77ValHis: 1.77 ± 0.054	4.621ValIle: 4.621 ± 0.095	2.34ValLys: 2.34 ± 0.061	8.041ValLeu: 8.041 ± 0.114	2.261ValMet: 2.261 ± 0.066	2.282ValAsn: 2.282 ± 0.061	4.499ValPro: 4.499 ± 0.087	1.939ValGln: 1.939 ± 0.056	5.579ValArg: 5.579 ± 0.092	5.583ValSer: 5.583 ± 0.1	6.154ValThr: 6.154 ± 0.092	8.498ValVal: 8.498 ± 0.131	1.176ValTrp: 1.176 ± 0.043	1.337ValTyr: 1.337 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	1.472TrpAla: 1.472 ± 0.048	0.333TrpCys: 0.333 ± 0.021	0.763TrpAsp: 0.763 ± 0.037	0.583TrpGlu: 0.583 ± 0.03	0.655TrpPhe: 0.655 ± 0.035	1.185TrpGly: 1.185 ± 0.044	0.45TrpHis: 0.45 ± 0.027	0.81TrpIle: 0.81 ± 0.035	0.452TrpLys: 0.452 ± 0.024	1.841TrpLeu: 1.841 ± 0.051	0.494TrpMet: 0.494 ± 0.024	0.487TrpAsn: 0.487 ± 0.027	1.02TrpPro: 1.02 ± 0.039	0.71TrpGln: 0.71 ± 0.031	1.54TrpArg: 1.54 ± 0.049	1.265TrpSer: 1.265 ± 0.042	1.074TrpThr: 1.074 ± 0.041	1.277TrpVal: 1.277 ± 0.037	0.458TrpTrp: 0.458 ± 0.026	0.338TrpTyr: 0.338 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.778TyrAla: 1.778 ± 0.055	0.246TyrCys: 0.246 ± 0.021	1.293TyrAsp: 1.293 ± 0.046	0.908TyrGlu: 0.908 ± 0.041	0.641TyrPhe: 0.641 ± 0.032	1.721TyrGly: 1.721 ± 0.046	0.49TyrHis: 0.49 ± 0.025	0.651TyrIle: 0.651 ± 0.031	0.409TyrLys: 0.409 ± 0.027	2.068TyrLeu: 2.068 ± 0.057	0.345TyrMet: 0.345 ± 0.021	0.452TyrAsn: 0.452 ± 0.027	1.074TyrPro: 1.074 ± 0.037	0.698TyrGln: 0.698 ± 0.035	1.612TyrArg: 1.612 ± 0.048	1.186TyrSer: 1.186 ± 0.048	1.047TyrThr: 1.047 ± 0.047	1.513TyrVal: 1.513 ± 0.045	0.358TyrTrp: 0.358 ± 0.021	0.444TyrTyr: 0.444 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3663 proteins (696179 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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