Amino acid dipepetide frequency for Xanthomonas phage XPV1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.023AlaAla: 17.023 ± 1.365
0.934AlaCys: 0.934 ± 0.27
7.327AlaAsp: 7.327 ± 0.885
5.315AlaGlu: 5.315 ± 0.777
2.729AlaPhe: 2.729 ± 0.488
10.056AlaGly: 10.056 ± 1.118
2.083AlaHis: 2.083 ± 0.434
4.956AlaIle: 4.956 ± 0.59
4.597AlaLys: 4.597 ± 0.667
12.211AlaLeu: 12.211 ± 1.095
3.232AlaMet: 3.232 ± 0.44
4.597AlaAsn: 4.597 ± 0.677
6.896AlaPro: 6.896 ± 0.833
5.962AlaGln: 5.962 ± 0.614
7.327AlaArg: 7.327 ± 0.872
7.039AlaSer: 7.039 ± 1.035
8.332AlaThr: 8.332 ± 0.77
7.829AlaVal: 7.829 ± 0.749
1.868AlaTrp: 1.868 ± 0.376
3.376AlaTyr: 3.376 ± 0.529
0.0AlaXaa: 0.0 ± 0.0
Cys
0.718CysAla: 0.718 ± 0.221
0.072CysCys: 0.072 ± 0.104
0.646CysAsp: 0.646 ± 0.208
0.431CysGlu: 0.431 ± 0.184
0.072CysPhe: 0.072 ± 0.074
0.646CysGly: 0.646 ± 0.248
0.0CysHis: 0.0 ± 0.0
0.359CysIle: 0.359 ± 0.173
0.287CysLys: 0.287 ± 0.159
0.646CysLeu: 0.646 ± 0.233
0.215CysMet: 0.215 ± 0.16
0.0CysAsn: 0.0 ± 0.0
0.575CysPro: 0.575 ± 0.296
0.287CysGln: 0.287 ± 0.136
0.862CysArg: 0.862 ± 0.286
0.79CysSer: 0.79 ± 0.327
0.359CysThr: 0.359 ± 0.144
0.431CysVal: 0.431 ± 0.144
0.072CysTrp: 0.072 ± 0.074
0.287CysTyr: 0.287 ± 0.142
0.0CysXaa: 0.0 ± 0.0
Asp
8.332AspAla: 8.332 ± 0.795
0.79AspCys: 0.79 ± 0.224
3.807AspAsp: 3.807 ± 0.628
2.586AspGlu: 2.586 ± 0.45
2.083AspPhe: 2.083 ± 0.445
5.028AspGly: 5.028 ± 0.551
0.287AspHis: 0.287 ± 0.133
3.16AspIle: 3.16 ± 0.57
2.227AspLys: 2.227 ± 0.322
6.393AspLeu: 6.393 ± 0.816
1.293AspMet: 1.293 ± 0.341
2.299AspAsn: 2.299 ± 0.305
3.879AspPro: 3.879 ± 0.511
2.442AspGln: 2.442 ± 0.378
3.232AspArg: 3.232 ± 0.52
3.232AspSer: 3.232 ± 0.504
3.52AspThr: 3.52 ± 0.568
5.028AspVal: 5.028 ± 0.584
1.868AspTrp: 1.868 ± 0.524
2.442AspTyr: 2.442 ± 0.432
0.0AspXaa: 0.0 ± 0.0
Glu
6.177GluAla: 6.177 ± 0.696
0.359GluCys: 0.359 ± 0.173
2.658GluAsp: 2.658 ± 0.405
1.796GluGlu: 1.796 ± 0.405
1.293GluPhe: 1.293 ± 0.298
2.873GluGly: 2.873 ± 0.467
0.934GluHis: 0.934 ± 0.333
2.299GluIle: 2.299 ± 0.466
0.862GluLys: 0.862 ± 0.211
5.315GluLeu: 5.315 ± 0.673
0.934GluMet: 0.934 ± 0.293
0.718GluAsn: 0.718 ± 0.243
2.299GluPro: 2.299 ± 0.454
1.437GluGln: 1.437 ± 0.344
3.879GluArg: 3.879 ± 0.556
2.729GluSer: 2.729 ± 0.411
2.442GluThr: 2.442 ± 0.422
3.376GluVal: 3.376 ± 0.559
0.862GluTrp: 0.862 ± 0.209
1.868GluTyr: 1.868 ± 0.287
0.0GluXaa: 0.0 ± 0.0
Phe
4.31PheAla: 4.31 ± 0.574
0.431PheCys: 0.431 ± 0.195
2.873PheAsp: 2.873 ± 0.473
1.437PheGlu: 1.437 ± 0.291
0.79PhePhe: 0.79 ± 0.197
3.304PheGly: 3.304 ± 0.444
0.215PheHis: 0.215 ± 0.112
1.006PheIle: 1.006 ± 0.323
0.79PheLys: 0.79 ± 0.209
1.437PheLeu: 1.437 ± 0.273
0.646PheMet: 0.646 ± 0.228
1.365PheAsn: 1.365 ± 0.338
1.006PhePro: 1.006 ± 0.233
0.575PheGln: 0.575 ± 0.197
1.58PheArg: 1.58 ± 0.366
1.58PheSer: 1.58 ± 0.353
1.508PheThr: 1.508 ± 0.273
3.089PheVal: 3.089 ± 0.405
0.503PheTrp: 0.503 ± 0.214
0.431PheTyr: 0.431 ± 0.204
0.0PheXaa: 0.0 ± 0.0
Gly
8.188GlyAla: 8.188 ± 1.094
0.718GlyCys: 0.718 ± 0.198
4.022GlyAsp: 4.022 ± 0.521
3.52GlyGlu: 3.52 ± 0.533
3.52GlyPhe: 3.52 ± 0.512
7.614GlyGly: 7.614 ± 1.866
0.79GlyHis: 0.79 ± 0.21
3.807GlyIle: 3.807 ± 0.483
3.376GlyLys: 3.376 ± 0.443
5.962GlyLeu: 5.962 ± 0.758
1.365GlyMet: 1.365 ± 0.307
2.155GlyAsn: 2.155 ± 0.37
2.658GlyPro: 2.658 ± 0.354
3.376GlyGln: 3.376 ± 0.595
5.674GlyArg: 5.674 ± 0.541
4.022GlySer: 4.022 ± 0.874
5.746GlyThr: 5.746 ± 0.72
7.255GlyVal: 7.255 ± 0.653
1.508GlyTrp: 1.508 ± 0.358
2.873GlyTyr: 2.873 ± 0.407
0.0GlyXaa: 0.0 ± 0.0
His
1.221HisAla: 1.221 ± 0.31
0.215HisCys: 0.215 ± 0.128
0.862HisAsp: 0.862 ± 0.193
0.575HisGlu: 0.575 ± 0.19
0.359HisPhe: 0.359 ± 0.173
1.149HisGly: 1.149 ± 0.261
0.287HisHis: 0.287 ± 0.149
0.79HisIle: 0.79 ± 0.202
0.359HisLys: 0.359 ± 0.186
0.79HisLeu: 0.79 ± 0.233
0.646HisMet: 0.646 ± 0.221
0.79HisAsn: 0.79 ± 0.219
1.077HisPro: 1.077 ± 0.258
0.287HisGln: 0.287 ± 0.137
0.862HisArg: 0.862 ± 0.276
1.077HisSer: 1.077 ± 0.302
0.934HisThr: 0.934 ± 0.275
1.58HisVal: 1.58 ± 0.338
0.144HisTrp: 0.144 ± 0.108
0.503HisTyr: 0.503 ± 0.174
0.0HisXaa: 0.0 ± 0.0
Ile
5.1IleAla: 5.1 ± 0.583
0.144IleCys: 0.144 ± 0.092
3.879IleAsp: 3.879 ± 0.535
2.586IleGlu: 2.586 ± 0.42
0.79IlePhe: 0.79 ± 0.238
3.591IleGly: 3.591 ± 0.531
0.718IleHis: 0.718 ± 0.226
1.724IleIle: 1.724 ± 0.404
1.724IleLys: 1.724 ± 0.36
2.801IleLeu: 2.801 ± 0.456
0.862IleMet: 0.862 ± 0.267
1.724IleAsn: 1.724 ± 0.359
2.299IlePro: 2.299 ± 0.319
1.58IleGln: 1.58 ± 0.304
3.232IleArg: 3.232 ± 0.434
2.873IleSer: 2.873 ± 0.335
3.089IleThr: 3.089 ± 0.53
4.382IleVal: 4.382 ± 0.604
0.575IleTrp: 0.575 ± 0.223
1.437IleTyr: 1.437 ± 0.387
0.0IleXaa: 0.0 ± 0.0
Lys
3.304LysAla: 3.304 ± 0.498
0.359LysCys: 0.359 ± 0.163
1.437LysAsp: 1.437 ± 0.371
1.365LysGlu: 1.365 ± 0.287
0.79LysPhe: 0.79 ± 0.216
2.514LysGly: 2.514 ± 0.381
0.718LysHis: 0.718 ± 0.215
1.939LysIle: 1.939 ± 0.292
0.503LysLys: 0.503 ± 0.16
3.16LysLeu: 3.16 ± 0.482
0.934LysMet: 0.934 ± 0.254
0.718LysAsn: 0.718 ± 0.188
1.508LysPro: 1.508 ± 0.353
1.437LysGln: 1.437 ± 0.433
2.37LysArg: 2.37 ± 0.431
1.939LysSer: 1.939 ± 0.455
1.796LysThr: 1.796 ± 0.42
2.083LysVal: 2.083 ± 0.403
0.575LysTrp: 0.575 ± 0.212
1.006LysTyr: 1.006 ± 0.243
0.0LysXaa: 0.0 ± 0.0
Leu
10.774LeuAla: 10.774 ± 1.056
0.718LeuCys: 0.718 ± 0.218
6.393LeuAsp: 6.393 ± 0.663
4.382LeuGlu: 4.382 ± 0.643
2.658LeuPhe: 2.658 ± 0.449
5.603LeuGly: 5.603 ± 0.525
1.221LeuHis: 1.221 ± 0.261
2.945LeuIle: 2.945 ± 0.341
2.299LeuLys: 2.299 ± 0.449
6.321LeuLeu: 6.321 ± 0.647
2.299LeuMet: 2.299 ± 0.499
2.801LeuAsn: 2.801 ± 0.468
5.674LeuPro: 5.674 ± 0.879
3.52LeuGln: 3.52 ± 0.485
6.536LeuArg: 6.536 ± 0.812
6.393LeuSer: 6.393 ± 0.62
6.752LeuThr: 6.752 ± 0.579
4.741LeuVal: 4.741 ± 0.682
0.862LeuTrp: 0.862 ± 0.284
1.939LeuTyr: 1.939 ± 0.443
0.0LeuXaa: 0.0 ± 0.0
Met
3.376MetAla: 3.376 ± 0.62
0.144MetCys: 0.144 ± 0.096
1.652MetAsp: 1.652 ± 0.309
0.503MetGlu: 0.503 ± 0.232
0.575MetPhe: 0.575 ± 0.188
0.862MetGly: 0.862 ± 0.234
0.431MetHis: 0.431 ± 0.16
1.006MetIle: 1.006 ± 0.259
1.365MetLys: 1.365 ± 0.332
1.724MetLeu: 1.724 ± 0.385
0.503MetMet: 0.503 ± 0.171
1.006MetAsn: 1.006 ± 0.245
1.006MetPro: 1.006 ± 0.214
0.718MetGln: 0.718 ± 0.251
1.796MetArg: 1.796 ± 0.346
2.011MetSer: 2.011 ± 0.377
2.442MetThr: 2.442 ± 0.382
1.077MetVal: 1.077 ± 0.288
0.215MetTrp: 0.215 ± 0.102
0.359MetTyr: 0.359 ± 0.139
0.0MetXaa: 0.0 ± 0.0
Asn
4.884AsnAla: 4.884 ± 0.609
0.287AsnCys: 0.287 ± 0.134
2.155AsnAsp: 2.155 ± 0.398
1.437AsnGlu: 1.437 ± 0.317
0.862AsnPhe: 0.862 ± 0.226
2.873AsnGly: 2.873 ± 0.507
0.431AsnHis: 0.431 ± 0.175
1.652AsnIle: 1.652 ± 0.373
0.718AsnLys: 0.718 ± 0.264
2.586AsnLeu: 2.586 ± 0.554
0.431AsnMet: 0.431 ± 0.168
1.221AsnAsn: 1.221 ± 0.369
3.089AsnPro: 3.089 ± 0.503
0.718AsnGln: 0.718 ± 0.232
1.652AsnArg: 1.652 ± 0.423
1.724AsnSer: 1.724 ± 0.304
2.658AsnThr: 2.658 ± 0.49
2.514AsnVal: 2.514 ± 0.512
0.79AsnTrp: 0.79 ± 0.236
1.006AsnTyr: 1.006 ± 0.32
0.0AsnXaa: 0.0 ± 0.0
Pro
6.536ProAla: 6.536 ± 0.619
0.0ProCys: 0.0 ± 0.0
4.453ProAsp: 4.453 ± 0.665
3.52ProGlu: 3.52 ± 0.596
1.58ProPhe: 1.58 ± 0.292
4.597ProGly: 4.597 ± 0.687
1.077ProHis: 1.077 ± 0.316
2.442ProIle: 2.442 ± 0.447
1.365ProLys: 1.365 ± 0.356
3.448ProLeu: 3.448 ± 0.539
1.293ProMet: 1.293 ± 0.278
1.868ProAsn: 1.868 ± 0.321
2.586ProPro: 2.586 ± 0.493
2.729ProGln: 2.729 ± 0.423
3.304ProArg: 3.304 ± 0.536
3.735ProSer: 3.735 ± 0.557
4.453ProThr: 4.453 ± 0.705
4.813ProVal: 4.813 ± 0.665
0.503ProTrp: 0.503 ± 0.19
1.939ProTyr: 1.939 ± 0.28
0.0ProXaa: 0.0 ± 0.0
Gln
5.243GlnAla: 5.243 ± 0.682
0.287GlnCys: 0.287 ± 0.152
1.939GlnAsp: 1.939 ± 0.444
1.006GlnGlu: 1.006 ± 0.279
1.437GlnPhe: 1.437 ± 0.296
2.514GlnGly: 2.514 ± 0.356
0.503GlnHis: 0.503 ± 0.198
2.155GlnIle: 2.155 ± 0.384
1.149GlnLys: 1.149 ± 0.31
4.813GlnLeu: 4.813 ± 0.636
0.575GlnMet: 0.575 ± 0.187
1.006GlnAsn: 1.006 ± 0.283
2.442GlnPro: 2.442 ± 0.339
2.586GlnGln: 2.586 ± 0.53
3.807GlnArg: 3.807 ± 0.593
2.658GlnSer: 2.658 ± 0.348
3.52GlnThr: 3.52 ± 0.563
2.729GlnVal: 2.729 ± 0.528
0.718GlnTrp: 0.718 ± 0.289
1.221GlnTyr: 1.221 ± 0.293
0.0GlnXaa: 0.0 ± 0.0
Arg
8.188ArgAla: 8.188 ± 0.967
0.359ArgCys: 0.359 ± 0.167
3.663ArgAsp: 3.663 ± 0.53
3.663ArgGlu: 3.663 ± 0.716
2.155ArgPhe: 2.155 ± 0.532
3.376ArgGly: 3.376 ± 0.5
1.365ArgHis: 1.365 ± 0.293
3.52ArgIle: 3.52 ± 0.443
1.939ArgLys: 1.939 ± 0.506
6.177ArgLeu: 6.177 ± 0.612
2.37ArgMet: 2.37 ± 0.391
2.299ArgAsn: 2.299 ± 0.357
2.801ArgPro: 2.801 ± 0.464
3.089ArgGln: 3.089 ± 0.535
3.951ArgArg: 3.951 ± 0.707
3.52ArgSer: 3.52 ± 0.439
4.884ArgThr: 4.884 ± 0.655
4.238ArgVal: 4.238 ± 0.473
1.365ArgTrp: 1.365 ± 0.378
2.801ArgTyr: 2.801 ± 0.471
0.0ArgXaa: 0.0 ± 0.0
Ser
7.542SerAla: 7.542 ± 0.77
0.431SerCys: 0.431 ± 0.185
3.807SerAsp: 3.807 ± 0.488
2.37SerGlu: 2.37 ± 0.442
1.796SerPhe: 1.796 ± 0.33
7.111SerGly: 7.111 ± 0.925
0.79SerHis: 0.79 ± 0.202
3.017SerIle: 3.017 ± 0.375
1.868SerLys: 1.868 ± 0.327
4.525SerLeu: 4.525 ± 0.6
1.221SerMet: 1.221 ± 0.273
1.796SerAsn: 1.796 ± 0.33
3.807SerPro: 3.807 ± 0.552
2.155SerGln: 2.155 ± 0.338
3.089SerArg: 3.089 ± 0.37
4.741SerSer: 4.741 ± 0.622
4.956SerThr: 4.956 ± 0.725
4.956SerVal: 4.956 ± 0.614
0.934SerTrp: 0.934 ± 0.247
1.508SerTyr: 1.508 ± 0.306
0.0SerXaa: 0.0 ± 0.0
Thr
8.619ThrAla: 8.619 ± 0.825
0.287ThrCys: 0.287 ± 0.127
4.669ThrAsp: 4.669 ± 0.63
1.939ThrGlu: 1.939 ± 0.376
1.939ThrPhe: 1.939 ± 0.347
5.674ThrGly: 5.674 ± 0.669
0.862ThrHis: 0.862 ± 0.21
3.017ThrIle: 3.017 ± 0.415
1.652ThrLys: 1.652 ± 0.469
6.824ThrLeu: 6.824 ± 0.812
0.934ThrMet: 0.934 ± 0.237
2.442ThrAsn: 2.442 ± 0.435
5.603ThrPro: 5.603 ± 0.577
3.663ThrGln: 3.663 ± 0.432
3.16ThrArg: 3.16 ± 0.436
4.022ThrSer: 4.022 ± 0.702
5.818ThrThr: 5.818 ± 0.83
5.89ThrVal: 5.89 ± 0.748
1.149ThrTrp: 1.149 ± 0.303
2.729ThrTyr: 2.729 ± 0.563
0.0ThrXaa: 0.0 ± 0.0
Val
8.835ValAla: 8.835 ± 0.974
0.503ValCys: 0.503 ± 0.183
4.31ValAsp: 4.31 ± 0.427
4.597ValGlu: 4.597 ± 0.561
1.939ValPhe: 1.939 ± 0.421
5.531ValGly: 5.531 ± 0.556
0.934ValHis: 0.934 ± 0.263
3.448ValIle: 3.448 ± 0.482
2.083ValLys: 2.083 ± 0.527
5.962ValLeu: 5.962 ± 0.7
2.155ValMet: 2.155 ± 0.359
3.52ValAsn: 3.52 ± 0.578
4.022ValPro: 4.022 ± 0.61
2.729ValGln: 2.729 ± 0.507
5.028ValArg: 5.028 ± 0.629
5.243ValSer: 5.243 ± 0.614
4.669ValThr: 4.669 ± 0.619
4.956ValVal: 4.956 ± 0.544
1.58ValTrp: 1.58 ± 0.378
2.37ValTyr: 2.37 ± 0.446
0.0ValXaa: 0.0 ± 0.0
Trp
2.155TrpAla: 2.155 ± 0.464
0.287TrpCys: 0.287 ± 0.184
1.077TrpAsp: 1.077 ± 0.265
1.221TrpGlu: 1.221 ± 0.283
0.503TrpPhe: 0.503 ± 0.184
0.646TrpGly: 0.646 ± 0.218
0.359TrpHis: 0.359 ± 0.157
0.503TrpIle: 0.503 ± 0.162
0.575TrpLys: 0.575 ± 0.175
1.365TrpLeu: 1.365 ± 0.303
0.431TrpMet: 0.431 ± 0.186
0.144TrpAsn: 0.144 ± 0.097
0.79TrpPro: 0.79 ± 0.251
1.006TrpGln: 1.006 ± 0.313
1.437TrpArg: 1.437 ± 0.3
1.006TrpSer: 1.006 ± 0.238
1.293TrpThr: 1.293 ± 0.32
0.934TrpVal: 0.934 ± 0.212
0.431TrpTrp: 0.431 ± 0.194
1.149TrpTyr: 1.149 ± 0.367
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.16TyrAla: 3.16 ± 0.452
0.431TyrCys: 0.431 ± 0.181
2.299TyrAsp: 2.299 ± 0.425
0.862TyrGlu: 0.862 ± 0.248
1.006TyrPhe: 1.006 ± 0.259
2.586TyrGly: 2.586 ± 0.407
0.503TyrHis: 0.503 ± 0.166
1.365TyrIle: 1.365 ± 0.359
0.79TyrLys: 0.79 ± 0.237
2.37TyrLeu: 2.37 ± 0.537
0.359TyrMet: 0.359 ± 0.201
1.221TyrAsn: 1.221 ± 0.357
2.227TyrPro: 2.227 ± 0.48
2.011TyrGln: 2.011 ± 0.288
2.945TyrArg: 2.945 ± 0.461
2.083TyrSer: 2.083 ± 0.485
1.724TyrThr: 1.724 ± 0.364
2.514TyrVal: 2.514 ± 0.539
0.79TyrTrp: 0.79 ± 0.276
0.575TyrTyr: 0.575 ± 0.236
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 77 proteins (13923 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski