Amino acid dipepetide frequency for Lottiidibacillus patelloidae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.623AlaAla: 4.623 ± 0.096	0.498AlaCys: 0.498 ± 0.025	2.97AlaAsp: 2.97 ± 0.064	4.159AlaGlu: 4.159 ± 0.068	3.106AlaPhe: 3.106 ± 0.066	4.549AlaGly: 4.549 ± 0.083	1.203AlaHis: 1.203 ± 0.035	6.164AlaIle: 6.164 ± 0.094	5.01AlaLys: 5.01 ± 0.083	6.749AlaLeu: 6.749 ± 0.101	1.948AlaMet: 1.948 ± 0.048	3.168AlaAsn: 3.168 ± 0.063	1.834AlaPro: 1.834 ± 0.053	1.872AlaGln: 1.872 ± 0.048	2.314AlaArg: 2.314 ± 0.052	3.763AlaSer: 3.763 ± 0.07	3.635AlaThr: 3.635 ± 0.078	4.7AlaVal: 4.7 ± 0.083	0.542AlaTrp: 0.542 ± 0.025	2.156AlaTyr: 2.156 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.393CysAla: 0.393 ± 0.023	0.104CysCys: 0.104 ± 0.013	0.416CysAsp: 0.416 ± 0.026	0.496CysGlu: 0.496 ± 0.023	0.329CysPhe: 0.329 ± 0.019	0.603CysGly: 0.603 ± 0.031	0.201CysHis: 0.201 ± 0.015	0.538CysIle: 0.538 ± 0.024	0.425CysLys: 0.425 ± 0.029	0.639CysLeu: 0.639 ± 0.029	0.148CysMet: 0.148 ± 0.015	0.353CysAsn: 0.353 ± 0.019	0.347CysPro: 0.347 ± 0.022	0.228CysGln: 0.228 ± 0.017	0.243CysArg: 0.243 ± 0.017	0.476CysSer: 0.476 ± 0.028	0.379CysThr: 0.379 ± 0.021	0.344CysVal: 0.344 ± 0.019	0.07CysTrp: 0.07 ± 0.008	0.283CysTyr: 0.283 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	3.119AspAla: 3.119 ± 0.071	0.385AspCys: 0.385 ± 0.022	2.576AspAsp: 2.576 ± 0.061	4.647AspGlu: 4.647 ± 0.078	2.422AspPhe: 2.422 ± 0.048	3.37AspGly: 3.37 ± 0.068	1.071AspHis: 1.071 ± 0.036	4.321AspIle: 4.321 ± 0.081	3.469AspLys: 3.469 ± 0.067	4.72AspLeu: 4.72 ± 0.07	1.244AspMet: 1.244 ± 0.043	2.199AspAsn: 2.199 ± 0.058	1.74AspPro: 1.74 ± 0.051	1.652AspGln: 1.652 ± 0.045	2.007AspArg: 2.007 ± 0.046	2.491AspSer: 2.491 ± 0.053	2.526AspThr: 2.526 ± 0.059	3.894AspVal: 3.894 ± 0.068	0.561AspTrp: 0.561 ± 0.025	2.241AspTyr: 2.241 ± 0.054	0.0AspXaa: 0.0 ± 0.0
Glu	5.061GluAla: 5.061 ± 0.08	0.361GluCys: 0.361 ± 0.019	4.131GluAsp: 4.131 ± 0.084	7.365GluGlu: 7.365 ± 0.148	2.488GluPhe: 2.488 ± 0.058	4.309GluGly: 4.309 ± 0.079	1.451GluHis: 1.451 ± 0.045	6.049GluIle: 6.049 ± 0.084	7.497GluLys: 7.497 ± 0.121	7.091GluLeu: 7.091 ± 0.111	2.377GluMet: 2.377 ± 0.055	4.557GluAsn: 4.557 ± 0.072	1.753GluPro: 1.753 ± 0.049	3.256GluGln: 3.256 ± 0.061	3.35GluArg: 3.35 ± 0.067	3.312GluSer: 3.312 ± 0.058	3.898GluThr: 3.898 ± 0.073	5.548GluVal: 5.548 ± 0.082	0.704GluTrp: 0.704 ± 0.028	2.366GluTyr: 2.366 ± 0.056	0.0GluXaa: 0.0 ± 0.0
