Amino acid dipepetide frequency for Streptomyces abyssalis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.672AlaAla: 20.672 ± 0.181
1.094AlaCys: 1.094 ± 0.029
7.782AlaAsp: 7.782 ± 0.075
9.083AlaGlu: 9.083 ± 0.104
3.445AlaPhe: 3.445 ± 0.047
14.127AlaGly: 14.127 ± 0.128
2.701AlaHis: 2.701 ± 0.043
2.902AlaIle: 2.902 ± 0.053
2.911AlaLys: 2.911 ± 0.064
13.553AlaLeu: 13.553 ± 0.128
2.576AlaMet: 2.576 ± 0.043
1.816AlaAsn: 1.816 ± 0.033
6.725AlaPro: 6.725 ± 0.08
3.786AlaGln: 3.786 ± 0.048
10.128AlaArg: 10.128 ± 0.104
6.084AlaSer: 6.084 ± 0.067
6.11AlaThr: 6.11 ± 0.055
11.944AlaVal: 11.944 ± 0.117
1.667AlaTrp: 1.667 ± 0.038
2.596AlaTyr: 2.596 ± 0.042
0.0AlaXaa: 0.0 ± 0.0
Cys
1.119CysAla: 1.119 ± 0.028
0.101CysCys: 0.101 ± 0.009
0.492CysAsp: 0.492 ± 0.02
0.46CysGlu: 0.46 ± 0.017
0.221CysPhe: 0.221 ± 0.011
1.022CysGly: 1.022 ± 0.027
0.201CysHis: 0.201 ± 0.012
0.186CysIle: 0.186 ± 0.011
0.112CysLys: 0.112 ± 0.009
0.727CysLeu: 0.727 ± 0.021
0.147CysMet: 0.147 ± 0.01
0.134CysAsn: 0.134 ± 0.008
0.459CysPro: 0.459 ± 0.018
0.153CysGln: 0.153 ± 0.009
0.635CysArg: 0.635 ± 0.021
0.453CysSer: 0.453 ± 0.017
0.523CysThr: 0.523 ± 0.018
0.702CysVal: 0.702 ± 0.022
0.131CysTrp: 0.131 ± 0.009
0.155CysTyr: 0.155 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
7.575AspAla: 7.575 ± 0.085
0.414AspCys: 0.414 ± 0.019
3.46AspAsp: 3.46 ± 0.055
4.351AspGlu: 4.351 ± 0.058
1.738AspPhe: 1.738 ± 0.03
6.755AspGly: 6.755 ± 0.075
1.283AspHis: 1.283 ± 0.029
1.819AspIle: 1.819 ± 0.036
1.275AspLys: 1.275 ± 0.035
5.5AspLeu: 5.5 ± 0.067
0.918AspMet: 0.918 ± 0.025
0.868AspAsn: 0.868 ± 0.026
4.167AspPro: 4.167 ± 0.048
1.468AspGln: 1.468 ± 0.037
4.452AspArg: 4.452 ± 0.054
2.773AspSer: 2.773 ± 0.045
2.766AspThr: 2.766 ± 0.041
4.822AspVal: 4.822 ± 0.056
0.949AspTrp: 0.949 ± 0.025
1.083AspTyr: 1.083 ± 0.028
0.0AspXaa: 0.0 ± 0.0
Glu
8.031GluAla: 8.031 ± 0.092
0.415GluCys: 0.415 ± 0.015
3.263GluAsp: 3.263 ± 0.052
4.318GluGlu: 4.318 ± 0.07
1.558GluPhe: 1.558 ± 0.031
5.102GluGly: 5.102 ± 0.059
1.641GluHis: 1.641 ± 0.035
2.295GluIle: 2.295 ± 0.041
1.783GluLys: 1.783 ± 0.035
7.242GluLeu: 7.242 ± 0.075
1.09GluMet: 1.09 ± 0.028
1.135GluAsn: 1.135 ± 0.028
3.571GluPro: 3.571 ± 0.047
2.47GluGln: 2.47 ± 0.04
5.987GluArg: 5.987 ± 0.076
3.134GluSer: 3.134 ± 0.05
3.164GluThr: 3.164 ± 0.048
4.622GluVal: 4.622 ± 0.054
0.899GluTrp: 0.899 ± 0.023
1.17GluTyr: 1.17 ± 0.028
0.0GluXaa: 0.0 ± 0.0
Phe
3.668PheAla: 3.668 ± 0.051
0.277PheCys: 0.277 ± 0.012
1.926PheAsp: 1.926 ± 0.033
1.549PheGlu: 1.549 ± 0.033
0.958PhePhe: 0.958 ± 0.027
3.194PheGly: 3.194 ± 0.051
0.618PheHis: 0.618 ± 0.019
0.811PheIle: 0.811 ± 0.022
0.552PheLys: 0.552 ± 0.02
2.606PheLeu: 2.606 ± 0.044
0.446PheMet: 0.446 ± 0.017
0.558PheAsn: 0.558 ± 0.019
1.402PhePro: 1.402 ± 0.03
0.662PheGln: 0.662 ± 0.02
1.866PheArg: 1.866 ± 0.034
1.515PheSer: 1.515 ± 0.032
1.96PheThr: 1.96 ± 0.032
2.233PheVal: 2.233 ± 0.038
0.418PheTrp: 0.418 ± 0.018
0.589PheTyr: 0.589 ± 0.019
0.0PheXaa: 0.0 ± 0.0
Gly
11.57GlyAla: 11.57 ± 0.11
0.889GlyCys: 0.889 ± 0.027
5.428GlyAsp: 5.428 ± 0.069
6.279GlyGlu: 6.279 ± 0.068
2.979GlyPhe: 2.979 ± 0.047
10.417GlyGly: 10.417 ± 0.124
2.454GlyHis: 2.454 ± 0.042
3.405GlyIle: 3.405 ± 0.045
2.827GlyLys: 2.827 ± 0.057
9.474GlyLeu: 9.474 ± 0.085
2.225GlyMet: 2.225 ± 0.039
1.857GlyAsn: 1.857 ± 0.034
5.526GlyPro: 5.526 ± 0.065
2.802GlyGln: 2.802 ± 0.056
8.146GlyArg: 8.146 ± 0.076
6.212GlySer: 6.212 ± 0.077
6.521GlyThr: 6.521 ± 0.069
7.625GlyVal: 7.625 ± 0.08
1.683GlyTrp: 1.683 ± 0.036
2.247GlyTyr: 2.247 ± 0.043
0.0GlyXaa: 0.0 ± 0.0
His
2.615HisAla: 2.615 ± 0.045
0.226HisCys: 0.226 ± 0.012
1.335HisAsp: 1.335 ± 0.028
1.337HisGlu: 1.337 ± 0.02
0.72HisPhe: 0.72 ± 0.021
2.6HisGly: 2.6 ± 0.043
0.615HisHis: 0.615 ± 0.02
0.719HisIle: 0.719 ± 0.02
0.383HisLys: 0.383 ± 0.017
2.268HisLeu: 2.268 ± 0.044
0.368HisMet: 0.368 ± 0.016
0.371HisAsn: 0.371 ± 0.015
1.726HisPro: 1.726 ± 0.033
0.609HisGln: 0.609 ± 0.02
1.984HisArg: 1.984 ± 0.041
1.142HisSer: 1.142 ± 0.028
1.294HisThr: 1.294 ± 0.027
1.676HisVal: 1.676 ± 0.032
0.347HisTrp: 0.347 ± 0.014
0.479HisTyr: 0.479 ± 0.017
0.0HisXaa: 0.0 ± 0.0
Ile
4.415IleAla: 4.415 ± 0.053
0.292IleCys: 0.292 ± 0.013
2.011IleAsp: 2.011 ± 0.033
1.989IleGlu: 1.989 ± 0.037
0.746IlePhe: 0.746 ± 0.023
3.437IleGly: 3.437 ± 0.056
0.585IleHis: 0.585 ± 0.017
0.871IleIle: 0.871 ± 0.025
0.76IleLys: 0.76 ± 0.025
2.223IleLeu: 2.223 ± 0.048
0.449IleMet: 0.449 ± 0.014
0.651IleAsn: 0.651 ± 0.018
1.644IlePro: 1.644 ± 0.031
0.653IleGln: 0.653 ± 0.024
2.081IleArg: 2.081 ± 0.041
1.73IleSer: 1.73 ± 0.033
2.016IleThr: 2.016 ± 0.045
2.631IleVal: 2.631 ± 0.049
0.362IleTrp: 0.362 ± 0.014
0.521IleTyr: 0.521 ± 0.02
0.0IleXaa: 0.0 ± 0.0
Lys
2.936LysAla: 2.936 ± 0.057
0.131LysCys: 0.131 ± 0.008
1.455LysAsp: 1.455 ± 0.037
1.39LysGlu: 1.39 ± 0.037
0.465LysPhe: 0.465 ± 0.018
2.101LysGly: 2.101 ± 0.044
0.49LysHis: 0.49 ± 0.025
0.862LysIle: 0.862 ± 0.025
1.07LysLys: 1.07 ± 0.04
2.194LysLeu: 2.194 ± 0.045
0.433LysMet: 0.433 ± 0.019
0.532LysAsn: 0.532 ± 0.021
1.462LysPro: 1.462 ± 0.042
0.773LysGln: 0.773 ± 0.025
1.636LysArg: 1.636 ± 0.031
1.365LysSer: 1.365 ± 0.034
1.256LysThr: 1.256 ± 0.03
1.887LysVal: 1.887 ± 0.039
0.289LysTrp: 0.289 ± 0.013
0.495LysTyr: 0.495 ± 0.018
0.0LysXaa: 0.0 ± 0.0
Leu
14.107LeuAla: 14.107 ± 0.127
0.847LeuCys: 0.847 ± 0.023
6.263LeuAsp: 6.263 ± 0.063
5.227LeuGlu: 5.227 ± 0.068
2.6LeuPhe: 2.6 ± 0.041
9.198LeuGly: 9.198 ± 0.076
2.269LeuHis: 2.269 ± 0.04
3.21LeuIle: 3.21 ± 0.053
2.039LeuLys: 2.039 ± 0.041
10.916LeuLeu: 10.916 ± 0.13
1.771LeuMet: 1.771 ± 0.034
1.63LeuAsn: 1.63 ± 0.031
6.302LeuPro: 6.302 ± 0.063
2.198LeuGln: 2.198 ± 0.038
8.663LeuArg: 8.663 ± 0.085
5.44LeuSer: 5.44 ± 0.06
6.517LeuThr: 6.517 ± 0.066
8.383LeuVal: 8.383 ± 0.092
1.223LeuTrp: 1.223 ± 0.027
1.762LeuTyr: 1.762 ± 0.031
0.0LeuXaa: 0.0 ± 0.0
Met
2.357MetAla: 2.357 ± 0.041
0.169MetCys: 0.169 ± 0.009
0.989MetAsp: 0.989 ± 0.028
0.879MetGlu: 0.879 ± 0.025
0.476MetPhe: 0.476 ± 0.017
1.419MetGly: 1.419 ± 0.028
0.423MetHis: 0.423 ± 0.015
0.661MetIle: 0.661 ± 0.019
0.466MetLys: 0.466 ± 0.019
1.942MetLeu: 1.942 ± 0.036
0.32MetMet: 0.32 ± 0.015
0.446MetAsn: 0.446 ± 0.018
1.281MetPro: 1.281 ± 0.029
0.483MetGln: 0.483 ± 0.018
1.621MetArg: 1.621 ± 0.03
1.401MetSer: 1.401 ± 0.027
1.541MetThr: 1.541 ± 0.031
1.326MetVal: 1.326 ± 0.029
0.255MetTrp: 0.255 ± 0.012
0.333MetTyr: 0.333 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
2.111AsnAla: 2.111 ± 0.036
0.178AsnCys: 0.178 ± 0.011
0.972AsnAsp: 0.972 ± 0.024
0.889AsnGlu: 0.889 ± 0.023
0.475AsnPhe: 0.475 ± 0.016
1.798AsnGly: 1.798 ± 0.04
0.381AsnHis: 0.381 ± 0.015
0.642AsnIle: 0.642 ± 0.022
0.436AsnLys: 0.436 ± 0.017
1.656AsnLeu: 1.656 ± 0.031
0.319AsnMet: 0.319 ± 0.014
0.426AsnAsn: 0.426 ± 0.016
1.274AsnPro: 1.274 ± 0.03
0.448AsnGln: 0.448 ± 0.019
1.259AsnArg: 1.259 ± 0.029
1.05AsnSer: 1.05 ± 0.032
1.018AsnThr: 1.018 ± 0.028
1.329AsnVal: 1.329 ± 0.029
0.272AsnTrp: 0.272 ± 0.013
0.431AsnTyr: 0.431 ± 0.017
0.0AsnXaa: 0.0 ± 0.0
Pro
7.968ProAla: 7.968 ± 0.089
0.34ProCys: 0.34 ± 0.014
4.268ProAsp: 4.268 ± 0.055
4.715ProGlu: 4.715 ± 0.059
1.508ProPhe: 1.508 ± 0.03
7.38ProGly: 7.38 ± 0.094
1.367ProHis: 1.367 ± 0.028
0.997ProIle: 0.997 ± 0.025
1.169ProLys: 1.169 ± 0.032
5.11ProLeu: 5.11 ± 0.056
1.044ProMet: 1.044 ± 0.027
0.796ProAsn: 0.796 ± 0.021
3.535ProPro: 3.535 ± 0.075
1.875ProGln: 1.875 ± 0.047
3.928ProArg: 3.928 ± 0.046
3.294ProSer: 3.294 ± 0.052
2.467ProThr: 2.467 ± 0.04
5.477ProVal: 5.477 ± 0.058
0.851ProTrp: 0.851 ± 0.025
1.42ProTyr: 1.42 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
3.534GlnAla: 3.534 ± 0.058
0.168GlnCys: 0.168 ± 0.011
1.435GlnAsp: 1.435 ± 0.035
1.642GlnGlu: 1.642 ± 0.039
0.704GlnPhe: 0.704 ± 0.022
2.399GlnGly: 2.399 ± 0.051
0.729GlnHis: 0.729 ± 0.024
1.043GlnIle: 1.043 ± 0.024
0.659GlnLys: 0.659 ± 0.025
3.175GlnLeu: 3.175 ± 0.043
0.559GlnMet: 0.559 ± 0.021
0.515GlnAsn: 0.515 ± 0.022
1.756GlnPro: 1.756 ± 0.044
1.417GlnGln: 1.417 ± 0.043
2.477GlnArg: 2.477 ± 0.048
1.327GlnSer: 1.327 ± 0.029
1.311GlnThr: 1.311 ± 0.031
2.25GlnVal: 2.25 ± 0.039
0.418GlnTrp: 0.418 ± 0.015
0.565GlnTyr: 0.565 ± 0.021
0.0GlnXaa: 0.0 ± 0.0
Arg
9.423ArgAla: 9.423 ± 0.102
0.611ArgCys: 0.611 ± 0.02
4.326ArgAsp: 4.326 ± 0.044
5.441ArgGlu: 5.441 ± 0.063
2.274ArgPhe: 2.274 ± 0.041
6.145ArgGly: 6.145 ± 0.069
2.094ArgHis: 2.094 ± 0.038
3.122ArgIle: 3.122 ± 0.047
1.895ArgLys: 1.895 ± 0.039
8.525ArgLeu: 8.525 ± 0.087
1.919ArgMet: 1.919 ± 0.036
1.431ArgAsn: 1.431 ± 0.03
4.69ArgPro: 4.69 ± 0.059
2.423ArgGln: 2.423 ± 0.043
7.732ArgArg: 7.732 ± 0.099
4.345ArgSer: 4.345 ± 0.052
5.448ArgThr: 5.448 ± 0.065
5.645ArgVal: 5.645 ± 0.062
1.32ArgTrp: 1.32 ± 0.029
1.792ArgTyr: 1.792 ± 0.034
0.0ArgXaa: 0.0 ± 0.0
Ser
7.146SerAla: 7.146 ± 0.068
0.422SerCys: 0.422 ± 0.017
2.809SerAsp: 2.809 ± 0.042
3.015SerGlu: 3.015 ± 0.043
1.682SerPhe: 1.682 ± 0.036
6.769SerGly: 6.769 ± 0.072
1.083SerHis: 1.083 ± 0.03
1.326SerIle: 1.326 ± 0.03
1.181SerLys: 1.181 ± 0.036
4.955SerLeu: 4.955 ± 0.056
1.157SerMet: 1.157 ± 0.028
0.844SerAsn: 0.844 ± 0.028
3.265SerPro: 3.265 ± 0.047
1.395SerGln: 1.395 ± 0.033
4.025SerArg: 4.025 ± 0.055
3.232SerSer: 3.232 ± 0.055
2.916SerThr: 2.916 ± 0.045
4.629SerVal: 4.629 ± 0.056
0.887SerTrp: 0.887 ± 0.025
1.246SerTyr: 1.246 ± 0.028
0.0SerXaa: 0.0 ± 0.0
Thr
8.217ThrAla: 8.217 ± 0.07
0.405ThrCys: 0.405 ± 0.015
3.383ThrAsp: 3.383 ± 0.045
3.293ThrGlu: 3.293 ± 0.046
1.582ThrPhe: 1.582 ± 0.032
6.917ThrGly: 6.917 ± 0.069
1.113ThrHis: 1.113 ± 0.029
1.474ThrIle: 1.474 ± 0.033
1.161ThrLys: 1.161 ± 0.025
5.338ThrLeu: 5.338 ± 0.059
0.958ThrMet: 0.958 ± 0.024
0.94ThrAsn: 0.94 ± 0.024
3.637ThrPro: 3.637 ± 0.049
1.266ThrGln: 1.266 ± 0.029
3.693ThrArg: 3.693 ± 0.047
3.068ThrSer: 3.068 ± 0.048
3.204ThrThr: 3.204 ± 0.044
5.893ThrVal: 5.893 ± 0.062
0.757ThrTrp: 0.757 ± 0.023
1.197ThrTyr: 1.197 ± 0.029
0.0ThrXaa: 0.0 ± 0.0
Val
10.091ValAla: 10.091 ± 0.092
0.841ValCys: 0.841 ± 0.023
4.604ValAsp: 4.604 ± 0.065
4.833ValGlu: 4.833 ± 0.057
2.473ValPhe: 2.473 ± 0.043
6.394ValGly: 6.394 ± 0.068
2.055ValHis: 2.055 ± 0.036
2.73ValIle: 2.73 ± 0.046
1.731ValLys: 1.731 ± 0.038
9.496ValLeu: 9.496 ± 0.084
1.494ValMet: 1.494 ± 0.033
1.638ValAsn: 1.638 ± 0.031
5.284ValPro: 5.284 ± 0.065
2.055ValGln: 2.055 ± 0.039
7.31ValArg: 7.31 ± 0.086
4.497ValSer: 4.497 ± 0.056
5.492ValThr: 5.492 ± 0.061
7.603ValVal: 7.603 ± 0.082
1.114ValTrp: 1.114 ± 0.028
1.47ValTyr: 1.47 ± 0.034
0.0ValXaa: 0.0 ± 0.0
Trp
1.491TrpAla: 1.491 ± 0.031
0.15TrpCys: 0.15 ± 0.01
0.815TrpAsp: 0.815 ± 0.026
0.763TrpGlu: 0.763 ± 0.022
0.538TrpPhe: 0.538 ± 0.018
1.025TrpGly: 1.025 ± 0.025
0.344TrpHis: 0.344 ± 0.015
0.513TrpIle: 0.513 ± 0.019
0.386TrpLys: 0.386 ± 0.018
1.737TrpLeu: 1.737 ± 0.038
0.317TrpMet: 0.317 ± 0.014
0.388TrpAsn: 0.388 ± 0.015
0.757TrpPro: 0.757 ± 0.022
0.625TrpGln: 0.625 ± 0.021
1.258TrpArg: 1.258 ± 0.03
0.911TrpSer: 0.911 ± 0.022
0.899TrpThr: 0.899 ± 0.024
0.921TrpVal: 0.921 ± 0.026
0.303TrpTrp: 0.303 ± 0.014
0.337TrpTyr: 0.337 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.655TyrAla: 2.655 ± 0.043
0.165TyrCys: 0.165 ± 0.01
1.419TyrAsp: 1.419 ± 0.03
1.44TyrGlu: 1.44 ± 0.029
0.668TyrPhe: 0.668 ± 0.021
2.369TyrGly: 2.369 ± 0.041
0.367TyrHis: 0.367 ± 0.016
0.48TyrIle: 0.48 ± 0.018
0.426TyrLys: 0.426 ± 0.018
1.928TyrLeu: 1.928 ± 0.032
0.275TyrMet: 0.275 ± 0.014
0.387TyrAsn: 0.387 ± 0.018
1.043TyrPro: 1.043 ± 0.024
0.522TyrGln: 0.522 ± 0.015
1.721TyrArg: 1.721 ± 0.032
1.01TyrSer: 1.01 ± 0.026
1.073TyrThr: 1.073 ± 0.026
1.608TyrVal: 1.608 ± 0.031
0.329TyrTrp: 0.329 ± 0.015
0.405TyrTyr: 0.405 ± 0.017
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5131 proteins (1675583 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski