Amino acid dipepetide frequency for Donghicola eburneus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.552AlaAla: 14.552 ± 0.166	1.06AlaCys: 1.06 ± 0.033	6.752AlaAsp: 6.752 ± 0.08	8.339AlaGlu: 8.339 ± 0.106	3.962AlaPhe: 3.962 ± 0.062	9.558AlaGly: 9.558 ± 0.097	2.088AlaHis: 2.088 ± 0.043	5.99AlaIle: 5.99 ± 0.064	4.344AlaLys: 4.344 ± 0.067	12.824AlaLeu: 12.824 ± 0.123	3.774AlaMet: 3.774 ± 0.058	2.943AlaAsn: 2.943 ± 0.053	5.407AlaPro: 5.407 ± 0.087	4.322AlaGln: 4.322 ± 0.067	7.211AlaArg: 7.211 ± 0.093	5.674AlaSer: 5.674 ± 0.075	5.781AlaThr: 5.781 ± 0.066	7.763AlaVal: 7.763 ± 0.087	1.348AlaTrp: 1.348 ± 0.033	2.586AlaTyr: 2.586 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	1.102CysAla: 1.102 ± 0.031	0.129CysCys: 0.129 ± 0.012	0.666CysAsp: 0.666 ± 0.029	0.458CysGlu: 0.458 ± 0.022	0.347CysPhe: 0.347 ± 0.02	0.929CysGly: 0.929 ± 0.029	0.276CysHis: 0.276 ± 0.017	0.451CysIle: 0.451 ± 0.018	0.238CysLys: 0.238 ± 0.014	0.837CysLeu: 0.837 ± 0.029	0.216CysMet: 0.216 ± 0.012	0.228CysAsn: 0.228 ± 0.013	0.529CysPro: 0.529 ± 0.021	0.242CysGln: 0.242 ± 0.014	0.512CysArg: 0.512 ± 0.021	0.486CysSer: 0.486 ± 0.021	0.497CysThr: 0.497 ± 0.024	0.65CysVal: 0.65 ± 0.024	0.132CysTrp: 0.132 ± 0.01	0.216CysTyr: 0.216 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.116AspAla: 7.116 ± 0.082	0.534AspCys: 0.534 ± 0.021	3.539AspAsp: 3.539 ± 0.084	3.624AspGlu: 3.624 ± 0.058	2.358AspPhe: 2.358 ± 0.045	5.522AspGly: 5.522 ± 0.08	1.358AspHis: 1.358 ± 0.037	3.337AspIle: 3.337 ± 0.053	1.965AspLys: 1.965 ± 0.044	6.669AspLeu: 6.669 ± 0.083	1.787AspMet: 1.787 ± 0.041	1.43AspAsn: 1.43 ± 0.039	3.38AspPro: 3.38 ± 0.059	2.064AspGln: 2.064 ± 0.045	4.004AspArg: 4.004 ± 0.062	2.438AspSer: 2.438 ± 0.05	3.305AspThr: 3.305 ± 0.075	4.463AspVal: 4.463 ± 0.072	1.135AspTrp: 1.135 ± 0.036	1.634AspTyr: 1.634 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	7.884GluAla: 7.884 ± 0.107	0.424GluCys: 0.424 ± 0.018	3.753GluAsp: 3.753 ± 0.068	4.122GluGlu: 4.122 ± 0.073	1.923GluPhe: 1.923 ± 0.039	5.071GluGly: 5.071 ± 0.07	1.252GluHis: 1.252 ± 0.035	3.856GluIle: 3.856 ± 0.06	2.366GluLys: 2.366 ± 0.051	5.43GluLeu: 5.43 ± 0.074	2.111GluMet: 2.111 ± 0.047	2.055GluAsn: 2.055 ± 0.041	2.384GluPro: 2.384 ± 0.044	2.245GluGln: 2.245 ± 0.044	4.242GluArg: 4.242 ± 0.067	2.395GluSer: 2.395 ± 0.048	4.003GluThr: 4.003 ± 0.06	4.489GluVal: 4.489 ± 0.063	0.741GluTrp: 0.741 ± 0.025	1.248GluTyr: 1.248 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.29PheAla: 4.29 ± 0.061	0.44PheCys: 0.44 ± 0.019	2.867PheAsp: 2.867 ± 0.049	2.328PheGlu: 2.328 ± 0.044	1.443PhePhe: 1.443 ± 0.037	3.702PheGly: 3.702 ± 0.068	0.743PheHis: 0.743 ± 0.027	1.675PheIle: 1.675 ± 0.04	1.139PheLys: 1.139 ± 0.027	3.234PheLeu: 3.234 ± 0.064	0.91PheMet: 0.91 ± 0.026	1.065PheAsn: 1.065 ± 0.033	1.484PhePro: 1.484 ± 0.035	1.06PheGln: 1.06 ± 0.029	2.082PheArg: 2.082 ± 0.041	2.245PheSer: 2.245 ± 0.046	2.034PheThr: 2.034 ± 0.039	2.787PheVal: 2.787 ± 0.05	0.54PheTrp: 0.54 ± 0.022	1.0PheTyr: 1.0 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	9.324GlyAla: 9.324 ± 0.091	0.852GlyCys: 0.852 ± 0.029	4.794GlyAsp: 4.794 ± 0.086	4.691GlyGlu: 4.691 ± 0.058	3.49GlyPhe: 3.49 ± 0.054	7.166GlyGly: 7.166 ± 0.115	1.887GlyHis: 1.887 ± 0.039	4.644GlyIle: 4.644 ± 0.066	3.2GlyLys: 3.2 ± 0.05	8.58GlyLeu: 8.58 ± 0.098	2.636GlyMet: 2.636 ± 0.051	2.4GlyAsn: 2.4 ± 0.067	3.251GlyPro: 3.251 ± 0.056	3.255GlyGln: 3.255 ± 0.057	5.196GlyArg: 5.196 ± 0.074	4.369GlySer: 4.369 ± 0.07	4.668GlyThr: 4.668 ± 0.063	6.347GlyVal: 6.347 ± 0.071	1.391GlyTrp: 1.391 ± 0.039	2.411GlyTyr: 2.411 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	2.166HisAla: 2.166 ± 0.044	0.233HisCys: 0.233 ± 0.014	1.246HisAsp: 1.246 ± 0.033	1.042HisGlu: 1.042 ± 0.031	0.832HisPhe: 0.832 ± 0.025	1.861HisGly: 1.861 ± 0.036	0.579HisHis: 0.579 ± 0.028	1.027HisIle: 1.027 ± 0.026	0.66HisLys: 0.66 ± 0.024	2.094HisLeu: 2.094 ± 0.048	0.638HisMet: 0.638 ± 0.024	0.51HisAsn: 0.51 ± 0.019	1.29HisPro: 1.29 ± 0.038	0.619HisGln: 0.619 ± 0.022	1.241HisArg: 1.241 ± 0.034	0.993HisSer: 0.993 ± 0.029	0.938HisThr: 0.938 ± 0.027	1.425HisVal: 1.425 ± 0.034	0.312HisTrp: 0.312 ± 0.015	0.564HisTyr: 0.564 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.983IleAla: 6.983 ± 0.08	0.655IleCys: 0.655 ± 0.023	3.529IleAsp: 3.529 ± 0.057	3.86IleGlu: 3.86 ± 0.064	1.841IlePhe: 1.841 ± 0.041	4.797IleGly: 4.797 ± 0.064	0.998IleHis: 0.998 ± 0.023	2.514IleIle: 2.514 ± 0.05	1.77IleLys: 1.77 ± 0.038	4.898IleLeu: 4.898 ± 0.079	1.238IleMet: 1.238 ± 0.037	1.496IleAsn: 1.496 ± 0.035	2.461IlePro: 2.461 ± 0.045	1.479IleGln: 1.479 ± 0.038	3.065IleArg: 3.065 ± 0.053	3.311IleSer: 3.311 ± 0.053	3.216IleThr: 3.216 ± 0.052	3.826IleVal: 3.826 ± 0.059	0.727IleTrp: 0.727 ± 0.024	1.258IleTyr: 1.258 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	4.235LysAla: 4.235 ± 0.064	0.227LysCys: 0.227 ± 0.013	2.049LysAsp: 2.049 ± 0.044	2.071LysGlu: 2.071 ± 0.044	1.126LysPhe: 1.126 ± 0.032	2.945LysGly: 2.945 ± 0.052	0.68LysHis: 0.68 ± 0.022	1.871LysIle: 1.871 ± 0.04	1.445LysLys: 1.445 ± 0.039	3.274LysLeu: 3.274 ± 0.049	1.054LysMet: 1.054 ± 0.029	0.968LysAsn: 0.968 ± 0.026	1.877LysPro: 1.877 ± 0.045	1.03LysGln: 1.03 ± 0.03	2.341LysArg: 2.341 ± 0.05	2.072LysSer: 2.072 ± 0.042	2.156LysThr: 2.156 ± 0.043	2.56LysVal: 2.56 ± 0.052	0.457LysTrp: 0.457 ± 0.02	0.777LysTyr: 0.777 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	11.389LeuAla: 11.389 ± 0.103	0.952LeuCys: 0.952 ± 0.03	5.985LeuAsp: 5.985 ± 0.074	5.6LeuGlu: 5.6 ± 0.085	3.507LeuPhe: 3.507 ± 0.069	8.026LeuGly: 8.026 ± 0.086	1.818LeuHis: 1.818 ± 0.043	5.316LeuIle: 5.316 ± 0.079	3.49LeuLys: 3.49 ± 0.059	8.518LeuLeu: 8.518 ± 0.117	2.816LeuMet: 2.816 ± 0.047	3.051LeuAsn: 3.051 ± 0.056	5.28LeuPro: 5.28 ± 0.068	2.995LeuGln: 2.995 ± 0.046	6.583LeuArg: 6.583 ± 0.082	6.838LeuSer: 6.838 ± 0.078	6.098LeuThr: 6.098 ± 0.073	6.578LeuVal: 6.578 ± 0.087	1.251LeuTrp: 1.251 ± 0.035	2.061LeuTyr: 2.061 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.486MetAla: 3.486 ± 0.059	0.232MetCys: 0.232 ± 0.014	1.603MetAsp: 1.603 ± 0.036	1.5MetGlu: 1.5 ± 0.033	0.882MetPhe: 0.882 ± 0.028	2.4MetGly: 2.4 ± 0.05	0.527MetHis: 0.527 ± 0.023	1.679MetIle: 1.679 ± 0.04	1.227MetLys: 1.227 ± 0.032	2.659MetLeu: 2.659 ± 0.051	0.871MetMet: 0.871 ± 0.027	0.943MetAsn: 0.943 ± 0.031	1.567MetPro: 1.567 ± 0.036	1.057MetGln: 1.057 ± 0.027	1.917MetArg: 1.917 ± 0.043	1.9MetSer: 1.9 ± 0.042	2.323MetThr: 2.323 ± 0.042	1.975MetVal: 1.975 ± 0.044	0.274MetTrp: 0.274 ± 0.013	0.421MetTyr: 0.421 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.447AsnAla: 3.447 ± 0.058	0.303AsnCys: 0.303 ± 0.016	1.813AsnAsp: 1.813 ± 0.045	1.432AsnGlu: 1.432 ± 0.037	1.023AsnPhe: 1.023 ± 0.027	2.795AsnGly: 2.795 ± 0.045	0.558AsnHis: 0.558 ± 0.02	1.507AsnIle: 1.507 ± 0.035	0.791AsnLys: 0.791 ± 0.027	2.686AsnLeu: 2.686 ± 0.043	0.806AsnMet: 0.806 ± 0.024	0.774AsnAsn: 0.774 ± 0.027	1.894AsnPro: 1.894 ± 0.04	0.871AsnGln: 0.871 ± 0.025	1.748AsnArg: 1.748 ± 0.043	1.309AsnSer: 1.309 ± 0.035	1.546AsnThr: 1.546 ± 0.041	1.975AsnVal: 1.975 ± 0.041	0.456AsnTrp: 0.456 ± 0.019	0.697AsnTyr: 0.697 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	5.32ProAla: 5.32 ± 0.084	0.347ProCys: 0.347 ± 0.018	3.698ProAsp: 3.698 ± 0.057	4.309ProGlu: 4.309 ± 0.057	1.923ProPhe: 1.923 ± 0.043	3.223ProGly: 3.223 ± 0.057	1.01ProHis: 1.01 ± 0.028	2.406ProIle: 2.406 ± 0.046	1.885ProLys: 1.885 ± 0.045	4.378ProLeu: 4.378 ± 0.063	1.383ProMet: 1.383 ± 0.036	1.439ProAsn: 1.439 ± 0.035	1.818ProPro: 1.818 ± 0.04	1.624ProGln: 1.624 ± 0.042	2.47ProArg: 2.47 ± 0.052	2.557ProSer: 2.557 ± 0.046	2.563ProThr: 2.563 ± 0.045	3.882ProVal: 3.882 ± 0.05	0.629ProTrp: 0.629 ± 0.025	1.213ProTyr: 1.213 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.863GlnAla: 3.863 ± 0.058	0.226GlnCys: 0.226 ± 0.014	1.851GlnAsp: 1.851 ± 0.037	1.816GlnGlu: 1.816 ± 0.04	1.146GlnPhe: 1.146 ± 0.03	2.717GlnGly: 2.717 ± 0.047	0.635GlnHis: 0.635 ± 0.021	2.384GlnIle: 2.384 ± 0.046	1.218GlnLys: 1.218 ± 0.035	2.929GlnLeu: 2.929 ± 0.05	1.245GlnMet: 1.245 ± 0.032	1.074GlnAsn: 1.074 ± 0.03	1.632GlnPro: 1.632 ± 0.04	1.236GlnGln: 1.236 ± 0.043	2.232GlnArg: 2.232 ± 0.042	2.037GlnSer: 2.037 ± 0.04	2.068GlnThr: 2.068 ± 0.044	2.404GlnVal: 2.404 ± 0.044	0.408GlnTrp: 0.408 ± 0.019	0.635GlnTyr: 0.635 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	6.99ArgAla: 6.99 ± 0.078	0.49ArgCys: 0.49 ± 0.021	3.907ArgAsp: 3.907 ± 0.064	3.661ArgGlu: 3.661 ± 0.058	2.506ArgPhe: 2.506 ± 0.049	4.268ArgGly: 4.268 ± 0.062	1.315ArgHis: 1.315 ± 0.031	3.584ArgIle: 3.584 ± 0.056	2.413ArgLys: 2.413 ± 0.048	6.592ArgLeu: 6.592 ± 0.098	1.946ArgMet: 1.946 ± 0.043	1.809ArgAsn: 1.809 ± 0.038	2.934ArgPro: 2.934 ± 0.052	2.339ArgGln: 2.339 ± 0.045	4.311ArgArg: 4.311 ± 0.072	3.249ArgSer: 3.249 ± 0.054	3.004ArgThr: 3.004 ± 0.046	4.355ArgVal: 4.355 ± 0.064	0.86ArgTrp: 0.86 ± 0.026	1.58ArgTyr: 1.58 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	6.023SerAla: 6.023 ± 0.077	0.452SerCys: 0.452 ± 0.02	3.475SerAsp: 3.475 ± 0.058	3.249SerGlu: 3.249 ± 0.056	2.345SerPhe: 2.345 ± 0.043	5.568SerGly: 5.568 ± 0.073	1.107SerHis: 1.107 ± 0.029	2.747SerIle: 2.747 ± 0.059	1.744SerLys: 1.744 ± 0.04	5.285SerLeu: 5.285 ± 0.066	1.522SerMet: 1.522 ± 0.034	1.598SerAsn: 1.598 ± 0.042	2.409SerPro: 2.409 ± 0.046	1.825SerGln: 1.825 ± 0.042	3.131SerArg: 3.131 ± 0.047	2.875SerSer: 2.875 ± 0.055	2.735SerThr: 2.735 ± 0.044	3.989SerVal: 3.989 ± 0.058	0.669SerTrp: 0.669 ± 0.022	1.452SerTyr: 1.452 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	6.206ThrAla: 6.206 ± 0.072	0.507ThrCys: 0.507 ± 0.02	3.419ThrAsp: 3.419 ± 0.059	3.385ThrGlu: 3.385 ± 0.048	2.114ThrPhe: 2.114 ± 0.045	5.289ThrGly: 5.289 ± 0.067	1.184ThrHis: 1.184 ± 0.034	2.914ThrIle: 2.914 ± 0.049	1.786ThrLys: 1.786 ± 0.036	6.195ThrLeu: 6.195 ± 0.07	1.298ThrMet: 1.298 ± 0.034	1.466ThrAsn: 1.466 ± 0.033	3.356ThrPro: 3.356 ± 0.049	1.833ThrGln: 1.833 ± 0.04	3.303ThrArg: 3.303 ± 0.056	2.998ThrSer: 2.998 ± 0.048	2.901ThrThr: 2.901 ± 0.054	4.347ThrVal: 4.347 ± 0.072	0.676ThrTrp: 0.676 ± 0.025	1.414ThrTyr: 1.414 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	8.034ValAla: 8.034 ± 0.088	0.688ValCys: 0.688 ± 0.025	4.222ValAsp: 4.222 ± 0.062	4.418ValGlu: 4.418 ± 0.063	2.83ValPhe: 2.83 ± 0.05	5.445ValGly: 5.445 ± 0.067	1.369ValHis: 1.369 ± 0.029	4.256ValIle: 4.256 ± 0.066	2.362ValLys: 2.362 ± 0.051	7.221ValLeu: 7.221 ± 0.084	2.194ValMet: 2.194 ± 0.047	2.056ValAsn: 2.056 ± 0.044	3.414ValPro: 3.414 ± 0.049	2.255ValGln: 2.255 ± 0.041	4.035ValArg: 4.035 ± 0.055	4.382ValSer: 4.382 ± 0.061	4.725ValThr: 4.725 ± 0.07	5.533ValVal: 5.533 ± 0.069	0.909ValTrp: 0.909 ± 0.029	1.584ValTyr: 1.584 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.279TrpAla: 1.279 ± 0.035	0.143TrpCys: 0.143 ± 0.011	0.75TrpAsp: 0.75 ± 0.029	0.65TrpGlu: 0.65 ± 0.025	0.534TrpPhe: 0.534 ± 0.022	1.008TrpGly: 1.008 ± 0.03	0.357TrpHis: 0.357 ± 0.016	0.694TrpIle: 0.694 ± 0.025	0.498TrpLys: 0.498 ± 0.021	1.523TrpLeu: 1.523 ± 0.037	0.438TrpMet: 0.438 ± 0.02	0.429TrpAsn: 0.429 ± 0.018	0.639TrpPro: 0.639 ± 0.021	0.588TrpGln: 0.588 ± 0.022	0.96TrpArg: 0.96 ± 0.029	0.798TrpSer: 0.798 ± 0.028	0.799TrpThr: 0.799 ± 0.026	0.891TrpVal: 0.891 ± 0.029	0.193TrpTrp: 0.193 ± 0.014	0.311TrpTyr: 0.311 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.586TyrAla: 2.586 ± 0.047	0.249TyrCys: 0.249 ± 0.014	1.747TyrAsp: 1.747 ± 0.039	1.439TyrGlu: 1.439 ± 0.036	0.936TyrPhe: 0.936 ± 0.028	2.262TyrGly: 2.262 ± 0.042	0.528TyrHis: 0.528 ± 0.021	1.07TyrIle: 1.07 ± 0.034	0.671TyrLys: 0.671 ± 0.022	2.328TyrLeu: 2.328 ± 0.045	0.56TyrMet: 0.56 ± 0.021	0.699TyrAsn: 0.699 ± 0.023	1.072TyrPro: 1.072 ± 0.03	0.82TyrGln: 0.82 ± 0.024	1.529TyrArg: 1.529 ± 0.035	1.275TyrSer: 1.275 ± 0.037	1.229TyrThr: 1.229 ± 0.033	1.693TyrVal: 1.693 ± 0.042	0.373TyrTrp: 0.373 ± 0.019	0.654TyrTyr: 0.654 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4047 proteins (1262338 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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