Amino acid dipepetide frequency for Saccharothrix australiensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.951AlaAla: 21.951 ± 0.189	1.105AlaCys: 1.105 ± 0.023	9.293AlaAsp: 9.293 ± 0.087	9.412AlaGlu: 9.412 ± 0.09	3.668AlaPhe: 3.668 ± 0.047	13.912AlaGly: 13.912 ± 0.11	3.147AlaHis: 3.147 ± 0.044	3.38AlaIle: 3.38 ± 0.042	2.467AlaLys: 2.467 ± 0.041	15.773AlaLeu: 15.773 ± 0.125	2.094AlaMet: 2.094 ± 0.032	2.098AlaAsn: 2.098 ± 0.03	6.902AlaPro: 6.902 ± 0.074	3.162AlaGln: 3.162 ± 0.049	11.558AlaArg: 11.558 ± 0.108	5.456AlaSer: 5.456 ± 0.048	7.093AlaThr: 7.093 ± 0.069	14.194AlaVal: 14.194 ± 0.124	1.99AlaTrp: 1.99 ± 0.03	2.222AlaTyr: 2.222 ± 0.03	0.0AlaXaa: 0.0 ± 0.0
Cys	1.204CysAla: 1.204 ± 0.024	0.093CysCys: 0.093 ± 0.005	0.488CysAsp: 0.488 ± 0.015	0.358CysGlu: 0.358 ± 0.012	0.215CysPhe: 0.215 ± 0.009	0.942CysGly: 0.942 ± 0.022	0.192CysHis: 0.192 ± 0.01	0.109CysIle: 0.109 ± 0.008	0.107CysLys: 0.107 ± 0.008	0.72CysLeu: 0.72 ± 0.021	0.103CysMet: 0.103 ± 0.007	0.108CysAsn: 0.108 ± 0.007	0.491CysPro: 0.491 ± 0.016	0.129CysGln: 0.129 ± 0.008	0.664CysArg: 0.664 ± 0.017	0.432CysSer: 0.432 ± 0.015	0.42CysThr: 0.42 ± 0.016	0.67CysVal: 0.67 ± 0.019	0.115CysTrp: 0.115 ± 0.008	0.165CysTyr: 0.165 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	8.389AspAla: 8.389 ± 0.089	0.388AspCys: 0.388 ± 0.015	4.03AspAsp: 4.03 ± 0.052	4.099AspGlu: 4.099 ± 0.049	1.645AspPhe: 1.645 ± 0.029	6.469AspGly: 6.469 ± 0.062	1.657AspHis: 1.657 ± 0.031	1.358AspIle: 1.358 ± 0.03	0.886AspLys: 0.886 ± 0.023	7.084AspLeu: 7.084 ± 0.062	0.631AspMet: 0.631 ± 0.019	0.915AspAsn: 0.915 ± 0.028	4.717AspPro: 4.717 ± 0.053	1.577AspGln: 1.577 ± 0.034	6.106AspArg: 6.106 ± 0.067	2.128AspSer: 2.128 ± 0.033	2.856AspThr: 2.856 ± 0.042	5.995AspVal: 5.995 ± 0.054	0.976AspTrp: 0.976 ± 0.022	1.14AspTyr: 1.14 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	6.863GluAla: 6.863 ± 0.068	0.369GluCys: 0.369 ± 0.013	2.711GluAsp: 2.711 ± 0.034	2.957GluGlu: 2.957 ± 0.048	1.658GluPhe: 1.658 ± 0.028	3.818GluGly: 3.818 ± 0.044	1.811GluHis: 1.811 ± 0.032	1.664GluIle: 1.664 ± 0.031	0.927GluLys: 0.927 ± 0.026	6.963GluLeu: 6.963 ± 0.063	0.667GluMet: 0.667 ± 0.02	0.794GluAsn: 0.794 ± 0.023	3.772GluPro: 3.772 ± 0.045	2.111GluGln: 2.111 ± 0.035	5.656GluArg: 5.656 ± 0.057	2.207GluSer: 2.207 ± 0.033	2.168GluThr: 2.168 ± 0.035	5.727GluVal: 5.727 ± 0.06	0.79GluTrp: 0.79 ± 0.022	0.939GluTyr: 0.939 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	4.003PheAla: 4.003 ± 0.045	0.242PheCys: 0.242 ± 0.01	2.208PheAsp: 2.208 ± 0.038	1.357PheGlu: 1.357 ± 0.026	0.797PhePhe: 0.797 ± 0.02	3.14PheGly: 3.14 ± 0.04	0.682PheHis: 0.682 ± 0.016	0.539PheIle: 0.539 ± 0.017	0.407PheLys: 0.407 ± 0.018	2.596PheLeu: 2.596 ± 0.041	0.299PheMet: 0.299 ± 0.013	0.465PheAsn: 0.465 ± 0.016	1.455PhePro: 1.455 ± 0.027	0.626PheGln: 0.626 ± 0.013	2.081PheArg: 2.081 ± 0.032	1.357PheSer: 1.357 ± 0.025	1.962PheThr: 1.962 ± 0.031	2.389PheVal: 2.389 ± 0.034	0.372PheTrp: 0.372 ± 0.012	0.519PheTyr: 0.519 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	11.447GlyAla: 11.447 ± 0.084	0.828GlyCys: 0.828 ± 0.022	5.496GlyAsp: 5.496 ± 0.059	5.085GlyGlu: 5.085 ± 0.046	2.957GlyPhe: 2.957 ± 0.035	9.276GlyGly: 9.276 ± 0.091	2.348GlyHis: 2.348 ± 0.034	2.793GlyIle: 2.793 ± 0.036	1.969GlyLys: 1.969 ± 0.036	9.638GlyLeu: 9.638 ± 0.09	1.81GlyMet: 1.81 ± 0.028	1.637GlyAsn: 1.637 ± 0.037	5.238GlyPro: 5.238 ± 0.059	2.382GlyGln: 2.382 ± 0.039	8.42GlyArg: 8.42 ± 0.073	4.862GlySer: 4.862 ± 0.05	5.611GlyThr: 5.611 ± 0.07	9.465GlyVal: 9.465 ± 0.097	1.689GlyTrp: 1.689 ± 0.029	2.184GlyTyr: 2.184 ± 0.033	0.0GlyXaa: 0.0 ± 0.0
His	2.922HisAla: 2.922 ± 0.039	0.207HisCys: 0.207 ± 0.01	1.534HisAsp: 1.534 ± 0.028	1.274HisGlu: 1.274 ± 0.025	0.596HisPhe: 0.596 ± 0.016	2.412HisGly: 2.412 ± 0.04	0.724HisHis: 0.724 ± 0.021	0.451HisIle: 0.451 ± 0.014	0.271HisLys: 0.271 ± 0.012	2.609HisLeu: 2.609 ± 0.037	0.233HisMet: 0.233 ± 0.01	0.359HisAsn: 0.359 ± 0.012	1.849HisPro: 1.849 ± 0.032	0.598HisGln: 0.598 ± 0.02	2.507HisArg: 2.507 ± 0.038	0.948HisSer: 0.948 ± 0.023	1.11HisThr: 1.11 ± 0.024	2.194HisVal: 2.194 ± 0.035	0.361HisTrp: 0.361 ± 0.014	0.49HisTyr: 0.49 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	4.233IleAla: 4.233 ± 0.056	0.204IleCys: 0.204 ± 0.011	1.758IleAsp: 1.758 ± 0.03	1.464IleGlu: 1.464 ± 0.027	0.476IlePhe: 0.476 ± 0.019	3.136IleGly: 3.136 ± 0.039	0.443IleHis: 0.443 ± 0.015	0.624IleIle: 0.624 ± 0.019	0.542IleLys: 0.542 ± 0.017	1.622IleLeu: 1.622 ± 0.032	0.31IleMet: 0.31 ± 0.013	0.5IleAsn: 0.5 ± 0.017	1.43IlePro: 1.43 ± 0.03	0.502IleGln: 0.502 ± 0.016	1.954IleArg: 1.954 ± 0.031	1.379IleSer: 1.379 ± 0.029	2.028IleThr: 2.028 ± 0.037	2.175IleVal: 2.175 ± 0.039	0.25IleTrp: 0.25 ± 0.011	0.385IleTyr: 0.385 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.261LysAla: 2.261 ± 0.045	0.102LysCys: 0.102 ± 0.007	0.879LysAsp: 0.879 ± 0.025	0.79LysGlu: 0.79 ± 0.023	0.405LysPhe: 0.405 ± 0.017	1.304LysGly: 1.304 ± 0.03	0.378LysHis: 0.378 ± 0.015	0.583LysIle: 0.583 ± 0.02	0.454LysLys: 0.454 ± 0.021	1.753LysLeu: 1.753 ± 0.036	0.273LysMet: 0.273 ± 0.012	0.32LysAsn: 0.32 ± 0.014	1.158LysPro: 1.158 ± 0.026	0.524LysGln: 0.524 ± 0.018	1.308LysArg: 1.308 ± 0.026	0.946LysSer: 0.946 ± 0.022	0.985LysThr: 0.985 ± 0.025	1.712LysVal: 1.712 ± 0.031	0.246LysTrp: 0.246 ± 0.012	0.335LysTyr: 0.335 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	16.581LeuAla: 16.581 ± 0.138	0.815LeuCys: 0.815 ± 0.02	7.373LeuAsp: 7.373 ± 0.066	4.423LeuGlu: 4.423 ± 0.049	2.701LeuPhe: 2.701 ± 0.042	9.619LeuGly: 9.619 ± 0.08	2.421LeuHis: 2.421 ± 0.031	2.509LeuIle: 2.509 ± 0.041	1.536LeuLys: 1.536 ± 0.036	11.367LeuLeu: 11.367 ± 0.122	1.235LeuMet: 1.235 ± 0.025	1.444LeuAsn: 1.444 ± 0.033	6.637LeuPro: 6.637 ± 0.065	1.707LeuGln: 1.707 ± 0.032	9.707LeuArg: 9.707 ± 0.081	5.205LeuSer: 5.205 ± 0.048	6.188LeuThr: 6.188 ± 0.06	11.139LeuVal: 11.139 ± 0.092	1.361LeuTrp: 1.361 ± 0.026	1.574LeuTyr: 1.574 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	1.903MetAla: 1.903 ± 0.033	0.108MetCys: 0.108 ± 0.007	0.672MetAsp: 0.672 ± 0.019	0.48MetGlu: 0.48 ± 0.013	0.369MetPhe: 0.369 ± 0.012	1.1MetGly: 1.1 ± 0.024	0.286MetHis: 0.286 ± 0.013	0.487MetIle: 0.487 ± 0.015	0.295MetLys: 0.295 ± 0.013	1.368MetLeu: 1.368 ± 0.029	0.207MetMet: 0.207 ± 0.011	0.319MetAsn: 0.319 ± 0.011	0.892MetPro: 0.892 ± 0.02	0.307MetGln: 0.307 ± 0.012	1.298MetArg: 1.298 ± 0.026	1.13MetSer: 1.13 ± 0.021	1.316MetThr: 1.316 ± 0.027	1.219MetVal: 1.219 ± 0.024	0.153MetTrp: 0.153 ± 0.008	0.221MetTyr: 0.221 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.129AsnAla: 2.129 ± 0.037	0.154AsnCys: 0.154 ± 0.009	0.828AsnAsp: 0.828 ± 0.018	0.661AsnGlu: 0.661 ± 0.02	0.446AsnPhe: 0.446 ± 0.016	1.749AsnGly: 1.749 ± 0.035	0.393AsnHis: 0.393 ± 0.013	0.467AsnIle: 0.467 ± 0.016	0.266AsnLys: 0.266 ± 0.013	1.634AsnLeu: 1.634 ± 0.032	0.204AsnMet: 0.204 ± 0.01	0.373AsnAsn: 0.373 ± 0.018	1.335AsnPro: 1.335 ± 0.033	0.47AsnGln: 0.47 ± 0.016	1.382AsnArg: 1.382 ± 0.024	0.763AsnSer: 0.763 ± 0.02	0.958AsnThr: 0.958 ± 0.029	1.265AsnVal: 1.265 ± 0.027	0.24AsnTrp: 0.24 ± 0.011	0.376AsnTyr: 0.376 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	8.951ProAla: 8.951 ± 0.086	0.383ProCys: 0.383 ± 0.013	5.052ProAsp: 5.052 ± 0.061	4.043ProGlu: 4.043 ± 0.05	1.582ProPhe: 1.582 ± 0.025	6.549ProGly: 6.549 ± 0.074	1.364ProHis: 1.364 ± 0.027	1.311ProIle: 1.311 ± 0.024	1.016ProLys: 1.016 ± 0.028	5.239ProLeu: 5.239 ± 0.058	0.854ProMet: 0.854 ± 0.021	0.994ProAsn: 0.994 ± 0.027	4.343ProPro: 4.343 ± 0.088	1.256ProGln: 1.256 ± 0.027	4.372ProArg: 4.372 ± 0.053	3.063ProSer: 3.063 ± 0.045	3.572ProThr: 3.572 ± 0.052	6.254ProVal: 6.254 ± 0.066	0.973ProTrp: 0.973 ± 0.023	1.009ProTyr: 1.009 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	3.427GlnAla: 3.427 ± 0.05	0.153GlnCys: 0.153 ± 0.01	1.127GlnAsp: 1.127 ± 0.023	1.106GlnGlu: 1.106 ± 0.021	0.622GlnPhe: 0.622 ± 0.016	1.919GlnGly: 1.919 ± 0.033	0.562GlnHis: 0.562 ± 0.015	0.597GlnIle: 0.597 ± 0.019	0.37GlnLys: 0.37 ± 0.014	2.598GlnLeu: 2.598 ± 0.042	0.288GlnMet: 0.288 ± 0.013	0.38GlnAsn: 0.38 ± 0.015	1.598GlnPro: 1.598 ± 0.037	0.94GlnGln: 0.94 ± 0.03	2.411GlnArg: 2.411 ± 0.032	0.958GlnSer: 0.958 ± 0.021	0.965GlnThr: 0.965 ± 0.022	2.586GlnVal: 2.586 ± 0.039	0.421GlnTrp: 0.421 ± 0.013	0.433GlnTyr: 0.433 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	11.627ArgAla: 11.627 ± 0.108	0.722ArgCys: 0.722 ± 0.017	4.95ArgAsp: 4.95 ± 0.053	4.865ArgGlu: 4.865 ± 0.046	2.686ArgPhe: 2.686 ± 0.034	6.736ArgGly: 6.736 ± 0.057	2.312ArgHis: 2.312 ± 0.037	2.656ArgIle: 2.656 ± 0.038	1.592ArgLys: 1.592 ± 0.032	9.705ArgLeu: 9.705 ± 0.093	1.762ArgMet: 1.762 ± 0.026	1.409ArgAsn: 1.409 ± 0.025	5.458ArgPro: 5.458 ± 0.075	2.203ArgGln: 2.203 ± 0.031	8.847ArgArg: 8.847 ± 0.096	4.24ArgSer: 4.24 ± 0.046	5.055ArgThr: 5.055 ± 0.048	7.77ArgVal: 7.77 ± 0.07	1.616ArgTrp: 1.616 ± 0.028	1.858ArgTyr: 1.858 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	6.707SerAla: 6.707 ± 0.054	0.394SerCys: 0.394 ± 0.012	2.423SerAsp: 2.423 ± 0.033	1.916SerGlu: 1.916 ± 0.028	1.431SerPhe: 1.431 ± 0.028	5.549SerGly: 5.549 ± 0.057	0.893SerHis: 0.893 ± 0.021	1.278SerIle: 1.278 ± 0.026	0.728SerLys: 0.728 ± 0.02	4.547SerLeu: 4.547 ± 0.055	0.861SerMet: 0.861 ± 0.017	0.772SerAsn: 0.772 ± 0.021	3.061SerPro: 3.061 ± 0.043	0.927SerGln: 0.927 ± 0.023	3.666SerArg: 3.666 ± 0.043	2.536SerSer: 2.536 ± 0.043	3.082SerThr: 3.082 ± 0.047	4.233SerVal: 4.233 ± 0.047	0.901SerTrp: 0.901 ± 0.024	1.001SerTyr: 1.001 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	8.685ThrAla: 8.685 ± 0.066	0.41ThrCys: 0.41 ± 0.014	3.268ThrAsp: 3.268 ± 0.044	2.67ThrGlu: 2.67 ± 0.033	1.489ThrPhe: 1.489 ± 0.028	6.661ThrGly: 6.661 ± 0.07	1.044ThrHis: 1.044 ± 0.024	1.505ThrIle: 1.505 ± 0.033	0.91ThrLys: 0.91 ± 0.023	4.865ThrLeu: 4.865 ± 0.051	0.765ThrMet: 0.765 ± 0.022	0.921ThrAsn: 0.921 ± 0.026	4.151ThrPro: 4.151 ± 0.065	0.99ThrGln: 0.99 ± 0.022	4.052ThrArg: 4.052 ± 0.045	3.067ThrSer: 3.067 ± 0.048	4.174ThrThr: 4.174 ± 0.075	5.502ThrVal: 5.502 ± 0.055	0.94ThrTrp: 0.94 ± 0.02	1.078ThrTyr: 1.078 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	13.602ValAla: 13.602 ± 0.106	0.746ValCys: 0.746 ± 0.019	6.859ValAsp: 6.859 ± 0.065	5.937ValGlu: 5.937 ± 0.052	2.675ValPhe: 2.675 ± 0.042	8.026ValGly: 8.026 ± 0.068	2.157ValHis: 2.157 ± 0.033	2.44ValIle: 2.44 ± 0.037	1.496ValLys: 1.496 ± 0.036	11.498ValLeu: 11.498 ± 0.101	1.158ValMet: 1.158 ± 0.023	1.63ValAsn: 1.63 ± 0.029	5.811ValPro: 5.811 ± 0.066	1.949ValGln: 1.949 ± 0.033	8.554ValArg: 8.554 ± 0.075	4.399ValSer: 4.399 ± 0.056	5.649ValThr: 5.649 ± 0.057	11.433ValVal: 11.433 ± 0.105	1.14ValTrp: 1.14 ± 0.021	1.419ValTyr: 1.419 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.683TrpAla: 1.683 ± 0.03	0.154TrpCys: 0.154 ± 0.008	0.806TrpAsp: 0.806 ± 0.019	0.698TrpGlu: 0.698 ± 0.019	0.495TrpPhe: 0.495 ± 0.016	1.033TrpGly: 1.033 ± 0.027	0.413TrpHis: 0.413 ± 0.015	0.377TrpIle: 0.377 ± 0.012	0.219TrpLys: 0.219 ± 0.011	1.914TrpLeu: 1.914 ± 0.026	0.226TrpMet: 0.226 ± 0.01	0.329TrpAsn: 0.329 ± 0.014	0.844TrpPro: 0.844 ± 0.019	0.578TrpGln: 0.578 ± 0.017	1.63TrpArg: 1.63 ± 0.03	1.001TrpSer: 1.001 ± 0.022	0.968TrpThr: 0.968 ± 0.019	1.217TrpVal: 1.217 ± 0.023	0.354TrpTrp: 0.354 ± 0.014	0.287TrpTyr: 0.287 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.308TyrAla: 2.308 ± 0.034	0.147TyrCys: 0.147 ± 0.009	1.292TyrAsp: 1.292 ± 0.033	0.976TyrGlu: 0.976 ± 0.021	0.58TyrPhe: 0.58 ± 0.017	1.786TyrGly: 1.786 ± 0.031	0.421TyrHis: 0.421 ± 0.015	0.288TyrIle: 0.288 ± 0.011	0.258TyrLys: 0.258 ± 0.012	2.05TyrLeu: 2.05 ± 0.036	0.151TyrMet: 0.151 ± 0.008	0.326TyrAsn: 0.326 ± 0.013	1.038TyrPro: 1.038 ± 0.023	0.52TyrGln: 0.52 ± 0.014	1.895TyrArg: 1.895 ± 0.031	0.829TyrSer: 0.829 ± 0.017	0.989TyrThr: 0.989 ± 0.026	1.44TyrVal: 1.44 ± 0.031	0.34TyrTrp: 0.34 ± 0.014	0.395TyrTyr: 0.395 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6519 proteins (2270699 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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