Amino acid dipepetide frequency for Chobar Gorge virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.577AlaAla: 8.577 ± 0.92
1.133AlaCys: 1.133 ± 0.422
3.722AlaAsp: 3.722 ± 0.733
5.664AlaGlu: 5.664 ± 0.583
2.428AlaPhe: 2.428 ± 0.57
3.399AlaGly: 3.399 ± 0.757
2.104AlaHis: 2.104 ± 0.43
5.503AlaIle: 5.503 ± 1.091
2.913AlaLys: 2.913 ± 0.778
10.52AlaLeu: 10.52 ± 1.321
2.104AlaMet: 2.104 ± 0.408
2.913AlaAsn: 2.913 ± 0.525
5.179AlaPro: 5.179 ± 0.913
5.179AlaGln: 5.179 ± 0.501
7.445AlaArg: 7.445 ± 1.432
4.046AlaSer: 4.046 ± 0.88
6.15AlaThr: 6.15 ± 1.291
6.635AlaVal: 6.635 ± 1.461
1.78AlaTrp: 1.78 ± 0.479
3.399AlaTyr: 3.399 ± 0.566
0.0AlaXaa: 0.0 ± 0.0
Cys
1.295CysAla: 1.295 ± 0.482
0.162CysCys: 0.162 ± 0.156
1.295CysAsp: 1.295 ± 0.35
1.133CysGlu: 1.133 ± 0.285
0.162CysPhe: 0.162 ± 0.164
1.295CysGly: 1.295 ± 0.432
0.162CysHis: 0.162 ± 0.135
0.486CysIle: 0.486 ± 0.22
0.162CysLys: 0.162 ± 0.164
1.133CysLeu: 1.133 ± 0.378
0.162CysMet: 0.162 ± 0.142
0.647CysAsn: 0.647 ± 0.285
0.809CysPro: 0.809 ± 0.438
0.324CysGln: 0.324 ± 0.195
0.486CysArg: 0.486 ± 0.193
0.486CysSer: 0.486 ± 0.242
1.295CysThr: 1.295 ± 0.361
1.295CysVal: 1.295 ± 0.446
0.0CysTrp: 0.0 ± 0.0
0.647CysTyr: 0.647 ± 0.311
0.0CysXaa: 0.0 ± 0.0
Asp
5.503AspAla: 5.503 ± 0.616
0.324AspCys: 0.324 ± 0.283
4.531AspAsp: 4.531 ± 0.841
2.913AspGlu: 2.913 ± 0.619
1.295AspPhe: 1.295 ± 0.255
3.399AspGly: 3.399 ± 0.822
0.486AspHis: 0.486 ± 0.195
2.428AspIle: 2.428 ± 0.582
0.647AspLys: 0.647 ± 0.394
5.341AspLeu: 5.341 ± 1.07
1.133AspMet: 1.133 ± 0.486
0.809AspAsn: 0.809 ± 0.317
3.399AspPro: 3.399 ± 0.913
1.618AspGln: 1.618 ± 0.495
4.37AspArg: 4.37 ± 0.971
4.046AspSer: 4.046 ± 0.746
4.046AspThr: 4.046 ± 0.822
6.474AspVal: 6.474 ± 0.979
0.647AspTrp: 0.647 ± 0.297
1.618AspTyr: 1.618 ± 0.56
0.0AspXaa: 0.0 ± 0.0
Glu
5.826GluAla: 5.826 ± 0.86
0.486GluCys: 0.486 ± 0.309
2.266GluAsp: 2.266 ± 0.279
4.855GluGlu: 4.855 ± 0.869
3.075GluPhe: 3.075 ± 0.867
3.884GluGly: 3.884 ± 0.517
1.618GluHis: 1.618 ± 0.667
4.208GluIle: 4.208 ± 0.496
2.913GluLys: 2.913 ± 0.529
4.046GluLeu: 4.046 ± 0.575
3.237GluMet: 3.237 ± 0.578
1.133GluAsn: 1.133 ± 0.292
1.295GluPro: 1.295 ± 0.659
1.618GluGln: 1.618 ± 0.542
5.341GluArg: 5.341 ± 0.682
4.37GluSer: 4.37 ± 0.891
4.37GluThr: 4.37 ± 0.794
3.399GluVal: 3.399 ± 0.859
0.809GluTrp: 0.809 ± 0.487
1.942GluTyr: 1.942 ± 0.453
0.0GluXaa: 0.0 ± 0.0
Phe
2.428PheAla: 2.428 ± 0.678
0.324PheCys: 0.324 ± 0.206
1.618PheAsp: 1.618 ± 0.422
0.809PheGlu: 0.809 ± 0.285
0.809PhePhe: 0.809 ± 0.212
1.942PheGly: 1.942 ± 0.626
1.133PheHis: 1.133 ± 0.305
1.295PheIle: 1.295 ± 0.528
0.486PheLys: 0.486 ± 0.309
3.56PheLeu: 3.56 ± 0.653
0.486PheMet: 0.486 ± 0.373
0.971PheAsn: 0.971 ± 0.434
1.942PhePro: 1.942 ± 0.534
1.295PheGln: 1.295 ± 0.396
3.075PheArg: 3.075 ± 0.515
2.751PheSer: 2.751 ± 0.587
2.428PheThr: 2.428 ± 0.474
1.78PheVal: 1.78 ± 0.358
0.324PheTrp: 0.324 ± 0.254
1.133PheTyr: 1.133 ± 0.332
0.0PheXaa: 0.0 ± 0.0
Gly
5.017GlyAla: 5.017 ± 1.473
0.647GlyCys: 0.647 ± 0.342
4.37GlyAsp: 4.37 ± 1.089
4.208GlyGlu: 4.208 ± 0.731
1.78GlyPhe: 1.78 ± 0.472
3.56GlyGly: 3.56 ± 0.808
1.133GlyHis: 1.133 ± 0.328
3.075GlyIle: 3.075 ± 0.68
1.942GlyLys: 1.942 ± 0.419
4.693GlyLeu: 4.693 ± 0.871
1.942GlyMet: 1.942 ± 0.444
1.618GlyAsn: 1.618 ± 0.57
2.913GlyPro: 2.913 ± 0.564
1.942GlyGln: 1.942 ± 0.513
5.179GlyArg: 5.179 ± 0.554
3.56GlySer: 3.56 ± 0.619
3.56GlyThr: 3.56 ± 0.817
4.855GlyVal: 4.855 ± 0.666
0.809GlyTrp: 0.809 ± 0.435
2.266GlyTyr: 2.266 ± 0.786
0.0GlyXaa: 0.0 ± 0.0
His
3.075HisAla: 3.075 ± 0.703
0.0HisCys: 0.0 ± 0.0
1.295HisAsp: 1.295 ± 0.358
1.133HisGlu: 1.133 ± 0.614
0.809HisPhe: 0.809 ± 0.368
2.104HisGly: 2.104 ± 0.581
0.324HisHis: 0.324 ± 0.205
0.809HisIle: 0.809 ± 0.229
0.162HisLys: 0.162 ± 0.164
2.428HisLeu: 2.428 ± 0.677
0.971HisMet: 0.971 ± 0.34
0.647HisAsn: 0.647 ± 0.294
2.428HisPro: 2.428 ± 0.596
0.809HisGln: 0.809 ± 0.389
1.78HisArg: 1.78 ± 0.615
1.457HisSer: 1.457 ± 0.469
1.457HisThr: 1.457 ± 0.514
2.104HisVal: 2.104 ± 0.925
0.324HisTrp: 0.324 ± 0.181
0.647HisTyr: 0.647 ± 0.216
0.0HisXaa: 0.0 ± 0.0
Ile
5.179IleAla: 5.179 ± 1.417
1.295IleCys: 1.295 ± 0.465
3.399IleAsp: 3.399 ± 0.892
2.428IleGlu: 2.428 ± 0.444
1.78IlePhe: 1.78 ± 0.422
3.56IleGly: 3.56 ± 0.859
1.618IleHis: 1.618 ± 0.472
2.751IleIle: 2.751 ± 0.593
2.104IleLys: 2.104 ± 0.381
4.531IleLeu: 4.531 ± 0.965
1.457IleMet: 1.457 ± 0.482
1.78IleAsn: 1.78 ± 0.574
2.104IlePro: 2.104 ± 0.355
1.618IleGln: 1.618 ± 0.568
6.474IleArg: 6.474 ± 0.986
4.208IleSer: 4.208 ± 0.56
3.237IleThr: 3.237 ± 0.591
2.589IleVal: 2.589 ± 0.295
0.486IleTrp: 0.486 ± 0.282
2.913IleTyr: 2.913 ± 0.452
0.0IleXaa: 0.0 ± 0.0
Lys
2.428LysAla: 2.428 ± 0.385
0.324LysCys: 0.324 ± 0.169
2.266LysAsp: 2.266 ± 0.664
1.78LysGlu: 1.78 ± 0.541
1.295LysPhe: 1.295 ± 0.309
1.618LysGly: 1.618 ± 0.47
0.809LysHis: 0.809 ± 0.387
2.266LysIle: 2.266 ± 0.629
2.104LysLys: 2.104 ± 0.631
3.722LysLeu: 3.722 ± 0.887
1.133LysMet: 1.133 ± 0.379
1.457LysAsn: 1.457 ± 0.365
0.324LysPro: 0.324 ± 0.187
1.295LysGln: 1.295 ± 0.619
2.913LysArg: 2.913 ± 0.696
2.266LysSer: 2.266 ± 0.828
2.428LysThr: 2.428 ± 0.518
1.133LysVal: 1.133 ± 0.228
0.486LysTrp: 0.486 ± 0.242
1.295LysTyr: 1.295 ± 0.407
0.0LysXaa: 0.0 ± 0.0
Leu
7.768LeuAla: 7.768 ± 1.131
2.104LeuCys: 2.104 ± 0.439
5.503LeuAsp: 5.503 ± 1.239
5.664LeuGlu: 5.664 ± 0.53
2.428LeuPhe: 2.428 ± 0.715
5.179LeuGly: 5.179 ± 0.613
1.942LeuHis: 1.942 ± 0.693
4.531LeuIle: 4.531 ± 0.696
4.046LeuLys: 4.046 ± 0.968
8.254LeuLeu: 8.254 ± 1.078
1.78LeuMet: 1.78 ± 0.69
3.56LeuAsn: 3.56 ± 0.608
5.503LeuPro: 5.503 ± 0.944
5.179LeuGln: 5.179 ± 0.663
8.416LeuArg: 8.416 ± 1.224
6.312LeuSer: 6.312 ± 1.167
4.855LeuThr: 4.855 ± 0.626
6.474LeuVal: 6.474 ± 1.037
0.971LeuTrp: 0.971 ± 0.45
2.751LeuTyr: 2.751 ± 0.495
0.0LeuXaa: 0.0 ± 0.0
Met
2.266MetAla: 2.266 ± 0.753
0.324MetCys: 0.324 ± 0.187
1.78MetAsp: 1.78 ± 0.694
1.618MetGlu: 1.618 ± 0.752
0.971MetPhe: 0.971 ± 0.529
0.971MetGly: 0.971 ± 0.469
0.486MetHis: 0.486 ± 0.178
1.457MetIle: 1.457 ± 0.361
0.809MetLys: 0.809 ± 0.247
3.399MetLeu: 3.399 ± 0.539
1.295MetMet: 1.295 ± 0.533
0.971MetAsn: 0.971 ± 0.409
0.647MetPro: 0.647 ± 0.299
2.104MetGln: 2.104 ± 0.893
2.751MetArg: 2.751 ± 0.503
2.266MetSer: 2.266 ± 0.566
1.295MetThr: 1.295 ± 0.371
1.295MetVal: 1.295 ± 0.549
0.162MetTrp: 0.162 ± 0.145
1.295MetTyr: 1.295 ± 0.331
0.0MetXaa: 0.0 ± 0.0
Asn
4.208AsnAla: 4.208 ± 0.677
0.162AsnCys: 0.162 ± 0.15
1.133AsnAsp: 1.133 ± 0.49
1.457AsnGlu: 1.457 ± 0.439
0.971AsnPhe: 0.971 ± 0.369
1.457AsnGly: 1.457 ± 0.463
0.486AsnHis: 0.486 ± 0.26
2.589AsnIle: 2.589 ± 0.699
0.486AsnLys: 0.486 ± 0.195
1.942AsnLeu: 1.942 ± 0.493
0.809AsnMet: 0.809 ± 0.387
0.486AsnAsn: 0.486 ± 0.253
1.942AsnPro: 1.942 ± 0.555
1.133AsnGln: 1.133 ± 0.365
1.457AsnArg: 1.457 ± 0.44
2.104AsnSer: 2.104 ± 0.785
1.942AsnThr: 1.942 ± 0.663
1.618AsnVal: 1.618 ± 0.526
0.486AsnTrp: 0.486 ± 0.193
0.971AsnTyr: 0.971 ± 0.25
0.0AsnXaa: 0.0 ± 0.0
Pro
4.208ProAla: 4.208 ± 0.305
0.486ProCys: 0.486 ± 0.226
2.589ProAsp: 2.589 ± 0.65
4.208ProGlu: 4.208 ± 0.831
1.295ProPhe: 1.295 ± 0.315
2.589ProGly: 2.589 ± 0.617
1.133ProHis: 1.133 ± 0.423
1.942ProIle: 1.942 ± 0.557
1.457ProLys: 1.457 ± 0.401
5.017ProLeu: 5.017 ± 0.827
1.457ProMet: 1.457 ± 0.319
0.971ProAsn: 0.971 ± 0.31
4.046ProPro: 4.046 ± 1.236
2.589ProGln: 2.589 ± 0.602
3.884ProArg: 3.884 ± 0.613
2.104ProSer: 2.104 ± 0.497
3.884ProThr: 3.884 ± 0.974
2.428ProVal: 2.428 ± 0.652
0.809ProTrp: 0.809 ± 0.455
2.589ProTyr: 2.589 ± 0.515
0.0ProXaa: 0.0 ± 0.0
Gln
2.589GlnAla: 2.589 ± 0.587
0.324GlnCys: 0.324 ± 0.251
1.295GlnAsp: 1.295 ± 0.592
1.295GlnGlu: 1.295 ± 0.322
0.647GlnPhe: 0.647 ± 0.227
1.78GlnGly: 1.78 ± 0.303
1.133GlnHis: 1.133 ± 0.31
3.237GlnIle: 3.237 ± 0.765
1.133GlnLys: 1.133 ± 0.494
4.37GlnLeu: 4.37 ± 0.734
0.809GlnMet: 0.809 ± 0.435
2.104GlnAsn: 2.104 ± 0.515
2.266GlnPro: 2.266 ± 0.449
0.809GlnGln: 0.809 ± 0.354
5.988GlnArg: 5.988 ± 0.957
2.913GlnSer: 2.913 ± 0.438
3.075GlnThr: 3.075 ± 0.676
2.589GlnVal: 2.589 ± 0.718
0.324GlnTrp: 0.324 ± 0.301
0.647GlnTyr: 0.647 ± 0.289
0.0GlnXaa: 0.0 ± 0.0
Arg
8.092ArgAla: 8.092 ± 1.386
1.295ArgCys: 1.295 ± 0.249
5.341ArgAsp: 5.341 ± 0.931
6.797ArgGlu: 6.797 ± 0.905
3.56ArgPhe: 3.56 ± 0.971
5.664ArgGly: 5.664 ± 0.923
2.266ArgHis: 2.266 ± 0.551
5.988ArgIle: 5.988 ± 0.734
2.104ArgLys: 2.104 ± 0.739
6.959ArgLeu: 6.959 ± 1.158
3.237ArgMet: 3.237 ± 0.699
2.913ArgAsn: 2.913 ± 0.488
3.722ArgPro: 3.722 ± 0.767
2.751ArgGln: 2.751 ± 0.639
7.121ArgArg: 7.121 ± 0.772
5.179ArgSer: 5.179 ± 1.072
5.988ArgThr: 5.988 ± 0.732
7.121ArgVal: 7.121 ± 0.716
1.295ArgTrp: 1.295 ± 0.325
2.104ArgTyr: 2.104 ± 0.5
0.0ArgXaa: 0.0 ± 0.0
Ser
5.664SerAla: 5.664 ± 0.996
0.971SerCys: 0.971 ± 0.377
3.399SerAsp: 3.399 ± 0.629
3.884SerGlu: 3.884 ± 1.058
2.266SerPhe: 2.266 ± 0.549
3.722SerGly: 3.722 ± 1.024
1.78SerHis: 1.78 ± 0.409
2.428SerIle: 2.428 ± 0.685
2.104SerLys: 2.104 ± 0.545
7.445SerLeu: 7.445 ± 2.039
2.266SerMet: 2.266 ± 0.568
0.486SerAsn: 0.486 ± 0.252
3.399SerPro: 3.399 ± 0.526
2.266SerGln: 2.266 ± 0.486
5.341SerArg: 5.341 ± 1.124
4.37SerSer: 4.37 ± 0.681
3.399SerThr: 3.399 ± 0.746
4.046SerVal: 4.046 ± 0.614
0.162SerTrp: 0.162 ± 0.164
3.075SerTyr: 3.075 ± 0.442
0.0SerXaa: 0.0 ± 0.0
Thr
4.855ThrAla: 4.855 ± 1.051
0.647ThrCys: 0.647 ± 0.347
2.913ThrAsp: 2.913 ± 0.736
3.237ThrGlu: 3.237 ± 0.655
1.133ThrPhe: 1.133 ± 0.452
4.693ThrGly: 4.693 ± 0.499
2.428ThrHis: 2.428 ± 0.469
3.722ThrIle: 3.722 ± 0.651
2.266ThrLys: 2.266 ± 0.73
5.017ThrLeu: 5.017 ± 0.942
1.133ThrMet: 1.133 ± 0.515
2.104ThrAsn: 2.104 ± 0.657
4.208ThrPro: 4.208 ± 0.735
2.266ThrGln: 2.266 ± 0.434
6.635ThrArg: 6.635 ± 0.991
3.884ThrSer: 3.884 ± 0.717
4.693ThrThr: 4.693 ± 1.303
6.797ThrVal: 6.797 ± 1.242
1.457ThrTrp: 1.457 ± 0.5
2.266ThrTyr: 2.266 ± 0.432
0.0ThrXaa: 0.0 ± 0.0
Val
7.121ValAla: 7.121 ± 0.7
1.457ValCys: 1.457 ± 0.364
3.884ValAsp: 3.884 ± 0.691
5.341ValGlu: 5.341 ± 1.099
2.428ValPhe: 2.428 ± 0.621
5.017ValGly: 5.017 ± 1.123
2.428ValHis: 2.428 ± 0.554
3.722ValIle: 3.722 ± 0.727
3.399ValLys: 3.399 ± 0.778
5.826ValLeu: 5.826 ± 0.767
2.266ValMet: 2.266 ± 0.722
0.809ValAsn: 0.809 ± 0.358
2.751ValPro: 2.751 ± 0.497
2.266ValGln: 2.266 ± 0.561
7.283ValArg: 7.283 ± 1.092
4.208ValSer: 4.208 ± 0.708
3.884ValThr: 3.884 ± 0.826
4.37ValVal: 4.37 ± 0.701
0.647ValTrp: 0.647 ± 0.266
2.913ValTyr: 2.913 ± 0.815
0.0ValXaa: 0.0 ± 0.0
Trp
1.133TrpAla: 1.133 ± 0.401
0.162TrpCys: 0.162 ± 0.156
0.647TrpAsp: 0.647 ± 0.264
0.971TrpGlu: 0.971 ± 0.263
0.809TrpPhe: 0.809 ± 0.256
0.324TrpGly: 0.324 ± 0.27
0.324TrpHis: 0.324 ± 0.201
0.971TrpIle: 0.971 ± 0.443
0.971TrpLys: 0.971 ± 0.296
1.457TrpLeu: 1.457 ± 0.603
0.0TrpMet: 0.0 ± 0.0
0.486TrpAsn: 0.486 ± 0.178
0.162TrpPro: 0.162 ± 0.164
0.971TrpGln: 0.971 ± 0.398
0.809TrpArg: 0.809 ± 0.354
0.486TrpSer: 0.486 ± 0.242
0.0TrpThr: 0.0 ± 0.0
1.133TrpVal: 1.133 ± 0.329
0.647TrpTrp: 0.647 ± 0.297
0.162TrpTyr: 0.162 ± 0.145
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.56TyrAla: 3.56 ± 0.849
0.809TyrCys: 0.809 ± 0.339
1.78TyrAsp: 1.78 ± 0.463
1.295TyrGlu: 1.295 ± 0.317
0.647TyrPhe: 0.647 ± 0.226
2.913TyrGly: 2.913 ± 0.602
0.971TyrHis: 0.971 ± 0.292
2.104TyrIle: 2.104 ± 0.537
1.133TyrLys: 1.133 ± 0.337
3.56TyrLeu: 3.56 ± 1.087
0.324TyrMet: 0.324 ± 0.276
0.971TyrAsn: 0.971 ± 0.426
0.647TyrPro: 0.647 ± 0.347
1.295TyrGln: 1.295 ± 0.32
2.751TyrArg: 2.751 ± 0.45
1.457TyrSer: 1.457 ± 0.509
4.37TyrThr: 4.37 ± 0.891
3.884TyrVal: 3.884 ± 0.411
0.0TyrTrp: 0.0 ± 0.0
1.133TyrTyr: 1.133 ± 0.57
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 12 proteins (6180 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski