Amino acid dipepetide frequency for Helicobacter bizzozeronii CCUG 35545

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.833AlaAla: 2.833 ± 0.088
1.481AlaCys: 1.481 ± 0.059
2.968AlaAsp: 2.968 ± 0.077
2.605AlaGlu: 2.605 ± 0.078
4.096AlaPhe: 4.096 ± 0.099
4.246AlaGly: 4.246 ± 0.094
2.771AlaHis: 2.771 ± 0.078
5.562AlaIle: 5.562 ± 0.117
5.915AlaLys: 5.915 ± 0.115
11.708AlaLeu: 11.708 ± 0.169
2.003AlaMet: 2.003 ± 0.061
3.553AlaAsn: 3.553 ± 0.072
3.331AlaPro: 3.331 ± 0.097
5.038AlaGln: 5.038 ± 0.103
3.694AlaArg: 3.694 ± 0.087
5.119AlaSer: 5.119 ± 0.101
3.706AlaThr: 3.706 ± 0.091
3.217AlaVal: 3.217 ± 0.083
0.724AlaTrp: 0.724 ± 0.037
3.094AlaTyr: 3.094 ± 0.078
0.0AlaXaa: 0.0 ± 0.0
Cys
1.359CysAla: 1.359 ± 0.056
0.212CysCys: 0.212 ± 0.022
0.658CysAsp: 0.658 ± 0.038
0.543CysGlu: 0.543 ± 0.035
0.711CysPhe: 0.711 ± 0.035
1.17CysGly: 1.17 ± 0.051
0.489CysHis: 0.489 ± 0.032
0.643CysIle: 0.643 ± 0.036
0.655CysLys: 0.655 ± 0.032
1.585CysLeu: 1.585 ± 0.057
0.452CysMet: 0.452 ± 0.028
0.407CysAsn: 0.407 ± 0.03
0.587CysPro: 0.587 ± 0.035
0.742CysGln: 0.742 ± 0.04
0.384CysArg: 0.384 ± 0.025
0.695CysSer: 0.695 ± 0.041
0.473CysThr: 0.473 ± 0.031
1.197CysVal: 1.197 ± 0.047
0.131CysTrp: 0.131 ± 0.017
0.423CysTyr: 0.423 ± 0.028
0.0CysXaa: 0.0 ± 0.0
Asp
3.018AspAla: 3.018 ± 0.088
0.647AspCys: 0.647 ± 0.038
1.697AspAsp: 1.697 ± 0.063
2.207AspGlu: 2.207 ± 0.07
3.256AspPhe: 3.256 ± 0.092
2.522AspGly: 2.522 ± 0.071
1.261AspHis: 1.261 ± 0.052
3.275AspIle: 3.275 ± 0.081
3.449AspLys: 3.449 ± 0.094
6.064AspLeu: 6.064 ± 0.12
1.242AspMet: 1.242 ± 0.052
1.835AspAsn: 1.835 ± 0.065
2.203AspPro: 2.203 ± 0.066
1.912AspGln: 1.912 ± 0.057
2.25AspArg: 2.25 ± 0.068
2.729AspSer: 2.729 ± 0.076
2.288AspThr: 2.288 ± 0.072
2.769AspVal: 2.769 ± 0.077
0.423AspTrp: 0.423 ± 0.029
2.082AspTyr: 2.082 ± 0.07
0.0AspXaa: 0.0 ± 0.0
Glu
4.227GluAla: 4.227 ± 0.085
0.799GluCys: 0.799 ± 0.041
2.545GluAsp: 2.545 ± 0.078
3.59GluGlu: 3.59 ± 0.113
2.458GluPhe: 2.458 ± 0.069
4.214GluGly: 4.214 ± 0.11
1.74GluHis: 1.74 ± 0.062
4.241GluIle: 4.241 ± 0.093
4.127GluLys: 4.127 ± 0.106
5.467GluLeu: 5.467 ± 0.127
1.429GluMet: 1.429 ± 0.059
2.758GluAsn: 2.758 ± 0.076
1.887GluPro: 1.887 ± 0.088
3.08GluGln: 3.08 ± 0.095
2.8GluArg: 2.8 ± 0.082
3.712GluSer: 3.712 ± 0.091
1.962GluThr: 1.962 ± 0.064
4.117GluVal: 4.117 ± 0.096
0.577GluTrp: 0.577 ± 0.036
1.636GluTyr: 1.636 ± 0.064
0.0GluXaa: 0.0 ± 0.0
Phe
3.339PheAla: 3.339 ± 0.078
0.865PheCys: 0.865 ± 0.041
2.499PheAsp: 2.499 ± 0.072
2.947PheGlu: 2.947 ± 0.08
3.011PhePhe: 3.011 ± 0.09
3.559PheGly: 3.559 ± 0.094
0.771PheHis: 0.771 ± 0.041
2.92PheIle: 2.92 ± 0.072
4.165PheLys: 4.165 ± 0.092
5.457PheLeu: 5.457 ± 0.126
1.5PheMet: 1.5 ± 0.057
2.497PheAsn: 2.497 ± 0.077
1.172PhePro: 1.172 ± 0.044
1.327PheGln: 1.327 ± 0.05
1.527PheArg: 1.527 ± 0.052
3.866PheSer: 3.866 ± 0.094
1.732PheThr: 1.732 ± 0.053
3.248PheVal: 3.248 ± 0.097
0.591PheTrp: 0.591 ± 0.038
2.373PheTyr: 2.373 ± 0.077
0.002PheXaa: 0.002 ± 0.002
Gly
5.334GlyAla: 5.334 ± 0.102
0.904GlyCys: 0.904 ± 0.051
3.325GlyAsp: 3.325 ± 0.081
3.074GlyGlu: 3.074 ± 0.087
4.129GlyPhe: 4.129 ± 0.096
5.471GlyGly: 5.471 ± 0.141
1.493GlyHis: 1.493 ± 0.061
4.704GlyIle: 4.704 ± 0.086
4.092GlyLys: 4.092 ± 0.102
7.272GlyLeu: 7.272 ± 0.12
2.059GlyMet: 2.059 ± 0.075
2.362GlyAsn: 2.362 ± 0.085
1.134GlyPro: 1.134 ± 0.05
2.271GlyGln: 2.271 ± 0.069
2.559GlyArg: 2.559 ± 0.074
3.76GlySer: 3.76 ± 0.103
2.686GlyThr: 2.686 ± 0.095
6.199GlyVal: 6.199 ± 0.121
0.651GlyTrp: 0.651 ± 0.038
2.835GlyTyr: 2.835 ± 0.074
0.0GlyXaa: 0.0 ± 0.0
His
2.804HisAla: 2.804 ± 0.083
0.334HisCys: 0.334 ± 0.026
0.964HisAsp: 0.964 ± 0.039
0.993HisGlu: 0.993 ± 0.045
1.726HisPhe: 1.726 ± 0.057
1.595HisGly: 1.595 ± 0.05
0.925HisHis: 0.925 ± 0.05
1.717HisIle: 1.717 ± 0.058
1.879HisLys: 1.879 ± 0.056
3.339HisLeu: 3.339 ± 0.092
0.72HisMet: 0.72 ± 0.034
1.193HisAsn: 1.193 ± 0.052
1.499HisPro: 1.499 ± 0.056
1.217HisGln: 1.217 ± 0.049
0.933HisArg: 0.933 ± 0.048
1.518HisSer: 1.518 ± 0.054
1.647HisThr: 1.647 ± 0.055
1.396HisVal: 1.396 ± 0.053
0.239HisTrp: 0.239 ± 0.027
1.186HisTyr: 1.186 ± 0.05
0.002HisXaa: 0.002 ± 0.002
Ile
6.096IleAla: 6.096 ± 0.101
0.904IleCys: 0.904 ± 0.043
3.318IleAsp: 3.318 ± 0.076
4.088IleGlu: 4.088 ± 0.098
3.049IlePhe: 3.049 ± 0.087
4.117IleGly: 4.117 ± 0.103
1.4IleHis: 1.4 ± 0.049
3.536IleIle: 3.536 ± 0.104
4.806IleLys: 4.806 ± 0.107
7.328IleLeu: 7.328 ± 0.139
1.134IleMet: 1.134 ± 0.04
2.922IleAsn: 2.922 ± 0.093
2.686IlePro: 2.686 ± 0.085
2.916IleGln: 2.916 ± 0.072
2.124IleArg: 2.124 ± 0.077
4.051IleSer: 4.051 ± 0.097
3.443IleThr: 3.443 ± 0.091
3.685IleVal: 3.685 ± 0.09
0.469IleTrp: 0.469 ± 0.029
2.532IleTyr: 2.532 ± 0.071
0.0IleXaa: 0.0 ± 0.0
Lys
5.778LysAla: 5.778 ± 0.122
0.608LysCys: 0.608 ± 0.035
4.273LysAsp: 4.273 ± 0.102
5.768LysGlu: 5.768 ± 0.145
2.03LysPhe: 2.03 ± 0.066
4.329LysGly: 4.329 ± 0.105
2.118LysHis: 2.118 ± 0.072
5.148LysIle: 5.148 ± 0.109
5.044LysLys: 5.044 ± 0.113
5.805LysLeu: 5.805 ± 0.105
1.719LysMet: 1.719 ± 0.058
3.93LysAsn: 3.93 ± 0.098
3.294LysPro: 3.294 ± 0.087
3.507LysGln: 3.507 ± 0.09
3.374LysArg: 3.374 ± 0.076
4.553LysSer: 4.553 ± 0.09
3.472LysThr: 3.472 ± 0.092
3.696LysVal: 3.696 ± 0.089
0.541LysTrp: 0.541 ± 0.038
1.846LysTyr: 1.846 ± 0.066
0.002LysXaa: 0.002 ± 0.002
Leu
9.009LeuAla: 9.009 ± 0.135
1.74LeuCys: 1.74 ± 0.062
6.328LeuAsp: 6.328 ± 0.117
9.97LeuGlu: 9.97 ± 0.172
5.023LeuPhe: 5.023 ± 0.119
8.327LeuGly: 8.327 ± 0.16
2.729LeuHis: 2.729 ± 0.083
5.93LeuIle: 5.93 ± 0.102
9.163LeuLys: 9.163 ± 0.152
10.965LeuLeu: 10.965 ± 0.198
2.46LeuMet: 2.46 ± 0.078
4.752LeuAsn: 4.752 ± 0.103
4.102LeuPro: 4.102 ± 0.08
5.84LeuGln: 5.84 ± 0.122
4.119LeuArg: 4.119 ± 0.093
7.63LeuSer: 7.63 ± 0.139
3.785LeuThr: 3.785 ± 0.096
6.324LeuVal: 6.324 ± 0.134
1.018LeuTrp: 1.018 ± 0.05
3.671LeuTyr: 3.671 ± 0.089
0.002LeuXaa: 0.002 ± 0.002
Met
2.072MetAla: 2.072 ± 0.069
0.276MetCys: 0.276 ± 0.027
1.367MetAsp: 1.367 ± 0.05
1.348MetGlu: 1.348 ± 0.056
1.023MetPhe: 1.023 ± 0.059
2.335MetGly: 2.335 ± 0.073
0.728MetHis: 0.728 ± 0.035
1.441MetIle: 1.441 ± 0.053
1.182MetLys: 1.182 ± 0.045
2.908MetLeu: 2.908 ± 0.081
0.429MetMet: 0.429 ± 0.034
0.682MetAsn: 0.682 ± 0.033
1.439MetPro: 1.439 ± 0.048
1.63MetGln: 1.63 ± 0.06
1.325MetArg: 1.325 ± 0.051
1.356MetSer: 1.356 ± 0.05
0.728MetThr: 0.728 ± 0.04
1.647MetVal: 1.647 ± 0.053
0.199MetTrp: 0.199 ± 0.019
0.427MetTyr: 0.427 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
4.337AsnAla: 4.337 ± 0.105
0.369AsnCys: 0.369 ± 0.03
1.779AsnAsp: 1.779 ± 0.063
1.732AsnGlu: 1.732 ± 0.055
2.134AsnPhe: 2.134 ± 0.067
2.315AsnGly: 2.315 ± 0.086
1.161AsnHis: 1.161 ± 0.046
2.943AsnIle: 2.943 ± 0.093
2.821AsnLys: 2.821 ± 0.087
5.063AsnLeu: 5.063 ± 0.091
1.047AsnMet: 1.047 ± 0.049
1.948AsnAsn: 1.948 ± 0.086
2.997AsnPro: 2.997 ± 0.079
2.144AsnGln: 2.144 ± 0.075
1.535AsnArg: 1.535 ± 0.054
2.246AsnSer: 2.246 ± 0.083
2.914AsnThr: 2.914 ± 0.08
2.014AsnVal: 2.014 ± 0.065
0.392AsnTrp: 0.392 ± 0.029
1.556AsnTyr: 1.556 ± 0.059
0.0AsnXaa: 0.0 ± 0.0
Pro
2.321ProAla: 2.321 ± 0.079
0.516ProCys: 0.516 ± 0.031
1.638ProAsp: 1.638 ± 0.059
1.79ProGlu: 1.79 ± 0.07
2.132ProPhe: 2.132 ± 0.066
1.439ProGly: 1.439 ± 0.061
1.497ProHis: 1.497 ± 0.052
2.846ProIle: 2.846 ± 0.075
3.986ProLys: 3.986 ± 0.1
5.343ProLeu: 5.343 ± 0.111
1.089ProMet: 1.089 ± 0.049
2.227ProAsn: 2.227 ± 0.07
2.313ProPro: 2.313 ± 0.096
2.356ProGln: 2.356 ± 0.071
1.249ProArg: 1.249 ± 0.05
3.032ProSer: 3.032 ± 0.083
2.9ProThr: 2.9 ± 0.084
1.697ProVal: 1.697 ± 0.063
0.299ProTrp: 0.299 ± 0.026
1.697ProTyr: 1.697 ± 0.059
0.004ProXaa: 0.004 ± 0.003
Gln
5.135GlnAla: 5.135 ± 0.104
0.365GlnCys: 0.365 ± 0.026
2.578GlnAsp: 2.578 ± 0.069
4.944GlnGlu: 4.944 ± 0.118
1.371GlnPhe: 1.371 ± 0.052
2.86GlnGly: 2.86 ± 0.077
1.334GlnHis: 1.334 ± 0.054
3.713GlnIle: 3.713 ± 0.085
4.059GlnLys: 4.059 ± 0.09
3.395GlnLeu: 3.395 ± 0.082
1.112GlnMet: 1.112 ± 0.047
2.559GlnAsn: 2.559 ± 0.077
1.462GlnPro: 1.462 ± 0.065
2.263GlnGln: 2.263 ± 0.073
2.142GlnArg: 2.142 ± 0.07
3.03GlnSer: 3.03 ± 0.086
2.553GlnThr: 2.553 ± 0.068
2.964GlnVal: 2.964 ± 0.082
0.309GlnTrp: 0.309 ± 0.026
1.066GlnTyr: 1.066 ± 0.045
0.0GlnXaa: 0.0 ± 0.0
Arg
3.754ArgAla: 3.754 ± 0.082
0.518ArgCys: 0.518 ± 0.031
1.869ArgAsp: 1.869 ± 0.064
2.242ArgGlu: 2.242 ± 0.074
2.283ArgPhe: 2.283 ± 0.063
2.702ArgGly: 2.702 ± 0.077
1.203ArgHis: 1.203 ± 0.045
2.644ArgIle: 2.644 ± 0.086
2.151ArgLys: 2.151 ± 0.078
4.528ArgLeu: 4.528 ± 0.102
1.045ArgMet: 1.045 ± 0.045
1.388ArgAsn: 1.388 ± 0.052
1.427ArgPro: 1.427 ± 0.065
1.611ArgGln: 1.611 ± 0.057
1.553ArgArg: 1.553 ± 0.052
2.192ArgSer: 2.192 ± 0.064
1.794ArgThr: 1.794 ± 0.068
2.839ArgVal: 2.839 ± 0.076
0.394ArgTrp: 0.394 ± 0.03
1.713ArgTyr: 1.713 ± 0.054
0.0ArgXaa: 0.0 ± 0.0
Ser
5.226SerAla: 5.226 ± 0.112
0.761SerCys: 0.761 ± 0.04
2.528SerAsp: 2.528 ± 0.078
2.279SerGlu: 2.279 ± 0.08
3.339SerPhe: 3.339 ± 0.093
3.928SerGly: 3.928 ± 0.101
1.709SerHis: 1.709 ± 0.059
3.939SerIle: 3.939 ± 0.101
4.472SerLys: 4.472 ± 0.093
7.983SerLeu: 7.983 ± 0.144
1.775SerMet: 1.775 ± 0.051
2.522SerAsn: 2.522 ± 0.092
2.968SerPro: 2.968 ± 0.078
3.043SerGln: 3.043 ± 0.079
1.871SerArg: 1.871 ± 0.059
3.866SerSer: 3.866 ± 0.096
3.124SerThr: 3.124 ± 0.087
4.457SerVal: 4.457 ± 0.087
0.622SerTrp: 0.622 ± 0.037
2.346SerTyr: 2.346 ± 0.069
0.0SerXaa: 0.0 ± 0.0
Thr
2.414ThrAla: 2.414 ± 0.069
0.583ThrCys: 0.583 ± 0.035
1.742ThrAsp: 1.742 ± 0.062
1.558ThrGlu: 1.558 ± 0.061
1.983ThrPhe: 1.983 ± 0.072
2.489ThrGly: 2.489 ± 0.077
1.906ThrHis: 1.906 ± 0.059
3.076ThrIle: 3.076 ± 0.086
2.918ThrLys: 2.918 ± 0.069
6.434ThrLeu: 6.434 ± 0.117
1.006ThrMet: 1.006 ± 0.04
2.111ThrAsn: 2.111 ± 0.069
3.835ThrPro: 3.835 ± 0.102
3.13ThrGln: 3.13 ± 0.084
1.925ThrArg: 1.925 ± 0.062
2.92ThrSer: 2.92 ± 0.091
2.748ThrThr: 2.748 ± 0.081
0.657ThrVal: 0.657 ± 0.041
0.417ThrTrp: 0.417 ± 0.031
1.761ThrTyr: 1.761 ± 0.059
0.0ThrXaa: 0.0 ± 0.0
Val
4.739ValAla: 4.739 ± 0.098
1.079ValCys: 1.079 ± 0.054
2.754ValAsp: 2.754 ± 0.073
3.219ValGlu: 3.219 ± 0.093
3.281ValPhe: 3.281 ± 0.07
5.314ValGly: 5.314 ± 0.115
1.255ValHis: 1.255 ± 0.05
3.856ValIle: 3.856 ± 0.097
3.182ValLys: 3.182 ± 0.075
7.328ValLeu: 7.328 ± 0.136
1.388ValMet: 1.388 ± 0.06
1.719ValAsn: 1.719 ± 0.068
2.234ValPro: 2.234 ± 0.064
2.702ValGln: 2.702 ± 0.068
2.705ValArg: 2.705 ± 0.07
3.878ValSer: 3.878 ± 0.109
1.566ValThr: 1.566 ± 0.058
5.123ValVal: 5.123 ± 0.123
0.599ValTrp: 0.599 ± 0.032
1.784ValTyr: 1.784 ± 0.071
0.0ValXaa: 0.0 ± 0.0
Trp
0.682TrpAla: 0.682 ± 0.036
0.126TrpCys: 0.126 ± 0.018
0.541TrpAsp: 0.541 ± 0.046
0.51TrpGlu: 0.51 ± 0.031
0.409TrpPhe: 0.409 ± 0.029
0.894TrpGly: 0.894 ± 0.048
0.346TrpHis: 0.346 ± 0.025
0.602TrpIle: 0.602 ± 0.031
0.351TrpLys: 0.351 ± 0.027
1.186TrpLeu: 1.186 ± 0.051
0.234TrpMet: 0.234 ± 0.021
0.334TrpAsn: 0.334 ± 0.032
0.104TrpPro: 0.104 ± 0.012
0.51TrpGln: 0.51 ± 0.03
0.419TrpArg: 0.419 ± 0.03
0.473TrpSer: 0.473 ± 0.029
0.218TrpThr: 0.218 ± 0.018
0.736TrpVal: 0.736 ± 0.041
0.127TrpTrp: 0.127 ± 0.016
0.239TrpTyr: 0.239 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.19TyrAla: 3.19 ± 0.081
0.431TyrCys: 0.431 ± 0.026
1.757TyrAsp: 1.757 ± 0.073
1.958TyrGlu: 1.958 ± 0.057
1.923TyrPhe: 1.923 ± 0.066
2.485TyrGly: 2.485 ± 0.068
0.991TyrHis: 0.991 ± 0.038
1.867TyrIle: 1.867 ± 0.058
2.416TyrLys: 2.416 ± 0.072
3.723TyrLeu: 3.723 ± 0.093
0.697TyrMet: 0.697 ± 0.036
1.748TyrAsn: 1.748 ± 0.065
1.694TyrPro: 1.694 ± 0.053
1.977TyrGln: 1.977 ± 0.068
1.359TyrArg: 1.359 ± 0.049
2.134TyrSer: 2.134 ± 0.07
1.873TyrThr: 1.873 ± 0.062
1.724TyrVal: 1.724 ± 0.057
0.319TyrTrp: 0.319 ± 0.027
1.674TyrTyr: 1.674 ± 0.071
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.002XaaPhe: 0.002 ± 0.002
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.002XaaLys: 0.002 ± 0.002
0.002XaaLeu: 0.002 ± 0.002
0.0XaaMet: 0.0 ± 0.0
0.002XaaAsn: 0.002 ± 0.002
0.004XaaPro: 0.004 ± 0.003
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2512 proteins (517845 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski