Amino acid dipepetide frequency for Microvirga aerophila

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.236AlaAla: 15.236 ± 0.105	1.034AlaCys: 1.034 ± 0.027	6.019AlaAsp: 6.019 ± 0.053	7.239AlaGlu: 7.239 ± 0.073	4.412AlaPhe: 4.412 ± 0.055	9.609AlaGly: 9.609 ± 0.07	2.244AlaHis: 2.244 ± 0.035	6.151AlaIle: 6.151 ± 0.067	4.025AlaLys: 4.025 ± 0.051	12.806AlaLeu: 12.806 ± 0.098	3.166AlaMet: 3.166 ± 0.046	2.688AlaAsn: 2.688 ± 0.047	5.205AlaPro: 5.205 ± 0.06	4.195AlaGln: 4.195 ± 0.055	8.173AlaArg: 8.173 ± 0.083	6.56AlaSer: 6.56 ± 0.062	5.658AlaThr: 5.658 ± 0.058	8.758AlaVal: 8.758 ± 0.072	1.534AlaTrp: 1.534 ± 0.033	2.691AlaTyr: 2.691 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.849CysAla: 0.849 ± 0.023	0.107CysCys: 0.107 ± 0.007	0.48CysAsp: 0.48 ± 0.016	0.463CysGlu: 0.463 ± 0.016	0.299CysPhe: 0.299 ± 0.012	0.814CysGly: 0.814 ± 0.024	0.253CysHis: 0.253 ± 0.012	0.407CysIle: 0.407 ± 0.015	0.185CysLys: 0.185 ± 0.009	0.8CysLeu: 0.8 ± 0.02	0.167CysMet: 0.167 ± 0.01	0.198CysAsn: 0.198 ± 0.011	0.463CysPro: 0.463 ± 0.014	0.236CysGln: 0.236 ± 0.011	0.701CysArg: 0.701 ± 0.017	0.477CysSer: 0.477 ± 0.017	0.382CysThr: 0.382 ± 0.014	0.57CysVal: 0.57 ± 0.017	0.115CysTrp: 0.115 ± 0.008	0.183CysTyr: 0.183 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	6.211AspAla: 6.211 ± 0.053	0.427AspCys: 0.427 ± 0.017	2.878AspAsp: 2.878 ± 0.057	3.675AspGlu: 3.675 ± 0.047	2.059AspPhe: 2.059 ± 0.039	4.735AspGly: 4.735 ± 0.065	1.228AspHis: 1.228 ± 0.025	2.837AspIle: 2.837 ± 0.041	1.631AspLys: 1.631 ± 0.031	6.164AspLeu: 6.164 ± 0.065	1.186AspMet: 1.186 ± 0.025	1.231AspAsn: 1.231 ± 0.025	3.566AspPro: 3.566 ± 0.044	1.949AspGln: 1.949 ± 0.035	4.399AspArg: 4.399 ± 0.052	1.997AspSer: 1.997 ± 0.037	2.609AspThr: 2.609 ± 0.054	4.213AspVal: 4.213 ± 0.051	0.931AspTrp: 0.931 ± 0.024	1.308AspTyr: 1.308 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	8.038GluAla: 8.038 ± 0.067	0.375GluCys: 0.375 ± 0.015	2.807GluAsp: 2.807 ± 0.041	3.38GluGlu: 3.38 ± 0.052	1.794GluPhe: 1.794 ± 0.032	4.354GluGly: 4.354 ± 0.061	1.31GluHis: 1.31 ± 0.028	3.398GluIle: 3.398 ± 0.041	2.086GluLys: 2.086 ± 0.038	5.348GluLeu: 5.348 ± 0.061	1.439GluMet: 1.439 ± 0.026	1.554GluAsn: 1.554 ± 0.027	2.996GluPro: 2.996 ± 0.043	2.393GluGln: 2.393 ± 0.035	5.548GluArg: 5.548 ± 0.071	2.501GluSer: 2.501 ± 0.036	3.522GluThr: 3.522 ± 0.043	4.044GluVal: 4.044 ± 0.047	0.755GluTrp: 0.755 ± 0.022	0.997GluTyr: 0.997 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	4.086PheAla: 4.086 ± 0.052	0.383PheCys: 0.383 ± 0.015	2.461PheAsp: 2.461 ± 0.036	2.196PheGlu: 2.196 ± 0.038	1.324PhePhe: 1.324 ± 0.029	3.583PheGly: 3.583 ± 0.05	0.706PheHis: 0.706 ± 0.022	1.747PheIle: 1.747 ± 0.032	1.059PheLys: 1.059 ± 0.024	3.406PheLeu: 3.406 ± 0.048	0.811PheMet: 0.811 ± 0.023	1.054PheAsn: 1.054 ± 0.027	1.626PhePro: 1.626 ± 0.028	1.115PheGln: 1.115 ± 0.023	2.379PheArg: 2.379 ± 0.032	2.177PheSer: 2.177 ± 0.036	2.015PheThr: 2.015 ± 0.042	2.852PheVal: 2.852 ± 0.041	0.58PheTrp: 0.58 ± 0.019	0.931PheTyr: 0.931 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	8.566GlyAla: 8.566 ± 0.083	0.826GlyCys: 0.826 ± 0.022	4.226GlyAsp: 4.226 ± 0.062	4.551GlyGlu: 4.551 ± 0.052	3.547GlyPhe: 3.547 ± 0.042	7.077GlyGly: 7.077 ± 0.096	1.905GlyHis: 1.905 ± 0.03	4.58GlyIle: 4.58 ± 0.045	2.933GlyLys: 2.933 ± 0.045	8.963GlyLeu: 8.963 ± 0.073	2.133GlyMet: 2.133 ± 0.037	2.215GlyAsn: 2.215 ± 0.054	3.687GlyPro: 3.687 ± 0.043	3.101GlyGln: 3.101 ± 0.041	6.283GlyArg: 6.283 ± 0.065	5.158GlySer: 5.158 ± 0.068	4.655GlyThr: 4.655 ± 0.054	5.892GlyVal: 5.892 ± 0.059	1.387GlyTrp: 1.387 ± 0.029	2.281GlyTyr: 2.281 ± 0.033	0.0GlyXaa: 0.0 ± 0.0
His	2.227HisAla: 2.227 ± 0.032	0.214HisCys: 0.214 ± 0.011	1.224HisAsp: 1.224 ± 0.025	1.212HisGlu: 1.212 ± 0.026	0.792HisPhe: 0.792 ± 0.019	1.936HisGly: 1.936 ± 0.032	0.619HisHis: 0.619 ± 0.024	0.951HisIle: 0.951 ± 0.024	0.515HisLys: 0.515 ± 0.015	2.285HisLeu: 2.285 ± 0.035	0.528HisMet: 0.528 ± 0.017	0.504HisAsn: 0.504 ± 0.015	1.468HisPro: 1.468 ± 0.031	0.67HisGln: 0.67 ± 0.018	1.66HisArg: 1.66 ± 0.032	1.026HisSer: 1.026 ± 0.026	0.88HisThr: 0.88 ± 0.021	1.57HisVal: 1.57 ± 0.029	0.339HisTrp: 0.339 ± 0.015	0.504HisTyr: 0.504 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	6.704IleAla: 6.704 ± 0.061	0.475IleCys: 0.475 ± 0.016	3.296IleAsp: 3.296 ± 0.041	3.579IleGlu: 3.579 ± 0.05	1.581IlePhe: 1.581 ± 0.029	4.998IleGly: 4.998 ± 0.065	0.993IleHis: 0.993 ± 0.022	2.338IleIle: 2.338 ± 0.041	1.519IleLys: 1.519 ± 0.032	4.887IleLeu: 4.887 ± 0.058	1.072IleMet: 1.072 ± 0.024	1.355IleAsn: 1.355 ± 0.025	2.464IlePro: 2.464 ± 0.043	1.44IleGln: 1.44 ± 0.027	3.493IleArg: 3.493 ± 0.042	2.771IleSer: 2.771 ± 0.04	2.751IleThr: 2.751 ± 0.035	4.298IleVal: 4.298 ± 0.059	0.608IleTrp: 0.608 ± 0.018	1.11IleTyr: 1.11 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	4.339LysAla: 4.339 ± 0.056	0.158LysCys: 0.158 ± 0.009	1.831LysAsp: 1.831 ± 0.035	1.715LysGlu: 1.715 ± 0.035	0.828LysPhe: 0.828 ± 0.022	2.808LysGly: 2.808 ± 0.045	0.648LysHis: 0.648 ± 0.019	1.601LysIle: 1.601 ± 0.033	1.225LysLys: 1.225 ± 0.033	3.203LysLeu: 3.203 ± 0.045	0.675LysMet: 0.675 ± 0.019	0.854LysAsn: 0.854 ± 0.022	2.154LysPro: 2.154 ± 0.032	1.054LysGln: 1.054 ± 0.026	2.555LysArg: 2.555 ± 0.044	1.8LysSer: 1.8 ± 0.027	1.9LysThr: 1.9 ± 0.033	2.467LysVal: 2.467 ± 0.044	0.34LysTrp: 0.34 ± 0.014	0.578LysTyr: 0.578 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	12.929LeuAla: 12.929 ± 0.095	0.839LeuCys: 0.839 ± 0.02	5.89LeuAsp: 5.89 ± 0.058	5.475LeuGlu: 5.475 ± 0.062	3.601LeuPhe: 3.601 ± 0.048	8.435LeuGly: 8.435 ± 0.075	1.948LeuHis: 1.948 ± 0.033	5.111LeuIle: 5.111 ± 0.054	3.816LeuLys: 3.816 ± 0.051	9.52LeuLeu: 9.52 ± 0.094	2.291LeuMet: 2.291 ± 0.039	2.696LeuAsn: 2.696 ± 0.037	5.571LeuPro: 5.571 ± 0.053	3.042LeuGln: 3.042 ± 0.049	7.212LeuArg: 7.212 ± 0.071	6.708LeuSer: 6.708 ± 0.063	5.701LeuThr: 5.701 ± 0.05	7.875LeuVal: 7.875 ± 0.073	1.212LeuTrp: 1.212 ± 0.03	2.054LeuTyr: 2.054 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	2.949MetAla: 2.949 ± 0.045	0.132MetCys: 0.132 ± 0.009	1.068MetAsp: 1.068 ± 0.023	1.092MetGlu: 1.092 ± 0.026	0.658MetPhe: 0.658 ± 0.02	1.741MetGly: 1.741 ± 0.032	0.455MetHis: 0.455 ± 0.014	1.294MetIle: 1.294 ± 0.027	0.92MetLys: 0.92 ± 0.024	2.295MetLeu: 2.295 ± 0.037	0.61MetMet: 0.61 ± 0.022	0.787MetAsn: 0.787 ± 0.019	1.487MetPro: 1.487 ± 0.026	0.768MetGln: 0.768 ± 0.02	1.833MetArg: 1.833 ± 0.03	1.631MetSer: 1.631 ± 0.027	1.791MetThr: 1.791 ± 0.029	1.632MetVal: 1.632 ± 0.027	0.212MetTrp: 0.212 ± 0.01	0.302MetTyr: 0.302 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.971AsnAla: 2.971 ± 0.045	0.209AsnCys: 0.209 ± 0.01	1.514AsnAsp: 1.514 ± 0.043	1.383AsnGlu: 1.383 ± 0.029	0.852AsnPhe: 0.852 ± 0.021	2.437AsnGly: 2.437 ± 0.047	0.516AsnHis: 0.516 ± 0.016	1.261AsnIle: 1.261 ± 0.024	0.778AsnLys: 0.778 ± 0.022	2.769AsnLeu: 2.769 ± 0.039	0.562AsnMet: 0.562 ± 0.016	0.733AsnAsn: 0.733 ± 0.021	1.918AsnPro: 1.918 ± 0.031	0.794AsnGln: 0.794 ± 0.022	1.904AsnArg: 1.904 ± 0.029	1.226AsnSer: 1.226 ± 0.027	1.304AsnThr: 1.304 ± 0.031	1.986AsnVal: 1.986 ± 0.037	0.393AsnTrp: 0.393 ± 0.014	0.649AsnTyr: 0.649 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	5.857ProAla: 5.857 ± 0.062	0.341ProCys: 0.341 ± 0.013	3.733ProAsp: 3.733 ± 0.055	3.816ProGlu: 3.816 ± 0.044	2.037ProPhe: 2.037 ± 0.033	4.541ProGly: 4.541 ± 0.049	1.169ProHis: 1.169 ± 0.024	2.43ProIle: 2.43 ± 0.042	1.845ProLys: 1.845 ± 0.035	4.744ProLeu: 4.744 ± 0.049	1.187ProMet: 1.187 ± 0.026	1.525ProAsn: 1.525 ± 0.027	2.688ProPro: 2.688 ± 0.046	1.843ProGln: 1.843 ± 0.034	3.12ProArg: 3.12 ± 0.043	3.277ProSer: 3.277 ± 0.048	2.678ProThr: 2.678 ± 0.035	4.32ProVal: 4.32 ± 0.047	0.748ProTrp: 0.748 ± 0.021	1.26ProTyr: 1.26 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	4.545GlnAla: 4.545 ± 0.048	0.211GlnCys: 0.211 ± 0.011	1.781GlnAsp: 1.781 ± 0.034	1.844GlnGlu: 1.844 ± 0.036	1.059GlnPhe: 1.059 ± 0.025	2.651GlnGly: 2.651 ± 0.042	0.746GlnHis: 0.746 ± 0.019	1.827GlnIle: 1.827 ± 0.031	1.094GlnLys: 1.094 ± 0.026	2.85GlnLeu: 2.85 ± 0.047	0.86GlnMet: 0.86 ± 0.02	0.923GlnAsn: 0.923 ± 0.019	1.913GlnPro: 1.913 ± 0.034	1.35GlnGln: 1.35 ± 0.036	2.724GlnArg: 2.724 ± 0.038	1.91GlnSer: 1.91 ± 0.031	1.858GlnThr: 1.858 ± 0.031	2.549GlnVal: 2.549 ± 0.036	0.439GlnTrp: 0.439 ± 0.016	0.623GlnTyr: 0.623 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	7.535ArgAla: 7.535 ± 0.076	0.559ArgCys: 0.559 ± 0.016	3.99ArgAsp: 3.99 ± 0.05	4.635ArgGlu: 4.635 ± 0.064	3.033ArgPhe: 3.033 ± 0.042	4.871ArgGly: 4.871 ± 0.047	1.807ArgHis: 1.807 ± 0.031	4.207ArgIle: 4.207 ± 0.052	2.405ArgLys: 2.405 ± 0.04	8.262ArgLeu: 8.262 ± 0.079	1.88ArgMet: 1.88 ± 0.032	1.979ArgAsn: 1.979 ± 0.031	3.789ArgPro: 3.789 ± 0.057	2.942ArgGln: 2.942 ± 0.047	6.135ArgArg: 6.135 ± 0.069	4.277ArgSer: 4.277 ± 0.05	3.698ArgThr: 3.698 ± 0.046	5.108ArgVal: 5.108 ± 0.059	1.123ArgTrp: 1.123 ± 0.023	1.826ArgTyr: 1.826 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	5.994SerAla: 5.994 ± 0.062	0.43SerCys: 0.43 ± 0.016	3.035SerAsp: 3.035 ± 0.044	2.959SerGlu: 2.959 ± 0.043	2.317SerPhe: 2.317 ± 0.035	5.588SerGly: 5.588 ± 0.059	1.207SerHis: 1.207 ± 0.025	2.879SerIle: 2.879 ± 0.047	1.708SerLys: 1.708 ± 0.032	6.022SerLeu: 6.022 ± 0.063	1.372SerMet: 1.372 ± 0.025	1.458SerAsn: 1.458 ± 0.03	3.135SerPro: 3.135 ± 0.044	1.773SerGln: 1.773 ± 0.031	4.086SerArg: 4.086 ± 0.051	3.356SerSer: 3.356 ± 0.054	2.906SerThr: 2.906 ± 0.044	4.04SerVal: 4.04 ± 0.044	0.815SerTrp: 0.815 ± 0.021	1.399SerTyr: 1.399 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	5.936ThrAla: 5.936 ± 0.062	0.42ThrCys: 0.42 ± 0.015	2.773ThrAsp: 2.773 ± 0.043	2.654ThrGlu: 2.654 ± 0.042	2.097ThrPhe: 2.097 ± 0.034	5.027ThrGly: 5.027 ± 0.061	1.074ThrHis: 1.074 ± 0.025	3.042ThrIle: 3.042 ± 0.048	1.636ThrLys: 1.636 ± 0.032	5.826ThrLeu: 5.826 ± 0.052	1.176ThrMet: 1.176 ± 0.028	1.406ThrAsn: 1.406 ± 0.031	3.245ThrPro: 3.245 ± 0.043	1.518ThrGln: 1.518 ± 0.03	3.444ThrArg: 3.444 ± 0.045	3.023ThrSer: 3.023 ± 0.038	2.917ThrThr: 2.917 ± 0.045	4.416ThrVal: 4.416 ± 0.06	0.729ThrTrp: 0.729 ± 0.02	1.32ThrTyr: 1.32 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	8.665ValAla: 8.665 ± 0.076	0.637ValCys: 0.637 ± 0.021	4.048ValAsp: 4.048 ± 0.048	4.856ValGlu: 4.856 ± 0.056	2.758ValPhe: 2.758 ± 0.044	5.719ValGly: 5.719 ± 0.061	1.432ValHis: 1.432 ± 0.029	4.05ValIle: 4.05 ± 0.051	2.317ValLys: 2.317 ± 0.042	7.795ValLeu: 7.795 ± 0.075	1.796ValMet: 1.796 ± 0.031	1.938ValAsn: 1.938 ± 0.035	3.899ValPro: 3.899 ± 0.05	2.3ValGln: 2.3 ± 0.034	5.336ValArg: 5.336 ± 0.062	4.554ValSer: 4.554 ± 0.049	4.491ValThr: 4.491 ± 0.054	6.145ValVal: 6.145 ± 0.06	0.992ValTrp: 0.992 ± 0.023	1.556ValTyr: 1.556 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.314TrpAla: 1.314 ± 0.028	0.142TrpCys: 0.142 ± 0.009	0.729TrpAsp: 0.729 ± 0.019	0.621TrpGlu: 0.621 ± 0.019	0.537TrpPhe: 0.537 ± 0.018	0.902TrpGly: 0.902 ± 0.026	0.373TrpHis: 0.373 ± 0.014	0.728TrpIle: 0.728 ± 0.019	0.426TrpLys: 0.426 ± 0.015	1.699TrpLeu: 1.699 ± 0.039	0.35TrpMet: 0.35 ± 0.016	0.451TrpAsn: 0.451 ± 0.016	0.692TrpPro: 0.692 ± 0.02	0.521TrpGln: 0.521 ± 0.019	1.249TrpArg: 1.249 ± 0.025	0.895TrpSer: 0.895 ± 0.024	0.836TrpThr: 0.836 ± 0.022	0.847TrpVal: 0.847 ± 0.022	0.236TrpTrp: 0.236 ± 0.012	0.306TrpTyr: 0.306 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.452TyrAla: 2.452 ± 0.034	0.231TyrCys: 0.231 ± 0.009	1.45TyrAsp: 1.45 ± 0.03	1.294TyrGlu: 1.294 ± 0.029	0.906TyrPhe: 0.906 ± 0.021	2.138TyrGly: 2.138 ± 0.035	0.491TyrHis: 0.491 ± 0.016	0.894TyrIle: 0.894 ± 0.022	0.611TyrLys: 0.611 ± 0.02	2.285TyrLeu: 2.285 ± 0.039	0.398TyrMet: 0.398 ± 0.016	0.607TyrAsn: 0.607 ± 0.02	1.194TyrPro: 1.194 ± 0.024	0.755TyrGln: 0.755 ± 0.022	1.827TyrArg: 1.827 ± 0.034	1.154TyrSer: 1.154 ± 0.025	1.124TyrThr: 1.124 ± 0.028	1.703TyrVal: 1.703 ± 0.03	0.364TyrTrp: 0.364 ± 0.016	0.638TyrTyr: 0.638 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7161 proteins (1921182 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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