Amino acid dipepetide frequency for Blastomyces parvus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.789AlaAla: 8.789 ± 0.068	0.935AlaCys: 0.935 ± 0.016	4.085AlaAsp: 4.085 ± 0.035	5.103AlaGlu: 5.103 ± 0.045	2.918AlaPhe: 2.918 ± 0.027	5.809AlaGly: 5.809 ± 0.048	1.735AlaHis: 1.735 ± 0.02	4.135AlaIle: 4.135 ± 0.036	4.035AlaLys: 4.035 ± 0.036	7.378AlaLeu: 7.378 ± 0.051	1.762AlaMet: 1.762 ± 0.02	2.997AlaAsn: 2.997 ± 0.029	4.703AlaPro: 4.703 ± 0.04	3.198AlaGln: 3.198 ± 0.037	4.92AlaArg: 4.92 ± 0.039	7.132AlaSer: 7.132 ± 0.047	5.178AlaThr: 5.178 ± 0.042	5.059AlaVal: 5.059 ± 0.039	0.979AlaTrp: 0.979 ± 0.018	1.958AlaTyr: 1.958 ± 0.023	0.0AlaXaa: 0.0 ± 0.0
Cys	0.879CysAla: 0.879 ± 0.015	0.229CysCys: 0.229 ± 0.008	0.634CysAsp: 0.634 ± 0.012	0.597CysGlu: 0.597 ± 0.012	0.495CysPhe: 0.495 ± 0.012	0.88CysGly: 0.88 ± 0.017	0.312CysHis: 0.312 ± 0.009	0.669CysIle: 0.669 ± 0.013	0.509CysLys: 0.509 ± 0.011	1.18CysLeu: 1.18 ± 0.017	0.243CysMet: 0.243 ± 0.008	0.396CysAsn: 0.396 ± 0.009	0.664CysPro: 0.664 ± 0.015	0.438CysGln: 0.438 ± 0.01	0.738CysArg: 0.738 ± 0.014	0.896CysSer: 0.896 ± 0.016	0.638CysThr: 0.638 ± 0.011	0.731CysVal: 0.731 ± 0.014	0.182CysTrp: 0.182 ± 0.007	0.338CysTyr: 0.338 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	4.395AspAla: 4.395 ± 0.03	0.609AspCys: 0.609 ± 0.015	4.423AspAsp: 4.423 ± 0.056	4.508AspGlu: 4.508 ± 0.038	2.101AspPhe: 2.101 ± 0.025	4.187AspGly: 4.187 ± 0.038	1.215AspHis: 1.215 ± 0.019	3.317AspIle: 3.317 ± 0.028	2.402AspLys: 2.402 ± 0.027	4.822AspLeu: 4.822 ± 0.04	1.243AspMet: 1.243 ± 0.019	2.014AspAsn: 2.014 ± 0.023	3.381AspPro: 3.381 ± 0.031	1.795AspGln: 1.795 ± 0.022	3.148AspArg: 3.148 ± 0.03	4.234AspSer: 4.234 ± 0.033	2.949AspThr: 2.949 ± 0.03	3.554AspVal: 3.554 ± 0.031	0.763AspTrp: 0.763 ± 0.013	1.533AspTyr: 1.533 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	5.083GluAla: 5.083 ± 0.041	0.641GluCys: 0.641 ± 0.013	4.13GluAsp: 4.13 ± 0.039	5.487GluGlu: 5.487 ± 0.064	1.966GluPhe: 1.966 ± 0.022	3.853GluGly: 3.853 ± 0.039	1.367GluHis: 1.367 ± 0.019	3.227GluIle: 3.227 ± 0.031	3.867GluLys: 3.867 ± 0.043	5.23GluLeu: 5.23 ± 0.049	1.465GluMet: 1.465 ± 0.019	2.547GluAsn: 2.547 ± 0.029	2.973GluPro: 2.973 ± 0.038	2.453GluGln: 2.453 ± 0.029	4.14GluArg: 4.14 ± 0.042	4.393GluSer: 4.393 ± 0.042	3.398GluThr: 3.398 ± 0.032	3.379GluVal: 3.379 ± 0.028	0.847GluTrp: 0.847 ± 0.015	1.706GluTyr: 1.706 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	2.861PheAla: 2.861 ± 0.033	0.528PheCys: 0.528 ± 0.012	2.179PheAsp: 2.179 ± 0.022	2.14PheGlu: 2.14 ± 0.024	1.486PhePhe: 1.486 ± 0.023	2.721PheGly: 2.721 ± 0.03	0.929PheHis: 0.929 ± 0.016	1.747PheIle: 1.747 ± 0.022	1.522PheLys: 1.522 ± 0.02	3.367PheLeu: 3.367 ± 0.032	0.72PheMet: 0.72 ± 0.013	1.403PheAsn: 1.403 ± 0.018	2.048PhePro: 2.048 ± 0.023	1.341PheGln: 1.341 ± 0.018	2.041PheArg: 2.041 ± 0.025	3.083PheSer: 3.083 ± 0.03	2.064PheThr: 2.064 ± 0.023	2.256PheVal: 2.256 ± 0.026	0.579PheTrp: 0.579 ± 0.013	1.053PheTyr: 1.053 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	5.179GlyAla: 5.179 ± 0.04	0.803GlyCys: 0.803 ± 0.014	3.828GlyAsp: 3.828 ± 0.029	3.91GlyGlu: 3.91 ± 0.036	2.609GlyPhe: 2.609 ± 0.027	6.338GlyGly: 6.338 ± 0.066	1.642GlyHis: 1.642 ± 0.022	3.484GlyIle: 3.484 ± 0.034	3.645GlyLys: 3.645 ± 0.039	5.664GlyLeu: 5.664 ± 0.043	1.597GlyMet: 1.597 ± 0.022	2.716GlyAsn: 2.716 ± 0.028	3.3GlyPro: 3.3 ± 0.031	2.476GlyGln: 2.476 ± 0.024	4.269GlyArg: 4.269 ± 0.038	5.827GlySer: 5.827 ± 0.044	3.845GlyThr: 3.845 ± 0.032	4.267GlyVal: 4.267 ± 0.039	1.088GlyTrp: 1.088 ± 0.017	2.028GlyTyr: 2.028 ± 0.026	0.0GlyXaa: 0.0 ± 0.0
His	1.851HisAla: 1.851 ± 0.021	0.315HisCys: 0.315 ± 0.009	1.322HisAsp: 1.322 ± 0.018	1.316HisGlu: 1.316 ± 0.016	0.907HisPhe: 0.907 ± 0.014	1.708HisGly: 1.708 ± 0.02	0.983HisHis: 0.983 ± 0.022	1.276HisIle: 1.276 ± 0.016	0.919HisLys: 0.919 ± 0.017	2.23HisLeu: 2.23 ± 0.026	0.468HisMet: 0.468 ± 0.011	0.915HisAsn: 0.915 ± 0.016	1.875HisPro: 1.875 ± 0.025	1.125HisGln: 1.125 ± 0.021	1.613HisArg: 1.613 ± 0.021	2.066HisSer: 2.066 ± 0.027	1.304HisThr: 1.304 ± 0.019	1.371HisVal: 1.371 ± 0.019	0.294HisTrp: 0.294 ± 0.009	0.668HisTyr: 0.668 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.009IleAla: 4.009 ± 0.038	0.757IleCys: 0.757 ± 0.014	2.92IleAsp: 2.92 ± 0.026	2.892IleGlu: 2.892 ± 0.026	2.021IlePhe: 2.021 ± 0.028	3.078IleGly: 3.078 ± 0.031	1.268IleHis: 1.268 ± 0.017	2.564IleIle: 2.564 ± 0.029	2.218IleLys: 2.218 ± 0.024	4.674IleLeu: 4.674 ± 0.039	0.971IleMet: 0.971 ± 0.015	1.859IleAsn: 1.859 ± 0.023	3.419IlePro: 3.419 ± 0.03	1.89IleGln: 1.89 ± 0.02	2.904IleArg: 2.904 ± 0.026	4.322IleSer: 4.322 ± 0.037	2.802IleThr: 2.802 ± 0.027	3.08IleVal: 3.08 ± 0.028	0.671IleTrp: 0.671 ± 0.013	1.458IleTyr: 1.458 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	