Phe	3.171PheAla: 3.171 ± 0.067	0.348PheCys: 0.348 ± 0.019	2.263PheAsp: 2.263 ± 0.052	2.931PheGlu: 2.931 ± 0.072	2.522PhePhe: 2.522 ± 0.073	3.165PheGly: 3.165 ± 0.069	1.084PheHis: 1.084 ± 0.037	4.497PheIle: 4.497 ± 0.083	2.613PheLys: 2.613 ± 0.064	4.742PheLeu: 4.742 ± 0.097	1.095PheMet: 1.095 ± 0.037	2.181PheAsn: 2.181 ± 0.059	1.709PhePro: 1.709 ± 0.046	1.489PheGln: 1.489 ± 0.042	1.469PheArg: 1.469 ± 0.039	3.358PheSer: 3.358 ± 0.07	2.787PheThr: 2.787 ± 0.06	3.116PheVal: 3.116 ± 0.068	0.482PheTrp: 0.482 ± 0.027	1.949PheTyr: 1.949 ± 0.046	0.0PheXaa: 0.0 ± 0.0
Gly	4.313GlyAla: 4.313 ± 0.095	0.538GlyCys: 0.538 ± 0.027	3.063GlyAsp: 3.063 ± 0.071	4.51GlyGlu: 4.51 ± 0.077	3.244GlyPhe: 3.244 ± 0.066	4.364GlyGly: 4.364 ± 0.104	1.338GlyHis: 1.338 ± 0.042	5.677GlyIle: 5.677 ± 0.084	5.265GlyLys: 5.265 ± 0.082	6.035GlyLeu: 6.035 ± 0.105	1.863GlyMet: 1.863 ± 0.053	2.975GlyAsn: 2.975 ± 0.069	1.671GlyPro: 1.671 ± 0.043	1.988GlyGln: 1.988 ± 0.051	2.399GlyArg: 2.399 ± 0.056	3.717GlySer: 3.717 ± 0.074	3.955GlyThr: 3.955 ± 0.089	4.574GlyVal: 4.574 ± 0.078	0.702GlyTrp: 0.702 ± 0.03	2.683GlyTyr: 2.683 ± 0.072	0.0GlyXaa: 0.0 ± 0.0
His	1.208HisAla: 1.208 ± 0.037	0.204HisCys: 0.204 ± 0.016	1.073HisAsp: 1.073 ± 0.04	1.44HisGlu: 1.44 ± 0.04	1.139HisPhe: 1.139 ± 0.038	1.311HisGly: 1.311 ± 0.042	0.615HisHis: 0.615 ± 0.031	1.622HisIle: 1.622 ± 0.042	1.134HisLys: 1.134 ± 0.033	2.146HisLeu: 2.146 ± 0.049	0.491HisMet: 0.491 ± 0.02	0.836HisAsn: 0.836 ± 0.037	1.062HisPro: 1.062 ± 0.037	0.694HisGln: 0.694 ± 0.03	0.821HisArg: 0.821 ± 0.032	1.189HisSer: 1.189 ± 0.04	1.022HisThr: 1.022 ± 0.034	1.383HisVal: 1.383 ± 0.039	0.225HisTrp: 0.225 ± 0.017	0.902HisTyr: 0.902 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.363IleAla: 6.363 ± 0.11	0.664IleCys: 0.664 ± 0.026	4.708IleAsp: 4.708 ± 0.09	6.289IleGlu: 6.289 ± 0.084	3.741IlePhe: 3.741 ± 0.087	5.99IleGly: 5.99 ± 0.092	1.678IleHis: 1.678 ± 0.05	7.024IleIle: 7.024 ± 0.11	5.423IleLys: 5.423 ± 0.088	7.082IleLeu: 7.082 ± 0.099	1.743IleMet: 1.743 ± 0.044	4.244IleAsn: 4.244 ± 0.071	3.265IlePro: 3.265 ± 0.064	2.424IleGln: 2.424 ± 0.05	2.825IleArg: 2.825 ± 0.056	5.731IleSer: 5.731 ± 0.082	4.983IleThr: 4.983 ± 0.083	6.103IleVal: 6.103 ± 0.089	0.658IleTrp: 0.658 ± 0.032	2.789IleTyr: 2.789 ± 0.064	0.0IleXaa: 0.0 ± 0.0
Lys	4.631LysAla: 4.631 ± 0.074	0.406LysCys: 0.406 ± 0.022	4.078LysAsp: 4.078 ± 0.075	7.469LysGlu: 7.469 ± 0.1	2.281LysPhe: 2.281 ± 0.051	4.393LysGly: 4.393 ± 0.072	1.5LysHis: 1.5 ± 0.046	5.371LysIle: 5.371 ± 0.084	6.775LysLys: 6.775 ± 0.103	6.616LysLeu: 6.616 ± 0.094	2.369LysMet: 2.369 ± 0.053	3.939LysAsn: 3.939 ± 0.079	2.213LysPro: 2.213 ± 0.055	3.324LysGln: 3.324 ± 0.068	3.418LysArg: 3.418 ± 0.061	3.82LysSer: 3.82 ± 0.067	3.848LysThr: 3.848 ± 0.066	5.41LysVal: 5.41 ± 0.074	0.836LysTrp: 0.836 ± 0.035	2.583LysTyr: 2.583 ± 0.062	0.0LysXaa: 0.0 ± 0.0
Leu	6.785LeuAla: 6.785 ± 0.103	0.643LeuCys: 0.643 ± 0.03	4.405LeuAsp: 4.405 ± 0.07	6.568LeuGlu: 6.568 ± 0.088	5.156LeuPhe: 5.156 ± 0.1	6.097LeuGly: 6.097 ± 0.093	2.055LeuHis: 2.055 ± 0.044	7.68LeuIle: 7.68 ± 0.103	7.097LeuLys: 7.097 ± 0.094	10.595LeuLeu: 10.595 ± 0.163	2.305LeuMet: 2.305 ± 0.048	4.576LeuAsn: 4.576 ± 0.078	3.762LeuPro: 3.762 ± 0.062	3.601LeuGln: 3.601 ± 0.071	3.335LeuArg: 3.335 ± 0.073	6.801LeuSer: 6.801 ± 0.086	5.547LeuThr: 5.547 ± 0.09	6.084LeuVal: 6.084 ± 0.098	0.833LeuTrp: 0.833 ± 0.034	3.187LeuTyr: 3.187 ± 0.066	0.0LeuXaa: 0.0 ± 0.0
Met	1.739MetAla: 1.739 ± 0.045	0.128MetCys: 0.128 ± 0.012	1.296MetAsp: 1.296 ± 0.04	2.085MetGlu: 2.085 ± 0.057	1.045MetPhe: 1.045 ± 0.039	1.431MetGly: 1.431 ± 0.046	0.482MetHis: 0.482 ± 0.023	1.982MetIle: 1.982 ± 0.053	2.723MetLys: 2.723 ± 0.055	2.51MetLeu: 2.51 ± 0.051	0.763MetMet: 0.763 ± 0.035	1.522MetAsn: 1.522 ± 0.039	1.015MetPro: 1.015 ± 0.039	1.001MetGln: 1.001 ± 0.039	0.993MetArg: 0.993 ± 0.032	1.576MetSer: 1.576 ± 0.042	1.53MetThr: 1.53 ± 0.042	1.587MetVal: 1.587 ± 0.039	0.19MetTrp: 0.19 ± 0.015	0.781MetTyr: 0.781 ± 0.033	0.0MetXaa: 0.0 ± 0.0
Asn	2.975AsnAla: 2.975 ± 0.068	0.348AsnCys: 0.348 ± 0.02	2.907AsnAsp: 2.907 ± 0.058	4.573AsnGlu: 4.573 ± 0.084	1.912AsnPhe: 1.912 ± 0.05	3.415AsnGly: 3.415 ± 0.075	1.054AsnHis: 1.054 ± 0.034	4.248AsnIle: 4.248 ± 0.073	3.853AsnLys: 3.853 ± 0.064	3.988AsnLeu: 3.988 ± 0.069	1.35AsnMet: 1.35 ± 0.044	2.923AsnAsn: 2.923 ± 0.069	2.009AsnPro: 2.009 ± 0.054	1.597AsnGln: 1.597 ± 0.051	2.061AsnArg: 2.061 ± 0.052	2.671AsnSer: 2.671 ± 0.064	2.357AsnThr: 2.357 ± 0.057	3.57AsnVal: 3.57 ± 0.06	0.585AsnTrp: 0.585 ± 0.027	2.022AsnTyr: 2.022 ± 0.05	0.0AsnXaa: 0.0 ± 0.0
Pro	1.869ProAla: 1.869 ± 0.051	0.198ProCys: 0.198 ± 0.017	1.671ProAsp: 1.671 ± 0.045	2.618ProGlu: 2.618 ± 0.052	2.019ProPhe: 2.019 ± 0.047	2.0ProGly: 2.0 ± 0.052	0.759ProHis: 0.759 ± 0.031	2.968ProIle: 2.968 ± 0.058	2.281ProLys: 2.281 ± 0.049	3.341ProLeu: 3.341 ± 0.06	0.773ProMet: 0.773 ± 0.042	1.837ProAsn: 1.837 ± 0.049	0.887ProPro: 0.887 ± 0.038	1.004ProGln: 1.004 ± 0.037	0.962ProArg: 0.962 ± 0.036	2.094ProSer: 2.094 ± 0.047	2.029ProThr: 2.029 ± 0.054	2.406ProVal: 2.406 ± 0.056	0.361ProTrp: 0.361 ± 0.02	1.48ProTyr: 1.48 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	2.23GlnAla: 2.23 ± 0.052	0.209GlnCys: 0.209 ± 0.016	1.444GlnAsp: 1.444 ± 0.043	2.508GlnGlu: 2.508 ± 0.062	1.57GlnPhe: 1.57 ± 0.039	2.017GlnGly: 2.017 ± 0.057	0.703GlnHis: 0.703 ± 0.029	2.362GlnIle: 2.362 ± 0.053	2.571GlnLys: 2.571 ± 0.056	4.034GlnLeu: 4.034 ± 0.073	1.039GlnMet: 1.039 ± 0.038	1.563GlnAsn: 1.563 ± 0.046	0.981GlnPro: 0.981 ± 0.038	1.58GlnGln: 1.58 ± 0.062	1.31GlnArg: 1.31 ± 0.041	1.9GlnSer: 1.9 ± 0.045	1.719GlnThr: 1.719 ± 0.048	2.225GlnVal: 2.225 ± 0.051	0.328GlnTrp: 0.328 ± 0.019	1.287GlnTyr: 1.287 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	2.154ArgAla: 2.154 ± 0.052	0.252ArgCys: 0.252 ± 0.019	1.885ArgAsp: 1.885 ± 0.049	2.978ArgGlu: 2.978 ± 0.064	1.804ArgPhe: 1.804 ± 0.044	2.311ArgGly: 2.311 ± 0.052	0.711ArgHis: 0.711 ± 0.03	2.905ArgIle: 2.905 ± 0.06	3.228ArgLys: 3.228 ± 0.057	3.704ArgLeu: 3.704 ± 0.065	1.115ArgMet: 1.115 ± 0.037	1.935ArgAsn: 1.935 ± 0.047	1.175ArgPro: 1.175 ± 0.035	1.222ArgGln: 1.222 ± 0.037	1.649ArgArg: 1.649 ± 0.046	2.046ArgSer: 2.046 ± 0.056	1.925ArgThr: 1.925 ± 0.046	2.343ArgVal: 2.343 ± 0.049	0.37ArgTrp: 0.37 ± 0.022	1.483ArgTyr: 1.483 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	3.381SerAla: 3.381 ± 0.076	0.424SerCys: 0.424 ± 0.022	2.829SerAsp: 2.829 ± 0.062	4.215SerGlu: 4.215 ± 0.08	3.517SerPhe: 3.517 ± 0.066	3.974SerGly: 3.974 ± 0.068	1.192SerHis: 1.192 ± 0.038	5.372SerIle: 5.372 ± 0.074	4.081SerLys: 4.081 ± 0.074	6.295SerLeu: 6.295 ± 0.091	1.552SerMet: 1.552 ± 0.041	3.03SerAsn: 3.03 ± 0.068	2.033SerPro: 2.033 ± 0.049	1.642SerGln: 1.642 ± 0.031	1.983SerArg: 1.983 ± 0.053	3.898SerSer: 3.898 ± 0.08	3.076SerThr: 3.076 ± 0.067	3.893SerVal: 3.893 ± 0.073	0.679SerTrp: 0.679 ± 0.03	2.438SerTyr: 2.438 ± 0.064	0.0SerXaa: 0.0 ± 0.0
Thr	3.446ThrAla: 3.446 ± 0.076	0.37ThrCys: 0.37 ± 0.023	2.64ThrAsp: 2.64 ± 0.055	3.567ThrGlu: 3.567 ± 0.068	2.968ThrPhe: 2.968 ± 0.057	3.857ThrGly: 3.857 ± 0.076	1.038ThrHis: 1.038 ± 0.037	5.205ThrIle: 5.205 ± 0.104	3.749ThrLys: 3.749 ± 0.072	5.499ThrLeu: 5.499 ± 0.083	1.327ThrMet: 1.327 ± 0.039	2.782ThrAsn: 2.782 ± 0.062	2.128ThrPro: 2.128 ± 0.057	1.258ThrGln: 1.258 ± 0.041	1.71ThrArg: 1.71 ± 0.04	3.313ThrSer: 3.313 ± 0.069	3.2ThrThr: 3.2 ± 0.093	4.197ThrVal: 4.197 ± 0.091	0.533ThrTrp: 0.533 ± 0.03	2.228ThrTyr: 2.228 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	4.907ValAla: 4.907 ± 0.082	0.54ValCys: 0.54 ± 0.026	3.584ValAsp: 3.584 ± 0.064	4.935ValGlu: 4.935 ± 0.09	3.201ValPhe: 3.201 ± 0.066	4.573ValGly: 4.573 ± 0.082	1.33ValHis: 1.33 ± 0.04	6.194ValIle: 6.194 ± 0.081	4.808ValLys: 4.808 ± 0.078	6.492ValLeu: 6.492 ± 0.088	1.723ValMet: 1.723 ± 0.044	3.41ValAsn: 3.41 ± 0.069	2.376ValPro: 2.376 ± 0.056	2.094ValGln: 2.094 ± 0.047	2.467ValArg: 2.467 ± 0.051	4.487ValSer: 4.487 ± 0.077	4.334ValThr: 4.334 ± 0.093	5.033ValVal: 5.033 ± 0.089	0.563ValTrp: 0.563 ± 0.024	2.313ValTyr: 2.313 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	0.526TrpAla: 0.526 ± 0.03	0.056TrpCys: 0.056 ± 0.008	0.529TrpAsp: 0.529 ± 0.026	0.7TrpGlu: 0.7 ± 0.03	0.501TrpPhe: 0.501 ± 0.028	0.612TrpGly: 0.612 ± 0.03	0.196TrpHis: 0.196 ± 0.014	0.782TrpIle: 0.782 ± 0.032	0.797TrpLys: 0.797 ± 0.032	1.084TrpLeu: 1.084 ± 0.032	0.297TrpMet: 0.297 ± 0.019	0.563TrpAsn: 0.563 ± 0.023	0.223TrpPro: 0.223 ± 0.017	0.376TrpGln: 0.376 ± 0.021	0.328TrpArg: 0.328 ± 0.019	0.587TrpSer: 0.587 ± 0.027	0.464TrpThr: 0.464 ± 0.028	0.618TrpVal: 0.618 ± 0.025	0.161TrpTrp: 0.161 ± 0.013	0.372TrpTyr: 0.372 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.069TyrAla: 2.069 ± 0.047	0.338TyrCys: 0.338 ± 0.019	2.188TyrAsp: 2.188 ± 0.056	2.873TyrGlu: 2.873 ± 0.063	2.005TyrPhe: 2.005 ± 0.049	2.535TyrGly: 2.535 ± 0.055	0.854TyrHis: 0.854 ± 0.03	2.765TyrIle: 2.765 ± 0.063	2.482TyrLys: 2.482 ± 0.058	3.752TyrLeu: 3.752 ± 0.076	0.853TyrMet: 0.853 ± 0.029	1.824TyrAsn: 1.824 ± 0.049	1.373TyrPro: 1.373 ± 0.039	1.279TyrGln: 1.279 ± 0.037	1.549TyrArg: 1.549 ± 0.049	2.273TyrSer: 2.273 ± 0.052	1.804TyrThr: 1.804 ± 0.051	2.337TyrVal: 2.337 ± 0.055	0.388TyrTrp: 0.388 ± 0.021	1.646TyrTyr: 1.646 ± 0.046	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3053 proteins (875866 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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