Amino acid dipepetide frequency for Candidatus Electrothrix communis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.005AlaAla: 8.005 ± 0.193
1.041AlaCys: 1.041 ± 0.075
4.899AlaAsp: 4.899 ± 0.132
6.309AlaGlu: 6.309 ± 0.167
2.923AlaPhe: 2.923 ± 0.123
6.658AlaGly: 6.658 ± 0.144
1.41AlaHis: 1.41 ± 0.07
4.29AlaIle: 4.29 ± 0.13
3.818AlaLys: 3.818 ± 0.117
8.896AlaLeu: 8.896 ± 0.193
2.534AlaMet: 2.534 ± 0.095
2.288AlaAsn: 2.288 ± 0.095
2.777AlaPro: 2.777 ± 0.089
3.046AlaGln: 3.046 ± 0.097
4.147AlaArg: 4.147 ± 0.127
4.127AlaSer: 4.127 ± 0.133
3.874AlaThr: 3.874 ± 0.125
6.575AlaVal: 6.575 ± 0.174
0.821AlaTrp: 0.821 ± 0.053
1.886AlaTyr: 1.886 ± 0.081
0.0AlaXaa: 0.0 ± 0.0
Cys
0.918CysAla: 0.918 ± 0.055
0.356CysCys: 0.356 ± 0.037
0.665CysAsp: 0.665 ± 0.057
0.765CysGlu: 0.765 ± 0.052
0.629CysPhe: 0.629 ± 0.045
1.244CysGly: 1.244 ± 0.068
0.429CysHis: 0.429 ± 0.048
0.645CysIle: 0.645 ± 0.039
0.476CysLys: 0.476 ± 0.038
1.41CysLeu: 1.41 ± 0.074
0.419CysMet: 0.419 ± 0.043
0.456CysAsn: 0.456 ± 0.035
0.851CysPro: 0.851 ± 0.06
0.525CysGln: 0.525 ± 0.039
0.881CysArg: 0.881 ± 0.059
1.084CysSer: 1.084 ± 0.065
0.792CysThr: 0.792 ± 0.052
0.639CysVal: 0.639 ± 0.044
0.2CysTrp: 0.2 ± 0.024
0.462CysTyr: 0.462 ± 0.036
0.0CysXaa: 0.0 ± 0.0
Asp
3.811AspAla: 3.811 ± 0.123
0.715AspCys: 0.715 ± 0.055
2.714AspAsp: 2.714 ± 0.11
3.745AspGlu: 3.745 ± 0.116
2.78AspPhe: 2.78 ± 0.091
3.848AspGly: 3.848 ± 0.133
1.117AspHis: 1.117 ± 0.058
3.864AspIle: 3.864 ± 0.105
2.943AspLys: 2.943 ± 0.093
5.314AspLeu: 5.314 ± 0.132
1.457AspMet: 1.457 ± 0.072
2.002AspAsn: 2.002 ± 0.078
2.581AspPro: 2.581 ± 0.099
2.351AspGln: 2.351 ± 0.091
2.883AspArg: 2.883 ± 0.098
3.043AspSer: 3.043 ± 0.109
2.601AspThr: 2.601 ± 0.09
3.519AspVal: 3.519 ± 0.107
0.702AspTrp: 0.702 ± 0.046
1.743AspTyr: 1.743 ± 0.078
0.0AspXaa: 0.0 ± 0.0
Glu
5.271GluAla: 5.271 ± 0.146
0.582GluCys: 0.582 ± 0.044
3.455GluAsp: 3.455 ± 0.122
5.73GluGlu: 5.73 ± 0.157
2.125GluPhe: 2.125 ± 0.092
4.34GluGly: 4.34 ± 0.117
1.54GluHis: 1.54 ± 0.076
4.742GluIle: 4.742 ± 0.135
5.464GluLys: 5.464 ± 0.167
7.087GluLeu: 7.087 ± 0.165
2.005GluMet: 2.005 ± 0.089
2.664GluAsn: 2.664 ± 0.102
2.355GluPro: 2.355 ± 0.086
4.503GluGln: 4.503 ± 0.145
4.13GluArg: 4.13 ± 0.12
3.113GluSer: 3.113 ± 0.087
3.106GluThr: 3.106 ± 0.11
4.423GluVal: 4.423 ± 0.137
0.615GluTrp: 0.615 ± 0.051
1.846GluTyr: 1.846 ± 0.088
0.0GluXaa: 0.0 ± 0.0
Phe
3.066PheAla: 3.066 ± 0.114
0.782PheCys: 0.782 ± 0.049
2.228PheAsp: 2.228 ± 0.09
1.985PheGlu: 1.985 ± 0.075
2.744PhePhe: 2.744 ± 0.114
2.956PheGly: 2.956 ± 0.102
0.948PheHis: 0.948 ± 0.061
2.544PheIle: 2.544 ± 0.089
1.706PheLys: 1.706 ± 0.081
4.885PheLeu: 4.885 ± 0.152
0.878PheMet: 0.878 ± 0.05
1.62PheAsn: 1.62 ± 0.068
1.866PhePro: 1.866 ± 0.083
1.45PheGln: 1.45 ± 0.074
2.348PheArg: 2.348 ± 0.093
3.652PheSer: 3.652 ± 0.128
2.418PheThr: 2.418 ± 0.084
2.488PheVal: 2.488 ± 0.101
0.529PheTrp: 0.529 ± 0.043
1.31PheTyr: 1.31 ± 0.074
0.0PheXaa: 0.0 ± 0.0
Gly
5.278GlyAla: 5.278 ± 0.144
1.267GlyCys: 1.267 ± 0.072
3.725GlyAsp: 3.725 ± 0.126
4.792GlyGlu: 4.792 ± 0.133
3.023GlyPhe: 3.023 ± 0.108
5.338GlyGly: 5.338 ± 0.146
1.49GlyHis: 1.49 ± 0.069
5.058GlyIle: 5.058 ± 0.126
4.829GlyLys: 4.829 ± 0.132
7.153GlyLeu: 7.153 ± 0.171
2.478GlyMet: 2.478 ± 0.092
2.81GlyAsn: 2.81 ± 0.108
2.281GlyPro: 2.281 ± 0.106
2.797GlyGln: 2.797 ± 0.102
4.174GlyArg: 4.174 ± 0.129
4.406GlySer: 4.406 ± 0.123
4.011GlyThr: 4.011 ± 0.13
5.062GlyVal: 5.062 ± 0.146
0.888GlyTrp: 0.888 ± 0.062
2.484GlyTyr: 2.484 ± 0.107
0.0GlyXaa: 0.0 ± 0.0
His
1.553HisAla: 1.553 ± 0.064
0.412HisCys: 0.412 ± 0.036
1.061HisAsp: 1.061 ± 0.065
1.141HisGlu: 1.141 ± 0.067
1.014HisPhe: 1.014 ± 0.066
1.553HisGly: 1.553 ± 0.075
0.648HisHis: 0.648 ± 0.052
1.344HisIle: 1.344 ± 0.065
0.998HisLys: 0.998 ± 0.047
2.232HisLeu: 2.232 ± 0.083
0.386HisMet: 0.386 ± 0.042
0.788HisAsn: 0.788 ± 0.061
1.27HisPro: 1.27 ± 0.073
0.958HisGln: 0.958 ± 0.049
1.277HisArg: 1.277 ± 0.066
1.25HisSer: 1.25 ± 0.067
1.054HisThr: 1.054 ± 0.052
1.167HisVal: 1.167 ± 0.072
0.239HisTrp: 0.239 ± 0.031
0.672HisTyr: 0.672 ± 0.045
0.0HisXaa: 0.0 ± 0.0
Ile
5.185IleAla: 5.185 ± 0.134
0.875IleCys: 0.875 ± 0.054
3.628IleAsp: 3.628 ± 0.117
3.838IleGlu: 3.838 ± 0.108
2.873IlePhe: 2.873 ± 0.099
4.613IleGly: 4.613 ± 0.147
1.383IleHis: 1.383 ± 0.063
4.367IleIle: 4.367 ± 0.131
3.262IleLys: 3.262 ± 0.114
6.192IleLeu: 6.192 ± 0.148
1.473IleMet: 1.473 ± 0.068
2.501IleAsn: 2.501 ± 0.095
2.737IlePro: 2.737 ± 0.102
2.138IleGln: 2.138 ± 0.09
3.768IleArg: 3.768 ± 0.116
4.174IleSer: 4.174 ± 0.121
3.662IleThr: 3.662 ± 0.112
3.881IleVal: 3.881 ± 0.106
0.605IleTrp: 0.605 ± 0.051
1.61IleTyr: 1.61 ± 0.075
0.0IleXaa: 0.0 ± 0.0
Lys
4.253LysAla: 4.253 ± 0.123
0.582LysCys: 0.582 ± 0.055
2.867LysAsp: 2.867 ± 0.087
4.939LysGlu: 4.939 ± 0.139
1.556LysPhe: 1.556 ± 0.065
4.067LysGly: 4.067 ± 0.128
1.001LysHis: 1.001 ± 0.064
4.117LysIle: 4.117 ± 0.115
5.567LysLys: 5.567 ± 0.177
4.51LysLeu: 4.51 ± 0.141
1.729LysMet: 1.729 ± 0.076
2.724LysAsn: 2.724 ± 0.101
1.962LysPro: 1.962 ± 0.076
2.245LysGln: 2.245 ± 0.088
2.937LysArg: 2.937 ± 0.098
2.754LysSer: 2.754 ± 0.111
3.203LysThr: 3.203 ± 0.101
3.638LysVal: 3.638 ± 0.102
0.353LysTrp: 0.353 ± 0.035
1.583LysTyr: 1.583 ± 0.074
0.0LysXaa: 0.0 ± 0.0
Leu
9.455LeuAla: 9.455 ± 0.205
1.417LeuCys: 1.417 ± 0.061
5.597LeuAsp: 5.597 ± 0.148
6.405LeuGlu: 6.405 ± 0.155
4.786LeuPhe: 4.786 ± 0.15
6.768LeuGly: 6.768 ± 0.152
2.518LeuHis: 2.518 ± 0.094
6.109LeuIle: 6.109 ± 0.157
5.358LeuLys: 5.358 ± 0.131
12.188LeuLeu: 12.188 ± 0.295
2.301LeuMet: 2.301 ± 0.085
3.588LeuAsn: 3.588 ± 0.114
5.211LeuPro: 5.211 ± 0.14
4.154LeuGln: 4.154 ± 0.125
5.57LeuArg: 5.57 ± 0.134
6.595LeuSer: 6.595 ± 0.163
5.514LeuThr: 5.514 ± 0.139
6.778LeuVal: 6.778 ± 0.148
0.898LeuTrp: 0.898 ± 0.062
2.784LeuTyr: 2.784 ± 0.11
0.0LeuXaa: 0.0 ± 0.0
Met
2.328MetAla: 2.328 ± 0.104
0.243MetCys: 0.243 ± 0.026
1.38MetAsp: 1.38 ± 0.067
1.916MetGlu: 1.916 ± 0.077
0.821MetPhe: 0.821 ± 0.05
1.849MetGly: 1.849 ± 0.074
0.509MetHis: 0.509 ± 0.043
1.586MetIle: 1.586 ± 0.068
1.64MetLys: 1.64 ± 0.079
2.757MetLeu: 2.757 ± 0.087
0.738MetMet: 0.738 ± 0.051
1.224MetAsn: 1.224 ± 0.066
1.204MetPro: 1.204 ± 0.062
1.284MetGln: 1.284 ± 0.067
1.423MetArg: 1.423 ± 0.073
1.57MetSer: 1.57 ± 0.071
1.669MetThr: 1.669 ± 0.081
2.045MetVal: 2.045 ± 0.093
0.153MetTrp: 0.153 ± 0.018
0.565MetTyr: 0.565 ± 0.043
0.0MetXaa: 0.0 ± 0.0
Asn
2.627AsnAla: 2.627 ± 0.097
0.452AsnCys: 0.452 ± 0.043
1.866AsnAsp: 1.866 ± 0.082
2.022AsnGlu: 2.022 ± 0.083
1.526AsnPhe: 1.526 ± 0.086
2.621AsnGly: 2.621 ± 0.104
0.678AsnHis: 0.678 ± 0.05
2.754AsnIle: 2.754 ± 0.096
2.105AsnLys: 2.105 ± 0.085
3.509AsnLeu: 3.509 ± 0.117
1.044AsnMet: 1.044 ± 0.065
1.51AsnAsn: 1.51 ± 0.091
2.029AsnPro: 2.029 ± 0.068
1.516AsnGln: 1.516 ± 0.075
2.378AsnArg: 2.378 ± 0.084
2.188AsnSer: 2.188 ± 0.097
1.802AsnThr: 1.802 ± 0.078
2.009AsnVal: 2.009 ± 0.084
0.416AsnTrp: 0.416 ± 0.039
1.111AsnTyr: 1.111 ± 0.066
0.0AsnXaa: 0.0 ± 0.0
Pro
3.628ProAla: 3.628 ± 0.119
0.552ProCys: 0.552 ± 0.041
3.123ProAsp: 3.123 ± 0.096
3.788ProGlu: 3.788 ± 0.118
1.822ProPhe: 1.822 ± 0.079
3.425ProGly: 3.425 ± 0.109
0.778ProHis: 0.778 ± 0.05
2.268ProIle: 2.268 ± 0.09
2.032ProLys: 2.032 ± 0.093
4.273ProLeu: 4.273 ± 0.099
1.161ProMet: 1.161 ± 0.06
1.304ProAsn: 1.304 ± 0.072
1.816ProPro: 1.816 ± 0.091
1.55ProGln: 1.55 ± 0.084
1.709ProArg: 1.709 ± 0.076
2.328ProSer: 2.328 ± 0.084
1.829ProThr: 1.829 ± 0.088
3.678ProVal: 3.678 ± 0.118
0.562ProTrp: 0.562 ± 0.044
1.137ProTyr: 1.137 ± 0.058
0.0ProXaa: 0.0 ± 0.0
Gln
3.894GlnAla: 3.894 ± 0.109
0.432GlnCys: 0.432 ± 0.042
2.049GlnAsp: 2.049 ± 0.088
3.941GlnGlu: 3.941 ± 0.137
1.38GlnPhe: 1.38 ± 0.06
3.472GlnGly: 3.472 ± 0.131
0.915GlnHis: 0.915 ± 0.052
2.105GlnIle: 2.105 ± 0.083
2.351GlnLys: 2.351 ± 0.079
4.091GlnLeu: 4.091 ± 0.126
0.895GlnMet: 0.895 ± 0.053
1.34GlnAsn: 1.34 ± 0.064
1.729GlnPro: 1.729 ± 0.09
2.727GlnGln: 2.727 ± 0.131
2.321GlnArg: 2.321 ± 0.091
2.002GlnSer: 2.002 ± 0.08
1.919GlnThr: 1.919 ± 0.084
2.99GlnVal: 2.99 ± 0.094
0.416GlnTrp: 0.416 ± 0.04
1.207GlnTyr: 1.207 ± 0.071
0.0GlnXaa: 0.0 ± 0.0
Arg
3.555ArgAla: 3.555 ± 0.108
0.718ArgCys: 0.718 ± 0.046
2.7ArgAsp: 2.7 ± 0.096
4.007ArgGlu: 4.007 ± 0.112
2.584ArgPhe: 2.584 ± 0.082
3.086ArgGly: 3.086 ± 0.11
1.304ArgHis: 1.304 ± 0.068
3.768ArgIle: 3.768 ± 0.111
3.795ArgLys: 3.795 ± 0.123
6.079ArgLeu: 6.079 ± 0.157
1.683ArgMet: 1.683 ± 0.071
2.248ArgAsn: 2.248 ± 0.081
2.251ArgPro: 2.251 ± 0.09
2.697ArgGln: 2.697 ± 0.104
3.256ArgArg: 3.256 ± 0.109
3.249ArgSer: 3.249 ± 0.108
2.574ArgThr: 2.574 ± 0.098
3.628ArgVal: 3.628 ± 0.124
0.535ArgTrp: 0.535 ± 0.049
1.739ArgTyr: 1.739 ± 0.078
0.0ArgXaa: 0.0 ± 0.0
Ser
4.25SerAla: 4.25 ± 0.121
1.068SerCys: 1.068 ± 0.062
2.853SerAsp: 2.853 ± 0.099
3.485SerGlu: 3.485 ± 0.112
2.903SerPhe: 2.903 ± 0.118
5.417SerGly: 5.417 ± 0.145
1.008SerHis: 1.008 ± 0.061
3.449SerIle: 3.449 ± 0.105
2.804SerLys: 2.804 ± 0.1
6.392SerLeu: 6.392 ± 0.144
1.746SerMet: 1.746 ± 0.075
1.693SerAsn: 1.693 ± 0.079
2.607SerPro: 2.607 ± 0.093
1.982SerGln: 1.982 ± 0.084
3.462SerArg: 3.462 ± 0.112
4.363SerSer: 4.363 ± 0.129
3.036SerThr: 3.036 ± 0.111
4.27SerVal: 4.27 ± 0.127
0.898SerTrp: 0.898 ± 0.049
1.932SerTyr: 1.932 ± 0.08
0.0SerXaa: 0.0 ± 0.0
Thr
4.925ThrAla: 4.925 ± 0.135
0.752ThrCys: 0.752 ± 0.05
2.87ThrAsp: 2.87 ± 0.097
3.439ThrGlu: 3.439 ± 0.1
1.929ThrPhe: 1.929 ± 0.083
4.759ThrGly: 4.759 ± 0.119
0.964ThrHis: 0.964 ± 0.052
3.09ThrIle: 3.09 ± 0.111
2.301ThrLys: 2.301 ± 0.087
5.308ThrLeu: 5.308 ± 0.145
1.27ThrMet: 1.27 ± 0.067
1.453ThrAsn: 1.453 ± 0.08
2.577ThrPro: 2.577 ± 0.102
1.48ThrGln: 1.48 ± 0.073
2.391ThrArg: 2.391 ± 0.088
3.016ThrSer: 3.016 ± 0.113
2.89ThrThr: 2.89 ± 0.113
4.579ThrVal: 4.579 ± 0.121
0.622ThrTrp: 0.622 ± 0.042
1.36ThrTyr: 1.36 ± 0.073
0.0ThrXaa: 0.0 ± 0.0
Val
5.564ValAla: 5.564 ± 0.168
0.948ValCys: 0.948 ± 0.058
4.014ValAsp: 4.014 ± 0.112
4.673ValGlu: 4.673 ± 0.13
3.06ValPhe: 3.06 ± 0.115
4.576ValGly: 4.576 ± 0.131
1.49ValHis: 1.49 ± 0.069
4.313ValIle: 4.313 ± 0.128
3.362ValLys: 3.362 ± 0.105
7.27ValLeu: 7.27 ± 0.169
1.842ValMet: 1.842 ± 0.082
2.401ValAsn: 2.401 ± 0.078
2.847ValPro: 2.847 ± 0.109
2.74ValGln: 2.74 ± 0.099
3.944ValArg: 3.944 ± 0.115
4.164ValSer: 4.164 ± 0.13
3.741ValThr: 3.741 ± 0.115
5.062ValVal: 5.062 ± 0.159
0.615ValTrp: 0.615 ± 0.052
1.936ValTyr: 1.936 ± 0.081
0.0ValXaa: 0.0 ± 0.0
Trp
0.745TrpAla: 0.745 ± 0.054
0.163TrpCys: 0.163 ± 0.023
0.549TrpAsp: 0.549 ± 0.043
0.632TrpGlu: 0.632 ± 0.048
0.479TrpPhe: 0.479 ± 0.038
0.722TrpGly: 0.722 ± 0.051
0.236TrpHis: 0.236 ± 0.03
0.589TrpIle: 0.589 ± 0.042
0.529TrpLys: 0.529 ± 0.043
1.257TrpLeu: 1.257 ± 0.079
0.299TrpMet: 0.299 ± 0.029
0.389TrpAsn: 0.389 ± 0.037
0.389TrpPro: 0.389 ± 0.038
0.718TrpGln: 0.718 ± 0.05
0.625TrpArg: 0.625 ± 0.047
0.652TrpSer: 0.652 ± 0.051
0.529TrpThr: 0.529 ± 0.047
0.612TrpVal: 0.612 ± 0.046
0.183TrpTrp: 0.183 ± 0.023
0.326TrpTyr: 0.326 ± 0.033
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.015TyrAla: 2.015 ± 0.097
0.489TyrCys: 0.489 ± 0.038
1.49TyrAsp: 1.49 ± 0.096
1.546TyrGlu: 1.546 ± 0.076
1.443TyrPhe: 1.443 ± 0.075
2.032TyrGly: 2.032 ± 0.074
0.652TyrHis: 0.652 ± 0.045
1.763TyrIle: 1.763 ± 0.085
1.247TyrLys: 1.247 ± 0.064
3.189TyrLeu: 3.189 ± 0.098
0.562TyrMet: 0.562 ± 0.042
1.161TyrAsn: 1.161 ± 0.066
1.423TyrPro: 1.423 ± 0.068
1.314TyrGln: 1.314 ± 0.065
1.832TyrArg: 1.832 ± 0.078
1.889TyrSer: 1.889 ± 0.074
1.753TyrThr: 1.753 ± 0.079
1.52TyrVal: 1.52 ± 0.075
0.372TyrTrp: 0.372 ± 0.036
0.958TyrTyr: 0.958 ± 0.064
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1454 proteins (300695 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski