Amino acid dipepetide frequency for Umatilla virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.756AlaAla: 4.756 ± 1.36
0.492AlaCys: 0.492 ± 0.2
2.132AlaAsp: 2.132 ± 0.556
4.592AlaGlu: 4.592 ± 0.917
2.132AlaPhe: 2.132 ± 0.84
2.296AlaGly: 2.296 ± 0.751
1.64AlaHis: 1.64 ± 0.304
5.577AlaIle: 5.577 ± 0.995
4.428AlaLys: 4.428 ± 1.062
7.381AlaLeu: 7.381 ± 0.662
1.968AlaMet: 1.968 ± 0.548
2.952AlaAsn: 2.952 ± 0.794
2.952AlaPro: 2.952 ± 0.617
2.952AlaGln: 2.952 ± 1.004
3.772AlaArg: 3.772 ± 0.856
3.116AlaSer: 3.116 ± 0.711
4.428AlaThr: 4.428 ± 1.092
4.428AlaVal: 4.428 ± 1.194
0.82AlaTrp: 0.82 ± 0.311
2.624AlaTyr: 2.624 ± 0.725
0.0AlaXaa: 0.0 ± 0.0
Cys
1.148CysAla: 1.148 ± 0.467
0.164CysCys: 0.164 ± 0.173
0.82CysAsp: 0.82 ± 0.552
0.492CysGlu: 0.492 ± 0.25
0.82CysPhe: 0.82 ± 0.448
1.312CysGly: 1.312 ± 0.268
0.328CysHis: 0.328 ± 0.203
0.82CysIle: 0.82 ± 0.358
0.0CysLys: 0.0 ± 0.0
0.328CysLeu: 0.328 ± 0.159
0.164CysMet: 0.164 ± 0.147
0.492CysAsn: 0.492 ± 0.307
0.328CysPro: 0.328 ± 0.261
0.656CysGln: 0.656 ± 0.452
0.82CysArg: 0.82 ± 0.457
1.148CysSer: 1.148 ± 0.459
0.0CysThr: 0.0 ± 0.0
1.312CysVal: 1.312 ± 0.673
0.0CysTrp: 0.0 ± 0.0
1.148CysTyr: 1.148 ± 0.524
0.0CysXaa: 0.0 ± 0.0
Asp
4.756AspAla: 4.756 ± 0.977
0.82AspCys: 0.82 ± 0.238
2.952AspAsp: 2.952 ± 0.463
4.428AspGlu: 4.428 ± 0.784
1.476AspPhe: 1.476 ± 0.532
3.444AspGly: 3.444 ± 1.45
1.148AspHis: 1.148 ± 0.369
4.264AspIle: 4.264 ± 0.795
2.296AspLys: 2.296 ± 0.74
6.725AspLeu: 6.725 ± 0.941
0.656AspMet: 0.656 ± 0.338
2.132AspAsn: 2.132 ± 0.397
3.28AspPro: 3.28 ± 0.711
2.296AspGln: 2.296 ± 0.676
3.608AspArg: 3.608 ± 0.715
4.1AspSer: 4.1 ± 0.91
2.952AspThr: 2.952 ± 0.714
4.264AspVal: 4.264 ± 0.745
0.656AspTrp: 0.656 ± 0.302
1.312AspTyr: 1.312 ± 0.407
0.0AspXaa: 0.0 ± 0.0
Glu
3.772GluAla: 3.772 ± 0.553
0.328GluCys: 0.328 ± 0.196
2.952GluAsp: 2.952 ± 0.71
5.741GluGlu: 5.741 ± 1.281
2.952GluPhe: 2.952 ± 0.807
3.608GluGly: 3.608 ± 0.613
1.64GluHis: 1.64 ± 0.461
4.428GluIle: 4.428 ± 0.906
3.772GluLys: 3.772 ± 0.976
5.741GluLeu: 5.741 ± 0.796
2.624GluMet: 2.624 ± 0.292
3.28GluAsn: 3.28 ± 0.695
1.804GluPro: 1.804 ± 0.52
2.788GluGln: 2.788 ± 0.564
6.725GluArg: 6.725 ± 1.083
5.084GluSer: 5.084 ± 1.186
3.608GluThr: 3.608 ± 0.611
3.772GluVal: 3.772 ± 0.794
1.312GluTrp: 1.312 ± 0.53
1.64GluTyr: 1.64 ± 0.903
0.0GluXaa: 0.0 ± 0.0
Phe
1.64PheAla: 1.64 ± 0.22
0.164PheCys: 0.164 ± 0.181
1.804PheAsp: 1.804 ± 0.567
1.804PheGlu: 1.804 ± 0.509
1.312PhePhe: 1.312 ± 0.362
2.952PheGly: 2.952 ± 0.811
0.984PheHis: 0.984 ± 0.32
2.296PheIle: 2.296 ± 0.644
2.296PheLys: 2.296 ± 0.834
4.264PheLeu: 4.264 ± 1.17
0.492PheMet: 0.492 ± 0.286
2.624PheAsn: 2.624 ± 0.63
0.82PhePro: 0.82 ± 0.299
1.476PheGln: 1.476 ± 0.633
2.788PheArg: 2.788 ± 0.672
3.444PheSer: 3.444 ± 0.956
2.296PheThr: 2.296 ± 0.415
1.64PheVal: 1.64 ± 0.48
0.328PheTrp: 0.328 ± 0.225
1.312PheTyr: 1.312 ± 0.457
0.0PheXaa: 0.0 ± 0.0
Gly
3.116GlyAla: 3.116 ± 0.749
0.328GlyCys: 0.328 ± 0.225
4.592GlyAsp: 4.592 ± 1.703
3.772GlyGlu: 3.772 ± 0.664
2.132GlyPhe: 2.132 ± 0.597
3.116GlyGly: 3.116 ± 0.874
2.132GlyHis: 2.132 ± 0.514
4.1GlyIle: 4.1 ± 0.965
4.1GlyLys: 4.1 ± 1.315
4.264GlyLeu: 4.264 ± 0.714
0.984GlyMet: 0.984 ± 0.454
2.132GlyAsn: 2.132 ± 0.565
1.968GlyPro: 1.968 ± 0.619
2.296GlyGln: 2.296 ± 0.618
4.1GlyArg: 4.1 ± 0.864
5.084GlySer: 5.084 ± 1.364
2.46GlyThr: 2.46 ± 0.834
4.756GlyVal: 4.756 ± 1.259
0.164GlyTrp: 0.164 ± 0.172
2.46GlyTyr: 2.46 ± 0.759
0.0GlyXaa: 0.0 ± 0.0
His
1.968HisAla: 1.968 ± 0.703
0.0HisCys: 0.0 ± 0.0
1.64HisAsp: 1.64 ± 0.384
0.82HisGlu: 0.82 ± 0.224
0.984HisPhe: 0.984 ± 0.354
1.476HisGly: 1.476 ± 0.594
0.82HisHis: 0.82 ± 0.342
1.476HisIle: 1.476 ± 0.551
0.984HisLys: 0.984 ± 0.417
3.772HisLeu: 3.772 ± 1.062
1.312HisMet: 1.312 ± 0.411
1.148HisAsn: 1.148 ± 0.235
0.492HisPro: 0.492 ± 0.226
1.476HisGln: 1.476 ± 0.612
2.132HisArg: 2.132 ± 0.515
2.132HisSer: 2.132 ± 0.476
0.656HisThr: 0.656 ± 0.239
2.296HisVal: 2.296 ± 0.979
0.492HisTrp: 0.492 ± 0.226
0.328HisTyr: 0.328 ± 0.169
0.0HisXaa: 0.0 ± 0.0
Ile
3.28IleAla: 3.28 ± 0.85
0.82IleCys: 0.82 ± 0.343
3.772IleAsp: 3.772 ± 0.973
6.725IleGlu: 6.725 ± 1.106
1.804IlePhe: 1.804 ± 0.444
3.608IleGly: 3.608 ± 0.661
2.132IleHis: 2.132 ± 0.625
4.592IleIle: 4.592 ± 0.813
4.592IleLys: 4.592 ± 1.112
6.725IleLeu: 6.725 ± 1.4
1.968IleMet: 1.968 ± 0.533
2.132IleAsn: 2.132 ± 0.597
2.46IlePro: 2.46 ± 0.825
2.46IleGln: 2.46 ± 0.477
3.444IleArg: 3.444 ± 0.465
4.756IleSer: 4.756 ± 0.563
3.444IleThr: 3.444 ± 0.597
3.772IleVal: 3.772 ± 0.476
0.82IleTrp: 0.82 ± 0.345
3.116IleTyr: 3.116 ± 0.65
0.0IleXaa: 0.0 ± 0.0
Lys
4.592LysAla: 4.592 ± 1.206
0.492LysCys: 0.492 ± 0.273
3.28LysAsp: 3.28 ± 1.232
3.936LysGlu: 3.936 ± 0.989
2.788LysPhe: 2.788 ± 0.584
3.116LysGly: 3.116 ± 0.515
0.984LysHis: 0.984 ± 0.547
6.069LysIle: 6.069 ± 0.833
2.132LysLys: 2.132 ± 0.574
4.592LysLeu: 4.592 ± 0.826
1.64LysMet: 1.64 ± 0.427
2.624LysAsn: 2.624 ± 0.735
1.148LysPro: 1.148 ± 0.323
2.624LysGln: 2.624 ± 1.021
4.1LysArg: 4.1 ± 1.212
2.952LysSer: 2.952 ± 0.817
3.28LysThr: 3.28 ± 0.68
2.46LysVal: 2.46 ± 0.847
0.656LysTrp: 0.656 ± 0.477
1.64LysTyr: 1.64 ± 0.653
0.0LysXaa: 0.0 ± 0.0
Leu
5.577LeuAla: 5.577 ± 1.025
0.82LeuCys: 0.82 ± 0.353
5.741LeuAsp: 5.741 ± 0.962
4.264LeuGlu: 4.264 ± 0.783
4.1LeuPhe: 4.1 ± 0.713
4.756LeuGly: 4.756 ± 1.24
2.952LeuHis: 2.952 ± 0.948
4.428LeuIle: 4.428 ± 0.796
5.248LeuLys: 5.248 ± 0.831
7.709LeuLeu: 7.709 ± 1.067
2.952LeuMet: 2.952 ± 0.53
5.577LeuAsn: 5.577 ± 1.063
5.577LeuPro: 5.577 ± 1.057
4.1LeuGln: 4.1 ± 0.669
7.381LeuArg: 7.381 ± 1.49
6.397LeuSer: 6.397 ± 1.206
6.233LeuThr: 6.233 ± 0.918
5.577LeuVal: 5.577 ± 0.869
1.148LeuTrp: 1.148 ± 0.519
2.952LeuTyr: 2.952 ± 0.742
0.0LeuXaa: 0.0 ± 0.0
Met
2.46MetAla: 2.46 ± 0.842
0.328MetCys: 0.328 ± 0.196
2.46MetAsp: 2.46 ± 0.795
1.476MetGlu: 1.476 ± 0.434
1.476MetPhe: 1.476 ± 0.499
0.984MetGly: 0.984 ± 0.343
1.476MetHis: 1.476 ± 0.482
1.476MetIle: 1.476 ± 0.474
0.656MetLys: 0.656 ± 0.21
3.608MetLeu: 3.608 ± 1.059
0.82MetMet: 0.82 ± 0.32
0.82MetAsn: 0.82 ± 0.23
0.82MetPro: 0.82 ± 0.319
0.82MetGln: 0.82 ± 0.282
2.46MetArg: 2.46 ± 0.807
1.968MetSer: 1.968 ± 0.519
1.968MetThr: 1.968 ± 0.534
1.148MetVal: 1.148 ± 0.316
0.164MetTrp: 0.164 ± 0.181
1.968MetTyr: 1.968 ± 0.408
0.0MetXaa: 0.0 ± 0.0
Asn
3.608AsnAla: 3.608 ± 0.824
0.492AsnCys: 0.492 ± 0.263
2.624AsnAsp: 2.624 ± 0.993
3.28AsnGlu: 3.28 ± 0.498
1.476AsnPhe: 1.476 ± 0.718
3.608AsnGly: 3.608 ± 0.708
1.148AsnHis: 1.148 ± 0.612
2.788AsnIle: 2.788 ± 0.734
2.132AsnLys: 2.132 ± 0.363
3.608AsnLeu: 3.608 ± 0.659
1.148AsnMet: 1.148 ± 0.337
1.476AsnAsn: 1.476 ± 0.455
1.148AsnPro: 1.148 ± 0.559
1.312AsnGln: 1.312 ± 0.53
3.444AsnArg: 3.444 ± 0.898
2.788AsnSer: 2.788 ± 0.81
1.968AsnThr: 1.968 ± 0.55
4.428AsnVal: 4.428 ± 0.942
0.328AsnTrp: 0.328 ± 0.257
2.296AsnTyr: 2.296 ± 0.747
0.0AsnXaa: 0.0 ± 0.0
Pro
1.312ProAla: 1.312 ± 0.465
0.164ProCys: 0.164 ± 0.181
1.804ProAsp: 1.804 ± 0.729
2.132ProGlu: 2.132 ± 0.599
1.804ProPhe: 1.804 ± 0.474
2.624ProGly: 2.624 ± 0.97
0.82ProHis: 0.82 ± 0.363
2.624ProIle: 2.624 ± 0.496
1.64ProLys: 1.64 ± 0.473
1.804ProLeu: 1.804 ± 0.586
0.82ProMet: 0.82 ± 0.331
1.476ProAsn: 1.476 ± 0.617
1.312ProPro: 1.312 ± 0.632
1.64ProGln: 1.64 ± 0.674
2.624ProArg: 2.624 ± 0.539
2.46ProSer: 2.46 ± 0.633
2.788ProThr: 2.788 ± 0.763
1.804ProVal: 1.804 ± 0.522
0.82ProTrp: 0.82 ± 0.352
2.132ProTyr: 2.132 ± 0.575
0.0ProXaa: 0.0 ± 0.0
Gln
3.116GlnAla: 3.116 ± 0.975
0.492GlnCys: 0.492 ± 0.25
1.64GlnAsp: 1.64 ± 0.401
2.788GlnGlu: 2.788 ± 0.36
0.984GlnPhe: 0.984 ± 0.307
2.46GlnGly: 2.46 ± 0.978
1.64GlnHis: 1.64 ± 0.376
3.444GlnIle: 3.444 ± 0.499
2.624GlnLys: 2.624 ± 1.148
3.772GlnLeu: 3.772 ± 0.789
2.296GlnMet: 2.296 ± 0.709
2.46GlnAsn: 2.46 ± 0.49
1.312GlnPro: 1.312 ± 0.558
1.312GlnGln: 1.312 ± 0.395
2.624GlnArg: 2.624 ± 0.518
1.968GlnSer: 1.968 ± 0.59
3.444GlnThr: 3.444 ± 0.67
1.968GlnVal: 1.968 ± 0.462
0.0GlnTrp: 0.0 ± 0.0
1.476GlnTyr: 1.476 ± 0.542
0.0GlnXaa: 0.0 ± 0.0
Arg
5.412ArgAla: 5.412 ± 0.94
1.804ArgCys: 1.804 ± 0.707
4.592ArgAsp: 4.592 ± 0.296
6.233ArgGlu: 6.233 ± 1.021
2.952ArgPhe: 2.952 ± 0.752
3.444ArgGly: 3.444 ± 0.49
0.984ArgHis: 0.984 ± 0.334
4.756ArgIle: 4.756 ± 0.815
2.788ArgLys: 2.788 ± 0.845
5.905ArgLeu: 5.905 ± 0.803
2.952ArgMet: 2.952 ± 0.719
4.264ArgAsn: 4.264 ± 0.482
2.132ArgPro: 2.132 ± 0.855
2.46ArgGln: 2.46 ± 0.418
2.624ArgArg: 2.624 ± 0.702
4.592ArgSer: 4.592 ± 0.68
3.936ArgThr: 3.936 ± 0.659
3.772ArgVal: 3.772 ± 0.655
0.656ArgTrp: 0.656 ± 0.273
2.46ArgTyr: 2.46 ± 0.816
0.0ArgXaa: 0.0 ± 0.0
Ser
4.428SerAla: 4.428 ± 0.758
1.148SerCys: 1.148 ± 0.421
5.084SerAsp: 5.084 ± 0.76
5.084SerGlu: 5.084 ± 1.014
2.296SerPhe: 2.296 ± 0.647
5.905SerGly: 5.905 ± 1.461
1.804SerHis: 1.804 ± 0.351
3.444SerIle: 3.444 ± 0.882
3.772SerLys: 3.772 ± 0.831
6.725SerLeu: 6.725 ± 0.713
1.64SerMet: 1.64 ± 0.614
2.296SerAsn: 2.296 ± 0.528
2.132SerPro: 2.132 ± 0.575
3.116SerGln: 3.116 ± 0.593
4.92SerArg: 4.92 ± 0.761
5.905SerSer: 5.905 ± 0.995
4.428SerThr: 4.428 ± 0.891
2.624SerVal: 2.624 ± 0.615
0.492SerTrp: 0.492 ± 0.252
2.296SerTyr: 2.296 ± 0.749
0.0SerXaa: 0.0 ± 0.0
Thr
3.936ThrAla: 3.936 ± 1.245
1.148ThrCys: 1.148 ± 0.568
2.132ThrAsp: 2.132 ± 0.546
3.936ThrGlu: 3.936 ± 0.916
2.132ThrPhe: 2.132 ± 0.514
3.116ThrGly: 3.116 ± 0.575
1.148ThrHis: 1.148 ± 0.445
3.772ThrIle: 3.772 ± 0.5
4.264ThrLys: 4.264 ± 0.876
6.889ThrLeu: 6.889 ± 1.079
1.64ThrMet: 1.64 ± 0.371
2.296ThrAsn: 2.296 ± 0.566
1.476ThrPro: 1.476 ± 0.452
3.444ThrGln: 3.444 ± 0.747
3.772ThrArg: 3.772 ± 0.38
4.428ThrSer: 4.428 ± 0.791
3.936ThrThr: 3.936 ± 0.898
2.952ThrVal: 2.952 ± 0.711
0.656ThrTrp: 0.656 ± 0.238
2.46ThrTyr: 2.46 ± 0.487
0.0ThrXaa: 0.0 ± 0.0
Val
3.444ValAla: 3.444 ± 0.63
1.476ValCys: 1.476 ± 0.348
3.608ValAsp: 3.608 ± 0.74
3.444ValGlu: 3.444 ± 0.581
1.804ValPhe: 1.804 ± 0.435
3.444ValGly: 3.444 ± 0.699
1.312ValHis: 1.312 ± 0.348
3.772ValIle: 3.772 ± 0.664
4.428ValLys: 4.428 ± 1.058
5.412ValLeu: 5.412 ± 1.023
2.296ValMet: 2.296 ± 0.513
2.132ValAsn: 2.132 ± 0.835
1.968ValPro: 1.968 ± 0.63
2.788ValGln: 2.788 ± 0.667
4.592ValArg: 4.592 ± 0.885
3.444ValSer: 3.444 ± 0.659
3.608ValThr: 3.608 ± 0.532
6.069ValVal: 6.069 ± 1.103
0.328ValTrp: 0.328 ± 0.198
3.28ValTyr: 3.28 ± 1.096
0.0ValXaa: 0.0 ± 0.0
Trp
0.656TrpAla: 0.656 ± 0.286
0.164TrpCys: 0.164 ± 0.116
0.656TrpAsp: 0.656 ± 0.267
0.984TrpGlu: 0.984 ± 0.418
0.328TrpPhe: 0.328 ± 0.222
0.0TrpGly: 0.0 ± 0.0
0.492TrpHis: 0.492 ± 0.243
0.656TrpIle: 0.656 ± 0.465
0.984TrpLys: 0.984 ± 0.461
0.656TrpLeu: 0.656 ± 0.211
0.328TrpMet: 0.328 ± 0.198
0.984TrpAsn: 0.984 ± 0.451
0.164TrpPro: 0.164 ± 0.171
0.164TrpGln: 0.164 ± 0.181
0.492TrpArg: 0.492 ± 0.334
0.656TrpSer: 0.656 ± 0.307
0.656TrpThr: 0.656 ± 0.357
0.656TrpVal: 0.656 ± 0.366
0.164TrpTrp: 0.164 ± 0.181
0.492TrpTyr: 0.492 ± 0.282
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.46TyrAla: 2.46 ± 0.653
0.656TyrCys: 0.656 ± 0.273
3.28TyrAsp: 3.28 ± 0.442
1.64TyrGlu: 1.64 ± 0.365
0.984TyrPhe: 0.984 ± 0.294
2.788TyrGly: 2.788 ± 0.859
0.82TyrHis: 0.82 ± 0.334
1.64TyrIle: 1.64 ± 0.601
1.968TyrLys: 1.968 ± 0.723
3.608TyrLeu: 3.608 ± 0.841
0.492TyrMet: 0.492 ± 0.269
1.804TyrAsn: 1.804 ± 0.765
1.312TyrPro: 1.312 ± 0.332
1.64TyrGln: 1.64 ± 0.513
2.46TyrArg: 2.46 ± 0.633
3.116TyrSer: 3.116 ± 0.489
3.444TyrThr: 3.444 ± 0.86
2.952TyrVal: 2.952 ± 0.329
0.328TyrTrp: 0.328 ± 0.197
1.804TyrTyr: 1.804 ± 0.451
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 10 proteins (6098 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski