Amino acid dipepetide frequency for Candidatus Vidania fulgoroideae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.535AlaAla: 0.535 ± 0.108
0.163AlaCys: 0.163 ± 0.066
0.396AlaAsp: 0.396 ± 0.099
0.489AlaGlu: 0.489 ± 0.122
0.884AlaPhe: 0.884 ± 0.152
1.071AlaGly: 1.071 ± 0.15
0.303AlaHis: 0.303 ± 0.08
2.258AlaIle: 2.258 ± 0.263
2.165AlaLys: 2.165 ± 0.24
1.559AlaLeu: 1.559 ± 0.202
0.303AlaMet: 0.303 ± 0.082
0.838AlaAsn: 0.838 ± 0.151
0.303AlaPro: 0.303 ± 0.077
0.349AlaGln: 0.349 ± 0.101
0.652AlaArg: 0.652 ± 0.124
1.117AlaSer: 1.117 ± 0.175
0.466AlaThr: 0.466 ± 0.123
0.791AlaVal: 0.791 ± 0.125
0.047AlaTrp: 0.047 ± 0.029
0.745AlaTyr: 0.745 ± 0.129
0.0AlaXaa: 0.0 ± 0.0
Cys
0.279CysAla: 0.279 ± 0.079
0.256CysCys: 0.256 ± 0.074
0.466CysAsp: 0.466 ± 0.092
0.489CysGlu: 0.489 ± 0.1
1.397CysPhe: 1.397 ± 0.179
0.884CysGly: 0.884 ± 0.136
0.163CysHis: 0.163 ± 0.059
1.839CysIle: 1.839 ± 0.194
2.933CysLys: 2.933 ± 0.268
1.397CysLeu: 1.397 ± 0.185
0.163CysMet: 0.163 ± 0.051
1.373CysAsn: 1.373 ± 0.164
0.303CysPro: 0.303 ± 0.075
0.279CysGln: 0.279 ± 0.067
0.396CysArg: 0.396 ± 0.087
1.257CysSer: 1.257 ± 0.18
0.372CysThr: 0.372 ± 0.097
0.675CysVal: 0.675 ± 0.109
0.093CysTrp: 0.093 ± 0.053
0.745CysTyr: 0.745 ± 0.153
0.0CysXaa: 0.0 ± 0.0
Asp
0.559AspAla: 0.559 ± 0.12
0.628AspCys: 0.628 ± 0.101
0.559AspAsp: 0.559 ± 0.09
1.024AspGlu: 1.024 ± 0.16
2.537AspPhe: 2.537 ± 0.221
0.978AspGly: 0.978 ± 0.16
0.163AspHis: 0.163 ± 0.049
5.004AspIle: 5.004 ± 0.301
3.747AspLys: 3.747 ± 0.251
2.56AspLeu: 2.56 ± 0.236
0.466AspMet: 0.466 ± 0.111
2.234AspAsn: 2.234 ± 0.255
0.698AspPro: 0.698 ± 0.089
0.419AspGln: 0.419 ± 0.089
0.815AspArg: 0.815 ± 0.154
1.699AspSer: 1.699 ± 0.18
1.303AspThr: 1.303 ± 0.196
1.257AspVal: 1.257 ± 0.162
0.116AspTrp: 0.116 ± 0.051
1.141AspTyr: 1.141 ± 0.152
0.047AspXaa: 0.047 ± 0.032
Glu
1.28GluAla: 1.28 ± 0.19
0.326GluCys: 0.326 ± 0.08
1.164GluAsp: 1.164 ± 0.174
2.304GluGlu: 2.304 ± 0.268
2.165GluPhe: 2.165 ± 0.262
1.746GluGly: 1.746 ± 0.213
0.326GluHis: 0.326 ± 0.083
7.076GluIle: 7.076 ± 0.438
8.077GluLys: 8.077 ± 0.445
1.885GluLeu: 1.885 ± 0.202
0.791GluMet: 0.791 ± 0.128
5.237GluAsn: 5.237 ± 0.435
0.768GluPro: 0.768 ± 0.14
0.722GluGln: 0.722 ± 0.131
1.327GluArg: 1.327 ± 0.188
1.978GluSer: 1.978 ± 0.193
1.746GluThr: 1.746 ± 0.214
1.443GluVal: 1.443 ± 0.27
0.023GluTrp: 0.023 ± 0.022
1.513GluTyr: 1.513 ± 0.191
0.0GluXaa: 0.0 ± 0.0
Phe
0.791PheAla: 0.791 ± 0.122
1.955PheCys: 1.955 ± 0.192
2.234PheAsp: 2.234 ± 0.201
2.537PheGlu: 2.537 ± 0.23
9.59PhePhe: 9.59 ± 0.71
2.397PheGly: 2.397 ± 0.229
0.675PheHis: 0.675 ± 0.099
7.891PheIle: 7.891 ± 0.545
12.057PheLys: 12.057 ± 0.574
8.752PheLeu: 8.752 ± 0.486
1.001PheMet: 1.001 ± 0.142
5.982PheAsn: 5.982 ± 0.407
1.699PhePro: 1.699 ± 0.193
0.605PheGln: 0.605 ± 0.115
1.653PheArg: 1.653 ± 0.152
6.68PheSer: 6.68 ± 0.479
1.792PheThr: 1.792 ± 0.169
2.84PheVal: 2.84 ± 0.25
0.116PheTrp: 0.116 ± 0.069
4.702PheTyr: 4.702 ± 0.36
0.0PheXaa: 0.0 ± 0.0
Gly
1.094GlyAla: 1.094 ± 0.174
0.745GlyCys: 0.745 ± 0.136
1.28GlyAsp: 1.28 ± 0.211
2.281GlyGlu: 2.281 ± 0.22
2.793GlyPhe: 2.793 ± 0.223
3.003GlyGly: 3.003 ± 0.284
0.652GlyHis: 0.652 ± 0.131
5.982GlyIle: 5.982 ± 0.378
5.214GlyLys: 5.214 ± 0.323
2.514GlyLeu: 2.514 ± 0.251
0.582GlyMet: 0.582 ± 0.099
2.63GlyAsn: 2.63 ± 0.255
0.768GlyPro: 0.768 ± 0.127
0.908GlyGln: 0.908 ± 0.166
1.653GlyArg: 1.653 ± 0.229
2.444GlySer: 2.444 ± 0.261
1.978GlyThr: 1.978 ± 0.203
1.909GlyVal: 1.909 ± 0.203
0.256GlyTrp: 0.256 ± 0.082
1.606GlyTyr: 1.606 ± 0.191
0.0GlyXaa: 0.0 ± 0.0
His
0.372HisAla: 0.372 ± 0.092
0.186HisCys: 0.186 ± 0.06
0.186HisAsp: 0.186 ± 0.064
0.279HisGlu: 0.279 ± 0.077
0.605HisPhe: 0.605 ± 0.111
0.582HisGly: 0.582 ± 0.122
0.14HisHis: 0.14 ± 0.062
1.466HisIle: 1.466 ± 0.183
1.28HisLys: 1.28 ± 0.141
0.815HisLeu: 0.815 ± 0.13
0.233HisMet: 0.233 ± 0.07
0.745HisAsn: 0.745 ± 0.131
0.396HisPro: 0.396 ± 0.102
0.209HisGln: 0.209 ± 0.064
0.209HisArg: 0.209 ± 0.059
0.791HisSer: 0.791 ± 0.123
0.442HisThr: 0.442 ± 0.087
0.349HisVal: 0.349 ± 0.114
0.047HisTrp: 0.047 ± 0.034
0.349HisTyr: 0.349 ± 0.103
0.0HisXaa: 0.0 ± 0.0
Ile
2.048IleAla: 2.048 ± 0.208
2.374IleCys: 2.374 ± 0.217
4.958IleAsp: 4.958 ± 0.367
6.587IleGlu: 6.587 ± 0.458
11.917IlePhe: 11.917 ± 0.59
5.633IleGly: 5.633 ± 0.446
1.606IleHis: 1.606 ± 0.204
18.178IleIle: 18.178 ± 0.709
27.861IleLys: 27.861 ± 0.931
13.43IleLeu: 13.43 ± 0.574
2.234IleMet: 2.234 ± 0.242
14.827IleAsn: 14.827 ± 0.621
2.886IlePro: 2.886 ± 0.271
1.397IleGln: 1.397 ± 0.197
4.469IleArg: 4.469 ± 0.292
10.218IleSer: 10.218 ± 0.503
3.887IleThr: 3.887 ± 0.29
5.167IleVal: 5.167 ± 0.402
0.396IleTrp: 0.396 ± 0.098
7.285IleTyr: 7.285 ± 0.439
0.047IleXaa: 0.047 ± 0.042
Lys
1.466LysAla: 1.466 ± 0.185
2.118LysCys: 2.118 ± 0.201
4.353LysAsp: 4.353 ± 0.374
7.984LysGlu: 7.984 ± 0.441
10.218LysPhe: 10.218 ± 0.461
4.05LysGly: 4.05 ± 0.392
1.373LysHis: 1.373 ± 0.174
33.936LysIle: 33.936 ± 1.082
50.555LysLys: 50.555 ± 1.679
9.147LysLeu: 9.147 ± 0.42
3.189LysMet: 3.189 ± 0.27
24.719LysAsn: 24.719 ± 0.805
1.699LysPro: 1.699 ± 0.164
1.862LysGln: 1.862 ± 0.197
4.772LysArg: 4.772 ± 0.322
7.518LysSer: 7.518 ± 0.425
6.727LysThr: 6.727 ± 0.389
5.214LysVal: 5.214 ± 0.359
0.582LysTrp: 0.582 ± 0.136
10.032LysTyr: 10.032 ± 0.486
0.047LysXaa: 0.047 ± 0.035
Leu
1.35LeuAla: 1.35 ± 0.16
0.978LeuCys: 0.978 ± 0.129
2.677LeuAsp: 2.677 ± 0.238
3.841LeuGlu: 3.841 ± 0.301
4.702LeuPhe: 4.702 ± 0.28
4.376LeuGly: 4.376 ± 0.313
0.815LeuHis: 0.815 ± 0.14
9.59LeuIle: 9.59 ± 0.409
15.432LeuLys: 15.432 ± 0.592
5.749LeuLeu: 5.749 ± 0.393
1.187LeuMet: 1.187 ± 0.177
8.147LeuAsn: 8.147 ± 0.427
1.141LeuPro: 1.141 ± 0.142
1.047LeuGln: 1.047 ± 0.171
2.374LeuArg: 2.374 ± 0.234
5.353LeuSer: 5.353 ± 0.364
2.328LeuThr: 2.328 ± 0.207
2.491LeuVal: 2.491 ± 0.215
0.303LeuTrp: 0.303 ± 0.085
4.073LeuTyr: 4.073 ± 0.328
0.023LeuXaa: 0.023 ± 0.018
Met
0.186MetAla: 0.186 ± 0.063
0.303MetCys: 0.303 ± 0.098
0.419MetAsp: 0.419 ± 0.096
0.466MetGlu: 0.466 ± 0.107
1.234MetPhe: 1.234 ± 0.15
0.884MetGly: 0.884 ± 0.127
0.14MetHis: 0.14 ± 0.055
1.746MetIle: 1.746 ± 0.225
3.468MetLys: 3.468 ± 0.286
1.536MetLeu: 1.536 ± 0.159
0.186MetMet: 0.186 ± 0.063
1.303MetAsn: 1.303 ± 0.17
0.349MetPro: 0.349 ± 0.128
0.209MetGln: 0.209 ± 0.066
0.419MetArg: 0.419 ± 0.093
1.024MetSer: 1.024 ± 0.141
0.303MetThr: 0.303 ± 0.077
0.512MetVal: 0.512 ± 0.09
0.07MetTrp: 0.07 ± 0.038
0.605MetTyr: 0.605 ± 0.107
0.0MetXaa: 0.0 ± 0.0
Asn
0.768AsnAla: 0.768 ± 0.163
1.536AsnCys: 1.536 ± 0.18
2.048AsnAsp: 2.048 ± 0.2
3.608AsnGlu: 3.608 ± 0.279
10.241AsnPhe: 10.241 ± 0.532
2.84AsnGly: 2.84 ± 0.277
0.535AsnHis: 0.535 ± 0.106
19.04AsnIle: 19.04 ± 0.662
17.969AsnLys: 17.969 ± 0.699
7.751AsnLeu: 7.751 ± 0.404
1.397AsnMet: 1.397 ± 0.182
9.59AsnAsn: 9.59 ± 0.583
1.466AsnPro: 1.466 ± 0.205
0.931AsnGln: 0.931 ± 0.149
2.584AsnArg: 2.584 ± 0.203
6.075AsnSer: 6.075 ± 0.419
2.188AsnThr: 2.188 ± 0.226
3.654AsnVal: 3.654 ± 0.258
0.256AsnTrp: 0.256 ± 0.074
4.934AsnTyr: 4.934 ± 0.309
0.023AsnXaa: 0.023 ± 0.025
Pro
0.419ProAla: 0.419 ± 0.08
0.349ProCys: 0.349 ± 0.08
0.466ProAsp: 0.466 ± 0.103
0.978ProGlu: 0.978 ± 0.152
1.234ProPhe: 1.234 ± 0.171
0.954ProGly: 0.954 ± 0.168
0.279ProHis: 0.279 ± 0.076
2.677ProIle: 2.677 ± 0.253
2.328ProLys: 2.328 ± 0.214
1.746ProLeu: 1.746 ± 0.185
0.163ProMet: 0.163 ± 0.054
1.28ProAsn: 1.28 ± 0.181
0.233ProPro: 0.233 ± 0.063
0.256ProGln: 0.256 ± 0.09
0.419ProArg: 0.419 ± 0.1
1.21ProSer: 1.21 ± 0.173
0.768ProThr: 0.768 ± 0.153
0.722ProVal: 0.722 ± 0.116
0.14ProTrp: 0.14 ± 0.055
1.071ProTyr: 1.071 ± 0.148
0.0ProXaa: 0.0 ± 0.0
Gln
0.489GlnAla: 0.489 ± 0.115
0.14GlnCys: 0.14 ± 0.056
0.326GlnAsp: 0.326 ± 0.1
0.535GlnGlu: 0.535 ± 0.144
0.722GlnPhe: 0.722 ± 0.114
0.559GlnGly: 0.559 ± 0.119
0.186GlnHis: 0.186 ± 0.067
2.118GlnIle: 2.118 ± 0.237
1.653GlnLys: 1.653 ± 0.187
0.628GlnLeu: 0.628 ± 0.117
0.233GlnMet: 0.233 ± 0.068
1.327GlnAsn: 1.327 ± 0.184
0.279GlnPro: 0.279 ± 0.076
0.186GlnGln: 0.186 ± 0.067
0.675GlnArg: 0.675 ± 0.137
0.768GlnSer: 0.768 ± 0.129
0.419GlnThr: 0.419 ± 0.092
0.372GlnVal: 0.372 ± 0.097
0.0GlnTrp: 0.0 ± 0.0
0.512GlnTyr: 0.512 ± 0.104
0.0GlnXaa: 0.0 ± 0.0
Arg
0.512ArgAla: 0.512 ± 0.105
0.326ArgCys: 0.326 ± 0.081
0.908ArgAsp: 0.908 ± 0.137
1.536ArgGlu: 1.536 ± 0.204
1.606ArgPhe: 1.606 ± 0.219
1.583ArgGly: 1.583 ± 0.234
0.372ArgHis: 0.372 ± 0.112
4.516ArgIle: 4.516 ± 0.293
5.726ArgLys: 5.726 ± 0.385
1.513ArgLeu: 1.513 ± 0.19
0.512ArgMet: 0.512 ± 0.113
3.166ArgAsn: 3.166 ± 0.297
0.466ArgPro: 0.466 ± 0.092
0.512ArgGln: 0.512 ± 0.1
0.815ArgArg: 0.815 ± 0.17
1.676ArgSer: 1.676 ± 0.18
1.071ArgThr: 1.071 ± 0.14
1.001ArgVal: 1.001 ± 0.165
0.0ArgTrp: 0.0 ± 0.0
1.187ArgTyr: 1.187 ± 0.162
0.0ArgXaa: 0.0 ± 0.0
Ser
1.164SerAla: 1.164 ± 0.171
1.373SerCys: 1.373 ± 0.146
1.862SerAsp: 1.862 ± 0.209
2.397SerGlu: 2.397 ± 0.253
4.841SerPhe: 4.841 ± 0.329
3.375SerGly: 3.375 ± 0.278
0.652SerHis: 0.652 ± 0.139
8.356SerIle: 8.356 ± 0.344
10.148SerLys: 10.148 ± 0.533
5.959SerLeu: 5.959 ± 0.352
1.094SerMet: 1.094 ± 0.179
5.726SerAsn: 5.726 ± 0.369
1.373SerPro: 1.373 ± 0.155
0.768SerGln: 0.768 ± 0.127
1.932SerArg: 1.932 ± 0.202
4.166SerSer: 4.166 ± 0.349
1.955SerThr: 1.955 ± 0.174
2.304SerVal: 2.304 ± 0.231
0.209SerTrp: 0.209 ± 0.061
3.142SerTyr: 3.142 ± 0.251
0.0SerXaa: 0.0 ± 0.0
Thr
0.582ThrAla: 0.582 ± 0.127
0.512ThrCys: 0.512 ± 0.108
1.071ThrAsp: 1.071 ± 0.162
1.21ThrGlu: 1.21 ± 0.221
2.188ThrPhe: 2.188 ± 0.23
1.932ThrGly: 1.932 ± 0.225
0.442ThrHis: 0.442 ± 0.103
3.817ThrIle: 3.817 ± 0.282
5.54ThrLys: 5.54 ± 0.369
2.584ThrLeu: 2.584 ± 0.24
0.489ThrMet: 0.489 ± 0.117
2.607ThrAsn: 2.607 ± 0.214
0.954ThrPro: 0.954 ± 0.141
0.442ThrGln: 0.442 ± 0.095
1.164ThrArg: 1.164 ± 0.174
2.095ThrSer: 2.095 ± 0.199
1.559ThrThr: 1.559 ± 0.182
1.071ThrVal: 1.071 ± 0.159
0.14ThrTrp: 0.14 ± 0.06
1.42ThrTyr: 1.42 ± 0.181
0.0ThrXaa: 0.0 ± 0.0
Val
0.815ValAla: 0.815 ± 0.136
0.559ValCys: 0.559 ± 0.109
0.978ValAsp: 0.978 ± 0.18
1.397ValGlu: 1.397 ± 0.202
2.723ValPhe: 2.723 ± 0.227
1.629ValGly: 1.629 ± 0.226
0.419ValHis: 0.419 ± 0.094
4.027ValIle: 4.027 ± 0.311
5.796ValLys: 5.796 ± 0.313
3.561ValLeu: 3.561 ± 0.343
0.466ValMet: 0.466 ± 0.106
2.77ValAsn: 2.77 ± 0.232
0.908ValPro: 0.908 ± 0.126
0.466ValGln: 0.466 ± 0.115
1.117ValArg: 1.117 ± 0.162
3.026ValSer: 3.026 ± 0.234
1.094ValThr: 1.094 ± 0.153
1.117ValVal: 1.117 ± 0.163
0.116ValTrp: 0.116 ± 0.052
1.746ValTyr: 1.746 ± 0.187
0.023ValXaa: 0.023 ± 0.022
Trp
0.047TrpAla: 0.047 ± 0.034
0.047TrpCys: 0.047 ± 0.029
0.163TrpAsp: 0.163 ± 0.078
0.093TrpGlu: 0.093 ± 0.044
0.209TrpPhe: 0.209 ± 0.083
0.14TrpGly: 0.14 ± 0.057
0.0TrpHis: 0.0 ± 0.0
0.419TrpIle: 0.419 ± 0.11
0.419TrpLys: 0.419 ± 0.08
0.303TrpLeu: 0.303 ± 0.077
0.116TrpMet: 0.116 ± 0.049
0.233TrpAsn: 0.233 ± 0.089
0.047TrpPro: 0.047 ± 0.031
0.047TrpGln: 0.047 ± 0.031
0.116TrpArg: 0.116 ± 0.059
0.279TrpSer: 0.279 ± 0.077
0.07TrpThr: 0.07 ± 0.036
0.233TrpVal: 0.233 ± 0.058
0.023TrpTrp: 0.023 ± 0.023
0.14TrpTyr: 0.14 ± 0.065
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.675TyrAla: 0.675 ± 0.104
0.884TyrCys: 0.884 ± 0.127
1.443TyrAsp: 1.443 ± 0.157
1.862TyrGlu: 1.862 ± 0.191
4.143TyrPhe: 4.143 ± 0.35
1.676TyrGly: 1.676 ± 0.23
0.442TyrHis: 0.442 ± 0.091
7.425TyrIle: 7.425 ± 0.367
9.147TyrLys: 9.147 ± 0.414
4.585TyrLeu: 4.585 ± 0.324
0.512TyrMet: 0.512 ± 0.111
4.702TyrAsn: 4.702 ± 0.362
0.954TyrPro: 0.954 ± 0.146
0.512TyrGln: 0.512 ± 0.108
1.443TyrArg: 1.443 ± 0.173
3.375TyrSer: 3.375 ± 0.256
1.327TyrThr: 1.327 ± 0.196
1.629TyrVal: 1.629 ± 0.189
0.209TyrTrp: 0.209 ± 0.075
2.816TyrTyr: 2.816 ± 0.251
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.047XaaIle: 0.047 ± 0.031
0.047XaaLys: 0.047 ± 0.029
0.023XaaLeu: 0.023 ± 0.021
0.023XaaMet: 0.023 ± 0.023
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.047XaaSer: 0.047 ± 0.031
0.023XaaThr: 0.023 ± 0.024
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 154 proteins (42964 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski