Amino acid dipepetide frequency for Cutibacterium acnes JCM 18920

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.819AlaAla: 12.819 ± 0.179	1.303AlaCys: 1.303 ± 0.042	6.493AlaAsp: 6.493 ± 0.097	5.958AlaGlu: 5.958 ± 0.118	2.866AlaPhe: 2.866 ± 0.066	9.538AlaGly: 9.538 ± 0.142	2.551AlaHis: 2.551 ± 0.067	5.483AlaIle: 5.483 ± 0.089	3.341AlaLys: 3.341 ± 0.081	9.824AlaLeu: 9.824 ± 0.118	3.193AlaMet: 3.193 ± 0.075	2.519AlaAsn: 2.519 ± 0.058	4.96AlaPro: 4.96 ± 0.09	3.361AlaGln: 3.361 ± 0.077	7.45AlaArg: 7.45 ± 0.106	6.938AlaSer: 6.938 ± 0.099	6.87AlaThr: 6.87 ± 0.103	9.245AlaVal: 9.245 ± 0.126	1.794AlaTrp: 1.794 ± 0.055	1.794AlaTyr: 1.794 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	1.225CysAla: 1.225 ± 0.044	0.305CysCys: 0.305 ± 0.022	0.678CysAsp: 0.678 ± 0.032	0.53CysGlu: 0.53 ± 0.027	0.322CysPhe: 0.322 ± 0.023	1.294CysGly: 1.294 ± 0.047	0.344CysHis: 0.344 ± 0.024	0.438CysIle: 0.438 ± 0.025	0.207CysLys: 0.207 ± 0.016	1.116CysLeu: 1.116 ± 0.031	0.292CysMet: 0.292 ± 0.021	0.232CysAsn: 0.232 ± 0.018	0.803CysPro: 0.803 ± 0.038	0.419CysGln: 0.419 ± 0.027	1.054CysArg: 1.054 ± 0.044	0.934CysSer: 0.934 ± 0.039	0.681CysThr: 0.681 ± 0.032	0.903CysVal: 0.903 ± 0.036	0.288CysTrp: 0.288 ± 0.021	0.246CysTyr: 0.246 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	6.352AspAla: 6.352 ± 0.121	0.487AspCys: 0.487 ± 0.027	4.396AspAsp: 4.396 ± 0.087	4.144AspGlu: 4.144 ± 0.096	1.53AspPhe: 1.53 ± 0.044	5.265AspGly: 5.265 ± 0.114	1.729AspHis: 1.729 ± 0.056	2.667AspIle: 2.667 ± 0.059	1.605AspLys: 1.605 ± 0.047	6.178AspLeu: 6.178 ± 0.103	1.248AspMet: 1.248 ± 0.043	1.333AspAsn: 1.333 ± 0.045	3.99AspPro: 3.99 ± 0.084	1.834AspGln: 1.834 ± 0.057	4.045AspArg: 4.045 ± 0.09	3.21AspSer: 3.21 ± 0.069	2.83AspThr: 2.83 ± 0.082	5.396AspVal: 5.396 ± 0.085	0.849AspTrp: 0.849 ± 0.036	1.257AspTyr: 1.257 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	5.749GluAla: 5.749 ± 0.11	0.41GluCys: 0.41 ± 0.025	2.685GluAsp: 2.685 ± 0.07	2.993GluGlu: 2.993 ± 0.08	1.547GluPhe: 1.547 ± 0.055	3.722GluGly: 3.722 ± 0.075	1.323GluHis: 1.323 ± 0.041	2.633GluIle: 2.633 ± 0.071	1.768GluLys: 1.768 ± 0.063	5.16GluLeu: 5.16 ± 0.095	1.228GluMet: 1.228 ± 0.044	1.219GluAsn: 1.219 ± 0.043	2.673GluPro: 2.673 ± 0.064	1.815GluGln: 1.815 ± 0.052	3.594GluArg: 3.594 ± 0.072	2.84GluSer: 2.84 ± 0.066	2.689GluThr: 2.689 ± 0.071	4.599GluVal: 4.599 ± 0.094	0.787GluTrp: 0.787 ± 0.032	1.075GluTyr: 1.075 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	3.033PheAla: 3.033 ± 0.059	0.394PheCys: 0.394 ± 0.023	2.064PheAsp: 2.064 ± 0.049	1.221PheGlu: 1.221 ± 0.052	1.065PhePhe: 1.065 ± 0.046	2.91PheGly: 2.91 ± 0.069	0.672PheHis: 0.672 ± 0.03	1.369PheIle: 1.369 ± 0.049	0.646PheLys: 0.646 ± 0.035	2.697PheLeu: 2.697 ± 0.076	0.679PheMet: 0.679 ± 0.033	0.841PheAsn: 0.841 ± 0.038	1.303PhePro: 1.303 ± 0.044	0.744PheGln: 0.744 ± 0.033	1.589PheArg: 1.589 ± 0.05	1.932PheSer: 1.932 ± 0.054	1.904PheThr: 1.904 ± 0.057	2.496PheVal: 2.496 ± 0.061	0.484PheTrp: 0.484 ± 0.026	0.576PheTyr: 0.576 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	8.016GlyAla: 8.016 ± 0.12	1.166GlyCys: 1.166 ± 0.044	4.395GlyAsp: 4.395 ± 0.074	3.93GlyGlu: 3.93 ± 0.078	2.814GlyPhe: 2.814 ± 0.075	6.343GlyGly: 6.343 ± 0.115	2.368GlyHis: 2.368 ± 0.07	4.579GlyIle: 4.579 ± 0.085	2.81GlyLys: 2.81 ± 0.077	8.121GlyLeu: 8.121 ± 0.135	2.454GlyMet: 2.454 ± 0.06	2.066GlyAsn: 2.066 ± 0.058	3.767GlyPro: 3.767 ± 0.077	2.843GlyGln: 2.843 ± 0.059	6.189GlyArg: 6.189 ± 0.104	5.594GlySer: 5.594 ± 0.093	5.15GlyThr: 5.15 ± 0.095	7.361GlyVal: 7.361 ± 0.105	1.809GlyTrp: 1.809 ± 0.055	2.079GlyTyr: 2.079 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	2.339HisAla: 2.339 ± 0.062	0.276HisCys: 0.276 ± 0.02	1.788HisAsp: 1.788 ± 0.049	1.339HisGlu: 1.339 ± 0.05	0.633HisPhe: 0.633 ± 0.034	2.274HisGly: 2.274 ± 0.061	0.864HisHis: 0.864 ± 0.035	1.075HisIle: 1.075 ± 0.037	0.558HisLys: 0.558 ± 0.031	2.31HisLeu: 2.31 ± 0.057	0.54HisMet: 0.54 ± 0.024	0.655HisAsn: 0.655 ± 0.035	1.827HisPro: 1.827 ± 0.056	0.868HisGln: 0.868 ± 0.036	2.117HisArg: 2.117 ± 0.053	1.393HisSer: 1.393 ± 0.04	1.359HisThr: 1.359 ± 0.05	1.975HisVal: 1.975 ± 0.053	0.338HisTrp: 0.338 ± 0.024	0.511HisTyr: 0.511 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.713IleAla: 5.713 ± 0.089	0.689IleCys: 0.689 ± 0.033	3.58IleAsp: 3.58 ± 0.079	2.474IleGlu: 2.474 ± 0.063	1.408IlePhe: 1.408 ± 0.054	4.639IleGly: 4.639 ± 0.098	1.036IleHis: 1.036 ± 0.04	2.507IleIle: 2.507 ± 0.072	1.284IleLys: 1.284 ± 0.048	4.017IleLeu: 4.017 ± 0.086	1.118IleMet: 1.118 ± 0.04	1.386IleAsn: 1.386 ± 0.053	2.669IlePro: 2.669 ± 0.06	1.028IleGln: 1.028 ± 0.038	2.83IleArg: 2.83 ± 0.058	3.024IleSer: 3.024 ± 0.062	3.149IleThr: 3.149 ± 0.07	4.54IleVal: 4.54 ± 0.085	0.573IleTrp: 0.573 ± 0.03	0.841IleTyr: 0.841 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	3.649LysAla: 3.649 ± 0.094	0.21LysCys: 0.21 ± 0.017	1.521LysAsp: 1.521 ± 0.059	1.363LysGlu: 1.363 ± 0.05	0.681LysPhe: 0.681 ± 0.031	2.093LysGly: 2.093 ± 0.056	0.606LysHis: 0.606 ± 0.027	1.473LysIle: 1.473 ± 0.048	1.212LysLys: 1.212 ± 0.05	2.519LysLeu: 2.519 ± 0.07	0.668LysMet: 0.668 ± 0.033	0.792LysAsn: 0.792 ± 0.043	1.75LysPro: 1.75 ± 0.059	0.869LysGln: 0.869 ± 0.032	1.86LysArg: 1.86 ± 0.058	1.642LysSer: 1.642 ± 0.058	1.723LysThr: 1.723 ± 0.056	2.821LysVal: 2.821 ± 0.074	0.307LysTrp: 0.307 ± 0.023	0.619LysTyr: 0.619 ± 0.036	0.0LysXaa: 0.0 ± 0.0
Leu	11.515LeuAla: 11.515 ± 0.156	1.058LeuCys: 1.058 ± 0.042	6.171LeuAsp: 6.171 ± 0.107	4.194LeuGlu: 4.194 ± 0.086	2.486LeuPhe: 2.486 ± 0.067	8.018LeuGly: 8.018 ± 0.127	1.985LeuHis: 1.985 ± 0.067	4.131LeuIle: 4.131 ± 0.087	2.293LeuLys: 2.293 ± 0.067	8.446LeuLeu: 8.446 ± 0.117	2.142LeuMet: 2.142 ± 0.05	2.176LeuAsn: 2.176 ± 0.055	5.369LeuPro: 5.369 ± 0.084	2.043LeuGln: 2.043 ± 0.049	6.138LeuArg: 6.138 ± 0.092	6.384LeuSer: 6.384 ± 0.101	6.413LeuThr: 6.413 ± 0.093	8.789LeuVal: 8.789 ± 0.135	1.234LeuTrp: 1.234 ± 0.045	1.431LeuTyr: 1.431 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	3.374MetAla: 3.374 ± 0.075	0.304MetCys: 0.304 ± 0.02	1.205MetAsp: 1.205 ± 0.04	0.987MetGlu: 0.987 ± 0.038	0.7MetPhe: 0.7 ± 0.034	2.084MetGly: 2.084 ± 0.056	0.517MetHis: 0.517 ± 0.028	1.337MetIle: 1.337 ± 0.042	0.832MetLys: 0.832 ± 0.033	2.182MetLeu: 2.182 ± 0.055	0.618MetMet: 0.618 ± 0.035	0.715MetAsn: 0.715 ± 0.034	1.511MetPro: 1.511 ± 0.052	0.579MetGln: 0.579 ± 0.029	1.706MetArg: 1.706 ± 0.05	2.217MetSer: 2.217 ± 0.05	2.305MetThr: 2.305 ± 0.062	2.22MetVal: 2.22 ± 0.055	0.422MetTrp: 0.422 ± 0.025	0.39MetTyr: 0.39 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	2.489AsnAla: 2.489 ± 0.068	0.268AsnCys: 0.268 ± 0.02	1.507AsnAsp: 1.507 ± 0.052	1.219AsnGlu: 1.219 ± 0.041	0.738AsnPhe: 0.738 ± 0.035	2.25AsnGly: 2.25 ± 0.065	0.753AsnHis: 0.753 ± 0.035	1.082AsnIle: 1.082 ± 0.037	0.724AsnLys: 0.724 ± 0.035	2.424AsnLeu: 2.424 ± 0.06	0.501AsnMet: 0.501 ± 0.032	0.681AsnAsn: 0.681 ± 0.037	1.948AsnPro: 1.948 ± 0.065	0.839AsnGln: 0.839 ± 0.039	1.66AsnArg: 1.66 ± 0.052	1.481AsnSer: 1.481 ± 0.048	1.493AsnThr: 1.493 ± 0.055	1.858AsnVal: 1.858 ± 0.052	0.403AsnTrp: 0.403 ± 0.025	0.607AsnTyr: 0.607 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	5.607ProAla: 5.607 ± 0.111	0.687ProCys: 0.687 ± 0.028	3.823ProAsp: 3.823 ± 0.079	3.321ProGlu: 3.321 ± 0.066	1.439ProPhe: 1.439 ± 0.043	4.9ProGly: 4.9 ± 0.09	1.48ProHis: 1.48 ± 0.052	2.303ProIle: 2.303 ± 0.058	1.503ProLys: 1.503 ± 0.05	4.443ProLeu: 4.443 ± 0.077	1.437ProMet: 1.437 ± 0.045	1.399ProAsn: 1.399 ± 0.052	2.425ProPro: 2.425 ± 0.072	1.841ProGln: 1.841 ± 0.053	3.814ProArg: 3.814 ± 0.08	4.161ProSer: 4.161 ± 0.083	3.984ProThr: 3.984 ± 0.076	4.678ProVal: 4.678 ± 0.088	1.031ProTrp: 1.031 ± 0.042	1.075ProTyr: 1.075 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	3.659GlnAla: 3.659 ± 0.066	0.289GlnCys: 0.289 ± 0.02	1.317GlnAsp: 1.317 ± 0.043	1.342GlnGlu: 1.342 ± 0.041	0.835GlnPhe: 0.835 ± 0.038	2.168GlnGly: 2.168 ± 0.051	0.646GlnHis: 0.646 ± 0.031	1.704GlnIle: 1.704 ± 0.053	0.753GlnLys: 0.753 ± 0.034	3.018GlnLeu: 3.018 ± 0.063	0.867GlnMet: 0.867 ± 0.035	0.718GlnAsn: 0.718 ± 0.031	1.67GlnPro: 1.67 ± 0.051	1.058GlnGln: 1.058 ± 0.039	2.404GlnArg: 2.404 ± 0.063	1.517GlnSer: 1.517 ± 0.049	1.723GlnThr: 1.723 ± 0.046	2.864GlnVal: 2.864 ± 0.064	0.605GlnTrp: 0.605 ± 0.027	0.618GlnTyr: 0.618 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	6.59ArgAla: 6.59 ± 0.094	1.159ArgCys: 1.159 ± 0.047	3.809ArgAsp: 3.809 ± 0.085	3.47ArgGlu: 3.47 ± 0.087	1.965ArgPhe: 1.965 ± 0.059	5.001ArgGly: 5.001 ± 0.089	2.312ArgHis: 2.312 ± 0.058	3.673ArgIle: 3.673 ± 0.07	1.965ArgLys: 1.965 ± 0.057	6.414ArgLeu: 6.414 ± 0.098	2.261ArgMet: 2.261 ± 0.056	1.851ArgAsn: 1.851 ± 0.054	4.128ArgPro: 4.128 ± 0.077	2.49ArgGln: 2.49 ± 0.055	7.135ArgArg: 7.135 ± 0.155	4.907ArgSer: 4.907 ± 0.104	4.243ArgThr: 4.243 ± 0.079	5.12ArgVal: 5.12 ± 0.093	1.432ArgTrp: 1.432 ± 0.047	1.494ArgTyr: 1.494 ± 0.058	0.0ArgXaa: 0.0 ± 0.0
Ser	6.5SerAla: 6.5 ± 0.094	0.908SerCys: 0.908 ± 0.039	3.472SerAsp: 3.472 ± 0.079	2.818SerGlu: 2.818 ± 0.071	1.913SerPhe: 1.913 ± 0.058	6.071SerGly: 6.071 ± 0.105	1.688SerHis: 1.688 ± 0.05	2.68SerIle: 2.68 ± 0.07	1.729SerLys: 1.729 ± 0.055	5.916SerLeu: 5.916 ± 0.102	2.061SerMet: 2.061 ± 0.054	1.478SerAsn: 1.478 ± 0.049	4.003SerPro: 4.003 ± 0.094	2.212SerGln: 2.212 ± 0.058	5.149SerArg: 5.149 ± 0.09	5.464SerSer: 5.464 ± 0.12	4.55SerThr: 4.55 ± 0.089	5.009SerVal: 5.009 ± 0.075	1.385SerTrp: 1.385 ± 0.047	1.247SerTyr: 1.247 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	6.715ThrAla: 6.715 ± 0.102	0.818ThrCys: 0.818 ± 0.037	3.694ThrAsp: 3.694 ± 0.092	2.83ThrGlu: 2.83 ± 0.063	1.937ThrPhe: 1.937 ± 0.049	5.487ThrGly: 5.487 ± 0.092	1.419ThrHis: 1.419 ± 0.045	3.255ThrIle: 3.255 ± 0.064	1.815ThrLys: 1.815 ± 0.053	5.415ThrLeu: 5.415 ± 0.092	1.736ThrMet: 1.736 ± 0.046	1.565ThrAsn: 1.565 ± 0.054	4.019ThrPro: 4.019 ± 0.072	1.568ThrGln: 1.568 ± 0.046	4.085ThrArg: 4.085 ± 0.076	4.692ThrSer: 4.692 ± 0.081	4.776ThrThr: 4.776 ± 0.086	5.912ThrVal: 5.912 ± 0.107	1.235ThrTrp: 1.235 ± 0.048	1.195ThrTyr: 1.195 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	9.618ValAla: 9.618 ± 0.141	1.064ValCys: 1.064 ± 0.041	5.667ValAsp: 5.667 ± 0.114	4.859ValGlu: 4.859 ± 0.091	2.394ValPhe: 2.394 ± 0.058	6.883ValGly: 6.883 ± 0.121	1.819ValHis: 1.819 ± 0.047	4.658ValIle: 4.658 ± 0.081	2.43ValLys: 2.43 ± 0.066	8.185ValLeu: 8.185 ± 0.134	2.336ValMet: 2.336 ± 0.057	2.345ValAsn: 2.345 ± 0.056	4.528ValPro: 4.528 ± 0.074	1.956ValGln: 1.956 ± 0.049	5.556ValArg: 5.556 ± 0.106	5.542ValSer: 5.542 ± 0.089	6.224ValThr: 6.224 ± 0.094	8.829ValVal: 8.829 ± 0.148	1.192ValTrp: 1.192 ± 0.043	1.36ValTyr: 1.36 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.507TrpAla: 1.507 ± 0.049	0.284TrpCys: 0.284 ± 0.021	0.779TrpAsp: 0.779 ± 0.031	0.576TrpGlu: 0.576 ± 0.027	0.672TrpPhe: 0.672 ± 0.029	1.205TrpGly: 1.205 ± 0.048	0.459TrpHis: 0.459 ± 0.028	0.819TrpIle: 0.819 ± 0.036	0.459TrpLys: 0.459 ± 0.024	1.886TrpLeu: 1.886 ± 0.057	0.471TrpMet: 0.471 ± 0.024	0.488TrpAsn: 0.488 ± 0.03	0.946TrpPro: 0.946 ± 0.041	0.717TrpGln: 0.717 ± 0.032	1.455TrpArg: 1.455 ± 0.047	1.19TrpSer: 1.19 ± 0.041	1.046TrpThr: 1.046 ± 0.044	1.257TrpVal: 1.257 ± 0.044	0.474TrpTrp: 0.474 ± 0.027	0.32TrpTyr: 0.32 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.829TyrAla: 1.829 ± 0.048	0.232TyrCys: 0.232 ± 0.019	1.303TyrAsp: 1.303 ± 0.046	0.941TyrGlu: 0.941 ± 0.039	0.674TyrPhe: 0.674 ± 0.036	1.707TyrGly: 1.707 ± 0.054	0.469TyrHis: 0.469 ± 0.027	0.641TyrIle: 0.641 ± 0.029	0.445TyrLys: 0.445 ± 0.029	2.142TyrLeu: 2.142 ± 0.057	0.353TyrMet: 0.353 ± 0.021	0.466TyrAsn: 0.466 ± 0.029	1.062TyrPro: 1.062 ± 0.042	0.691TyrGln: 0.691 ± 0.031	1.589TyrArg: 1.589 ± 0.046	1.193TyrSer: 1.193 ± 0.047	1.054TyrThr: 1.054 ± 0.037	1.573TyrVal: 1.573 ± 0.051	0.368TyrTrp: 0.368 ± 0.023	0.445TyrTyr: 0.445 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3343 proteins (694728 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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