Amino acid dipepetide frequency for Candidatus Phycosocius bacilliformis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.282AlaAla: 17.282 ± 0.198	1.361AlaCys: 1.361 ± 0.036	7.061AlaAsp: 7.061 ± 0.089	6.734AlaGlu: 6.734 ± 0.09	4.539AlaPhe: 4.539 ± 0.066	10.724AlaGly: 10.724 ± 0.11	2.51AlaHis: 2.51 ± 0.053	6.593AlaIle: 6.593 ± 0.078	4.702AlaLys: 4.702 ± 0.087	13.413AlaLeu: 13.413 ± 0.134	3.505AlaMet: 3.505 ± 0.066	3.635AlaAsn: 3.635 ± 0.061	5.973AlaPro: 5.973 ± 0.105	4.855AlaGln: 4.855 ± 0.069	9.41AlaArg: 9.41 ± 0.111	6.945AlaSer: 6.945 ± 0.107	6.552AlaThr: 6.552 ± 0.089	7.934AlaVal: 7.934 ± 0.091	1.812AlaTrp: 1.812 ± 0.051	2.598AlaTyr: 2.598 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	1.066CysAla: 1.066 ± 0.03	0.09CysCys: 0.09 ± 0.009	0.537CysAsp: 0.537 ± 0.023	0.45CysGlu: 0.45 ± 0.022	0.354CysPhe: 0.354 ± 0.022	0.855CysGly: 0.855 ± 0.033	0.222CysHis: 0.222 ± 0.016	0.364CysIle: 0.364 ± 0.02	0.207CysLys: 0.207 ± 0.014	0.945CysLeu: 0.945 ± 0.034	0.133CysMet: 0.133 ± 0.011	0.206CysAsn: 0.206 ± 0.014	0.492CysPro: 0.492 ± 0.025	0.302CysGln: 0.302 ± 0.019	0.525CysArg: 0.525 ± 0.022	0.467CysSer: 0.467 ± 0.022	0.402CysThr: 0.402 ± 0.023	0.69CysVal: 0.69 ± 0.027	0.112CysTrp: 0.112 ± 0.012	0.201CysTyr: 0.201 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.443AspAla: 6.443 ± 0.078	0.461AspCys: 0.461 ± 0.025	2.887AspAsp: 2.887 ± 0.06	3.02AspGlu: 3.02 ± 0.059	2.275AspPhe: 2.275 ± 0.056	5.358AspGly: 5.358 ± 0.07	1.333AspHis: 1.333 ± 0.036	2.834AspIle: 2.834 ± 0.053	1.793AspLys: 1.793 ± 0.052	6.494AspLeu: 6.494 ± 0.102	1.407AspMet: 1.407 ± 0.035	1.306AspAsn: 1.306 ± 0.038	3.861AspPro: 3.861 ± 0.065	2.333AspGln: 2.333 ± 0.05	4.142AspArg: 4.142 ± 0.063	2.259AspSer: 2.259 ± 0.045	2.48AspThr: 2.48 ± 0.051	4.26AspVal: 4.26 ± 0.064	1.106AspTrp: 1.106 ± 0.034	1.499AspTyr: 1.499 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	8.243GluAla: 8.243 ± 0.108	0.294GluCys: 0.294 ± 0.019	2.711GluAsp: 2.711 ± 0.05	2.672GluGlu: 2.672 ± 0.06	1.497GluPhe: 1.497 ± 0.045	3.963GluGly: 3.963 ± 0.066	1.001GluHis: 1.001 ± 0.032	3.178GluIle: 3.178 ± 0.057	1.889GluLys: 1.889 ± 0.056	4.674GluLeu: 4.674 ± 0.08	1.218GluMet: 1.218 ± 0.038	1.349GluAsn: 1.349 ± 0.039	2.504GluPro: 2.504 ± 0.051	1.753GluGln: 1.753 ± 0.04	3.984GluArg: 3.984 ± 0.065	2.258GluSer: 2.258 ± 0.059	3.574GluThr: 3.574 ± 0.059	3.619GluVal: 3.619 ± 0.061	0.557GluTrp: 0.557 ± 0.025	0.793GluTyr: 0.793 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.74PheAla: 4.74 ± 0.07	0.38PheCys: 0.38 ± 0.021	2.812PheAsp: 2.812 ± 0.064	2.261PheGlu: 2.261 ± 0.049	1.401PhePhe: 1.401 ± 0.044	3.756PheGly: 3.756 ± 0.066	0.674PheHis: 0.674 ± 0.027	1.685PheIle: 1.685 ± 0.049	1.284PheLys: 1.284 ± 0.035	3.306PheLeu: 3.306 ± 0.072	0.829PheMet: 0.829 ± 0.027	1.112PheAsn: 1.112 ± 0.041	1.474PhePro: 1.474 ± 0.041	1.199PheGln: 1.199 ± 0.036	1.899PheArg: 1.899 ± 0.047	2.145PheSer: 2.145 ± 0.051	1.867PheThr: 1.867 ± 0.042	2.725PheVal: 2.725 ± 0.059	0.554PheTrp: 0.554 ± 0.023	0.932PheTyr: 0.932 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	9.251GlyAla: 9.251 ± 0.112	0.805GlyCys: 0.805 ± 0.03	4.381GlyAsp: 4.381 ± 0.074	4.237GlyGlu: 4.237 ± 0.071	3.885GlyPhe: 3.885 ± 0.065	7.207GlyGly: 7.207 ± 0.116	1.759GlyHis: 1.759 ± 0.047	4.154GlyIle: 4.154 ± 0.069	3.414GlyLys: 3.414 ± 0.064	10.065GlyLeu: 10.065 ± 0.128	2.038GlyMet: 2.038 ± 0.055	2.031GlyAsn: 2.031 ± 0.055	4.416GlyPro: 4.416 ± 0.078	3.663GlyGln: 3.663 ± 0.067	5.864GlyArg: 5.864 ± 0.079	4.714GlySer: 4.714 ± 0.079	4.023GlyThr: 4.023 ± 0.067	6.298GlyVal: 6.298 ± 0.079	1.373GlyTrp: 1.373 ± 0.036	2.026GlyTyr: 2.026 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.337HisAla: 2.337 ± 0.054	0.206HisCys: 0.206 ± 0.014	1.151HisAsp: 1.151 ± 0.034	1.053HisGlu: 1.053 ± 0.033	0.825HisPhe: 0.825 ± 0.028	1.82HisGly: 1.82 ± 0.047	0.575HisHis: 0.575 ± 0.027	0.931HisIle: 0.931 ± 0.031	0.555HisLys: 0.555 ± 0.028	1.991HisLeu: 1.991 ± 0.052	0.513HisMet: 0.513 ± 0.025	0.496HisAsn: 0.496 ± 0.02	1.194HisPro: 1.194 ± 0.038	0.728HisGln: 0.728 ± 0.025	1.208HisArg: 1.208 ± 0.037	0.805HisSer: 0.805 ± 0.031	0.787HisThr: 0.787 ± 0.026	1.611HisVal: 1.611 ± 0.041	0.356HisTrp: 0.356 ± 0.022	0.541HisTyr: 0.541 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.889IleAla: 6.889 ± 0.088	0.546IleCys: 0.546 ± 0.022	3.467IleAsp: 3.467 ± 0.055	3.255IleGlu: 3.255 ± 0.062	1.617IlePhe: 1.617 ± 0.044	5.05IleGly: 5.05 ± 0.075	0.951IleHis: 0.951 ± 0.032	2.357IleIle: 2.357 ± 0.055	1.648IleLys: 1.648 ± 0.049	4.987IleLeu: 4.987 ± 0.084	1.075IleMet: 1.075 ± 0.035	1.494IleAsn: 1.494 ± 0.046	2.269IlePro: 2.269 ± 0.041	1.537IleGln: 1.537 ± 0.047	2.89IleArg: 2.89 ± 0.055	3.112IleSer: 3.112 ± 0.057	2.673IleThr: 2.673 ± 0.05	3.81IleVal: 3.81 ± 0.069	0.734IleTrp: 0.734 ± 0.029	1.143IleTyr: 1.143 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	5.152LysAla: 5.152 ± 0.083	0.142LysCys: 0.142 ± 0.012	1.92LysAsp: 1.92 ± 0.052	1.444LysGlu: 1.444 ± 0.047	0.905LysPhe: 0.905 ± 0.033	2.706LysGly: 2.706 ± 0.057	0.557LysHis: 0.557 ± 0.024	1.818LysIle: 1.818 ± 0.043	1.283LysLys: 1.283 ± 0.049	3.363LysLeu: 3.363 ± 0.058	0.787LysMet: 0.787 ± 0.034	0.861LysAsn: 0.861 ± 0.033	2.555LysPro: 2.555 ± 0.058	1.133LysGln: 1.133 ± 0.032	2.352LysArg: 2.352 ± 0.061	2.135LysSer: 2.135 ± 0.055	2.135LysThr: 2.135 ± 0.044	2.524LysVal: 2.524 ± 0.058	0.378LysTrp: 0.378 ± 0.02	0.52LysTyr: 0.52 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	14.283LeuAla: 14.283 ± 0.143	0.86LeuCys: 0.86 ± 0.031	6.264LeuAsp: 6.264 ± 0.087	5.286LeuGlu: 5.286 ± 0.086	3.561LeuPhe: 3.561 ± 0.067	8.314LeuGly: 8.314 ± 0.108	1.721LeuHis: 1.721 ± 0.045	5.506LeuIle: 5.506 ± 0.09	3.841LeuLys: 3.841 ± 0.07	8.306LeuLeu: 8.306 ± 0.117	2.487LeuMet: 2.487 ± 0.055	2.845LeuAsn: 2.845 ± 0.053	5.271LeuPro: 5.271 ± 0.077	2.992LeuGln: 2.992 ± 0.052	6.038LeuArg: 6.038 ± 0.088	6.615LeuSer: 6.615 ± 0.086	5.79LeuThr: 5.79 ± 0.081	7.415LeuVal: 7.415 ± 0.097	1.191LeuTrp: 1.191 ± 0.04	2.013LeuTyr: 2.013 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	3.377MetAla: 3.377 ± 0.063	0.187MetCys: 0.187 ± 0.014	1.2MetAsp: 1.2 ± 0.036	1.047MetGlu: 1.047 ± 0.035	0.709MetPhe: 0.709 ± 0.027	1.964MetGly: 1.964 ± 0.044	0.351MetHis: 0.351 ± 0.018	1.34MetIle: 1.34 ± 0.037	0.898MetLys: 0.898 ± 0.031	2.064MetLeu: 2.064 ± 0.051	0.7MetMet: 0.7 ± 0.029	0.704MetAsn: 0.704 ± 0.031	1.305MetPro: 1.305 ± 0.04	0.797MetGln: 0.797 ± 0.026	1.719MetArg: 1.719 ± 0.038	1.701MetSer: 1.701 ± 0.045	1.811MetThr: 1.811 ± 0.05	1.754MetVal: 1.754 ± 0.043	0.247MetTrp: 0.247 ± 0.018	0.247MetTyr: 0.247 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.97AsnAla: 2.97 ± 0.067	0.245AsnCys: 0.245 ± 0.017	1.338AsnAsp: 1.338 ± 0.041	1.199AsnGlu: 1.199 ± 0.036	1.033AsnPhe: 1.033 ± 0.04	2.334AsnGly: 2.334 ± 0.06	0.519AsnHis: 0.519 ± 0.022	1.326AsnIle: 1.326 ± 0.043	0.81AsnLys: 0.81 ± 0.034	3.032AsnLeu: 3.032 ± 0.054	0.615AsnMet: 0.615 ± 0.025	0.757AsnAsn: 0.757 ± 0.035	2.16AsnPro: 2.16 ± 0.05	1.144AsnGln: 1.144 ± 0.038	1.9AsnArg: 1.9 ± 0.047	1.44AsnSer: 1.44 ± 0.042	1.236AsnThr: 1.236 ± 0.044	1.923AsnVal: 1.923 ± 0.051	0.5AsnTrp: 0.5 ± 0.023	0.658AsnTyr: 0.658 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	6.703ProAla: 6.703 ± 0.11	0.364ProCys: 0.364 ± 0.017	3.885ProAsp: 3.885 ± 0.068	3.383ProGlu: 3.383 ± 0.06	2.002ProPhe: 2.002 ± 0.039	4.441ProGly: 4.441 ± 0.07	1.101ProHis: 1.101 ± 0.034	2.795ProIle: 2.795 ± 0.051	2.04ProLys: 2.04 ± 0.048	4.611ProLeu: 4.611 ± 0.07	1.223ProMet: 1.223 ± 0.038	1.661ProAsn: 1.661 ± 0.042	2.998ProPro: 2.998 ± 0.091	1.817ProGln: 1.817 ± 0.04	2.976ProArg: 2.976 ± 0.059	3.065ProSer: 3.065 ± 0.061	2.952ProThr: 2.952 ± 0.054	4.149ProVal: 4.149 ± 0.062	0.712ProTrp: 0.712 ± 0.029	1.059ProTyr: 1.059 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	5.751GlnAla: 5.751 ± 0.085	0.215GlnCys: 0.215 ± 0.017	1.964GlnAsp: 1.964 ± 0.048	1.692GlnGlu: 1.692 ± 0.044	1.238GlnPhe: 1.238 ± 0.036	2.867GlnGly: 2.867 ± 0.056	0.597GlnHis: 0.597 ± 0.025	2.208GlnIle: 2.208 ± 0.048	1.259GlnLys: 1.259 ± 0.035	3.053GlnLeu: 3.053 ± 0.053	0.871GlnMet: 0.871 ± 0.027	1.025GlnAsn: 1.025 ± 0.03	1.925GlnPro: 1.925 ± 0.051	1.129GlnGln: 1.129 ± 0.037	2.409GlnArg: 2.409 ± 0.047	2.235GlnSer: 2.235 ± 0.056	2.392GlnThr: 2.392 ± 0.053	2.658GlnVal: 2.658 ± 0.054	0.424GlnTrp: 0.424 ± 0.023	0.511GlnTyr: 0.511 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	8.368ArgAla: 8.368 ± 0.103	0.494ArgCys: 0.494 ± 0.025	3.979ArgAsp: 3.979 ± 0.064	3.327ArgGlu: 3.327 ± 0.063	2.974ArgPhe: 2.974 ± 0.06	4.673ArgGly: 4.673 ± 0.074	1.479ArgHis: 1.479 ± 0.045	3.568ArgIle: 3.568 ± 0.058	2.198ArgLys: 2.198 ± 0.053	8.014ArgLeu: 8.014 ± 0.093	1.708ArgMet: 1.708 ± 0.044	1.702ArgAsn: 1.702 ± 0.04	3.638ArgPro: 3.638 ± 0.07	2.734ArgGln: 2.734 ± 0.058	4.839ArgArg: 4.839 ± 0.085	3.2ArgSer: 3.2 ± 0.061	3.469ArgThr: 3.469 ± 0.056	4.584ArgVal: 4.584 ± 0.076	0.904ArgTrp: 0.904 ± 0.034	1.484ArgTyr: 1.484 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.455SerAla: 6.455 ± 0.093	0.425SerCys: 0.425 ± 0.026	3.045SerAsp: 3.045 ± 0.059	2.632SerGlu: 2.632 ± 0.059	2.3SerPhe: 2.3 ± 0.05	5.388SerGly: 5.388 ± 0.085	1.161SerHis: 1.161 ± 0.037	2.744SerIle: 2.744 ± 0.052	1.772SerLys: 1.772 ± 0.045	5.909SerLeu: 5.909 ± 0.071	1.263SerMet: 1.263 ± 0.036	1.498SerAsn: 1.498 ± 0.049	3.302SerPro: 3.302 ± 0.064	2.223SerGln: 2.223 ± 0.052	3.689SerArg: 3.689 ± 0.058	2.945SerSer: 2.945 ± 0.059	2.75SerThr: 2.75 ± 0.067	3.844SerVal: 3.844 ± 0.067	0.891SerTrp: 0.891 ± 0.03	1.249SerTyr: 1.249 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	6.217ThrAla: 6.217 ± 0.082	0.503ThrCys: 0.503 ± 0.021	2.795ThrAsp: 2.795 ± 0.057	2.317ThrGlu: 2.317 ± 0.058	1.877ThrPhe: 1.877 ± 0.047	5.313ThrGly: 5.313 ± 0.081	1.11ThrHis: 1.11 ± 0.032	2.97ThrIle: 2.97 ± 0.059	1.695ThrLys: 1.695 ± 0.042	5.785ThrLeu: 5.785 ± 0.08	1.192ThrMet: 1.192 ± 0.041	1.555ThrAsn: 1.555 ± 0.044	3.477ThrPro: 3.477 ± 0.066	2.177ThrGln: 2.177 ± 0.054	3.513ThrArg: 3.513 ± 0.053	3.131ThrSer: 3.131 ± 0.062	3.025ThrThr: 3.025 ± 0.071	3.29ThrVal: 3.29 ± 0.066	0.75ThrTrp: 0.75 ± 0.028	1.362ThrTyr: 1.362 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	8.836ValAla: 8.836 ± 0.099	0.687ValCys: 0.687 ± 0.03	4.041ValAsp: 4.041 ± 0.058	4.012ValGlu: 4.012 ± 0.072	2.637ValPhe: 2.637 ± 0.051	5.68ValGly: 5.68 ± 0.081	1.248ValHis: 1.248 ± 0.038	3.727ValIle: 3.727 ± 0.064	2.315ValLys: 2.315 ± 0.053	6.875ValLeu: 6.875 ± 0.086	1.782ValMet: 1.782 ± 0.036	1.922ValAsn: 1.922 ± 0.052	3.433ValPro: 3.433 ± 0.06	2.264ValGln: 2.264 ± 0.044	5.058ValArg: 5.058 ± 0.08	4.411ValSer: 4.411 ± 0.068	4.37ValThr: 4.37 ± 0.073	5.487ValVal: 5.487 ± 0.083	1.001ValTrp: 1.001 ± 0.03	1.403ValTyr: 1.403 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.452TrpAla: 1.452 ± 0.04	0.131TrpCys: 0.131 ± 0.011	0.701TrpAsp: 0.701 ± 0.028	0.556TrpGlu: 0.556 ± 0.024	0.555TrpPhe: 0.555 ± 0.026	1.027TrpGly: 1.027 ± 0.033	0.341TrpHis: 0.341 ± 0.018	0.658TrpIle: 0.658 ± 0.028	0.462TrpLys: 0.462 ± 0.022	1.646TrpLeu: 1.646 ± 0.045	0.397TrpMet: 0.397 ± 0.021	0.409TrpAsn: 0.409 ± 0.021	0.729TrpPro: 0.729 ± 0.025	0.68TrpGln: 0.68 ± 0.025	1.206TrpArg: 1.206 ± 0.038	0.879TrpSer: 0.879 ± 0.035	0.895TrpThr: 0.895 ± 0.037	0.97TrpVal: 0.97 ± 0.032	0.218TrpTrp: 0.218 ± 0.015	0.261TrpTyr: 0.261 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.327TyrAla: 2.327 ± 0.051	0.224TyrCys: 0.224 ± 0.017	1.413TyrAsp: 1.413 ± 0.04	1.152TyrGlu: 1.152 ± 0.034	0.851TyrPhe: 0.851 ± 0.033	2.162TyrGly: 2.162 ± 0.051	0.473TyrHis: 0.473 ± 0.021	0.748TyrIle: 0.748 ± 0.028	0.602TyrLys: 0.602 ± 0.026	2.067TyrLeu: 2.067 ± 0.053	0.379TyrMet: 0.379 ± 0.02	0.569TyrAsn: 0.569 ± 0.031	0.959TyrPro: 0.959 ± 0.034	0.965TyrGln: 0.965 ± 0.033	1.713TyrArg: 1.713 ± 0.043	1.022TyrSer: 1.022 ± 0.032	0.874TyrThr: 0.874 ± 0.035	1.646TyrVal: 1.646 ± 0.038	0.354TyrTrp: 0.354 ± 0.016	0.516TyrTyr: 0.516 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3121 proteins (996773 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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