Amino acid dipepetide frequency for Marinobacter sp. F3R11

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.805AlaAla: 9.805 ± 0.131
1.035AlaCys: 1.035 ± 0.036
5.574AlaAsp: 5.574 ± 0.075
6.341AlaGlu: 6.341 ± 0.088
3.596AlaPhe: 3.596 ± 0.068
8.639AlaGly: 8.639 ± 0.116
1.728AlaHis: 1.728 ± 0.042
5.678AlaIle: 5.678 ± 0.076
3.076AlaLys: 3.076 ± 0.063
11.005AlaLeu: 11.005 ± 0.133
2.92AlaMet: 2.92 ± 0.057
2.879AlaAsn: 2.879 ± 0.049
3.756AlaPro: 3.756 ± 0.069
3.356AlaGln: 3.356 ± 0.058
6.309AlaArg: 6.309 ± 0.089
6.035AlaSer: 6.035 ± 0.081
4.678AlaThr: 4.678 ± 0.073
6.91AlaVal: 6.91 ± 0.091
1.336AlaTrp: 1.336 ± 0.035
2.28AlaTyr: 2.28 ± 0.045
0.0AlaXaa: 0.0 ± 0.0
Cys
0.842CysAla: 0.842 ± 0.034
0.142CysCys: 0.142 ± 0.013
0.559CysAsp: 0.559 ± 0.024
0.575CysGlu: 0.575 ± 0.025
0.375CysPhe: 0.375 ± 0.022
0.916CysGly: 0.916 ± 0.033
0.325CysHis: 0.325 ± 0.02
0.486CysIle: 0.486 ± 0.021
0.352CysLys: 0.352 ± 0.022
0.941CysLeu: 0.941 ± 0.032
0.212CysMet: 0.212 ± 0.016
0.297CysAsn: 0.297 ± 0.017
0.501CysPro: 0.501 ± 0.026
0.36CysGln: 0.36 ± 0.018
0.654CysArg: 0.654 ± 0.026
0.607CysSer: 0.607 ± 0.024
0.479CysThr: 0.479 ± 0.02
0.628CysVal: 0.628 ± 0.025
0.135CysTrp: 0.135 ± 0.01
0.264CysTyr: 0.264 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
5.051AspAla: 5.051 ± 0.073
0.532AspCys: 0.532 ± 0.024
3.251AspAsp: 3.251 ± 0.075
4.032AspGlu: 4.032 ± 0.069
2.195AspPhe: 2.195 ± 0.049
4.377AspGly: 4.377 ± 0.102
1.289AspHis: 1.289 ± 0.034
3.463AspIle: 3.463 ± 0.054
2.123AspLys: 2.123 ± 0.053
5.637AspLeu: 5.637 ± 0.075
1.555AspMet: 1.555 ± 0.04
2.018AspAsn: 2.018 ± 0.06
2.675AspPro: 2.675 ± 0.057
2.323AspGln: 2.323 ± 0.048
3.325AspArg: 3.325 ± 0.067
3.279AspSer: 3.279 ± 0.066
2.88AspThr: 2.88 ± 0.061
3.986AspVal: 3.986 ± 0.072
0.899AspTrp: 0.899 ± 0.031
1.818AspTyr: 1.818 ± 0.043
0.0AspXaa: 0.0 ± 0.0
Glu
6.604GluAla: 6.604 ± 0.078
0.499GluCys: 0.499 ± 0.02
3.274GluAsp: 3.274 ± 0.056
3.967GluGlu: 3.967 ± 0.078
2.253GluPhe: 2.253 ± 0.049
4.5GluGly: 4.5 ± 0.068
1.583GluHis: 1.583 ± 0.047
3.485GluIle: 3.485 ± 0.064
3.029GluLys: 3.029 ± 0.053
7.175GluLeu: 7.175 ± 0.087
1.615GluMet: 1.615 ± 0.045
2.425GluAsn: 2.425 ± 0.049
2.715GluPro: 2.715 ± 0.049
3.381GluGln: 3.381 ± 0.062
4.44GluArg: 4.44 ± 0.081
3.745GluSer: 3.745 ± 0.061
3.543GluThr: 3.543 ± 0.054
4.505GluVal: 4.505 ± 0.063
0.818GluTrp: 0.818 ± 0.027
1.586GluTyr: 1.586 ± 0.04
0.0GluXaa: 0.0 ± 0.0
Phe
3.377PheAla: 3.377 ± 0.065
0.471PheCys: 0.471 ± 0.02
2.404PheAsp: 2.404 ± 0.054
2.28PheGlu: 2.28 ± 0.045
1.663PhePhe: 1.663 ± 0.048
3.276PheGly: 3.276 ± 0.064
0.793PheHis: 0.793 ± 0.03
2.125PheIle: 2.125 ± 0.055
1.136PheLys: 1.136 ± 0.034
3.588PheLeu: 3.588 ± 0.075
0.966PheMet: 0.966 ± 0.031
1.376PheAsn: 1.376 ± 0.039
1.588PhePro: 1.588 ± 0.037
1.215PheGln: 1.215 ± 0.04
2.401PheArg: 2.401 ± 0.049
2.911PheSer: 2.911 ± 0.056
2.027PheThr: 2.027 ± 0.043
2.74PheVal: 2.74 ± 0.052
0.556PheTrp: 0.556 ± 0.027
1.151PheTyr: 1.151 ± 0.039
0.0PheXaa: 0.0 ± 0.0
Gly
6.811GlyAla: 6.811 ± 0.091
0.914GlyCys: 0.914 ± 0.031
4.25GlyAsp: 4.25 ± 0.087
4.976GlyGlu: 4.976 ± 0.078
3.465GlyPhe: 3.465 ± 0.06
5.903GlyGly: 5.903 ± 0.098
1.84GlyHis: 1.84 ± 0.041
4.955GlyIle: 4.955 ± 0.064
3.594GlyLys: 3.594 ± 0.07
8.482GlyLeu: 8.482 ± 0.102
2.387GlyMet: 2.387 ± 0.052
2.569GlyAsn: 2.569 ± 0.051
2.56GlyPro: 2.56 ± 0.052
3.178GlyGln: 3.178 ± 0.056
4.473GlyArg: 4.473 ± 0.071
4.874GlySer: 4.874 ± 0.089
4.102GlyThr: 4.102 ± 0.08
5.836GlyVal: 5.836 ± 0.078
1.226GlyTrp: 1.226 ± 0.039
2.514GlyTyr: 2.514 ± 0.052
0.0GlyXaa: 0.0 ± 0.0
His
1.746HisAla: 1.746 ± 0.043
0.295HisCys: 0.295 ± 0.016
1.071HisAsp: 1.071 ± 0.031
1.289HisGlu: 1.289 ± 0.039
0.922HisPhe: 0.922 ± 0.033
1.729HisGly: 1.729 ± 0.043
0.605HisHis: 0.605 ± 0.027
1.155HisIle: 1.155 ± 0.036
0.797HisLys: 0.797 ± 0.027
2.138HisLeu: 2.138 ± 0.046
0.511HisMet: 0.511 ± 0.023
0.698HisAsn: 0.698 ± 0.026
1.353HisPro: 1.353 ± 0.042
0.949HisGln: 0.949 ± 0.037
1.401HisArg: 1.401 ± 0.037
1.36HisSer: 1.36 ± 0.042
1.055HisThr: 1.055 ± 0.035
1.259HisVal: 1.259 ± 0.036
0.349HisTrp: 0.349 ± 0.018
0.802HisTyr: 0.802 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
5.981IleAla: 5.981 ± 0.086
0.591IleCys: 0.591 ± 0.022
3.385IleAsp: 3.385 ± 0.058
3.797IleGlu: 3.797 ± 0.065
1.826IlePhe: 1.826 ± 0.048
4.402IleGly: 4.402 ± 0.07
1.199IleHis: 1.199 ± 0.038
2.886IleIle: 2.886 ± 0.063
1.839IleLys: 1.839 ± 0.046
4.965IleLeu: 4.965 ± 0.076
1.227IleMet: 1.227 ± 0.035
2.099IleAsn: 2.099 ± 0.051
2.76IlePro: 2.76 ± 0.053
1.872IleGln: 1.872 ± 0.046
3.649IleArg: 3.649 ± 0.059
3.738IleSer: 3.738 ± 0.061
3.323IleThr: 3.323 ± 0.071
3.671IleVal: 3.671 ± 0.066
0.578IleTrp: 0.578 ± 0.025
1.285IleTyr: 1.285 ± 0.035
0.0IleXaa: 0.0 ± 0.0
Lys
4.136LysAla: 4.136 ± 0.073
0.221LysCys: 0.221 ± 0.015
2.103LysAsp: 2.103 ± 0.054
2.366LysGlu: 2.366 ± 0.063
1.009LysPhe: 1.009 ± 0.035
2.788LysGly: 2.788 ± 0.059
0.801LysHis: 0.801 ± 0.027
1.879LysIle: 1.879 ± 0.049
1.761LysLys: 1.761 ± 0.053
3.955LysLeu: 3.955 ± 0.065
0.916LysMet: 0.916 ± 0.032
1.236LysAsn: 1.236 ± 0.034
2.127LysPro: 2.127 ± 0.053
1.594LysGln: 1.594 ± 0.043
2.342LysArg: 2.342 ± 0.053
2.163LysSer: 2.163 ± 0.047
2.286LysThr: 2.286 ± 0.047
2.854LysVal: 2.854 ± 0.056
0.396LysTrp: 0.396 ± 0.023
0.823LysTyr: 0.823 ± 0.029
0.0LysXaa: 0.0 ± 0.0
Leu
11.409LeuAla: 11.409 ± 0.132
1.011LeuCys: 1.011 ± 0.035
6.063LeuAsp: 6.063 ± 0.095
6.859LeuGlu: 6.859 ± 0.09
3.933LeuPhe: 3.933 ± 0.078
8.017LeuGly: 8.017 ± 0.102
1.946LeuHis: 1.946 ± 0.048
5.686LeuIle: 5.686 ± 0.076
4.46LeuLys: 4.46 ± 0.07
10.728LeuLeu: 10.728 ± 0.144
2.858LeuMet: 2.858 ± 0.057
3.594LeuAsn: 3.594 ± 0.063
5.395LeuPro: 5.395 ± 0.075
3.794LeuGln: 3.794 ± 0.068
6.105LeuArg: 6.105 ± 0.088
7.239LeuSer: 7.239 ± 0.076
5.781LeuThr: 5.781 ± 0.076
7.717LeuVal: 7.717 ± 0.098
1.22LeuTrp: 1.22 ± 0.042
2.327LeuTyr: 2.327 ± 0.053
0.0LeuXaa: 0.0 ± 0.0
Met
2.997MetAla: 2.997 ± 0.057
0.178MetCys: 0.178 ± 0.012
1.422MetAsp: 1.422 ± 0.042
1.453MetGlu: 1.453 ± 0.036
0.816MetPhe: 0.816 ± 0.03
2.045MetGly: 2.045 ± 0.045
0.499MetHis: 0.499 ± 0.022
1.402MetIle: 1.402 ± 0.039
1.201MetLys: 1.201 ± 0.034
2.771MetLeu: 2.771 ± 0.061
0.715MetMet: 0.715 ± 0.032
1.029MetAsn: 1.029 ± 0.034
1.398MetPro: 1.398 ± 0.04
0.944MetGln: 0.944 ± 0.03
1.351MetArg: 1.351 ± 0.044
1.861MetSer: 1.861 ± 0.043
1.655MetThr: 1.655 ± 0.042
1.994MetVal: 1.994 ± 0.053
0.18MetTrp: 0.18 ± 0.013
0.458MetTyr: 0.458 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
3.009AsnAla: 3.009 ± 0.065
0.33AsnCys: 0.33 ± 0.019
1.795AsnAsp: 1.795 ± 0.044
1.976AsnGlu: 1.976 ± 0.046
1.101AsnPhe: 1.101 ± 0.033
2.715AsnGly: 2.715 ± 0.06
0.806AsnHis: 0.806 ± 0.03
1.828AsnIle: 1.828 ± 0.043
1.186AsnLys: 1.186 ± 0.034
3.627AsnLeu: 3.627 ± 0.06
0.826AsnMet: 0.826 ± 0.031
1.206AsnAsn: 1.206 ± 0.037
2.126AsnPro: 2.126 ± 0.046
1.344AsnGln: 1.344 ± 0.036
2.252AsnArg: 2.252 ± 0.05
1.885AsnSer: 1.885 ± 0.042
1.823AsnThr: 1.823 ± 0.047
2.005AsnVal: 2.005 ± 0.043
0.492AsnTrp: 0.492 ± 0.021
0.967AsnTyr: 0.967 ± 0.031
0.0AsnXaa: 0.0 ± 0.0
Pro
4.621ProAla: 4.621 ± 0.069
0.331ProCys: 0.331 ± 0.018
3.55ProAsp: 3.55 ± 0.059
4.54ProGlu: 4.54 ± 0.07
1.753ProPhe: 1.753 ± 0.043
4.207ProGly: 4.207 ± 0.073
0.877ProHis: 0.877 ± 0.033
1.955ProIle: 1.955 ± 0.044
1.479ProLys: 1.479 ± 0.044
4.574ProLeu: 4.574 ± 0.073
1.148ProMet: 1.148 ± 0.033
1.179ProAsn: 1.179 ± 0.038
1.727ProPro: 1.727 ± 0.046
1.513ProGln: 1.513 ± 0.04
2.188ProArg: 2.188 ± 0.048
2.488ProSer: 2.488 ± 0.052
1.922ProThr: 1.922 ± 0.041
4.369ProVal: 4.369 ± 0.078
0.711ProTrp: 0.711 ± 0.028
1.162ProTyr: 1.162 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
4.309GlnAla: 4.309 ± 0.074
0.312GlnCys: 0.312 ± 0.018
1.755GlnAsp: 1.755 ± 0.043
2.296GlnGlu: 2.296 ± 0.055
1.367GlnPhe: 1.367 ± 0.038
2.814GlnGly: 2.814 ± 0.046
0.863GlnHis: 0.863 ± 0.028
2.075GlnIle: 2.075 ± 0.043
1.612GlnLys: 1.612 ± 0.044
4.053GlnLeu: 4.053 ± 0.063
0.968GlnMet: 0.968 ± 0.03
1.237GlnAsn: 1.237 ± 0.037
1.84GlnPro: 1.84 ± 0.045
2.089GlnGln: 2.089 ± 0.052
2.538GlnArg: 2.538 ± 0.062
2.43GlnSer: 2.43 ± 0.047
1.922GlnThr: 1.922 ± 0.053
3.05GlnVal: 3.05 ± 0.056
0.603GlnTrp: 0.603 ± 0.026
0.939GlnTyr: 0.939 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
5.075ArgAla: 5.075 ± 0.072
0.556ArgCys: 0.556 ± 0.023
3.367ArgAsp: 3.367 ± 0.063
4.413ArgGlu: 4.413 ± 0.077
2.727ArgPhe: 2.727 ± 0.056
3.672ArgGly: 3.672 ± 0.067
1.509ArgHis: 1.509 ± 0.042
3.668ArgIle: 3.668 ± 0.059
2.829ArgLys: 2.829 ± 0.065
6.992ArgLeu: 6.992 ± 0.088
1.675ArgMet: 1.675 ± 0.037
2.265ArgAsn: 2.265 ± 0.05
2.463ArgPro: 2.463 ± 0.048
2.844ArgGln: 2.844 ± 0.06
3.974ArgArg: 3.974 ± 0.08
3.444ArgSer: 3.444 ± 0.066
2.843ArgThr: 2.843 ± 0.059
4.436ArgVal: 4.436 ± 0.069
0.907ArgTrp: 0.907 ± 0.032
1.98ArgTyr: 1.98 ± 0.05
0.0ArgXaa: 0.0 ± 0.0
Ser
5.954SerAla: 5.954 ± 0.084
0.541SerCys: 0.541 ± 0.022
3.563SerAsp: 3.563 ± 0.07
4.078SerGlu: 4.078 ± 0.062
2.45SerPhe: 2.45 ± 0.045
5.941SerGly: 5.941 ± 0.097
1.29SerHis: 1.29 ± 0.039
3.095SerIle: 3.095 ± 0.057
2.014SerLys: 2.014 ± 0.049
6.671SerLeu: 6.671 ± 0.09
1.667SerMet: 1.667 ± 0.045
1.88SerAsn: 1.88 ± 0.046
2.894SerPro: 2.894 ± 0.047
2.356SerGln: 2.356 ± 0.051
3.97SerArg: 3.97 ± 0.063
3.908SerSer: 3.908 ± 0.065
3.003SerThr: 3.003 ± 0.065
4.748SerVal: 4.748 ± 0.081
0.864SerTrp: 0.864 ± 0.031
1.613SerTyr: 1.613 ± 0.045
0.0SerXaa: 0.0 ± 0.0
Thr
4.873ThrAla: 4.873 ± 0.081
0.488ThrCys: 0.488 ± 0.026
3.002ThrAsp: 3.002 ± 0.068
3.183ThrGlu: 3.183 ± 0.062
1.894ThrPhe: 1.894 ± 0.045
5.105ThrGly: 5.105 ± 0.075
1.151ThrHis: 1.151 ± 0.036
2.738ThrIle: 2.738 ± 0.064
1.293ThrLys: 1.293 ± 0.034
6.406ThrLeu: 6.406 ± 0.086
1.167ThrMet: 1.167 ± 0.034
1.473ThrAsn: 1.473 ± 0.037
2.999ThrPro: 2.999 ± 0.061
1.646ThrGln: 1.646 ± 0.038
3.192ThrArg: 3.192 ± 0.051
3.152ThrSer: 3.152 ± 0.073
2.734ThrThr: 2.734 ± 0.065
3.885ThrVal: 3.885 ± 0.088
0.66ThrTrp: 0.66 ± 0.029
1.252ThrTyr: 1.252 ± 0.043
0.0ThrXaa: 0.0 ± 0.0
Val
7.155ValAla: 7.155 ± 0.08
0.754ValCys: 0.754 ± 0.031
4.168ValAsp: 4.168 ± 0.079
4.452ValGlu: 4.452 ± 0.072
3.039ValPhe: 3.039 ± 0.054
4.838ValGly: 4.838 ± 0.076
1.409ValHis: 1.409 ± 0.042
4.562ValIle: 4.562 ± 0.076
2.578ValLys: 2.578 ± 0.055
7.521ValLeu: 7.521 ± 0.109
2.126ValMet: 2.126 ± 0.051
2.476ValAsn: 2.476 ± 0.051
3.451ValPro: 3.451 ± 0.056
2.331ValGln: 2.331 ± 0.042
4.321ValArg: 4.321 ± 0.07
4.979ValSer: 4.979 ± 0.083
4.291ValThr: 4.291 ± 0.092
5.935ValVal: 5.935 ± 0.088
0.887ValTrp: 0.887 ± 0.034
1.818ValTyr: 1.818 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
1.004TrpAla: 1.004 ± 0.032
0.139TrpCys: 0.139 ± 0.01
0.619TrpAsp: 0.619 ± 0.027
0.653TrpGlu: 0.653 ± 0.032
0.617TrpPhe: 0.617 ± 0.022
0.875TrpGly: 0.875 ± 0.031
0.359TrpHis: 0.359 ± 0.018
0.702TrpIle: 0.702 ± 0.024
0.49TrpLys: 0.49 ± 0.023
1.903TrpLeu: 1.903 ± 0.052
0.371TrpMet: 0.371 ± 0.02
0.491TrpAsn: 0.491 ± 0.021
0.644TrpPro: 0.644 ± 0.029
0.803TrpGln: 0.803 ± 0.03
0.832TrpArg: 0.832 ± 0.032
0.78TrpSer: 0.78 ± 0.027
0.634TrpThr: 0.634 ± 0.029
0.973TrpVal: 0.973 ± 0.032
0.204TrpTrp: 0.204 ± 0.016
0.339TrpTyr: 0.339 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.177TyrAla: 2.177 ± 0.047
0.308TyrCys: 0.308 ± 0.018
1.529TyrAsp: 1.529 ± 0.042
1.612TyrGlu: 1.612 ± 0.039
1.042TyrPhe: 1.042 ± 0.035
2.151TyrGly: 2.151 ± 0.05
0.611TyrHis: 0.611 ± 0.025
1.251TyrIle: 1.251 ± 0.039
0.905TyrLys: 0.905 ± 0.031
3.011TyrLeu: 3.011 ± 0.049
0.539TyrMet: 0.539 ± 0.022
0.87TyrAsn: 0.87 ± 0.03
1.325TyrPro: 1.325 ± 0.042
1.179TyrGln: 1.179 ± 0.036
1.922TyrArg: 1.922 ± 0.051
1.621TyrSer: 1.621 ± 0.042
1.316TyrThr: 1.316 ± 0.043
1.594TyrVal: 1.594 ± 0.038
0.412TyrTrp: 0.412 ± 0.019
0.797TyrTyr: 0.797 ± 0.034
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3017 proteins (1025962 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski