Amino acid dipepetide frequency for Stenotrophomonas sp. 278

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.096AlaAla: 17.096 ± 0.18	1.085AlaCys: 1.085 ± 0.03	6.899AlaAsp: 6.899 ± 0.078	6.764AlaGlu: 6.764 ± 0.086	3.923AlaPhe: 3.923 ± 0.062	10.634AlaGly: 10.634 ± 0.112	2.441AlaHis: 2.441 ± 0.051	4.835AlaIle: 4.835 ± 0.065	3.281AlaLys: 3.281 ± 0.07	15.026AlaLeu: 15.026 ± 0.14	3.154AlaMet: 3.154 ± 0.042	3.089AlaAsn: 3.089 ± 0.061	6.23AlaPro: 6.23 ± 0.101	5.819AlaGln: 5.819 ± 0.074	8.882AlaArg: 8.882 ± 0.092	6.671AlaSer: 6.671 ± 0.098	6.309AlaThr: 6.309 ± 0.105	8.926AlaVal: 8.926 ± 0.111	1.849AlaTrp: 1.849 ± 0.037	2.443AlaTyr: 2.443 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.958CysAla: 0.958 ± 0.029	0.105CysCys: 0.105 ± 0.009	0.458CysAsp: 0.458 ± 0.021	0.4CysGlu: 0.4 ± 0.019	0.249CysPhe: 0.249 ± 0.013	0.794CysGly: 0.794 ± 0.028	0.223CysHis: 0.223 ± 0.014	0.335CysIle: 0.335 ± 0.018	0.168CysLys: 0.168 ± 0.012	0.754CysLeu: 0.754 ± 0.024	0.143CysMet: 0.143 ± 0.011	0.201CysAsn: 0.201 ± 0.012	0.378CysPro: 0.378 ± 0.017	0.275CysGln: 0.275 ± 0.014	0.551CysArg: 0.551 ± 0.02	0.471CysSer: 0.471 ± 0.019	0.463CysThr: 0.463 ± 0.021	0.621CysVal: 0.621 ± 0.02	0.129CysTrp: 0.129 ± 0.009	0.183CysTyr: 0.183 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	8.125AspAla: 8.125 ± 0.078	0.39AspCys: 0.39 ± 0.019	3.251AspAsp: 3.251 ± 0.045	3.151AspGlu: 3.151 ± 0.057	1.972AspPhe: 1.972 ± 0.038	5.462AspGly: 5.462 ± 0.083	1.239AspHis: 1.239 ± 0.034	2.406AspIle: 2.406 ± 0.043	1.49AspLys: 1.49 ± 0.04	5.495AspLeu: 5.495 ± 0.067	1.112AspMet: 1.112 ± 0.03	1.486AspAsn: 1.486 ± 0.044	3.413AspPro: 3.413 ± 0.06	1.96AspGln: 1.96 ± 0.04	3.775AspArg: 3.775 ± 0.049	2.716AspSer: 2.716 ± 0.052	2.917AspThr: 2.917 ± 0.057	4.389AspVal: 4.389 ± 0.057	1.052AspTrp: 1.052 ± 0.028	1.621AspTyr: 1.621 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	6.672GluAla: 6.672 ± 0.088	0.327GluCys: 0.327 ± 0.016	2.51GluAsp: 2.51 ± 0.046	2.489GluGlu: 2.489 ± 0.058	1.661GluPhe: 1.661 ± 0.037	4.12GluGly: 4.12 ± 0.054	1.371GluHis: 1.371 ± 0.04	2.294GluIle: 2.294 ± 0.046	1.648GluLys: 1.648 ± 0.045	5.944GluLeu: 5.944 ± 0.073	1.091GluMet: 1.091 ± 0.029	1.298GluAsn: 1.298 ± 0.037	2.445GluPro: 2.445 ± 0.05	2.985GluGln: 2.985 ± 0.047	4.828GluArg: 4.828 ± 0.072	2.555GluSer: 2.555 ± 0.053	2.581GluThr: 2.581 ± 0.055	4.003GluVal: 4.003 ± 0.056	0.704GluTrp: 0.704 ± 0.022	1.135GluTyr: 1.135 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	3.95PheAla: 3.95 ± 0.061	0.302PheCys: 0.302 ± 0.015	2.6PheAsp: 2.6 ± 0.045	1.861PheGlu: 1.861 ± 0.046	1.127PhePhe: 1.127 ± 0.033	3.298PheGly: 3.298 ± 0.059	0.743PheHis: 0.743 ± 0.024	1.277PheIle: 1.277 ± 0.036	0.935PheLys: 0.935 ± 0.03	2.848PheLeu: 2.848 ± 0.057	0.679PheMet: 0.679 ± 0.024	1.231PheAsn: 1.231 ± 0.033	1.364PhePro: 1.364 ± 0.033	1.103PheGln: 1.103 ± 0.028	1.987PheArg: 1.987 ± 0.04	2.133PheSer: 2.133 ± 0.043	1.799PheThr: 1.799 ± 0.041	2.474PheVal: 2.474 ± 0.054	0.502PheTrp: 0.502 ± 0.022	0.81PheTyr: 0.81 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	8.544GlyAla: 8.544 ± 0.118	0.771GlyCys: 0.771 ± 0.026	4.586GlyAsp: 4.586 ± 0.061	4.676GlyGlu: 4.676 ± 0.071	3.292GlyPhe: 3.292 ± 0.055	7.156GlyGly: 7.156 ± 0.116	1.984GlyHis: 1.984 ± 0.039	3.755GlyIle: 3.755 ± 0.059	3.035GlyLys: 3.035 ± 0.059	8.717GlyLeu: 8.717 ± 0.105	2.267GlyMet: 2.267 ± 0.041	2.638GlyAsn: 2.638 ± 0.067	3.067GlyPro: 3.067 ± 0.049	3.696GlyGln: 3.696 ± 0.053	5.783GlyArg: 5.783 ± 0.071	5.17GlySer: 5.17 ± 0.088	4.94GlyThr: 4.94 ± 0.095	6.649GlyVal: 6.649 ± 0.075	1.657GlyTrp: 1.657 ± 0.037	2.443GlyTyr: 2.443 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.921HisAla: 2.921 ± 0.057	0.231HisCys: 0.231 ± 0.013	1.345HisAsp: 1.345 ± 0.03	1.086HisGlu: 1.086 ± 0.031	0.779HisPhe: 0.779 ± 0.026	2.161HisGly: 2.161 ± 0.047	0.625HisHis: 0.625 ± 0.024	0.768HisIle: 0.768 ± 0.027	0.447HisLys: 0.447 ± 0.021	2.167HisLeu: 2.167 ± 0.048	0.43HisMet: 0.43 ± 0.019	0.526HisAsn: 0.526 ± 0.018	1.422HisPro: 1.422 ± 0.033	0.734HisGln: 0.734 ± 0.023	1.596HisArg: 1.596 ± 0.033	1.069HisSer: 1.069 ± 0.03	1.049HisThr: 1.049 ± 0.03	1.626HisVal: 1.626 ± 0.038	0.452HisTrp: 0.452 ± 0.018	0.631HisTyr: 0.631 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.791IleAla: 5.791 ± 0.074	0.343IleCys: 0.343 ± 0.016	3.016IleAsp: 3.016 ± 0.056	2.8IleGlu: 2.8 ± 0.046	1.054IlePhe: 1.054 ± 0.031	4.105IleGly: 4.105 ± 0.068	0.837IleHis: 0.837 ± 0.027	1.428IleIle: 1.428 ± 0.036	1.176IleLys: 1.176 ± 0.037	2.969IleLeu: 2.969 ± 0.053	0.544IleMet: 0.544 ± 0.025	1.438IleAsn: 1.438 ± 0.038	1.997IlePro: 1.997 ± 0.041	1.25IleGln: 1.25 ± 0.029	2.565IleArg: 2.565 ± 0.044	2.42IleSer: 2.42 ± 0.048	2.479IleThr: 2.479 ± 0.049	3.028IleVal: 3.028 ± 0.048	0.428IleTrp: 0.428 ± 0.021	0.821IleTyr: 0.821 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	3.523LysAla: 3.523 ± 0.065	0.148LysCys: 0.148 ± 0.01	1.481LysAsp: 1.481 ± 0.041	1.266LysGlu: 1.266 ± 0.036	0.736LysPhe: 0.736 ± 0.025	2.2LysGly: 2.2 ± 0.045	0.602LysHis: 0.602 ± 0.02	1.134LysIle: 1.134 ± 0.03	1.034LysLys: 1.034 ± 0.042	3.035LysLeu: 3.035 ± 0.048	0.625LysMet: 0.625 ± 0.022	0.691LysAsn: 0.691 ± 0.023	1.803LysPro: 1.803 ± 0.047	1.277LysGln: 1.277 ± 0.032	2.127LysArg: 2.127 ± 0.05	1.344LysSer: 1.344 ± 0.036	1.476LysThr: 1.476 ± 0.038	2.403LysVal: 2.403 ± 0.052	0.317LysTrp: 0.317 ± 0.015	0.638LysTyr: 0.638 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	13.791LeuAla: 13.791 ± 0.129	0.898LeuCys: 0.898 ± 0.028	6.597LeuAsp: 6.597 ± 0.085	5.401LeuGlu: 5.401 ± 0.083	3.314LeuPhe: 3.314 ± 0.062	8.724LeuGly: 8.724 ± 0.108	2.431LeuHis: 2.431 ± 0.053	4.051LeuIle: 4.051 ± 0.063	3.2LeuLys: 3.2 ± 0.055	11.809LeuLeu: 11.809 ± 0.15	2.194LeuMet: 2.194 ± 0.048	2.685LeuAsn: 2.685 ± 0.056	6.62LeuPro: 6.62 ± 0.091	4.876LeuGln: 4.876 ± 0.062	8.482LeuArg: 8.482 ± 0.111	6.127LeuSer: 6.127 ± 0.075	5.218LeuThr: 5.218 ± 0.077	7.711LeuVal: 7.711 ± 0.089	1.352LeuTrp: 1.352 ± 0.043	2.174LeuTyr: 2.174 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	2.754MetAla: 2.754 ± 0.052	0.159MetCys: 0.159 ± 0.01	1.125MetAsp: 1.125 ± 0.032	0.961MetGlu: 0.961 ± 0.024	0.638MetPhe: 0.638 ± 0.022	1.59MetGly: 1.59 ± 0.035	0.435MetHis: 0.435 ± 0.018	0.905MetIle: 0.905 ± 0.026	0.808MetLys: 0.808 ± 0.029	2.382MetLeu: 2.382 ± 0.047	0.485MetMet: 0.485 ± 0.021	0.71MetAsn: 0.71 ± 0.021	1.315MetPro: 1.315 ± 0.033	1.017MetGln: 1.017 ± 0.03	1.707MetArg: 1.707 ± 0.04	1.598MetSer: 1.598 ± 0.035	1.433MetThr: 1.433 ± 0.035	1.489MetVal: 1.489 ± 0.037	0.242MetTrp: 0.242 ± 0.015	0.367MetTyr: 0.367 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.594AsnAla: 3.594 ± 0.061	0.203AsnCys: 0.203 ± 0.017	1.622AsnAsp: 1.622 ± 0.053	1.314AsnGlu: 1.314 ± 0.035	0.899AsnPhe: 0.899 ± 0.03	2.696AsnGly: 2.696 ± 0.06	0.539AsnHis: 0.539 ± 0.022	1.148AsnIle: 1.148 ± 0.029	0.683AsnLys: 0.683 ± 0.027	2.671AsnLeu: 2.671 ± 0.048	0.461AsnMet: 0.461 ± 0.017	0.835AsnAsn: 0.835 ± 0.027	1.845AsnPro: 1.845 ± 0.042	0.958AsnGln: 0.958 ± 0.028	1.818AsnArg: 1.818 ± 0.038	1.351AsnSer: 1.351 ± 0.041	1.532AsnThr: 1.532 ± 0.041	2.088AsnVal: 2.088 ± 0.049	0.415AsnTrp: 0.415 ± 0.018	0.713AsnTyr: 0.713 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	7.178ProAla: 7.178 ± 0.099	0.306ProCys: 0.306 ± 0.018	3.397ProAsp: 3.397 ± 0.061	3.279ProGlu: 3.279 ± 0.057	1.624ProPhe: 1.624 ± 0.039	4.785ProGly: 4.785 ± 0.059	1.102ProHis: 1.102 ± 0.032	1.845ProIle: 1.845 ± 0.037	1.413ProLys: 1.413 ± 0.039	5.474ProLeu: 5.474 ± 0.072	1.303ProMet: 1.303 ± 0.031	1.28ProAsn: 1.28 ± 0.035	2.728ProPro: 2.728 ± 0.06	2.107ProGln: 2.107 ± 0.039	3.16ProArg: 3.16 ± 0.047	2.769ProSer: 2.769 ± 0.042	2.692ProThr: 2.692 ± 0.057	4.547ProVal: 4.547 ± 0.078	0.843ProTrp: 0.843 ± 0.028	1.161ProTyr: 1.161 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	5.805GlnAla: 5.805 ± 0.072	0.29GlnCys: 0.29 ± 0.013	1.842GlnAsp: 1.842 ± 0.04	1.65GlnGlu: 1.65 ± 0.042	1.296GlnPhe: 1.296 ± 0.035	3.197GlnGly: 3.197 ± 0.049	0.986GlnHis: 0.986 ± 0.03	1.777GlnIle: 1.777 ± 0.036	1.017GlnLys: 1.017 ± 0.03	4.909GlnLeu: 4.909 ± 0.058	0.938GlnMet: 0.938 ± 0.027	0.921GlnAsn: 0.921 ± 0.029	2.423GlnPro: 2.423 ± 0.049	2.552GlnGln: 2.552 ± 0.048	3.895GlnArg: 3.895 ± 0.06	1.996GlnSer: 1.996 ± 0.042	1.881GlnThr: 1.881 ± 0.038	3.584GlnVal: 3.584 ± 0.057	0.804GlnTrp: 0.804 ± 0.027	0.915GlnTyr: 0.915 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	7.832ArgAla: 7.832 ± 0.09	0.547ArgCys: 0.547 ± 0.022	4.323ArgAsp: 4.323 ± 0.057	4.432ArgGlu: 4.432 ± 0.074	2.836ArgPhe: 2.836 ± 0.045	5.027ArgGly: 5.027 ± 0.07	1.825ArgHis: 1.825 ± 0.037	3.522ArgIle: 3.522 ± 0.053	1.94ArgLys: 1.94 ± 0.046	7.855ArgLeu: 7.855 ± 0.098	1.969ArgMet: 1.969 ± 0.045	2.121ArgAsn: 2.121 ± 0.042	3.304ArgPro: 3.304 ± 0.051	3.214ArgGln: 3.214 ± 0.053	5.475ArgArg: 5.475 ± 0.089	3.931ArgSer: 3.931 ± 0.056	3.488ArgThr: 3.488 ± 0.056	5.284ArgVal: 5.284 ± 0.067	1.493ArgTrp: 1.493 ± 0.037	2.137ArgTyr: 2.137 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.749SerAla: 6.749 ± 0.084	0.386SerCys: 0.386 ± 0.016	2.89SerAsp: 2.89 ± 0.042	2.726SerGlu: 2.726 ± 0.047	1.902SerPhe: 1.902 ± 0.036	5.288SerGly: 5.288 ± 0.085	1.112SerHis: 1.112 ± 0.031	2.257SerIle: 2.257 ± 0.043	1.419SerLys: 1.419 ± 0.035	5.804SerLeu: 5.804 ± 0.075	1.167SerMet: 1.167 ± 0.029	1.619SerAsn: 1.619 ± 0.04	2.97SerPro: 2.97 ± 0.049	1.996SerGln: 1.996 ± 0.037	3.879SerArg: 3.879 ± 0.055	3.324SerSer: 3.324 ± 0.069	3.135SerThr: 3.135 ± 0.055	4.11SerVal: 4.11 ± 0.063	0.882SerTrp: 0.882 ± 0.027	1.389SerTyr: 1.389 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	6.532ThrAla: 6.532 ± 0.11	0.377ThrCys: 0.377 ± 0.019	2.776ThrAsp: 2.776 ± 0.055	2.364ThrGlu: 2.364 ± 0.046	1.726ThrPhe: 1.726 ± 0.042	4.866ThrGly: 4.866 ± 0.088	1.096ThrHis: 1.096 ± 0.032	1.939ThrIle: 1.939 ± 0.042	1.058ThrLys: 1.058 ± 0.028	6.648ThrLeu: 6.648 ± 0.073	0.895ThrMet: 0.895 ± 0.027	1.148ThrAsn: 1.148 ± 0.042	3.649ThrPro: 3.649 ± 0.068	1.92ThrGln: 1.92 ± 0.044	3.626ThrArg: 3.626 ± 0.061	2.683ThrSer: 2.683 ± 0.054	2.98ThrThr: 2.98 ± 0.083	4.387ThrVal: 4.387 ± 0.087	0.75ThrTrp: 0.75 ± 0.027	1.175ThrTyr: 1.175 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	9.392ValAla: 9.392 ± 0.094	0.651ValCys: 0.651 ± 0.03	4.602ValAsp: 4.602 ± 0.055	4.295ValGlu: 4.295 ± 0.065	2.512ValPhe: 2.512 ± 0.049	5.685ValGly: 5.685 ± 0.074	1.626ValHis: 1.626 ± 0.033	3.38ValIle: 3.38 ± 0.054	2.005ValLys: 2.005 ± 0.046	8.491ValLeu: 8.491 ± 0.087	1.756ValMet: 1.756 ± 0.042	2.197ValAsn: 2.197 ± 0.051	4.115ValPro: 4.115 ± 0.066	3.028ValGln: 3.028 ± 0.046	5.225ValArg: 5.225 ± 0.063	4.468ValSer: 4.468 ± 0.061	4.121ValThr: 4.121 ± 0.073	6.386ValVal: 6.386 ± 0.106	0.972ValTrp: 0.972 ± 0.029	1.57ValTyr: 1.57 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.368TrpAla: 1.368 ± 0.038	0.137TrpCys: 0.137 ± 0.01	0.692TrpAsp: 0.692 ± 0.025	0.611TrpGlu: 0.611 ± 0.021	0.589TrpPhe: 0.589 ± 0.02	0.996TrpGly: 0.996 ± 0.035	0.382TrpHis: 0.382 ± 0.017	0.676TrpIle: 0.676 ± 0.025	0.525TrpLys: 0.525 ± 0.018	2.179TrpLeu: 2.179 ± 0.053	0.506TrpMet: 0.506 ± 0.02	0.532TrpAsn: 0.532 ± 0.022	0.759TrpPro: 0.759 ± 0.021	0.896TrpGln: 0.896 ± 0.03	1.266TrpArg: 1.266 ± 0.031	0.882TrpSer: 0.882 ± 0.026	0.803TrpThr: 0.803 ± 0.026	1.091TrpVal: 1.091 ± 0.029	0.336TrpTrp: 0.336 ± 0.02	0.376TrpTyr: 0.376 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.779TyrAla: 2.779 ± 0.046	0.202TyrCys: 0.202 ± 0.012	1.411TyrAsp: 1.411 ± 0.046	1.135TyrGlu: 1.135 ± 0.034	0.892TyrPhe: 0.892 ± 0.026	2.043TyrGly: 2.043 ± 0.04	0.466TyrHis: 0.466 ± 0.018	0.757TyrIle: 0.757 ± 0.024	0.579TyrLys: 0.579 ± 0.021	2.482TyrLeu: 2.482 ± 0.05	0.399TyrMet: 0.399 ± 0.015	0.741TyrAsn: 0.741 ± 0.024	1.147TyrPro: 1.147 ± 0.03	1.015TyrGln: 1.015 ± 0.033	1.926TyrArg: 1.926 ± 0.036	1.325TyrSer: 1.325 ± 0.034	1.297TyrThr: 1.297 ± 0.038	1.68TyrVal: 1.68 ± 0.041	0.423TyrTrp: 0.423 ± 0.021	0.684TyrTyr: 0.684 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4280 proteins (1357534 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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