Amino acid dipepetide frequency for Arthrobacter phage Beans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.851AlaAla: 18.851 ± 2.004
0.892AlaCys: 0.892 ± 0.275
6.178AlaAsp: 6.178 ± 0.628
9.617AlaGlu: 9.617 ± 1.16
2.866AlaPhe: 2.866 ± 0.524
10.19AlaGly: 10.19 ± 0.812
2.038AlaHis: 2.038 ± 0.345
4.776AlaIle: 4.776 ± 0.547
5.413AlaLys: 5.413 ± 0.58
9.871AlaLeu: 9.871 ± 0.851
3.184AlaMet: 3.184 ± 0.524
3.757AlaAsn: 3.757 ± 0.462
5.413AlaPro: 5.413 ± 0.779
5.668AlaGln: 5.668 ± 0.571
7.77AlaArg: 7.77 ± 0.807
6.432AlaSer: 6.432 ± 0.556
8.024AlaThr: 8.024 ± 1.306
8.852AlaVal: 8.852 ± 0.751
1.401AlaTrp: 1.401 ± 0.298
2.484AlaTyr: 2.484 ± 0.316
0.0AlaXaa: 0.0 ± 0.0
Cys
0.637CysAla: 0.637 ± 0.229
0.0CysCys: 0.0 ± 0.0
0.382CysAsp: 0.382 ± 0.159
0.255CysGlu: 0.255 ± 0.131
0.064CysPhe: 0.064 ± 0.057
0.637CysGly: 0.637 ± 0.238
0.191CysHis: 0.191 ± 0.111
0.318CysIle: 0.318 ± 0.148
0.191CysLys: 0.191 ± 0.106
0.637CysLeu: 0.637 ± 0.243
0.127CysMet: 0.127 ± 0.083
0.191CysAsn: 0.191 ± 0.124
0.701CysPro: 0.701 ± 0.241
0.127CysGln: 0.127 ± 0.086
0.382CysArg: 0.382 ± 0.172
0.382CysSer: 0.382 ± 0.173
0.446CysThr: 0.446 ± 0.163
0.701CysVal: 0.701 ± 0.188
0.191CysTrp: 0.191 ± 0.143
0.191CysTyr: 0.191 ± 0.11
0.0CysXaa: 0.0 ± 0.0
Asp
8.598AspAla: 8.598 ± 0.937
0.382AspCys: 0.382 ± 0.135
5.095AspAsp: 5.095 ± 0.741
5.668AspGlu: 5.668 ± 0.714
1.465AspPhe: 1.465 ± 0.279
5.986AspGly: 5.986 ± 0.586
0.955AspHis: 0.955 ± 0.301
3.121AspIle: 3.121 ± 0.42
2.484AspLys: 2.484 ± 0.357
3.694AspLeu: 3.694 ± 0.482
0.701AspMet: 0.701 ± 0.221
2.102AspAsn: 2.102 ± 0.321
3.248AspPro: 3.248 ± 0.501
1.401AspGln: 1.401 ± 0.312
3.375AspArg: 3.375 ± 0.5
2.675AspSer: 2.675 ± 0.365
3.248AspThr: 3.248 ± 0.483
4.84AspVal: 4.84 ± 0.477
1.21AspTrp: 1.21 ± 0.277
1.656AspTyr: 1.656 ± 0.307
0.0AspXaa: 0.0 ± 0.0
Glu
6.369GluAla: 6.369 ± 0.717
0.701GluCys: 0.701 ± 0.261
3.63GluAsp: 3.63 ± 0.515
3.248GluGlu: 3.248 ± 0.524
1.401GluPhe: 1.401 ± 0.343
4.267GluGly: 4.267 ± 0.643
1.72GluHis: 1.72 ± 0.409
3.757GluIle: 3.757 ± 0.615
3.057GluLys: 3.057 ± 0.48
7.451GluLeu: 7.451 ± 0.89
2.229GluMet: 2.229 ± 0.363
1.72GluAsn: 1.72 ± 0.296
4.458GluPro: 4.458 ± 0.623
3.057GluGln: 3.057 ± 0.406
4.904GluArg: 4.904 ± 0.795
3.184GluSer: 3.184 ± 0.502
3.184GluThr: 3.184 ± 0.522
3.821GluVal: 3.821 ± 0.483
0.764GluTrp: 0.764 ± 0.217
