Amino acid dipepetide frequency for Hyphopichia burtonii NRRL Y-1933

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.775AlaAla: 3.775 ± 0.058	0.596AlaCys: 0.596 ± 0.014	2.524AlaAsp: 2.524 ± 0.034	2.837AlaGlu: 2.837 ± 0.041	2.213AlaPhe: 2.213 ± 0.032	2.846AlaGly: 2.846 ± 0.047	0.977AlaHis: 0.977 ± 0.015	3.592AlaIle: 3.592 ± 0.041	3.904AlaLys: 3.904 ± 0.04	4.866AlaLeu: 4.866 ± 0.052	0.929AlaMet: 0.929 ± 0.019	3.147AlaAsn: 3.147 ± 0.031	2.384AlaPro: 2.384 ± 0.04	1.893AlaGln: 1.893 ± 0.033	2.072AlaArg: 2.072 ± 0.029	4.854AlaSer: 4.854 ± 0.062	2.942AlaThr: 2.942 ± 0.036	2.782AlaVal: 2.782 ± 0.038	0.456AlaTrp: 0.456 ± 0.014	1.663AlaTyr: 1.663 ± 0.026	0.0AlaXaa: 0.0 ± 0.0
Cys	0.496CysAla: 0.496 ± 0.013	0.233CysCys: 0.233 ± 0.011	0.615CysAsp: 0.615 ± 0.015	0.525CysGlu: 0.525 ± 0.012	0.64CysPhe: 0.64 ± 0.015	0.724CysGly: 0.724 ± 0.019	0.285CysHis: 0.285 ± 0.011	0.81CysIle: 0.81 ± 0.017	0.627CysLys: 0.627 ± 0.016	1.198CysLeu: 1.198 ± 0.02	0.207CysMet: 0.207 ± 0.009	0.547CysAsn: 0.547 ± 0.014	0.442CysPro: 0.442 ± 0.014	0.399CysGln: 0.399 ± 0.015	0.376CysArg: 0.376 ± 0.014	0.826CysSer: 0.826 ± 0.02	0.47CysThr: 0.47 ± 0.015	0.548CysVal: 0.548 ± 0.015	0.146CysTrp: 0.146 ± 0.007	0.419CysTyr: 0.419 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	2.769AspAla: 2.769 ± 0.037	0.581AspCys: 0.581 ± 0.016	5.361AspAsp: 5.361 ± 0.075	5.367AspGlu: 5.367 ± 0.055	2.996AspPhe: 2.996 ± 0.037	2.732AspGly: 2.732 ± 0.037	1.329AspHis: 1.329 ± 0.03	4.299AspIle: 4.299 ± 0.04	3.962AspLys: 3.962 ± 0.045	6.498AspLeu: 6.498 ± 0.05	0.969AspMet: 0.969 ± 0.021	3.336AspAsn: 3.336 ± 0.037	2.535AspPro: 2.535 ± 0.034	2.311AspGln: 2.311 ± 0.036	1.902AspArg: 1.902 ± 0.029	5.263AspSer: 5.263 ± 0.056	2.701AspThr: 2.701 ± 0.033	3.102AspVal: 3.102 ± 0.032	0.659AspTrp: 0.659 ± 0.016	2.541AspTyr: 2.541 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	3.322GluAla: 3.322 ± 0.04	0.537GluCys: 0.537 ± 0.015	4.51GluAsp: 4.51 ± 0.051	6.166GluGlu: 6.166 ± 0.092	2.876GluPhe: 2.876 ± 0.031	2.579GluGly: 2.579 ± 0.029	1.134GluHis: 1.134 ± 0.024	4.61GluIle: 4.61 ± 0.045	5.065GluLys: 5.065 ± 0.057	6.513GluLeu: 6.513 ± 0.065	1.14GluMet: 1.14 ± 0.018	4.352GluAsn: 4.352 ± 0.052	2.017GluPro: 2.017 ± 0.032	2.382GluGln: 2.382 ± 0.032	2.505GluArg: 2.505 ± 0.034	5.37GluSer: 5.37 ± 0.051	3.217GluThr: 3.217 ± 0.039	3.338GluVal: 3.338 ± 0.041	0.613GluTrp: 0.613 ± 0.015	2.289GluTyr: 2.289 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	2.374PheAla: 2.374 ± 0.032	0.502PheCys: 0.502 ± 0.016	3.111PheAsp: 3.111 ± 0.033	2.948PheGlu: 2.948 ± 0.032	2.192PhePhe: 2.192 ± 0.032	2.774PheGly: 2.774 ± 0.044	0.993PheHis: 0.993 ± 0.02	3.407PheIle: 3.407 ± 0.045	3.542PheLys: 3.542 ± 0.037	4.236PheLeu: 4.236 ± 0.043	0.86PheMet: 0.86 ± 0.018	3.417PheAsn: 3.417 ± 0.036	1.808PhePro: 1.808 ± 0.024	1.827PheGln: 1.827 ± 0.024	1.522PheArg: 1.522 ± 0.027	3.466PheSer: 3.466 ± 0.04	2.467PheThr: 2.467 ± 0.027	2.422PheVal: 2.422 ± 0.034	0.527PheTrp: 0.527 ± 0.014	1.605PheTyr: 1.605 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	2.804GlyAla: 2.804 ± 0.043	0.66GlyCys: 0.66 ± 0.017	2.8GlyAsp: 2.8 ± 0.035	2.863GlyGlu: 2.863 ± 0.036	2.683GlyPhe: 2.683 ± 0.035	3.595GlyGly: 3.595 ± 0.058	1.075GlyHis: 1.075 ± 0.022	3.609GlyIle: 3.609 ± 0.04	3.529GlyLys: 3.529 ± 0.041	5.032GlyLeu: 5.032 ± 0.049	0.866GlyMet: 0.866 ± 0.02	2.827GlyAsn: 2.827 ± 0.037	1.685GlyPro: 1.685 ± 0.028	1.624GlyGln: 1.624 ± 0.027	1.912GlyArg: 1.912 ± 0.027	4.673GlySer: 4.673 ± 0.057	2.59GlyThr: 2.59 ± 0.038	3.022GlyVal: 3.022 ± 0.037	0.618GlyTrp: 0.618 ± 0.016	2.005GlyTyr: 2.005 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	0.906HisAla: 0.906 ± 0.016	0.266HisCys: 0.266 ± 0.009	1.269HisAsp: 1.269 ± 0.024	1.334HisGlu: 1.334 ± 0.025	1.01HisPhe: 1.01 ± 0.019	1.089HisGly: 1.089 ± 0.02	0.818HisHis: 0.818 ± 0.024	1.411HisIle: 1.411 ± 0.024	1.382HisLys: 1.382 ± 0.026	2.267HisLeu: 2.267 ± 0.029	0.333HisMet: 0.333 ± 0.011	1.299HisAsn: 1.299 ± 0.022	1.188HisPro: 1.188 ± 0.02	1.098HisGln: 1.098 ± 0.024	0.888HisArg: 0.888 ± 0.017	1.832HisSer: 1.832 ± 0.026	0.936HisThr: 0.936 ± 0.018	0.967HisVal: 0.967 ± 0.018	0.224HisTrp: 0.224 ± 0.009	0.837HisTyr: 0.837 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	3.417IleAla: 3.417 ± 0.039	0.794IleCys: 0.794 ± 0.018	4.875IleAsp: 4.875 ± 0.054	4.694IleGlu: 4.694 ± 0.047	3.133IlePhe: 3.133 ± 0.036	3.608IleGly: 3.608 ± 0.04	1.594IleHis: 1.594 ± 0.025	5.038IleIle: 5.038 ± 0.057	5.335IleLys: 5.335 ± 0.051	6.747IleLeu: 6.747 ± 0.062	1.28IleMet: 1.28 ± 0.02	5.131IleAsn: 5.131 ± 0.059	3.561IlePro: 3.561 ± 0.034	2.58IleGln: 2.58 ± 0.03	2.665IleArg: 2.665 ± 0.032	6.058IleSer: 6.058 ± 0.053	3.827IleThr: 3.827 ± 0.039	3.583IleVal: 3.583 ± 0.039	0.749IleTrp: 0.749 ± 0.017	2.405IleTyr: 2.405 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	3.617LysAla: 3.617 ± 0.047	0.643LysCys: 0.643 ± 0.017	4.413LysAsp: 4.413 ± 0.047	5.081LysGlu: 5.081 ± 0.064	3.489LysPhe: 3.489 ± 0.036	2.922LysGly: 2.922 ± 0.037	1.526LysHis: 1.526 ± 0.025	5.323LysIle: 5.323 ± 0.056	6.459LysLys: 6.459 ± 0.068	8.063LysLeu: 8.063 ± 0.062	1.184LysMet: 1.184 ± 0.022	4.9LysAsn: 4.9 ± 0.043	3.342LysPro: 3.342 ± 0.044	3.058LysGln: 3.058 ± 0.043	3.291LysArg: 3.291 ± 0.041	6.375LysSer: 6.375 ± 0.059	3.774LysThr: 3.774 ± 0.035	3.96LysVal: 3.96 ± 0.04	0.735LysTrp: 0.735 ± 0.018	2.863LysTyr: 2.863 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	5.384LeuAla: 5.384 ± 0.055	1.073LeuCys: 1.073 ± 0.019	5.511LeuAsp: 5.511 ± 0.05	5.783LeuGlu: 5.783 ± 0.052	4.205LeuPhe: 4.205 ± 0.043	4.822LeuGly: 4.822 ± 0.049	1.928LeuHis: 1.928 ± 0.03	7.415LeuIle: 7.415 ± 0.074	8.068LeuLys: 8.068 ± 0.067	9.344LeuLeu: 9.344 ± 0.084	1.802LeuMet: 1.802 ± 0.031	6.98LeuAsn: 6.98 ± 0.068	4.621LeuPro: 4.621 ± 0.042	3.964LeuGln: 3.964 ± 0.036	3.82LeuArg: 3.82 ± 0.042	8.97LeuSer: 8.97 ± 0.065	5.399LeuThr: 5.399 ± 0.045	5.405LeuVal: 5.405 ± 0.049	0.845LeuTrp: 0.845 ± 0.018	3.158LeuTyr: 3.158 ± 0.038	0.0LeuXaa: 0.0 ± 0.0
Met	1.151MetAla: 1.151 ± 0.025	0.195MetCys: 0.195 ± 0.009	0.977MetAsp: 0.977 ± 0.019	0.948MetGlu: 0.948 ± 0.018	0.721MetPhe: 0.721 ± 0.016	0.987MetGly: 0.987 ± 0.021	0.254MetHis: 0.254 ± 0.008	1.312MetIle: 1.312 ± 0.024	1.393MetLys: 1.393 ± 0.024	1.42MetLeu: 1.42 ± 0.024	0.448MetMet: 0.448 ± 0.014	1.263MetAsn: 1.263 ± 0.027	0.622MetPro: 0.622 ± 0.014	0.489MetGln: 0.489 ± 0.013	0.609MetArg: 0.609 ± 0.016	1.821MetSer: 1.821 ± 0.024	0.967MetThr: 0.967 ± 0.021	1.037MetVal: 1.037 ± 0.021	0.137MetTrp: 0.137 ± 0.007	0.499MetTyr: 0.499 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.826AsnAla: 2.826 ± 0.037	0.641AsnCys: 0.641 ± 0.016	4.846AsnAsp: 4.846 ± 0.048	4.781AsnGlu: 4.781 ± 0.042	2.995AsnPhe: 2.995 ± 0.037	3.437AsnGly: 3.437 ± 0.05	1.748AsnHis: 1.748 ± 0.029	4.161AsnIle: 4.161 ± 0.046	4.819AsnLys: 4.819 ± 0.05	6.6AsnLeu: 6.6 ± 0.065	1.047AsnMet: 1.047 ± 0.022	5.255AsnAsn: 5.255 ± 0.072	3.03AsnPro: 3.03 ± 0.04	3.154AsnGln: 3.154 ± 0.045	2.213AsnArg: 2.213 ± 0.028	6.19AsnSer: 6.19 ± 0.069	3.233AsnThr: 3.233 ± 0.038	3.028AsnVal: 3.028 ± 0.033	0.714AsnTrp: 0.714 ± 0.018	2.672AsnTyr: 2.672 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	2.289ProAla: 2.289 ± 0.037	0.311ProCys: 0.311 ± 0.011	2.276ProAsp: 2.276 ± 0.027	2.975ProGlu: 2.975 ± 0.037	1.97ProPhe: 1.97 ± 0.029	2.026ProGly: 2.026 ± 0.029	0.92ProHis: 0.92 ± 0.021	3.277ProIle: 3.277 ± 0.039	3.264ProLys: 3.264 ± 0.043	3.928ProLeu: 3.928 ± 0.038	0.679ProMet: 0.679 ± 0.019	3.013ProAsn: 3.013 ± 0.038	2.868ProPro: 2.868 ± 0.086	2.13ProGln: 2.13 ± 0.043	1.617ProArg: 1.617 ± 0.022	4.401ProSer: 4.401 ± 0.051	2.781ProThr: 2.781 ± 0.037	2.542ProVal: 2.542 ± 0.036	0.393ProTrp: 0.393 ± 0.014	1.401ProTyr: 1.401 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	2.111GlnAla: 2.111 ± 0.035	0.35GlnCys: 0.35 ± 0.012	2.175GlnAsp: 2.175 ± 0.029	2.559GlnGlu: 2.559 ± 0.036	1.85GlnPhe: 1.85 ± 0.028	1.706GlnGly: 1.706 ± 0.027	0.911GlnHis: 0.911 ± 0.023	2.694GlnIle: 2.694 ± 0.031	2.583GlnLys: 2.583 ± 0.028	4.375GlnLeu: 4.375 ± 0.042	0.704GlnMet: 0.704 ± 0.018	2.512GlnAsn: 2.512 ± 0.032	2.001GlnPro: 2.001 ± 0.036	3.133GlnGln: 3.133 ± 0.1	1.631GlnArg: 1.631 ± 0.028	3.293GlnSer: 3.293 ± 0.042	1.975GlnThr: 1.975 ± 0.028	2.166GlnVal: 2.166 ± 0.03	0.357GlnTrp: 0.357 ± 0.012	1.458GlnTyr: 1.458 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	1.979ArgAla: 1.979 ± 0.032	0.421ArgCys: 0.421 ± 0.013	2.07ArgAsp: 2.07 ± 0.03	2.315ArgGlu: 2.315 ± 0.032	1.856ArgPhe: 1.856 ± 0.028	1.874ArgGly: 1.874 ± 0.032	0.831ArgHis: 0.831 ± 0.018	2.665ArgIle: 2.665 ± 0.031	3.154ArgLys: 3.154 ± 0.04	3.97ArgLeu: 3.97 ± 0.046	0.674ArgMet: 0.674 ± 0.016	2.338ArgAsn: 2.338 ± 0.033	1.578ArgPro: 1.578 ± 0.028	1.581ArgGln: 1.581 ± 0.027	2.247ArgArg: 2.247 ± 0.038	3.273ArgSer: 3.273 ± 0.038	1.803ArgThr: 1.803 ± 0.025	2.028ArgVal: 2.028 ± 0.029	0.389ArgTrp: 0.389 ± 0.014	1.378ArgTyr: 1.378 ± 0.024	0.0ArgXaa: 0.0 ± 0.0
Ser	4.177SerAla: 4.177 ± 0.051	0.806SerCys: 0.806 ± 0.018	4.847SerAsp: 4.847 ± 0.05	4.528SerGlu: 4.528 ± 0.051	4.063SerPhe: 4.063 ± 0.041	4.423SerGly: 4.423 ± 0.055	1.848SerHis: 1.848 ± 0.025	6.942SerIle: 6.942 ± 0.058	6.934SerLys: 6.934 ± 0.063	8.692SerLeu: 8.692 ± 0.068	1.55SerMet: 1.55 ± 0.025	7.087SerAsn: 7.087 ± 0.077	4.108SerPro: 4.108 ± 0.052	3.341SerGln: 3.341 ± 0.038	3.405SerArg: 3.405 ± 0.041	10.357SerSer: 10.357 ± 0.148	5.391SerThr: 5.391 ± 0.062	4.369SerVal: 4.369 ± 0.043	0.815SerTrp: 0.815 ± 0.02	2.791SerTyr: 2.791 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	2.765ThrAla: 2.765 ± 0.039	0.606ThrCys: 0.606 ± 0.016	2.761ThrAsp: 2.761 ± 0.035	2.71ThrGlu: 2.71 ± 0.027	2.299ThrPhe: 2.299 ± 0.029	2.944ThrGly: 2.944 ± 0.046	1.066ThrHis: 1.066 ± 0.018	3.764ThrIle: 3.764 ± 0.039	3.993ThrLys: 3.993 ± 0.039	4.881ThrLeu: 4.881 ± 0.04	0.816ThrMet: 0.816 ± 0.019	3.718ThrAsn: 3.718 ± 0.042	3.065ThrPro: 3.065 ± 0.038	1.795ThrGln: 1.795 ± 0.028	2.034ThrArg: 2.034 ± 0.027	5.229ThrSer: 5.229 ± 0.053	3.334ThrThr: 3.334 ± 0.049	2.773ThrVal: 2.773 ± 0.034	0.507ThrTrp: 0.507 ± 0.016	1.729ThrTyr: 1.729 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	2.997ValAla: 2.997 ± 0.043	0.619ValCys: 0.619 ± 0.016	3.358ValAsp: 3.358 ± 0.035	3.423ValGlu: 3.423 ± 0.035	2.514ValPhe: 2.514 ± 0.034	2.877ValGly: 2.877 ± 0.04	1.035ValHis: 1.035 ± 0.02	3.673ValIle: 3.673 ± 0.038	3.866ValLys: 3.866 ± 0.035	5.058ValLeu: 5.058 ± 0.049	0.969ValMet: 0.969 ± 0.018	3.236ValAsn: 3.236 ± 0.032	2.463ValPro: 2.463 ± 0.031	1.723ValGln: 1.723 ± 0.025	1.92ValArg: 1.92 ± 0.028	4.547ValSer: 4.547 ± 0.043	2.749ValThr: 2.749 ± 0.03	3.14ValVal: 3.14 ± 0.038	0.545ValTrp: 0.545 ± 0.015	1.858ValTyr: 1.858 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	0.492TrpAla: 0.492 ± 0.013	0.218TrpCys: 0.218 ± 0.01	0.643TrpAsp: 0.643 ± 0.018	0.539TrpGlu: 0.539 ± 0.015	0.541TrpPhe: 0.541 ± 0.013	0.557TrpGly: 0.557 ± 0.016	0.197TrpHis: 0.197 ± 0.009	0.708TrpIle: 0.708 ± 0.015	0.728TrpLys: 0.728 ± 0.016	1.039TrpLeu: 1.039 ± 0.022	0.186TrpMet: 0.186 ± 0.008	0.667TrpAsn: 0.667 ± 0.015	0.29TrpPro: 0.29 ± 0.01	0.339TrpGln: 0.339 ± 0.012	0.453TrpArg: 0.453 ± 0.015	0.851TrpSer: 0.851 ± 0.019	0.479TrpThr: 0.479 ± 0.015	0.541TrpVal: 0.541 ± 0.015	0.162TrpTrp: 0.162 ± 0.007	0.386TrpTyr: 0.386 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.601TyrAla: 1.601 ± 0.026	0.481TyrCys: 0.481 ± 0.014	2.273TyrAsp: 2.273 ± 0.03	2.157TyrGlu: 2.157 ± 0.032	1.756TyrPhe: 1.756 ± 0.026	1.949TyrGly: 1.949 ± 0.032	0.885TyrHis: 0.885 ± 0.018	2.363TyrIle: 2.363 ± 0.033	2.413TyrLys: 2.413 ± 0.031	3.771TyrLeu: 3.771 ± 0.036	0.605TyrMet: 0.605 ± 0.014	2.366TyrAsn: 2.366 ± 0.031	1.455TyrPro: 1.455 ± 0.026	1.722TyrGln: 1.722 ± 0.027	1.341TyrArg: 1.341 ± 0.019	2.825TyrSer: 2.825 ± 0.033	1.752TyrThr: 1.752 ± 0.021	1.816TyrVal: 1.816 ± 0.026	0.426TyrTrp: 0.426 ± 0.011	1.579TyrTyr: 1.579 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 5994 proteins (2810767 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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