4.103LysAla: 4.103 ± 0.036	0.529LysCys: 0.529 ± 0.012	2.723LysAsp: 2.723 ± 0.029	3.475LysGlu: 3.475 ± 0.042	1.568LysPhe: 1.568 ± 0.021	3.072LysGly: 3.072 ± 0.031	1.164LysHis: 1.164 ± 0.019	2.429LysIle: 2.429 ± 0.026	3.415LysLys: 3.415 ± 0.052	4.325LysLeu: 4.325 ± 0.037	1.004LysMet: 1.004 ± 0.016	1.833LysAsn: 1.833 ± 0.022	3.051LysPro: 3.051 ± 0.033	1.978LysGln: 1.978 ± 0.026	3.716LysArg: 3.716 ± 0.036	3.781LysSer: 3.781 ± 0.033	2.726LysThr: 2.726 ± 0.027	2.709LysVal: 2.709 ± 0.029	0.645LysTrp: 0.645 ± 0.013	1.429LysTyr: 1.429 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	7.455LeuAla: 7.455 ± 0.047	1.136LeuCys: 1.136 ± 0.017	5.052LeuAsp: 5.052 ± 0.042	5.555LeuGlu: 5.555 ± 0.049	3.252LeuPhe: 3.252 ± 0.031	5.63LeuGly: 5.63 ± 0.039	2.244LeuHis: 2.244 ± 0.03	3.9LeuIle: 3.9 ± 0.04	4.395LeuLys: 4.395 ± 0.035	8.409LeuLeu: 8.409 ± 0.07	1.685LeuMet: 1.685 ± 0.019	3.22LeuAsn: 3.22 ± 0.026	5.637LeuPro: 5.637 ± 0.045	3.767LeuGln: 3.767 ± 0.039	5.826LeuArg: 5.826 ± 0.038	7.522LeuSer: 7.522 ± 0.057	4.673LeuThr: 4.673 ± 0.037	5.077LeuVal: 5.077 ± 0.039	1.082LeuTrp: 1.082 ± 0.018	2.262LeuTyr: 2.262 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	2.091MetAla: 2.091 ± 0.023	0.228MetCys: 0.228 ± 0.007	1.242MetAsp: 1.242 ± 0.017	1.348MetGlu: 1.348 ± 0.022	0.694MetPhe: 0.694 ± 0.013	1.427MetGly: 1.427 ± 0.022	0.439MetHis: 0.439 ± 0.01	0.94MetIle: 0.94 ± 0.016	1.059MetLys: 1.059 ± 0.016	1.754MetLeu: 1.754 ± 0.024	0.504MetMet: 0.504 ± 0.012	0.793MetAsn: 0.793 ± 0.015	1.172MetPro: 1.172 ± 0.018	0.786MetGln: 0.786 ± 0.013	1.222MetArg: 1.222 ± 0.015	1.774MetSer: 1.774 ± 0.022	1.194MetThr: 1.194 ± 0.017	1.253MetVal: 1.253 ± 0.019	0.24MetTrp: 0.24 ± 0.008	0.467MetTyr: 0.467 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.126AsnAla: 3.126 ± 0.029	0.45AsnCys: 0.45 ± 0.011	2.163AsnAsp: 2.163 ± 0.024	2.183AsnGlu: 2.183 ± 0.025	1.352AsnPhe: 1.352 ± 0.02	3.138AsnGly: 3.138 ± 0.038	0.963AsnHis: 0.963 ± 0.017	2.217AsnIle: 2.217 ± 0.025	1.66AsnLys: 1.66 ± 0.018	3.3AsnLeu: 3.3 ± 0.028	0.83AsnMet: 0.83 ± 0.016	1.953AsnAsn: 1.953 ± 0.037	2.788AsnPro: 2.788 ± 0.032	1.403AsnGln: 1.403 ± 0.019	2.137AsnArg: 2.137 ± 0.022	3.05AsnSer: 3.05 ± 0.028	2.267AsnThr: 2.267 ± 0.023	2.274AsnVal: 2.274 ± 0.026	0.492AsnTrp: 0.492 ± 0.011	1.027AsnTyr: 1.027 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	5.351ProAla: 5.351 ± 0.047	0.513ProCys: 0.513 ± 0.013	3.295ProAsp: 3.295 ± 0.03	3.849ProGlu: 3.849 ± 0.035	2.116ProPhe: 2.116 ± 0.026	4.049ProGly: 4.049 ± 0.038	1.556ProHis: 1.556 ± 0.024	2.774ProIle: 2.774 ± 0.028	2.82ProLys: 2.82 ± 0.031	5.041ProLeu: 5.041 ± 0.038	1.045ProMet: 1.045 ± 0.018	2.479ProAsn: 2.479 ± 0.025	6.354ProPro: 6.354 ± 0.091	2.783ProGln: 2.783 ± 0.037	3.639ProArg: 3.639 ± 0.036	6.774ProSer: 6.774 ± 0.06	4.421ProThr: 4.421 ± 0.048	3.466ProVal: 3.466 ± 0.031	0.665ProTrp: 0.665 ± 0.015	1.529ProTyr: 1.529 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	3.215GlnAla: 3.215 ± 0.036	0.419GlnCys: 0.419 ± 0.009	1.938GlnAsp: 1.938 ± 0.022	2.336GlnGlu: 2.336 ± 0.032	1.29GlnPhe: 1.29 ± 0.017	2.3GlnGly: 2.3 ± 0.024	1.227GlnHis: 1.227 ± 0.022	1.905GlnIle: 1.905 ± 0.023	2.076GlnLys: 2.076 ± 0.026	3.494GlnLeu: 3.494 ± 0.031	0.823GlnMet: 0.823 ± 0.014	1.698GlnAsn: 1.698 ± 0.021	2.862GlnPro: 2.862 ± 0.042	2.945GlnGln: 2.945 ± 0.07	2.74GlnArg: 2.74 ± 0.029	3.227GlnSer: 3.227 ± 0.037	2.263GlnThr: 2.263 ± 0.026	1.986GlnVal: 1.986 ± 0.021	0.484GlnTrp: 0.484 ± 0.012	1.09GlnTyr: 1.09 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	4.784ArgAla: 4.784 ± 0.037	0.713ArgCys: 0.713 ± 0.016	3.492ArgAsp: 3.492 ± 0.035	4.093ArgGlu: 4.093 ± 0.04	2.174ArgPhe: 2.174 ± 0.026	4.022ArgGly: 4.022 ± 0.042	1.613ArgHis: 1.613 ± 0.02	3.001ArgIle: 3.001 ± 0.025	3.74ArgLys: 3.74 ± 0.035	5.473ArgLeu: 5.473 ± 0.039	1.321ArgMet: 1.321 ± 0.02	2.483ArgAsn: 2.483 ± 0.026	3.682ArgPro: 3.682 ± 0.035	2.705ArgGln: 2.705 ± 0.027	5.519ArgArg: 5.519 ± 0.05	5.086ArgSer: 5.086 ± 0.046	3.371ArgThr: 3.371 ± 0.031	3.358ArgVal: 3.358 ± 0.025	0.881ArgTrp: 0.881 ± 0.015	1.678ArgTyr: 1.678 ± 0.021	0.0ArgXaa: 0.0 ± 0.0
Ser	6.685SerAla: 6.685 ± 0.048	0.843SerCys: 0.843 ± 0.016	4.206SerAsp: 4.206 ± 0.038	4.166SerGlu: 4.166 ± 0.033	3.043SerPhe: 3.043 ± 0.029	5.681SerGly: 5.681 ± 0.039	2.151SerHis: 2.151 ± 0.026	4.137SerIle: 4.137 ± 0.033	4.028SerLys: 4.028 ± 0.037	7.372SerLeu: 7.372 ± 0.051	1.703SerMet: 1.703 ± 0.022	3.398SerAsn: 3.398 ± 0.033	6.38SerPro: 6.38 ± 0.064	3.477SerGln: 3.477 ± 0.038	5.558SerArg: 5.558 ± 0.052	9.928SerSer: 9.928 ± 0.087	6.005SerThr: 6.005 ± 0.045	4.412SerVal: 4.412 ± 0.036	1.032SerTrp: 1.032 ± 0.016	2.017SerTyr: 2.017 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	5.183ThrAla: 5.183 ± 0.038	0.699ThrCys: 0.699 ± 0.013	2.85ThrAsp: 2.85 ± 0.025	3.053ThrGlu: 3.053 ± 0.034	2.163ThrPhe: 2.163 ± 0.024	3.996ThrGly: 3.996 ± 0.031	1.358ThrHis: 1.358 ± 0.016	3.059ThrIle: 3.059 ± 0.03	2.654ThrLys: 2.654 ± 0.025	5.068ThrLeu: 5.068 ± 0.04	1.104ThrMet: 1.104 ± 0.015	2.237ThrAsn: 2.237 ± 0.025	4.672ThrPro: 4.672 ± 0.045	2.043ThrGln: 2.043 ± 0.025	3.184ThrArg: 3.184 ± 0.027	5.647ThrSer: 5.647 ± 0.044	4.701ThrThr: 4.701 ± 0.051	3.43ThrVal: 3.43 ± 0.031	0.698ThrTrp: 0.698 ± 0.013	1.503ThrTyr: 1.503 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	4.781ValAla: 4.781 ± 0.035	0.756ValCys: 0.756 ± 0.012	3.658ValAsp: 3.658 ± 0.026	3.823ValGlu: 3.823 ± 0.035	2.268ValPhe: 2.268 ± 0.027	3.916ValGly: 3.916 ± 0.036	1.308ValHis: 1.308 ± 0.019	2.877ValIle: 2.877 ± 0.028	2.873ValLys: 2.873 ± 0.034	5.211ValLeu: 5.211 ± 0.046	1.22ValMet: 1.22 ± 0.017	2.2ValAsn: 2.2 ± 0.025	3.441ValPro: 3.441 ± 0.032	2.171ValGln: 2.171 ± 0.022	3.376ValArg: 3.376 ± 0.028	4.499ValSer: 4.499 ± 0.034	3.251ValThr: 3.251 ± 0.032	3.99ValVal: 3.99 ± 0.039	0.768ValTrp: 0.768 ± 0.014	1.576ValTyr: 1.576 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	1.021TrpAla: 1.021 ± 0.017	0.169TrpCys: 0.169 ± 0.007	0.836TrpAsp: 0.836 ± 0.017	0.828TrpGlu: 0.828 ± 0.013	0.472TrpPhe: 0.472 ± 0.014	0.82TrpGly: 0.82 ± 0.016	0.309TrpHis: 0.309 ± 0.009	0.688TrpIle: 0.688 ± 0.013	0.767TrpLys: 0.767 ± 0.013	1.197TrpLeu: 1.197 ± 0.017	0.335TrpMet: 0.335 ± 0.009	0.569TrpAsn: 0.569 ± 0.012	0.531TrpPro: 0.531 ± 0.012	0.486TrpGln: 0.486 ± 0.011	0.924TrpArg: 0.924 ± 0.016	0.913TrpSer: 0.913 ± 0.015	0.763TrpThr: 0.763 ± 0.014	0.789TrpVal: 0.789 ± 0.014	0.241TrpTrp: 0.241 ± 0.009	0.352TrpTyr: 0.352 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.967TyrAla: 1.967 ± 0.022	0.38TyrCys: 0.38 ± 0.01	1.617TyrAsp: 1.617 ± 0.023	1.49TyrGlu: 1.49 ± 0.02	1.174TyrPhe: 1.174 ± 0.02	1.889TyrGly: 1.889 ± 0.023	0.743TyrHis: 0.743 ± 0.014	1.431TyrIle: 1.431 ± 0.016	1.073TyrLys: 1.073 ± 0.017	2.589TyrLeu: 2.589 ± 0.029	0.584TyrMet: 0.584 ± 0.014	1.065TyrAsn: 1.065 ± 0.015	1.584TyrPro: 1.584 ± 0.028	1.055TyrGln: 1.055 ± 0.017	1.576TyrArg: 1.576 ± 0.02	2.066TyrSer: 2.066 ± 0.024	1.491TyrThr: 1.491 ± 0.02	1.52TyrVal: 1.52 ± 0.021	0.375TyrTrp: 0.375 ± 0.011	0.865TyrTyr: 0.865 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8197 proteins (4200543 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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