2.038GluTyr: 2.038 ± 0.341
0.0GluXaa: 0.0 ± 0.0
Phe
3.121PheAla: 3.121 ± 0.462
0.127PheCys: 0.127 ± 0.085
2.102PheAsp: 2.102 ± 0.382
2.293PheGlu: 2.293 ± 0.408
0.446PhePhe: 0.446 ± 0.187
2.547PheGly: 2.547 ± 0.419
0.255PheHis: 0.255 ± 0.144
1.083PheIle: 1.083 ± 0.201
1.465PheLys: 1.465 ± 0.326
1.274PheLeu: 1.274 ± 0.267
0.892PheMet: 0.892 ± 0.229
0.892PheAsn: 0.892 ± 0.24
1.528PhePro: 1.528 ± 0.325
0.509PheGln: 0.509 ± 0.168
1.592PheArg: 1.592 ± 0.325
1.656PheSer: 1.656 ± 0.261
2.165PheThr: 2.165 ± 0.342
2.484PheVal: 2.484 ± 0.319
0.701PheTrp: 0.701 ± 0.228
0.509PheTyr: 0.509 ± 0.212
0.0PheXaa: 0.0 ± 0.0
Gly
8.279GlyAla: 8.279 ± 0.774
0.382GlyCys: 0.382 ± 0.188
5.477GlyAsp: 5.477 ± 0.59
4.649GlyGlu: 4.649 ± 0.689
1.911GlyPhe: 1.911 ± 0.354
7.069GlyGly: 7.069 ± 1.128
1.401GlyHis: 1.401 ± 0.274
3.503GlyIle: 3.503 ± 0.469
3.375GlyLys: 3.375 ± 0.523
5.795GlyLeu: 5.795 ± 0.741
1.847GlyMet: 1.847 ± 0.362
2.993GlyAsn: 2.993 ± 0.59
3.057GlyPro: 3.057 ± 0.579
2.356GlyGln: 2.356 ± 0.404
5.095GlyArg: 5.095 ± 0.522
5.159GlySer: 5.159 ± 0.663
5.604GlyThr: 5.604 ± 0.693
6.56GlyVal: 6.56 ± 0.796
1.592GlyTrp: 1.592 ± 0.425
2.165GlyTyr: 2.165 ± 0.378
0.0GlyXaa: 0.0 ± 0.0
His
2.102HisAla: 2.102 ± 0.393
0.064HisCys: 0.064 ± 0.081
0.955HisAsp: 0.955 ± 0.207
1.083HisGlu: 1.083 ± 0.262
0.382HisPhe: 0.382 ± 0.146
0.509HisGly: 0.509 ± 0.157
0.318HisHis: 0.318 ± 0.173
1.083HisIle: 1.083 ± 0.27
0.701HisLys: 0.701 ± 0.242
1.465HisLeu: 1.465 ± 0.295
0.318HisMet: 0.318 ± 0.171
0.446HisAsn: 0.446 ± 0.16
0.955HisPro: 0.955 ± 0.257
0.318HisGln: 0.318 ± 0.141
0.892HisArg: 0.892 ± 0.239
0.764HisSer: 0.764 ± 0.212
1.465HisThr: 1.465 ± 0.381
1.592HisVal: 1.592 ± 0.319
0.255HisTrp: 0.255 ± 0.122
0.509HisTyr: 0.509 ± 0.21
0.0HisXaa: 0.0 ± 0.0
Ile
5.923IleAla: 5.923 ± 0.645
0.191IleCys: 0.191 ± 0.144
3.312IleAsp: 3.312 ± 0.491
4.776IleGlu: 4.776 ± 0.6
1.274IlePhe: 1.274 ± 0.234
4.203IleGly: 4.203 ± 0.733
0.509IleHis: 0.509 ± 0.15
2.675IleIle: 2.675 ± 0.385
2.356IleLys: 2.356 ± 0.368
2.547IleLeu: 2.547 ± 0.469
1.21IleMet: 1.21 ± 0.262
1.783IleAsn: 1.783 ± 0.365
2.038IlePro: 2.038 ± 0.392
0.892IleGln: 0.892 ± 0.276
2.293IleArg: 2.293 ± 0.38
2.165IleSer: 2.165 ± 0.303
3.057IleThr: 3.057 ± 0.464
4.585IleVal: 4.585 ± 0.448
0.382IleTrp: 0.382 ± 0.167
1.274IleTyr: 1.274 ± 0.277
0.0IleXaa: 0.0 ± 0.0
Lys
5.35LysAla: 5.35 ± 0.616
0.382LysCys: 0.382 ± 0.159
1.72LysAsp: 1.72 ± 0.312
1.974LysGlu: 1.974 ± 0.43
1.72LysPhe: 1.72 ± 0.322
2.802LysGly: 2.802 ± 0.396
1.083LysHis: 1.083 ± 0.24
2.42LysIle: 2.42 ± 0.462
1.21LysLys: 1.21 ± 0.333
3.885LysLeu: 3.885 ± 0.495
1.146LysMet: 1.146 ± 0.292
0.892LysAsn: 0.892 ± 0.2
2.802LysPro: 2.802 ± 0.544
2.484LysGln: 2.484 ± 0.477
3.566LysArg: 3.566 ± 0.52
2.165LysSer: 2.165 ± 0.481
3.375LysThr: 3.375 ± 0.442
2.165LysVal: 2.165 ± 0.402
0.764LysTrp: 0.764 ± 0.223
0.955LysTyr: 0.955 ± 0.242
0.0LysXaa: 0.0 ± 0.0
Leu
8.534LeuAla: 8.534 ± 0.696
0.191LeuCys: 0.191 ± 0.112
4.84LeuAsp: 4.84 ± 0.515
3.757LeuGlu: 3.757 ± 0.547
1.911LeuPhe: 1.911 ± 0.34
5.541LeuGly: 5.541 ± 0.932
1.274LeuHis: 1.274 ± 0.285
3.757LeuIle: 3.757 ± 0.595
4.012LeuLys: 4.012 ± 0.507
7.133LeuLeu: 7.133 ± 0.947
2.102LeuMet: 2.102 ± 0.389
2.866LeuAsn: 2.866 ± 0.4
3.821LeuPro: 3.821 ± 0.54
3.566LeuGln: 3.566 ± 0.477
6.05LeuArg: 6.05 ± 0.681
5.923LeuSer: 5.923 ± 0.72
6.942LeuThr: 6.942 ± 0.632
6.05LeuVal: 6.05 ± 0.667
0.892LeuTrp: 0.892 ± 0.3
1.592LeuTyr: 1.592 ± 0.304
0.0LeuXaa: 0.0 ± 0.0
Met
2.866MetAla: 2.866 ± 0.459
0.064MetCys: 0.064 ± 0.057
0.701MetAsp: 0.701 ± 0.223
0.637MetGlu: 0.637 ± 0.255
0.573MetPhe: 0.573 ± 0.162
1.528MetGly: 1.528 ± 0.38
0.127MetHis: 0.127 ± 0.089
1.083MetIle: 1.083 ± 0.324
1.083MetLys: 1.083 ± 0.221
1.465MetLeu: 1.465 ± 0.305
0.318MetMet: 0.318 ± 0.132
0.955MetAsn: 0.955 ± 0.243
1.911MetPro: 1.911 ± 0.466
1.083MetGln: 1.083 ± 0.296
2.038MetArg: 2.038 ± 0.341
1.656MetSer: 1.656 ± 0.368
2.802MetThr: 2.802 ± 0.492
1.528MetVal: 1.528 ± 0.366
0.318MetTrp: 0.318 ± 0.127
0.573MetTyr: 0.573 ± 0.189
0.0MetXaa: 0.0 ± 0.0
Asn
4.776AsnAla: 4.776 ± 0.43
0.509AsnCys: 0.509 ± 0.185
2.42AsnAsp: 2.42 ± 0.393
2.356AsnGlu: 2.356 ± 0.374
0.637AsnPhe: 0.637 ± 0.199
2.802AsnGly: 2.802 ± 0.347
0.255AsnHis: 0.255 ± 0.132
1.528AsnIle: 1.528 ± 0.364
1.592AsnLys: 1.592 ± 0.317
2.102AsnLeu: 2.102 ± 0.34
0.509AsnMet: 0.509 ± 0.171
1.337AsnAsn: 1.337 ± 0.341
2.42AsnPro: 2.42 ± 0.494
0.764AsnGln: 0.764 ± 0.231
2.038AsnArg: 2.038 ± 0.401
1.274AsnSer: 1.274 ± 0.274
2.038AsnThr: 2.038 ± 0.343
1.911AsnVal: 1.911 ± 0.325
1.146AsnTrp: 1.146 ± 0.272
0.828AsnTyr: 0.828 ± 0.199
0.0AsnXaa: 0.0 ± 0.0
Pro
7.515ProAla: 7.515 ± 1.033
0.318ProCys: 0.318 ± 0.126
3.375ProAsp: 3.375 ± 0.466
4.331ProGlu: 4.331 ± 0.589
1.21ProPhe: 1.21 ± 0.329
4.331ProGly: 4.331 ± 0.464
1.146ProHis: 1.146 ± 0.246
2.866ProIle: 2.866 ± 0.602
2.356ProLys: 2.356 ± 0.391
3.821ProLeu: 3.821 ± 0.627
0.637ProMet: 0.637 ± 0.238
1.974ProAsn: 1.974 ± 0.406
2.802ProPro: 2.802 ± 0.572
1.847ProGln: 1.847 ± 0.278
2.42ProArg: 2.42 ± 0.428
3.312ProSer: 3.312 ± 0.631
2.293ProThr: 2.293 ± 0.471
3.248ProVal: 3.248 ± 0.565
0.573ProTrp: 0.573 ± 0.171
1.019ProTyr: 1.019 ± 0.28
0.0ProXaa: 0.0 ± 0.0
Gln
5.095GlnAla: 5.095 ± 0.725
0.382GlnCys: 0.382 ± 0.179
1.401GlnAsp: 1.401 ± 0.261
1.465GlnGlu: 1.465 ± 0.356
1.337GlnPhe: 1.337 ± 0.422
2.802GlnGly: 2.802 ± 0.551
0.701GlnHis: 0.701 ± 0.208
1.528GlnIle: 1.528 ± 0.28
1.592GlnLys: 1.592 ± 0.291
4.522GlnLeu: 4.522 ± 0.629
0.764GlnMet: 0.764 ± 0.242
0.637GlnAsn: 0.637 ± 0.184
1.72GlnPro: 1.72 ± 0.335
1.592GlnGln: 1.592 ± 0.349
2.866GlnArg: 2.866 ± 0.513
1.783GlnSer: 1.783 ± 0.381
2.229GlnThr: 2.229 ± 0.389
2.739GlnVal: 2.739 ± 0.32
0.382GlnTrp: 0.382 ± 0.153
0.573GlnTyr: 0.573 ± 0.188
0.0GlnXaa: 0.0 ± 0.0
Arg
7.133ArgAla: 7.133 ± 0.652
0.637ArgCys: 0.637 ± 0.196
4.331ArgAsp: 4.331 ± 0.491
4.585ArgGlu: 4.585 ± 0.692
2.038ArgPhe: 2.038 ± 0.33
3.949ArgGly: 3.949 ± 0.555
0.701ArgHis: 0.701 ± 0.214
2.293ArgIle: 2.293 ± 0.359
3.121ArgLys: 3.121 ± 0.384
5.286ArgLeu: 5.286 ± 0.623
1.592ArgMet: 1.592 ± 0.325
1.911ArgAsn: 1.911 ± 0.404
2.802ArgPro: 2.802 ± 0.582
2.547ArgGln: 2.547 ± 0.417
4.713ArgArg: 4.713 ± 0.799
3.503ArgSer: 3.503 ± 0.401
3.757ArgThr: 3.757 ± 0.487
5.222ArgVal: 5.222 ± 0.61
1.592ArgTrp: 1.592 ± 0.352
2.229ArgTyr: 2.229 ± 0.414
0.0ArgXaa: 0.0 ± 0.0
Ser
6.305SerAla: 6.305 ± 0.728
0.509SerCys: 0.509 ± 0.185
3.566SerAsp: 3.566 ± 0.402
3.121SerGlu: 3.121 ± 0.396
1.911SerPhe: 1.911 ± 0.404
5.668SerGly: 5.668 ± 0.86
0.828SerHis: 0.828 ± 0.275
2.611SerIle: 2.611 ± 0.4
1.911SerLys: 1.911 ± 0.366
4.713SerLeu: 4.713 ± 0.549
1.146SerMet: 1.146 ± 0.28
1.656SerAsn: 1.656 ± 0.329
2.165SerPro: 2.165 ± 0.289
0.892SerGln: 0.892 ± 0.263
2.739SerArg: 2.739 ± 0.374
2.93SerSer: 2.93 ± 0.471
5.477SerThr: 5.477 ± 0.678
4.84SerVal: 4.84 ± 0.557
0.955SerTrp: 0.955 ± 0.3
1.72SerTyr: 1.72 ± 0.33
0.0SerXaa: 0.0 ± 0.0
Thr
9.171ThrAla: 9.171 ± 0.879
0.446ThrCys: 0.446 ± 0.164
3.694ThrAsp: 3.694 ± 0.517
3.184ThrGlu: 3.184 ± 0.494
2.993ThrPhe: 2.993 ± 0.459
5.222ThrGly: 5.222 ± 0.668
1.274ThrHis: 1.274 ± 0.35
3.821ThrIle: 3.821 ± 0.385
2.293ThrLys: 2.293 ± 0.521
5.859ThrLeu: 5.859 ± 0.525
1.274ThrMet: 1.274 ± 0.246
1.974ThrAsn: 1.974 ± 0.437
4.203ThrPro: 4.203 ± 0.646
2.356ThrGln: 2.356 ± 0.336
3.566ThrArg: 3.566 ± 0.467
3.694ThrSer: 3.694 ± 0.676
4.84ThrThr: 4.84 ± 0.793
5.859ThrVal: 5.859 ± 0.718
0.828ThrTrp: 0.828 ± 0.263
1.72ThrTyr: 1.72 ± 0.277
0.0ThrXaa: 0.0 ± 0.0
Val
8.916ValAla: 8.916 ± 0.824
0.318ValCys: 0.318 ± 0.14
6.241ValAsp: 6.241 ± 0.686
5.668ValGlu: 5.668 ± 0.643
2.165ValPhe: 2.165 ± 0.314
5.286ValGly: 5.286 ± 0.857
0.701ValHis: 0.701 ± 0.207
3.757ValIle: 3.757 ± 0.506
2.611ValLys: 2.611 ± 0.432
6.241ValLeu: 6.241 ± 0.63
2.165ValMet: 2.165 ± 0.342
2.993ValAsn: 2.993 ± 0.413
3.694ValPro: 3.694 ± 0.419
3.184ValGln: 3.184 ± 0.289
4.968ValArg: 4.968 ± 0.516
4.649ValSer: 4.649 ± 0.666
5.222ValThr: 5.222 ± 0.686
6.942ValVal: 6.942 ± 0.663
0.764ValTrp: 0.764 ± 0.169
1.401ValTyr: 1.401 ± 0.221
0.0ValXaa: 0.0 ± 0.0
Trp
2.038TrpAla: 2.038 ± 0.447
0.064TrpCys: 0.064 ± 0.074
0.955TrpAsp: 0.955 ± 0.245
0.701TrpGlu: 0.701 ± 0.172
0.637TrpPhe: 0.637 ± 0.254
0.828TrpGly: 0.828 ± 0.182
0.191TrpHis: 0.191 ± 0.107
0.637TrpIle: 0.637 ± 0.198
0.764TrpLys: 0.764 ± 0.19
1.911TrpLeu: 1.911 ± 0.46
0.382TrpMet: 0.382 ± 0.148
0.764TrpAsn: 0.764 ± 0.215
0.701TrpPro: 0.701 ± 0.236
0.446TrpGln: 0.446 ± 0.165
1.274TrpArg: 1.274 ± 0.338
0.573TrpSer: 0.573 ± 0.149
0.828TrpThr: 0.828 ± 0.29
1.019TrpVal: 1.019 ± 0.226
0.255TrpTrp: 0.255 ± 0.106
0.318TrpTyr: 0.318 ± 0.172
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.102TyrAla: 2.102 ± 0.273
0.191TyrCys: 0.191 ± 0.124
1.592TyrAsp: 1.592 ± 0.316
1.592TyrGlu: 1.592 ± 0.465
0.701TyrPhe: 0.701 ± 0.204
2.102TyrGly: 2.102 ± 0.42
0.509TyrHis: 0.509 ± 0.169
0.828TyrIle: 0.828 ± 0.204
1.274TyrLys: 1.274 ± 0.29
1.083TyrLeu: 1.083 ± 0.219
0.701TyrMet: 0.701 ± 0.19
1.401TyrAsn: 1.401 ± 0.294
0.955TyrPro: 0.955 ± 0.291
1.019TyrGln: 1.019 ± 0.277
1.401TyrArg: 1.401 ± 0.307
1.783TyrSer: 1.783 ± 0.37
1.274TyrThr: 1.274 ± 0.281
2.93TyrVal: 2.93 ± 0.468
0.318TyrTrp: 0.318 ± 0.174
0.701TyrTyr: 0.701 ± 0.243
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 73 proteins (15703 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski