Amino acid dipepetide frequency for Mesorhizobium australicum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.694AlaAla: 17.694 ± 0.143	1.02AlaCys: 1.02 ± 0.025	6.994AlaAsp: 6.994 ± 0.066	7.932AlaGlu: 7.932 ± 0.083	4.751AlaPhe: 4.751 ± 0.068	11.322AlaGly: 11.322 ± 0.091	2.151AlaHis: 2.151 ± 0.038	6.877AlaIle: 6.877 ± 0.072	4.355AlaLys: 4.355 ± 0.06	12.838AlaLeu: 12.838 ± 0.114	3.672AlaMet: 3.672 ± 0.046	2.891AlaAsn: 2.891 ± 0.043	5.329AlaPro: 5.329 ± 0.068	3.513AlaGln: 3.513 ± 0.049	8.794AlaArg: 8.794 ± 0.081	6.632AlaSer: 6.632 ± 0.069	6.009AlaThr: 6.009 ± 0.063	8.953AlaVal: 8.953 ± 0.077	1.551AlaTrp: 1.551 ± 0.033	2.681AlaTyr: 2.681 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.948CysAla: 0.948 ± 0.023	0.105CysCys: 0.105 ± 0.009	0.486CysAsp: 0.486 ± 0.019	0.409CysGlu: 0.409 ± 0.015	0.321CysPhe: 0.321 ± 0.014	0.866CysGly: 0.866 ± 0.023	0.22CysHis: 0.22 ± 0.011	0.37CysIle: 0.37 ± 0.016	0.171CysLys: 0.171 ± 0.01	0.766CysLeu: 0.766 ± 0.023	0.154CysMet: 0.154 ± 0.008	0.189CysAsn: 0.189 ± 0.01	0.38CysPro: 0.38 ± 0.017	0.189CysGln: 0.189 ± 0.012	0.64CysArg: 0.64 ± 0.02	0.422CysSer: 0.422 ± 0.017	0.38CysThr: 0.38 ± 0.016	0.625CysVal: 0.625 ± 0.021	0.104CysTrp: 0.104 ± 0.009	0.206CysTyr: 0.206 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	6.753AspAla: 6.753 ± 0.069	0.456AspCys: 0.456 ± 0.018	2.982AspAsp: 2.982 ± 0.046	3.663AspGlu: 3.663 ± 0.055	2.287AspPhe: 2.287 ± 0.041	5.251AspGly: 5.251 ± 0.054	1.209AspHis: 1.209 ± 0.025	3.167AspIle: 3.167 ± 0.045	1.719AspLys: 1.719 ± 0.032	5.659AspLeu: 5.659 ± 0.053	1.457AspMet: 1.457 ± 0.03	1.25AspAsn: 1.25 ± 0.027	3.44AspPro: 3.44 ± 0.045	1.538AspGln: 1.538 ± 0.042	4.482AspArg: 4.482 ± 0.054	1.98AspSer: 1.98 ± 0.038	2.577AspThr: 2.577 ± 0.038	4.103AspVal: 4.103 ± 0.043	0.981AspTrp: 0.981 ± 0.024	1.489AspTyr: 1.489 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	7.691GluAla: 7.691 ± 0.071	0.365GluCys: 0.365 ± 0.015	2.761GluAsp: 2.761 ± 0.048	3.412GluGlu: 3.412 ± 0.055	1.926GluPhe: 1.926 ± 0.029	4.364GluGly: 4.364 ± 0.048	1.142GluHis: 1.142 ± 0.027	3.797GluIle: 3.797 ± 0.047	2.6GluLys: 2.6 ± 0.039	5.328GluLeu: 5.328 ± 0.061	1.672GluMet: 1.672 ± 0.028	1.608GluAsn: 1.608 ± 0.029	2.892GluPro: 2.892 ± 0.047	1.986GluGln: 1.986 ± 0.034	5.07GluArg: 5.07 ± 0.062	2.298GluSer: 2.298 ± 0.042	3.631GluThr: 3.631 ± 0.049	3.814GluVal: 3.814 ± 0.05	0.793GluTrp: 0.793 ± 0.021	1.022GluTyr: 1.022 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	4.837PheAla: 4.837 ± 0.058	0.393PheCys: 0.393 ± 0.016	2.696PheAsp: 2.696 ± 0.046	2.27PheGlu: 2.27 ± 0.033	1.524PhePhe: 1.524 ± 0.037	3.95PheGly: 3.95 ± 0.056	0.775PheHis: 0.775 ± 0.018	1.768PheIle: 1.768 ± 0.039	0.951PheLys: 0.951 ± 0.028	3.512PheLeu: 3.512 ± 0.052	0.85PheMet: 0.85 ± 0.022	1.022PheAsn: 1.022 ± 0.025	1.684PhePro: 1.684 ± 0.034	0.969PheGln: 0.969 ± 0.023	2.444PheArg: 2.444 ± 0.038	2.361PheSer: 2.361 ± 0.042	1.881PheThr: 1.881 ± 0.035	3.087PheVal: 3.087 ± 0.049	0.572PheTrp: 0.572 ± 0.019	0.903PheTyr: 0.903 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	9.362GlyAla: 9.362 ± 0.086	0.786GlyCys: 0.786 ± 0.023	4.372GlyAsp: 4.372 ± 0.051	5.11GlyGlu: 5.11 ± 0.054	3.731GlyPhe: 3.731 ± 0.047	7.506GlyGly: 7.506 ± 0.088	1.84GlyHis: 1.84 ± 0.035	4.972GlyIle: 4.972 ± 0.06	3.458GlyLys: 3.458 ± 0.045	8.773GlyLeu: 8.773 ± 0.081	2.55GlyMet: 2.55 ± 0.04	2.164GlyAsn: 2.164 ± 0.038	3.472GlyPro: 3.472 ± 0.042	2.68GlyGln: 2.68 ± 0.039	6.421GlyArg: 6.421 ± 0.065	4.784GlySer: 4.784 ± 0.052	4.507GlyThr: 4.507 ± 0.049	6.346GlyVal: 6.346 ± 0.059	1.422GlyTrp: 1.422 ± 0.031	2.432GlyTyr: 2.432 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.218HisAla: 2.218 ± 0.032	0.225HisCys: 0.225 ± 0.012	1.176HisAsp: 1.176 ± 0.03	1.023HisGlu: 1.023 ± 0.025	0.824HisPhe: 0.824 ± 0.023	1.909HisGly: 1.909 ± 0.035	0.565HisHis: 0.565 ± 0.019	0.974HisIle: 0.974 ± 0.024	0.437HisLys: 0.437 ± 0.016	1.941HisLeu: 1.941 ± 0.035	0.502HisMet: 0.502 ± 0.017	0.414HisAsn: 0.414 ± 0.015	1.27HisPro: 1.27 ± 0.028	0.539HisGln: 0.539 ± 0.019	1.396HisArg: 1.396 ± 0.032	0.938HisSer: 0.938 ± 0.025	0.811HisThr: 0.811 ± 0.022	1.565HisVal: 1.565 ± 0.032	0.302HisTrp: 0.302 ± 0.013	0.549HisTyr: 0.549 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	7.802IleAla: 7.802 ± 0.066	0.496IleCys: 0.496 ± 0.015	3.624IleAsp: 3.624 ± 0.045	3.715IleGlu: 3.715 ± 0.053	1.795IlePhe: 1.795 ± 0.033	5.133IleGly: 5.133 ± 0.058	0.947IleHis: 0.947 ± 0.022	2.302IleIle: 2.302 ± 0.04	1.318IleLys: 1.318 ± 0.027	4.688IleLeu: 4.688 ± 0.057	1.055IleMet: 1.055 ± 0.026	1.352IleAsn: 1.352 ± 0.029	2.41IlePro: 2.41 ± 0.039	1.164IleGln: 1.164 ± 0.023	3.519IleArg: 3.519 ± 0.049	3.065IleSer: 3.065 ± 0.042	2.524IleThr: 2.524 ± 0.037	4.912IleVal: 4.912 ± 0.059	0.636IleTrp: 0.636 ± 0.018	1.191IleTyr: 1.191 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	4.569LysAla: 4.569 ± 0.061	0.156LysCys: 0.156 ± 0.009	1.781LysAsp: 1.781 ± 0.032	1.701LysGlu: 1.701 ± 0.033	0.899LysPhe: 0.899 ± 0.025	2.809LysGly: 2.809 ± 0.045	0.598LysHis: 0.598 ± 0.02	1.759LysIle: 1.759 ± 0.034	1.381LysLys: 1.381 ± 0.031	3.343LysLeu: 3.343 ± 0.047	0.826LysMet: 0.826 ± 0.023	0.847LysAsn: 0.847 ± 0.023	2.126LysPro: 2.126 ± 0.042	0.964LysGln: 0.964 ± 0.024	2.458LysArg: 2.458 ± 0.037	1.913LysSer: 1.913 ± 0.031	1.937LysThr: 1.937 ± 0.036	2.62LysVal: 2.62 ± 0.049	0.369LysTrp: 0.369 ± 0.016	0.624LysTyr: 0.624 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	13.548LeuAla: 13.548 ± 0.084	0.798LeuCys: 0.798 ± 0.022	5.94LeuAsp: 5.94 ± 0.063	4.975LeuGlu: 4.975 ± 0.056	3.757LeuPhe: 3.757 ± 0.052	8.214LeuGly: 8.214 ± 0.077	1.753LeuHis: 1.753 ± 0.033	4.953LeuIle: 4.953 ± 0.06	3.63LeuLys: 3.63 ± 0.043	8.932LeuLeu: 8.932 ± 0.099	2.327LeuMet: 2.327 ± 0.04	2.387LeuAsn: 2.387 ± 0.035	5.402LeuPro: 5.402 ± 0.061	2.331LeuGln: 2.331 ± 0.036	6.573LeuArg: 6.573 ± 0.065	6.521LeuSer: 6.521 ± 0.07	5.26LeuThr: 5.26 ± 0.068	7.652LeuVal: 7.652 ± 0.071	1.124LeuTrp: 1.124 ± 0.026	2.03LeuTyr: 2.03 ± 0.036	0.0LeuXaa: 0.0 ± 0.0
Met	3.161MetAla: 3.161 ± 0.038	0.155MetCys: 0.155 ± 0.011	1.131MetAsp: 1.131 ± 0.024	1.145MetGlu: 1.145 ± 0.028	0.777MetPhe: 0.777 ± 0.024	1.885MetGly: 1.885 ± 0.037	0.479MetHis: 0.479 ± 0.016	1.496MetIle: 1.496 ± 0.034	1.073MetLys: 1.073 ± 0.025	2.537MetLeu: 2.537 ± 0.036	0.748MetMet: 0.748 ± 0.019	0.891MetAsn: 0.891 ± 0.023	1.573MetPro: 1.573 ± 0.034	0.858MetGln: 0.858 ± 0.023	1.972MetArg: 1.972 ± 0.034	1.802MetSer: 1.802 ± 0.032	1.945MetThr: 1.945 ± 0.036	1.795MetVal: 1.795 ± 0.035	0.249MetTrp: 0.249 ± 0.012	0.329MetTyr: 0.329 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.101AsnAla: 3.101 ± 0.045	0.234AsnCys: 0.234 ± 0.013	1.333AsnAsp: 1.333 ± 0.023	1.28AsnGlu: 1.28 ± 0.028	0.953AsnPhe: 0.953 ± 0.023	2.387AsnGly: 2.387 ± 0.046	0.471AsnHis: 0.471 ± 0.019	1.388AsnIle: 1.388 ± 0.028	0.65AsnLys: 0.65 ± 0.019	2.559AsnLeu: 2.559 ± 0.04	0.61AsnMet: 0.61 ± 0.02	0.655AsnAsn: 0.655 ± 0.023	1.842AsnPro: 1.842 ± 0.032	0.7AsnGln: 0.7 ± 0.022	1.774AsnArg: 1.774 ± 0.029	1.19AsnSer: 1.19 ± 0.029	1.208AsnThr: 1.208 ± 0.026	1.986AsnVal: 1.986 ± 0.032	0.401AsnTrp: 0.401 ± 0.016	0.662AsnTyr: 0.662 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	6.508ProAla: 6.508 ± 0.058	0.279ProCys: 0.279 ± 0.013	3.708ProAsp: 3.708 ± 0.051	3.569ProGlu: 3.569 ± 0.048	2.068ProPhe: 2.068 ± 0.032	4.42ProGly: 4.42 ± 0.054	1.006ProHis: 1.006 ± 0.023	2.31ProIle: 2.31 ± 0.039	1.781ProLys: 1.781 ± 0.035	4.669ProLeu: 4.669 ± 0.056	1.193ProMet: 1.193 ± 0.025	1.329ProAsn: 1.329 ± 0.029	2.532ProPro: 2.532 ± 0.051	1.504ProGln: 1.504 ± 0.029	3.028ProArg: 3.028 ± 0.046	2.789ProSer: 2.789 ± 0.04	2.441ProThr: 2.441 ± 0.035	4.306ProVal: 4.306 ± 0.052	0.685ProTrp: 0.685 ± 0.02	1.24ProTyr: 1.24 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.763GlnAla: 3.763 ± 0.046	0.182GlnCys: 0.182 ± 0.012	1.285GlnAsp: 1.285 ± 0.025	1.442GlnGlu: 1.442 ± 0.029	0.996GlnPhe: 0.996 ± 0.025	2.115GlnGly: 2.115 ± 0.038	0.531GlnHis: 0.531 ± 0.019	1.718GlnIle: 1.718 ± 0.038	1.082GlnLys: 1.082 ± 0.026	2.554GlnLeu: 2.554 ± 0.039	0.909GlnMet: 0.909 ± 0.021	0.791GlnAsn: 0.791 ± 0.021	1.621GlnPro: 1.621 ± 0.038	1.004GlnGln: 1.004 ± 0.029	2.129GlnArg: 2.129 ± 0.036	1.569GlnSer: 1.569 ± 0.033	1.53GlnThr: 1.53 ± 0.026	2.128GlnVal: 2.128 ± 0.043	0.34GlnTrp: 0.34 ± 0.014	0.537GlnTyr: 0.537 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	7.953ArgAla: 7.953 ± 0.08	0.46ArgCys: 0.46 ± 0.018	4.177ArgAsp: 4.177 ± 0.051	4.309ArgGlu: 4.309 ± 0.056	2.996ArgPhe: 2.996 ± 0.039	4.901ArgGly: 4.901 ± 0.051	1.704ArgHis: 1.704 ± 0.033	4.231ArgIle: 4.231 ± 0.052	2.469ArgLys: 2.469 ± 0.041	7.76ArgLeu: 7.76 ± 0.074	1.966ArgMet: 1.966 ± 0.039	1.863ArgAsn: 1.863 ± 0.034	3.71ArgPro: 3.71 ± 0.046	2.459ArgGln: 2.459 ± 0.038	5.924ArgArg: 5.924 ± 0.072	3.828ArgSer: 3.828 ± 0.051	3.502ArgThr: 3.502 ± 0.051	4.638ArgVal: 4.638 ± 0.054	1.006ArgTrp: 1.006 ± 0.023	1.745ArgTyr: 1.745 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.377SerAla: 6.377 ± 0.07	0.427SerCys: 0.427 ± 0.015	2.911SerAsp: 2.911 ± 0.047	2.865SerGlu: 2.865 ± 0.048	2.327SerPhe: 2.327 ± 0.039	5.762SerGly: 5.762 ± 0.059	1.041SerHis: 1.041 ± 0.027	2.927SerIle: 2.927 ± 0.044	1.589SerLys: 1.589 ± 0.033	5.421SerLeu: 5.421 ± 0.06	1.433SerMet: 1.433 ± 0.029	1.376SerAsn: 1.376 ± 0.03	2.836SerPro: 2.836 ± 0.043	1.485SerGln: 1.485 ± 0.033	3.737SerArg: 3.737 ± 0.045	3.08SerSer: 3.08 ± 0.047	2.795SerThr: 2.795 ± 0.048	4.211SerVal: 4.211 ± 0.054	0.74SerTrp: 0.74 ± 0.02	1.307SerTyr: 1.307 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	6.106ThrAla: 6.106 ± 0.063	0.406ThrCys: 0.406 ± 0.016	2.718ThrAsp: 2.718 ± 0.037	2.674ThrGlu: 2.674 ± 0.039	2.047ThrPhe: 2.047 ± 0.036	5.053ThrGly: 5.053 ± 0.056	0.95ThrHis: 0.95 ± 0.025	3.041ThrIle: 3.041 ± 0.041	1.507ThrLys: 1.507 ± 0.029	5.534ThrLeu: 5.534 ± 0.055	1.308ThrMet: 1.308 ± 0.026	1.317ThrAsn: 1.317 ± 0.029	3.098ThrPro: 3.098 ± 0.047	1.291ThrGln: 1.291 ± 0.03	3.255ThrArg: 3.255 ± 0.042	2.818ThrSer: 2.818 ± 0.037	2.812ThrThr: 2.812 ± 0.046	4.379ThrVal: 4.379 ± 0.051	0.649ThrTrp: 0.649 ± 0.02	1.216ThrTyr: 1.216 ± 0.024	0.0ThrXaa: 0.0 ± 0.0
Val	9.775ValAla: 9.775 ± 0.093	0.625ValCys: 0.625 ± 0.019	4.249ValAsp: 4.249 ± 0.05	4.858ValGlu: 4.858 ± 0.054	2.969ValPhe: 2.969 ± 0.045	5.726ValGly: 5.726 ± 0.074	1.414ValHis: 1.414 ± 0.031	3.977ValIle: 3.977 ± 0.057	2.373ValLys: 2.373 ± 0.037	7.389ValLeu: 7.389 ± 0.076	1.94ValMet: 1.94 ± 0.035	1.999ValAsn: 1.999 ± 0.042	3.894ValPro: 3.894 ± 0.042	1.877ValGln: 1.877 ± 0.034	5.054ValArg: 5.054 ± 0.056	4.555ValSer: 4.555 ± 0.056	4.479ValThr: 4.479 ± 0.048	6.217ValVal: 6.217 ± 0.06	0.955ValTrp: 0.955 ± 0.025	1.538ValTyr: 1.538 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	1.255TrpAla: 1.255 ± 0.03	0.145TrpCys: 0.145 ± 0.009	0.638TrpAsp: 0.638 ± 0.019	0.566TrpGlu: 0.566 ± 0.02	0.576TrpPhe: 0.576 ± 0.018	0.906TrpGly: 0.906 ± 0.023	0.312TrpHis: 0.312 ± 0.015	0.715TrpIle: 0.715 ± 0.023	0.522TrpLys: 0.522 ± 0.016	1.611TrpLeu: 1.611 ± 0.032	0.366TrpMet: 0.366 ± 0.012	0.47TrpAsn: 0.47 ± 0.016	0.733TrpPro: 0.733 ± 0.018	0.514TrpGln: 0.514 ± 0.015	1.143TrpArg: 1.143 ± 0.028	0.837TrpSer: 0.837 ± 0.021	0.852TrpThr: 0.852 ± 0.024	0.789TrpVal: 0.789 ± 0.021	0.217TrpTrp: 0.217 ± 0.01	0.296TrpTyr: 0.296 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.539TyrAla: 2.539 ± 0.036	0.238TyrCys: 0.238 ± 0.011	1.479TyrAsp: 1.479 ± 0.028	1.255TyrGlu: 1.255 ± 0.029	0.925TyrPhe: 0.925 ± 0.024	2.207TyrGly: 2.207 ± 0.036	0.467TyrHis: 0.467 ± 0.016	0.907TyrIle: 0.907 ± 0.023	0.616TyrLys: 0.616 ± 0.02	2.291TyrLeu: 2.291 ± 0.034	0.465TyrMet: 0.465 ± 0.017	0.571TyrAsn: 0.571 ± 0.017	1.121TyrPro: 1.121 ± 0.026	0.664TyrGln: 0.664 ± 0.019	1.788TyrArg: 1.788 ± 0.031	1.265TyrSer: 1.265 ± 0.028	1.098TyrThr: 1.098 ± 0.024	1.737TyrVal: 1.737 ± 0.031	0.365TyrTrp: 0.365 ± 0.014	0.594TyrTyr: 0.594 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5684 proteins (1733231 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---