Amino acid dipepetide frequency for Breoghania corrubedonensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.482AlaAla: 16.482 ± 0.16	1.19AlaCys: 1.19 ± 0.033	7.354AlaAsp: 7.354 ± 0.084	7.719AlaGlu: 7.719 ± 0.079	4.533AlaPhe: 4.533 ± 0.054	11.358AlaGly: 11.358 ± 0.108	2.338AlaHis: 2.338 ± 0.041	6.5AlaIle: 6.5 ± 0.076	3.822AlaLys: 3.822 ± 0.058	13.095AlaLeu: 13.095 ± 0.117	3.547AlaMet: 3.547 ± 0.049	3.004AlaAsn: 3.004 ± 0.048	5.399AlaPro: 5.399 ± 0.072	3.654AlaGln: 3.654 ± 0.05	9.217AlaArg: 9.217 ± 0.093	6.542AlaSer: 6.542 ± 0.077	6.217AlaThr: 6.217 ± 0.094	8.757AlaVal: 8.757 ± 0.081	1.4AlaTrp: 1.4 ± 0.035	2.535AlaTyr: 2.535 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.011CysAla: 1.011 ± 0.029	0.131CysCys: 0.131 ± 0.011	0.598CysAsp: 0.598 ± 0.022	0.501CysGlu: 0.501 ± 0.017	0.329CysPhe: 0.329 ± 0.015	0.976CysGly: 0.976 ± 0.029	0.266CysHis: 0.266 ± 0.015	0.381CysIle: 0.381 ± 0.016	0.226CysLys: 0.226 ± 0.011	0.801CysLeu: 0.801 ± 0.022	0.178CysMet: 0.178 ± 0.01	0.228CysAsn: 0.228 ± 0.01	0.485CysPro: 0.485 ± 0.02	0.221CysGln: 0.221 ± 0.013	0.642CysArg: 0.642 ± 0.021	0.463CysSer: 0.463 ± 0.019	0.423CysThr: 0.423 ± 0.02	0.664CysVal: 0.664 ± 0.021	0.112CysTrp: 0.112 ± 0.008	0.193CysTyr: 0.193 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.209AspAla: 7.209 ± 0.077	0.482AspCys: 0.482 ± 0.019	3.516AspAsp: 3.516 ± 0.06	3.905AspGlu: 3.905 ± 0.062	2.273AspPhe: 2.273 ± 0.039	5.404AspGly: 5.404 ± 0.083	1.235AspHis: 1.235 ± 0.032	3.265AspIle: 3.265 ± 0.051	1.825AspLys: 1.825 ± 0.043	6.218AspLeu: 6.218 ± 0.071	1.588AspMet: 1.588 ± 0.033	1.374AspAsn: 1.374 ± 0.03	3.521AspPro: 3.521 ± 0.047	1.547AspGln: 1.547 ± 0.028	4.12AspArg: 4.12 ± 0.061	1.944AspSer: 1.944 ± 0.036	3.012AspThr: 3.012 ± 0.051	4.397AspVal: 4.397 ± 0.055	0.967AspTrp: 0.967 ± 0.027	1.571AspTyr: 1.571 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	8.161GluAla: 8.161 ± 0.093	0.371GluCys: 0.371 ± 0.015	3.101GluAsp: 3.101 ± 0.044	3.766GluGlu: 3.766 ± 0.058	1.746GluPhe: 1.746 ± 0.037	4.517GluGly: 4.517 ± 0.061	1.198GluHis: 1.198 ± 0.027	3.978GluIle: 3.978 ± 0.052	2.5GluLys: 2.5 ± 0.05	5.192GluLeu: 5.192 ± 0.068	1.691GluMet: 1.691 ± 0.033	1.743GluAsn: 1.743 ± 0.035	2.892GluPro: 2.892 ± 0.048	1.88GluGln: 1.88 ± 0.038	5.141GluArg: 5.141 ± 0.073	2.312GluSer: 2.312 ± 0.042	4.168GluThr: 4.168 ± 0.062	4.013GluVal: 4.013 ± 0.049	0.615GluTrp: 0.615 ± 0.02	0.994GluTyr: 0.994 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	4.759PheAla: 4.759 ± 0.062	0.435PheCys: 0.435 ± 0.016	2.622PheAsp: 2.622 ± 0.042	2.257PheGlu: 2.257 ± 0.042	1.45PhePhe: 1.45 ± 0.035	3.562PheGly: 3.562 ± 0.053	0.762PheHis: 0.762 ± 0.023	1.721PheIle: 1.721 ± 0.041	0.965PheLys: 0.965 ± 0.028	3.397PheLeu: 3.397 ± 0.06	0.839PheMet: 0.839 ± 0.021	1.016PheAsn: 1.016 ± 0.027	1.535PhePro: 1.535 ± 0.032	0.955PheGln: 0.955 ± 0.025	2.167PheArg: 2.167 ± 0.037	2.415PheSer: 2.415 ± 0.045	1.985PheThr: 1.985 ± 0.038	2.932PheVal: 2.932 ± 0.052	0.527PheTrp: 0.527 ± 0.02	0.861PheTyr: 0.861 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	9.603GlyAla: 9.603 ± 0.099	0.889GlyCys: 0.889 ± 0.027	4.752GlyAsp: 4.752 ± 0.063	5.317GlyGlu: 5.317 ± 0.064	3.622GlyPhe: 3.622 ± 0.056	7.53GlyGly: 7.53 ± 0.106	1.958GlyHis: 1.958 ± 0.042	4.644GlyIle: 4.644 ± 0.056	3.297GlyLys: 3.297 ± 0.058	8.952GlyLeu: 8.952 ± 0.089	2.353GlyMet: 2.353 ± 0.045	2.23GlyAsn: 2.23 ± 0.046	3.412GlyPro: 3.412 ± 0.045	2.588GlyGln: 2.588 ± 0.044	6.112GlyArg: 6.112 ± 0.07	4.748GlySer: 4.748 ± 0.074	4.902GlyThr: 4.902 ± 0.09	6.103GlyVal: 6.103 ± 0.074	1.323GlyTrp: 1.323 ± 0.032	2.366GlyTyr: 2.366 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.302HisAla: 2.302 ± 0.045	0.243HisCys: 0.243 ± 0.014	1.271HisAsp: 1.271 ± 0.032	1.141HisGlu: 1.141 ± 0.029	0.83HisPhe: 0.83 ± 0.025	1.868HisGly: 1.868 ± 0.037	0.559HisHis: 0.559 ± 0.029	0.959HisIle: 0.959 ± 0.023	0.518HisLys: 0.518 ± 0.02	1.984HisLeu: 1.984 ± 0.037	0.519HisMet: 0.519 ± 0.019	0.462HisAsn: 0.462 ± 0.017	1.259HisPro: 1.259 ± 0.027	0.54HisGln: 0.54 ± 0.019	1.349HisArg: 1.349 ± 0.031	0.945HisSer: 0.945 ± 0.025	0.888HisThr: 0.888 ± 0.026	1.543HisVal: 1.543 ± 0.032	0.32HisTrp: 0.32 ± 0.013	0.55HisTyr: 0.55 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	7.631IleAla: 7.631 ± 0.08	0.542IleCys: 0.542 ± 0.018	3.759IleAsp: 3.759 ± 0.052	3.575IleGlu: 3.575 ± 0.048	1.772IlePhe: 1.772 ± 0.038	5.175IleGly: 5.175 ± 0.067	0.933IleHis: 0.933 ± 0.026	2.315IleIle: 2.315 ± 0.042	1.384IleLys: 1.384 ± 0.037	4.591IleLeu: 4.591 ± 0.063	1.031IleMet: 1.031 ± 0.026	1.401IleAsn: 1.401 ± 0.029	2.283IlePro: 2.283 ± 0.043	1.183IleGln: 1.183 ± 0.027	3.399IleArg: 3.399 ± 0.043	3.121IleSer: 3.121 ± 0.058	2.676IleThr: 2.676 ± 0.05	4.433IleVal: 4.433 ± 0.058	0.588IleTrp: 0.588 ± 0.019	1.14IleTyr: 1.14 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	4.476LysAla: 4.476 ± 0.062	0.171LysCys: 0.171 ± 0.011	1.731LysAsp: 1.731 ± 0.041	1.687LysGlu: 1.687 ± 0.043	0.853LysPhe: 0.853 ± 0.022	2.717LysGly: 2.717 ± 0.053	0.538LysHis: 0.538 ± 0.017	1.729LysIle: 1.729 ± 0.037	1.346LysLys: 1.346 ± 0.033	3.166LysLeu: 3.166 ± 0.052	0.782LysMet: 0.782 ± 0.028	0.879LysAsn: 0.879 ± 0.028	2.018LysPro: 2.018 ± 0.037	0.929LysGln: 0.929 ± 0.024	2.457LysArg: 2.457 ± 0.05	1.855LysSer: 1.855 ± 0.037	2.103LysThr: 2.103 ± 0.034	2.499LysVal: 2.499 ± 0.05	0.341LysTrp: 0.341 ± 0.016	0.608LysTyr: 0.608 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	13.203LeuAla: 13.203 ± 0.11	0.907LeuCys: 0.907 ± 0.025	6.11LeuAsp: 6.11 ± 0.068	5.676LeuGlu: 5.676 ± 0.063	3.591LeuPhe: 3.591 ± 0.06	8.055LeuGly: 8.055 ± 0.081	1.786LeuHis: 1.786 ± 0.035	5.076LeuIle: 5.076 ± 0.069	3.813LeuLys: 3.813 ± 0.058	8.646LeuLeu: 8.646 ± 0.108	2.402LeuMet: 2.402 ± 0.042	2.561LeuAsn: 2.561 ± 0.042	5.089LeuPro: 5.089 ± 0.053	2.464LeuGln: 2.464 ± 0.042	6.345LeuArg: 6.345 ± 0.08	6.555LeuSer: 6.555 ± 0.082	5.377LeuThr: 5.377 ± 0.068	7.81LeuVal: 7.81 ± 0.08	0.98LeuTrp: 0.98 ± 0.028	2.052LeuTyr: 2.052 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	3.129MetAla: 3.129 ± 0.045	0.158MetCys: 0.158 ± 0.011	1.158MetAsp: 1.158 ± 0.027	1.361MetGlu: 1.361 ± 0.037	0.701MetPhe: 0.701 ± 0.021	1.885MetGly: 1.885 ± 0.041	0.437MetHis: 0.437 ± 0.017	1.41MetIle: 1.41 ± 0.028	1.053MetLys: 1.053 ± 0.026	2.487MetLeu: 2.487 ± 0.035	0.675MetMet: 0.675 ± 0.021	0.794MetAsn: 0.794 ± 0.021	1.534MetPro: 1.534 ± 0.035	0.753MetGln: 0.753 ± 0.021	1.964MetArg: 1.964 ± 0.035	1.805MetSer: 1.805 ± 0.034	1.964MetThr: 1.964 ± 0.04	1.825MetVal: 1.825 ± 0.039	0.215MetTrp: 0.215 ± 0.013	0.318MetTyr: 0.318 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.268AsnAla: 3.268 ± 0.05	0.219AsnCys: 0.219 ± 0.012	1.519AsnAsp: 1.519 ± 0.032	1.419AsnGlu: 1.419 ± 0.034	0.869AsnPhe: 0.869 ± 0.025	2.43AsnGly: 2.43 ± 0.043	0.452AsnHis: 0.452 ± 0.015	1.313AsnIle: 1.313 ± 0.029	0.7AsnLys: 0.7 ± 0.024	2.472AsnLeu: 2.472 ± 0.039	0.627AsnMet: 0.627 ± 0.02	0.634AsnAsn: 0.634 ± 0.025	1.735AsnPro: 1.735 ± 0.037	0.72AsnGln: 0.72 ± 0.02	1.853AsnArg: 1.853 ± 0.033	1.245AsnSer: 1.245 ± 0.039	1.323AsnThr: 1.323 ± 0.034	1.947AsnVal: 1.947 ± 0.039	0.387AsnTrp: 0.387 ± 0.016	0.638AsnTyr: 0.638 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	6.084ProAla: 6.084 ± 0.082	0.357ProCys: 0.357 ± 0.017	3.742ProAsp: 3.742 ± 0.044	3.527ProGlu: 3.527 ± 0.055	1.964ProPhe: 1.964 ± 0.036	4.517ProGly: 4.517 ± 0.063	1.109ProHis: 1.109 ± 0.029	2.164ProIle: 2.164 ± 0.04	1.628ProLys: 1.628 ± 0.034	4.605ProLeu: 4.605 ± 0.057	1.137ProMet: 1.137 ± 0.027	1.173ProAsn: 1.173 ± 0.028	2.154ProPro: 2.154 ± 0.045	1.65ProGln: 1.65 ± 0.038	2.852ProArg: 2.852 ± 0.047	2.576ProSer: 2.576 ± 0.04	2.285ProThr: 2.285 ± 0.043	4.258ProVal: 4.258 ± 0.057	0.651ProTrp: 0.651 ± 0.02	1.14ProTyr: 1.14 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.83GlnAla: 3.83 ± 0.058	0.193GlnCys: 0.193 ± 0.012	1.412GlnAsp: 1.412 ± 0.03	1.544GlnGlu: 1.544 ± 0.034	0.948GlnPhe: 0.948 ± 0.027	2.231GlnGly: 2.231 ± 0.038	0.523GlnHis: 0.523 ± 0.019	1.817GlnIle: 1.817 ± 0.037	0.998GlnLys: 0.998 ± 0.028	2.537GlnLeu: 2.537 ± 0.046	0.852GlnMet: 0.852 ± 0.023	0.777GlnAsn: 0.777 ± 0.023	1.511GlnPro: 1.511 ± 0.041	0.963GlnGln: 0.963 ± 0.034	2.12GlnArg: 2.12 ± 0.044	1.696GlnSer: 1.696 ± 0.038	1.706GlnThr: 1.706 ± 0.038	2.073GlnVal: 2.073 ± 0.035	0.354GlnTrp: 0.354 ± 0.014	0.496GlnTyr: 0.496 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	8.038ArgAla: 8.038 ± 0.089	0.568ArgCys: 0.568 ± 0.021	4.139ArgAsp: 4.139 ± 0.055	4.432ArgGlu: 4.432 ± 0.061	2.915ArgPhe: 2.915 ± 0.042	4.686ArgGly: 4.686 ± 0.068	1.679ArgHis: 1.679 ± 0.033	4.171ArgIle: 4.171 ± 0.048	2.454ArgLys: 2.454 ± 0.045	7.88ArgLeu: 7.88 ± 0.086	1.955ArgMet: 1.955 ± 0.039	1.803ArgAsn: 1.803 ± 0.036	3.403ArgPro: 3.403 ± 0.046	2.368ArgGln: 2.368 ± 0.045	5.622ArgArg: 5.622 ± 0.082	3.583ArgSer: 3.583 ± 0.052	3.569ArgThr: 3.569 ± 0.044	4.657ArgVal: 4.657 ± 0.061	0.868ArgTrp: 0.868 ± 0.024	1.619ArgTyr: 1.619 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	6.264SerAla: 6.264 ± 0.081	0.429SerCys: 0.429 ± 0.016	3.311SerAsp: 3.311 ± 0.053	3.001SerGlu: 3.001 ± 0.049	2.277SerPhe: 2.277 ± 0.045	5.917SerGly: 5.917 ± 0.094	1.071SerHis: 1.071 ± 0.027	2.74SerIle: 2.74 ± 0.05	1.532SerLys: 1.532 ± 0.033	5.371SerLeu: 5.371 ± 0.072	1.376SerMet: 1.376 ± 0.027	1.356SerAsn: 1.356 ± 0.033	2.644SerPro: 2.644 ± 0.045	1.667SerGln: 1.667 ± 0.038	3.691SerArg: 3.691 ± 0.054	3.137SerSer: 3.137 ± 0.062	2.749SerThr: 2.749 ± 0.064	4.171SerVal: 4.171 ± 0.057	0.641SerTrp: 0.641 ± 0.02	1.331SerTyr: 1.331 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	6.306ThrAla: 6.306 ± 0.091	0.472ThrCys: 0.472 ± 0.021	2.905ThrAsp: 2.905 ± 0.047	2.606ThrGlu: 2.606 ± 0.049	2.19ThrPhe: 2.19 ± 0.041	5.372ThrGly: 5.372 ± 0.098	1.048ThrHis: 1.048 ± 0.024	3.156ThrIle: 3.156 ± 0.058	1.446ThrLys: 1.446 ± 0.036	5.822ThrLeu: 5.822 ± 0.078	1.244ThrMet: 1.244 ± 0.028	1.424ThrAsn: 1.424 ± 0.041	3.152ThrPro: 3.152 ± 0.043	1.438ThrGln: 1.438 ± 0.033	3.568ThrArg: 3.568 ± 0.055	3.097ThrSer: 3.097 ± 0.066	3.012ThrThr: 3.012 ± 0.072	4.557ThrVal: 4.557 ± 0.068	0.672ThrTrp: 0.672 ± 0.023	1.331ThrTyr: 1.331 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	9.329ValAla: 9.329 ± 0.085	0.677ValCys: 0.677 ± 0.021	4.278ValAsp: 4.278 ± 0.055	4.738ValGlu: 4.738 ± 0.059	2.874ValPhe: 2.874 ± 0.053	5.546ValGly: 5.546 ± 0.071	1.402ValHis: 1.402 ± 0.03	4.019ValIle: 4.019 ± 0.054	2.324ValLys: 2.324 ± 0.046	7.536ValLeu: 7.536 ± 0.076	2.009ValMet: 2.009 ± 0.039	1.941ValAsn: 1.941 ± 0.033	3.822ValPro: 3.822 ± 0.054	1.855ValGln: 1.855 ± 0.038	4.986ValArg: 4.986 ± 0.064	4.669ValSer: 4.669 ± 0.069	4.649ValThr: 4.649 ± 0.061	5.954ValVal: 5.954 ± 0.063	0.863ValTrp: 0.863 ± 0.025	1.509ValTyr: 1.509 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.148TrpAla: 1.148 ± 0.03	0.129TrpCys: 0.129 ± 0.008	0.58TrpAsp: 0.58 ± 0.02	0.535TrpGlu: 0.535 ± 0.018	0.493TrpPhe: 0.493 ± 0.018	0.874TrpGly: 0.874 ± 0.027	0.281TrpHis: 0.281 ± 0.013	0.655TrpIle: 0.655 ± 0.018	0.471TrpLys: 0.471 ± 0.022	1.511TrpLeu: 1.511 ± 0.035	0.352TrpMet: 0.352 ± 0.016	0.391TrpAsn: 0.391 ± 0.015	0.662TrpPro: 0.662 ± 0.02	0.512TrpGln: 0.512 ± 0.02	1.054TrpArg: 1.054 ± 0.027	0.767TrpSer: 0.767 ± 0.024	0.697TrpThr: 0.697 ± 0.02	0.766TrpVal: 0.766 ± 0.021	0.198TrpTrp: 0.198 ± 0.012	0.288TrpTyr: 0.288 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.428TyrAla: 2.428 ± 0.047	0.267TyrCys: 0.267 ± 0.012	1.517TyrAsp: 1.517 ± 0.033	1.273TyrGlu: 1.273 ± 0.03	0.931TyrPhe: 0.931 ± 0.024	2.086TyrGly: 2.086 ± 0.039	0.472TyrHis: 0.472 ± 0.017	0.918TyrIle: 0.918 ± 0.025	0.583TyrLys: 0.583 ± 0.019	2.232TyrLeu: 2.232 ± 0.041	0.469TyrMet: 0.469 ± 0.016	0.577TyrAsn: 0.577 ± 0.02	1.064TyrPro: 1.064 ± 0.026	0.693TyrGln: 0.693 ± 0.024	1.753TyrArg: 1.753 ± 0.037	1.202TyrSer: 1.202 ± 0.029	1.111TyrThr: 1.111 ± 0.028	1.622TyrVal: 1.622 ± 0.034	0.343TyrTrp: 0.343 ± 0.014	0.586TyrTyr: 0.586 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4681 proteins (1532312 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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