Amino acid dipepetide frequency for Salmonella phage vB_StyS-sam

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.774AlaAla: 12.774 ± 1.607
1.052AlaCys: 1.052 ± 0.27
5.861AlaAsp: 5.861 ± 0.632
6.462AlaGlu: 6.462 ± 0.819
3.757AlaPhe: 3.757 ± 0.559
6.613AlaGly: 6.613 ± 0.75
1.728AlaHis: 1.728 ± 0.364
4.133AlaIle: 4.133 ± 0.748
5.11AlaLys: 5.11 ± 0.688
7.063AlaLeu: 7.063 ± 0.848
2.329AlaMet: 2.329 ± 0.506
3.607AlaAsn: 3.607 ± 0.422
3.006AlaPro: 3.006 ± 0.432
3.081AlaGln: 3.081 ± 0.637
5.185AlaArg: 5.185 ± 0.529
5.936AlaSer: 5.936 ± 0.869
5.335AlaThr: 5.335 ± 0.837
6.988AlaVal: 6.988 ± 0.839
1.277AlaTrp: 1.277 ± 0.22
3.381AlaTyr: 3.381 ± 0.445
0.0AlaXaa: 0.0 ± 0.0
Cys
1.052CysAla: 1.052 ± 0.236
0.301CysCys: 0.301 ± 0.199
1.052CysAsp: 1.052 ± 0.293
0.977CysGlu: 0.977 ± 0.252
0.376CysPhe: 0.376 ± 0.157
0.751CysGly: 0.751 ± 0.238
0.15CysHis: 0.15 ± 0.08
0.225CysIle: 0.225 ± 0.127
0.902CysLys: 0.902 ± 0.261
1.052CysLeu: 1.052 ± 0.328
0.451CysMet: 0.451 ± 0.215
0.751CysAsn: 0.751 ± 0.215
0.451CysPro: 0.451 ± 0.171
0.075CysGln: 0.075 ± 0.078
1.202CysArg: 1.202 ± 0.291
0.601CysSer: 0.601 ± 0.221
0.676CysThr: 0.676 ± 0.232
0.526CysVal: 0.526 ± 0.207
0.15CysTrp: 0.15 ± 0.104
0.15CysTyr: 0.15 ± 0.088
0.0CysXaa: 0.0 ± 0.0
Asp
6.162AspAla: 6.162 ± 0.612
0.751AspCys: 0.751 ± 0.231
3.381AspAsp: 3.381 ± 0.516
3.532AspGlu: 3.532 ± 0.579
2.78AspPhe: 2.78 ± 0.519
5.485AspGly: 5.485 ± 0.686
0.902AspHis: 0.902 ± 0.212
3.306AspIle: 3.306 ± 0.431
3.231AspLys: 3.231 ± 0.515
4.433AspLeu: 4.433 ± 0.516
1.202AspMet: 1.202 ± 0.23
3.006AspAsn: 3.006 ± 0.603
2.104AspPro: 2.104 ± 0.414
0.526AspGln: 0.526 ± 0.183
2.63AspArg: 2.63 ± 0.376
3.907AspSer: 3.907 ± 0.515
4.058AspThr: 4.058 ± 0.477
3.907AspVal: 3.907 ± 0.516
1.052AspTrp: 1.052 ± 0.29
1.653AspTyr: 1.653 ± 0.382
0.0AspXaa: 0.0 ± 0.0
Glu
6.011GluAla: 6.011 ± 0.677
0.601GluCys: 0.601 ± 0.233
3.607GluAsp: 3.607 ± 0.473
4.509GluGlu: 4.509 ± 0.896
3.006GluPhe: 3.006 ± 0.799
4.809GluGly: 4.809 ± 0.683
1.127GluHis: 1.127 ± 0.322
3.306GluIle: 3.306 ± 0.398
3.532GluLys: 3.532 ± 0.562
6.237GluLeu: 6.237 ± 0.719
2.705GluMet: 2.705 ± 0.418
2.63GluAsn: 2.63 ± 0.415
1.879GluPro: 1.879 ± 0.545
3.381GluGln: 3.381 ± 0.513
3.832GluArg: 3.832 ± 0.537
3.607GluSer: 3.607 ± 0.535
3.832GluThr: 3.832 ± 0.639
4.433GluVal: 4.433 ± 0.509
0.751GluTrp: 0.751 ± 0.231
1.653GluTyr: 1.653 ± 0.392
0.0GluXaa: 0.0 ± 0.0
Phe
3.156PheAla: 3.156 ± 0.504
1.052PheCys: 1.052 ± 0.252
2.48PheAsp: 2.48 ± 0.392
2.329PheGlu: 2.329 ± 0.509
1.052PhePhe: 1.052 ± 0.288
2.705PheGly: 2.705 ± 0.388
0.751PheHis: 0.751 ± 0.205
2.63PheIle: 2.63 ± 0.502
1.728PheLys: 1.728 ± 0.389
1.428PheLeu: 1.428 ± 0.243
0.376PheMet: 0.376 ± 0.169
1.428PheAsn: 1.428 ± 0.374
1.803PhePro: 1.803 ± 0.508
0.902PheGln: 0.902 ± 0.262
2.254PheArg: 2.254 ± 0.392
2.931PheSer: 2.931 ± 0.662
3.607PheThr: 3.607 ± 0.554
2.405PheVal: 2.405 ± 0.378
0.676PheTrp: 0.676 ± 0.247
1.202PheTyr: 1.202 ± 0.307
0.0PheXaa: 0.0 ± 0.0
Gly
6.537GlyAla: 6.537 ± 0.713
0.827GlyCys: 0.827 ± 0.268
4.058GlyAsp: 4.058 ± 0.619
5.936GlyGlu: 5.936 ± 0.82
3.006GlyPhe: 3.006 ± 0.572
5.561GlyGly: 5.561 ± 0.762
1.503GlyHis: 1.503 ± 0.456
3.607GlyIle: 3.607 ± 0.523
4.584GlyLys: 4.584 ± 0.557
5.711GlyLeu: 5.711 ± 0.622
1.954GlyMet: 1.954 ± 0.64
3.607GlyAsn: 3.607 ± 0.638
2.179GlyPro: 2.179 ± 0.384
2.78GlyGln: 2.78 ± 0.45
4.433GlyArg: 4.433 ± 0.488
4.959GlySer: 4.959 ± 0.796
3.682GlyThr: 3.682 ± 0.512
6.087GlyVal: 6.087 ± 0.753
0.977GlyTrp: 0.977 ± 0.283
3.231GlyTyr: 3.231 ± 0.448
0.0GlyXaa: 0.0 ± 0.0
His
1.202HisAla: 1.202 ± 0.311
0.225HisCys: 0.225 ± 0.126
0.751HisAsp: 0.751 ± 0.182
0.827HisGlu: 0.827 ± 0.242
0.601HisPhe: 0.601 ± 0.216
1.202HisGly: 1.202 ± 0.323
0.751HisHis: 0.751 ± 0.293
1.353HisIle: 1.353 ± 0.291
1.052HisLys: 1.052 ± 0.263
1.277HisLeu: 1.277 ± 0.323
0.526HisMet: 0.526 ± 0.166
0.676HisAsn: 0.676 ± 0.239
0.902HisPro: 0.902 ± 0.232
1.052HisGln: 1.052 ± 0.307
1.127HisArg: 1.127 ± 0.336
1.052HisSer: 1.052 ± 0.315
0.902HisThr: 0.902 ± 0.364
0.827HisVal: 0.827 ± 0.248
0.15HisTrp: 0.15 ± 0.109
0.676HisTyr: 0.676 ± 0.197
0.0HisXaa: 0.0 ± 0.0
Ile
3.983IleAla: 3.983 ± 0.724
0.902IleCys: 0.902 ± 0.269
3.757IleAsp: 3.757 ± 0.571
2.78IleGlu: 2.78 ± 0.428
1.503IlePhe: 1.503 ± 0.344
3.381IleGly: 3.381 ± 0.394
0.526IleHis: 0.526 ± 0.187
2.329IleIle: 2.329 ± 0.439
2.931IleLys: 2.931 ± 0.559
3.081IleLeu: 3.081 ± 0.544
1.277IleMet: 1.277 ± 0.343
2.555IleAsn: 2.555 ± 0.446
3.081IlePro: 3.081 ± 0.502
1.879IleGln: 1.879 ± 0.473
2.855IleArg: 2.855 ± 0.382
3.381IleSer: 3.381 ± 0.464
4.659IleThr: 4.659 ± 0.554
3.607IleVal: 3.607 ± 0.515
0.601IleTrp: 0.601 ± 0.23
1.277IleTyr: 1.277 ± 0.344
0.0IleXaa: 0.0 ± 0.0
Lys
5.11LysAla: 5.11 ± 0.681
0.601LysCys: 0.601 ± 0.261
3.306LysAsp: 3.306 ± 0.451
4.433LysGlu: 4.433 ± 0.57
2.329LysPhe: 2.329 ± 0.363
3.983LysGly: 3.983 ± 0.529
1.127LysHis: 1.127 ± 0.299
1.428LysIle: 1.428 ± 0.334
3.231LysLys: 3.231 ± 0.583
5.335LysLeu: 5.335 ± 0.645
2.705LysMet: 2.705 ± 0.501
2.254LysAsn: 2.254 ± 0.357
2.78LysPro: 2.78 ± 0.604
2.329LysGln: 2.329 ± 0.468
4.058LysArg: 4.058 ± 0.69
2.78LysSer: 2.78 ± 0.516
3.757LysThr: 3.757 ± 0.471
3.682LysVal: 3.682 ± 0.545
0.601LysTrp: 0.601 ± 0.187
2.104LysTyr: 2.104 ± 0.427
0.0LysXaa: 0.0 ± 0.0
Leu
7.289LeuAla: 7.289 ± 0.736
1.052LeuCys: 1.052 ± 0.318
3.832LeuAsp: 3.832 ± 0.53
4.809LeuGlu: 4.809 ± 0.635
1.879LeuPhe: 1.879 ± 0.382
4.734LeuGly: 4.734 ± 0.473
1.052LeuHis: 1.052 ± 0.271
4.584LeuIle: 4.584 ± 0.624
4.959LeuLys: 4.959 ± 0.707
5.861LeuLeu: 5.861 ± 0.738
1.803LeuMet: 1.803 ± 0.335
4.058LeuAsn: 4.058 ± 0.524
4.133LeuPro: 4.133 ± 0.601
2.48LeuGln: 2.48 ± 0.395
6.162LeuArg: 6.162 ± 0.769
4.809LeuSer: 4.809 ± 0.622
5.26LeuThr: 5.26 ± 0.521
5.41LeuVal: 5.41 ± 0.633
0.977LeuTrp: 0.977 ± 0.329
2.329LeuTyr: 2.329 ± 0.413
0.0LeuXaa: 0.0 ± 0.0
Met
2.179MetAla: 2.179 ± 0.319
0.301MetCys: 0.301 ± 0.136
1.052MetAsp: 1.052 ± 0.341
1.353MetGlu: 1.353 ± 0.258
0.751MetPhe: 0.751 ± 0.223
1.503MetGly: 1.503 ± 0.353
0.376MetHis: 0.376 ± 0.147
1.052MetIle: 1.052 ± 0.289
1.202MetLys: 1.202 ± 0.259
2.555MetLeu: 2.555 ± 0.452
0.451MetMet: 0.451 ± 0.197
0.751MetAsn: 0.751 ± 0.275
1.202MetPro: 1.202 ± 0.349
1.052MetGln: 1.052 ± 0.267
1.728MetArg: 1.728 ± 0.34
2.254MetSer: 2.254 ± 0.313
1.879MetThr: 1.879 ± 0.348
2.179MetVal: 2.179 ± 0.379
0.526MetTrp: 0.526 ± 0.179
0.751MetTyr: 0.751 ± 0.222
0.0MetXaa: 0.0 ± 0.0
Asn
3.907AsnAla: 3.907 ± 0.527
0.526AsnCys: 0.526 ± 0.194
2.48AsnAsp: 2.48 ± 0.401
2.104AsnGlu: 2.104 ± 0.35
1.728AsnPhe: 1.728 ± 0.342
4.734AsnGly: 4.734 ± 0.643
0.827AsnHis: 0.827 ± 0.27
3.081AsnIle: 3.081 ± 0.385
2.329AsnLys: 2.329 ± 0.441
3.457AsnLeu: 3.457 ± 0.379
0.451AsnMet: 0.451 ± 0.199
2.48AsnAsn: 2.48 ± 0.487
1.803AsnPro: 1.803 ± 0.382
1.277AsnGln: 1.277 ± 0.294
3.231AsnArg: 3.231 ± 0.513
2.254AsnSer: 2.254 ± 0.332
2.48AsnThr: 2.48 ± 0.424
3.607AsnVal: 3.607 ± 0.467
0.751AsnTrp: 0.751 ± 0.238
1.503AsnTyr: 1.503 ± 0.37
0.0AsnXaa: 0.0 ± 0.0
Pro
3.156ProAla: 3.156 ± 0.513
0.376ProCys: 0.376 ± 0.154
2.855ProAsp: 2.855 ± 0.504
3.757ProGlu: 3.757 ± 0.556
1.578ProPhe: 1.578 ± 0.298
2.931ProGly: 2.931 ± 0.482
0.676ProHis: 0.676 ± 0.218
1.202ProIle: 1.202 ± 0.302
2.855ProLys: 2.855 ± 0.503
3.306ProLeu: 3.306 ± 0.513
1.052ProMet: 1.052 ± 0.29
1.803ProAsn: 1.803 ± 0.453
1.428ProPro: 1.428 ± 0.386
1.277ProGln: 1.277 ± 0.239
2.254ProArg: 2.254 ± 0.416
3.231ProSer: 3.231 ± 0.521
1.954ProThr: 1.954 ± 0.403
3.607ProVal: 3.607 ± 0.444
0.376ProTrp: 0.376 ± 0.17
1.428ProTyr: 1.428 ± 0.338
0.0ProXaa: 0.0 ± 0.0
Gln
4.133GlnAla: 4.133 ± 0.656
0.301GlnCys: 0.301 ± 0.151
1.578GlnAsp: 1.578 ± 0.358
1.954GlnGlu: 1.954 ± 0.457
1.353GlnPhe: 1.353 ± 0.308
1.803GlnGly: 1.803 ± 0.369
0.676GlnHis: 0.676 ± 0.202
1.954GlnIle: 1.954 ± 0.342
1.879GlnLys: 1.879 ± 0.371
3.006GlnLeu: 3.006 ± 0.38
1.052GlnMet: 1.052 ± 0.302
1.503GlnAsn: 1.503 ± 0.318
2.029GlnPro: 2.029 ± 0.389
2.254GlnGln: 2.254 ± 0.515
1.653GlnArg: 1.653 ± 0.321
2.104GlnSer: 2.104 ± 0.371
1.728GlnThr: 1.728 ± 0.319
2.555GlnVal: 2.555 ± 0.518
0.601GlnTrp: 0.601 ± 0.194
0.977GlnTyr: 0.977 ± 0.215
0.0GlnXaa: 0.0 ± 0.0
Arg
4.809ArgAla: 4.809 ± 0.456
0.526ArgCys: 0.526 ± 0.185
3.532ArgAsp: 3.532 ± 0.433
3.983ArgGlu: 3.983 ± 0.538
2.029ArgPhe: 2.029 ± 0.375
3.983ArgGly: 3.983 ± 0.423
0.977ArgHis: 0.977 ± 0.292
3.832ArgIle: 3.832 ± 0.597
4.358ArgLys: 4.358 ± 0.611
4.358ArgLeu: 4.358 ± 0.523
2.029ArgMet: 2.029 ± 0.36
3.682ArgAsn: 3.682 ± 0.52
2.254ArgPro: 2.254 ± 0.442
3.081ArgGln: 3.081 ± 0.451
4.509ArgArg: 4.509 ± 0.663
3.156ArgSer: 3.156 ± 0.491
2.931ArgThr: 2.931 ± 0.451
4.133ArgVal: 4.133 ± 0.546
0.827ArgTrp: 0.827 ± 0.243
1.353ArgTyr: 1.353 ± 0.395
0.0ArgXaa: 0.0 ± 0.0
Ser
6.838SerAla: 6.838 ± 1.08
0.376SerCys: 0.376 ± 0.189
3.381SerAsp: 3.381 ± 0.539
3.682SerGlu: 3.682 ± 0.538
2.329SerPhe: 2.329 ± 0.389
7.063SerGly: 7.063 ± 0.706
1.277SerHis: 1.277 ± 0.317
3.156SerIle: 3.156 ± 0.483
2.855SerLys: 2.855 ± 0.473
5.861SerLeu: 5.861 ± 0.72
1.127SerMet: 1.127 ± 0.271
2.48SerAsn: 2.48 ± 0.393
2.104SerPro: 2.104 ± 0.587
1.879SerGln: 1.879 ± 0.347
3.532SerArg: 3.532 ± 0.566
3.682SerSer: 3.682 ± 0.637
4.659SerThr: 4.659 ± 0.616
5.861SerVal: 5.861 ± 0.708
0.977SerTrp: 0.977 ± 0.229
1.879SerTyr: 1.879 ± 0.391
0.0SerXaa: 0.0 ± 0.0
Thr
5.936ThrAla: 5.936 ± 0.828
0.601ThrCys: 0.601 ± 0.178
3.682ThrAsp: 3.682 ± 0.56
3.081ThrGlu: 3.081 ± 0.392
2.48ThrPhe: 2.48 ± 0.447
6.838ThrGly: 6.838 ± 0.846
0.902ThrHis: 0.902 ± 0.276
3.081ThrIle: 3.081 ± 0.428
2.931ThrLys: 2.931 ± 0.473
5.035ThrLeu: 5.035 ± 0.738
0.751ThrMet: 0.751 ± 0.264
2.104ThrAsn: 2.104 ± 0.376
4.058ThrPro: 4.058 ± 0.568
1.728ThrGln: 1.728 ± 0.313
3.231ThrArg: 3.231 ± 0.462
5.41ThrSer: 5.41 ± 0.593
4.058ThrThr: 4.058 ± 0.5
5.335ThrVal: 5.335 ± 0.68
0.977ThrTrp: 0.977 ± 0.25
2.179ThrTyr: 2.179 ± 0.495
0.0ThrXaa: 0.0 ± 0.0
Val
7.063ValAla: 7.063 ± 0.798
0.902ValCys: 0.902 ± 0.23
4.433ValAsp: 4.433 ± 0.523
6.162ValGlu: 6.162 ± 0.682
2.104ValPhe: 2.104 ± 0.479
3.757ValGly: 3.757 ± 0.573
0.827ValHis: 0.827 ± 0.183
3.832ValIle: 3.832 ± 0.605
5.035ValLys: 5.035 ± 0.732
4.809ValLeu: 4.809 ± 0.592
1.277ValMet: 1.277 ± 0.339
3.757ValAsn: 3.757 ± 0.547
2.329ValPro: 2.329 ± 0.605
2.179ValGln: 2.179 ± 0.324
3.457ValArg: 3.457 ± 0.491
6.537ValSer: 6.537 ± 0.779
5.936ValThr: 5.936 ± 0.802
5.26ValVal: 5.26 ± 0.769
1.052ValTrp: 1.052 ± 0.252
2.855ValTyr: 2.855 ± 0.45
0.0ValXaa: 0.0 ± 0.0
Trp
1.127TrpAla: 1.127 ± 0.399
0.225TrpCys: 0.225 ± 0.119
0.676TrpAsp: 0.676 ± 0.222
0.451TrpGlu: 0.451 ± 0.169
0.977TrpPhe: 0.977 ± 0.313
0.827TrpGly: 0.827 ± 0.275
0.301TrpHis: 0.301 ± 0.161
0.526TrpIle: 0.526 ± 0.196
0.601TrpLys: 0.601 ± 0.214
1.503TrpLeu: 1.503 ± 0.286
0.451TrpMet: 0.451 ± 0.207
0.376TrpAsn: 0.376 ± 0.167
0.526TrpPro: 0.526 ± 0.251
0.601TrpGln: 0.601 ± 0.219
1.127TrpArg: 1.127 ± 0.345
0.827TrpSer: 0.827 ± 0.221
0.751TrpThr: 0.751 ± 0.199
1.277TrpVal: 1.277 ± 0.233
0.075TrpTrp: 0.075 ± 0.08
0.301TrpTyr: 0.301 ± 0.179
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.254TyrAla: 2.254 ± 0.362
0.376TyrCys: 0.376 ± 0.17
2.254TyrAsp: 2.254 ± 0.515
2.329TyrGlu: 2.329 ± 0.415
1.277TyrPhe: 1.277 ± 0.316
2.555TyrGly: 2.555 ± 0.405
0.676TyrHis: 0.676 ± 0.198
1.728TyrIle: 1.728 ± 0.337
2.63TyrLys: 2.63 ± 0.504
2.179TyrLeu: 2.179 ± 0.432
1.052TyrMet: 1.052 ± 0.183
1.503TyrAsn: 1.503 ± 0.301
1.052TyrPro: 1.052 ± 0.352
1.277TyrGln: 1.277 ± 0.316
1.879TyrArg: 1.879 ± 0.409
1.578TyrSer: 1.578 ± 0.332
2.254TyrThr: 2.254 ± 0.405
1.879TyrVal: 1.879 ± 0.309
0.15TyrTrp: 0.15 ± 0.139
0.977TyrTyr: 0.977 ± 0.23
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 66 proteins (13309 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski