Amino acid dipepetide frequency for Peronospora effusa

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.223AlaAla: 8.223 ± 0.071	1.215AlaCys: 1.215 ± 0.019	3.953AlaAsp: 3.953 ± 0.035	4.788AlaGlu: 4.788 ± 0.046	3.199AlaPhe: 3.199 ± 0.031	4.417AlaGly: 4.417 ± 0.038	1.707AlaHis: 1.707 ± 0.021	3.891AlaIle: 3.891 ± 0.033	4.529AlaLys: 4.529 ± 0.041	8.117AlaLeu: 8.117 ± 0.06	2.306AlaMet: 2.306 ± 0.026	2.913AlaAsn: 2.913 ± 0.03	3.341AlaPro: 3.341 ± 0.04	3.253AlaGln: 3.253 ± 0.034	4.355AlaArg: 4.355 ± 0.039	6.937AlaSer: 6.937 ± 0.053	5.216AlaThr: 5.216 ± 0.039	5.895AlaVal: 5.895 ± 0.04	0.781AlaTrp: 0.781 ± 0.014	1.852AlaTyr: 1.852 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	1.263CysAla: 1.263 ± 0.02	0.413CysCys: 0.413 ± 0.011	0.917CysAsp: 0.917 ± 0.015	0.935CysGlu: 0.935 ± 0.014	0.737CysPhe: 0.737 ± 0.014	1.221CysGly: 1.221 ± 0.022	0.445CysHis: 0.445 ± 0.011	0.837CysIle: 0.837 ± 0.014	0.826CysLys: 0.826 ± 0.016	1.486CysLeu: 1.486 ± 0.02	0.435CysMet: 0.435 ± 0.011	0.656CysAsn: 0.656 ± 0.015	0.731CysPro: 0.731 ± 0.017	0.574CysGln: 0.574 ± 0.013	1.015CysArg: 1.015 ± 0.02	1.432CysSer: 1.432 ± 0.024	0.961CysThr: 0.961 ± 0.016	1.321CysVal: 1.321 ± 0.022	0.222CysTrp: 0.222 ± 0.008	0.453CysTyr: 0.453 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	4.961AspAla: 4.961 ± 0.042	0.814AspCys: 0.814 ± 0.014	4.526AspAsp: 4.526 ± 0.056	4.998AspGlu: 4.998 ± 0.054	2.208AspPhe: 2.208 ± 0.026	3.777AspGly: 3.777 ± 0.036	1.195AspHis: 1.195 ± 0.018	2.713AspIle: 2.713 ± 0.029	2.863AspLys: 2.863 ± 0.029	4.823AspLeu: 4.823 ± 0.038	1.456AspMet: 1.456 ± 0.019	2.04AspAsn: 2.04 ± 0.023	2.308AspPro: 2.308 ± 0.025	1.86AspGln: 1.86 ± 0.023	2.765AspArg: 2.765 ± 0.031	4.045AspSer: 4.045 ± 0.034	3.103AspThr: 3.103 ± 0.03	4.616AspVal: 4.616 ± 0.038	0.61AspTrp: 0.61 ± 0.012	1.432AspTyr: 1.432 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	5.261GluAla: 5.261 ± 0.046	0.959GluCys: 0.959 ± 0.016	4.278GluAsp: 4.278 ± 0.046	6.29GluGlu: 6.29 ± 0.078	2.219GluPhe: 2.219 ± 0.028	3.117GluGly: 3.117 ± 0.03	1.543GluHis: 1.543 ± 0.022	3.2GluIle: 3.2 ± 0.033	4.668GluLys: 4.668 ± 0.053	6.59GluLeu: 6.59 ± 0.054	2.023GluMet: 2.023 ± 0.027	2.761GluAsn: 2.761 ± 0.027	2.029GluPro: 2.029 ± 0.021	2.988GluGln: 2.988 ± 0.037	3.94GluArg: 3.94 ± 0.04	4.423GluSer: 4.423 ± 0.037	3.784GluThr: 3.784 ± 0.039	4.295GluVal: 4.295 ± 0.041	0.745GluTrp: 0.745 ± 0.013	1.699GluTyr: 1.699 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	3.021PheAla: 3.021 ± 0.027	0.807PheCys: 0.807 ± 0.017	2.336PheAsp: 2.336 ± 0.027	2.355PheGlu: 2.355 ± 0.025	1.69PhePhe: 1.69 ± 0.022	2.718PheGly: 2.718 ± 0.036	0.999PheHis: 0.999 ± 0.016	1.653PheIle: 1.653 ± 0.025	1.609PheLys: 1.609 ± 0.021	3.708PheLeu: 3.708 ± 0.038	0.971PheMet: 0.971 ± 0.015	1.341PheAsn: 1.341 ± 0.019	1.637PhePro: 1.637 ± 0.02	1.589PheGln: 1.589 ± 0.022	2.096PheArg: 2.096 ± 0.026	3.072PheSer: 3.072 ± 0.029	2.076PheThr: 2.076 ± 0.02	3.084PheVal: 3.084 ± 0.028	0.438PheTrp: 0.438 ± 0.012	1.209PheTyr: 1.209 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	4.337GlyAla: 4.337 ± 0.038	1.021GlyCys: 1.021 ± 0.017	3.473GlyAsp: 3.473 ± 0.036	3.295GlyGlu: 3.295 ± 0.029	2.426GlyPhe: 2.426 ± 0.027	4.539GlyGly: 4.539 ± 0.062	1.485GlyHis: 1.485 ± 0.026	2.962GlyIle: 2.962 ± 0.035	3.378GlyLys: 3.378 ± 0.032	4.922GlyLeu: 4.922 ± 0.038	1.569GlyMet: 1.569 ± 0.023	2.471GlyAsn: 2.471 ± 0.027	1.914GlyPro: 1.914 ± 0.025	1.947GlyGln: 1.947 ± 0.027	3.337GlyArg: 3.337 ± 0.041	4.949GlySer: 4.949 ± 0.043	3.232GlyThr: 3.232 ± 0.031	4.242GlyVal: 4.242 ± 0.037	0.681GlyTrp: 0.681 ± 0.015	1.726GlyTyr: 1.726 ± 0.026	0.0GlyXaa: 0.0 ± 0.0
His	1.851HisAla: 1.851 ± 0.022	0.451HisCys: 0.451 ± 0.012	1.318HisAsp: 1.318 ± 0.02	1.628HisGlu: 1.628 ± 0.024	1.063HisPhe: 1.063 ± 0.016	1.628HisGly: 1.628 ± 0.026	0.781HisHis: 0.781 ± 0.015	1.038HisIle: 1.038 ± 0.018	1.153HisLys: 1.153 ± 0.022	2.366HisLeu: 2.366 ± 0.029	0.607HisMet: 0.607 ± 0.013	0.859HisAsn: 0.859 ± 0.015	1.194HisPro: 1.194 ± 0.017	1.058HisGln: 1.058 ± 0.019	1.541HisArg: 1.541 ± 0.02	1.828HisSer: 1.828 ± 0.022	1.221HisThr: 1.221 ± 0.019	1.976HisVal: 1.976 ± 0.026	0.279HisTrp: 0.279 ± 0.008	0.721HisTyr: 0.721 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	3.957IleAla: 3.957 ± 0.03	0.907IleCys: 0.907 ± 0.018	2.724IleAsp: 2.724 ± 0.025	2.969IleGlu: 2.969 ± 0.032	1.753IlePhe: 1.753 ± 0.027	2.73IleGly: 2.73 ± 0.032	1.065IleHis: 1.065 ± 0.016	1.937IleIle: 1.937 ± 0.026	2.36IleLys: 2.36 ± 0.027	3.981IleLeu: 3.981 ± 0.032	1.118IleMet: 1.118 ± 0.019	1.665IleAsn: 1.665 ± 0.023	2.162IlePro: 2.162 ± 0.025	1.811IleGln: 1.811 ± 0.019	2.564IleArg: 2.564 ± 0.024	3.47IleSer: 3.47 ± 0.029	2.438IleThr: 2.438 ± 0.029	3.557IleVal: 3.557 ± 0.032	0.501IleTrp: 0.501 ± 0.012	1.195IleTyr: 1.195 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	4.129LysAla: 4.129 ± 0.044	0.897LysCys: 0.897 ± 0.016	2.932LysAsp: 2.932 ± 0.034	4.194LysGlu: 4.194 ± 0.055	1.809LysPhe: 1.809 ± 0.024	2.534LysGly: 2.534 ± 0.026	1.443LysHis: 1.443 ± 0.021	2.442LysIle: 2.442 ± 0.025	4.998LysLys: 4.998 ± 0.064	5.509LysLeu: 5.509 ± 0.043	1.648LysMet: 1.648 ± 0.02	2.281LysAsn: 2.281 ± 0.023	2.096LysPro: 2.096 ± 0.023	2.649LysGln: 2.649 ± 0.029	4.091LysArg: 4.091 ± 0.037	3.927LysSer: 3.927 ± 0.034	3.473LysThr: 3.473 ± 0.038	3.5LysVal: 3.5 ± 0.034	0.727LysTrp: 0.727 ± 0.015	1.639LysTyr: 1.639 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	7.639LeuAla: 7.639 ± 0.053	1.699LeuCys: 1.699 ± 0.024	5.236LeuAsp: 5.236 ± 0.035	6.469LeuGlu: 6.469 ± 0.056	3.588LeuPhe: 3.588 ± 0.038	4.914LeuGly: 4.914 ± 0.035	2.701LeuHis: 2.701 ± 0.029	3.59LeuIle: 3.59 ± 0.032	5.091LeuLys: 5.091 ± 0.046	10.324LeuLeu: 10.324 ± 0.082	2.436LeuMet: 2.436 ± 0.027	3.423LeuAsn: 3.423 ± 0.03	4.563LeuPro: 4.563 ± 0.035	4.95LeuGln: 4.95 ± 0.039	6.144LeuArg: 6.144 ± 0.046	7.595LeuSer: 7.595 ± 0.048	5.068LeuThr: 5.068 ± 0.039	6.692LeuVal: 6.692 ± 0.051	1.029LeuTrp: 1.029 ± 0.02	2.549LeuTyr: 2.549 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	2.198MetAla: 2.198 ± 0.023	0.406MetCys: 0.406 ± 0.011	1.614MetAsp: 1.614 ± 0.02	2.034MetGlu: 2.034 ± 0.026	0.871MetPhe: 0.871 ± 0.017	1.454MetGly: 1.454 ± 0.022	0.662MetHis: 0.662 ± 0.012	1.047MetIle: 1.047 ± 0.016	1.633MetLys: 1.633 ± 0.021	2.705MetLeu: 2.705 ± 0.027	0.84MetMet: 0.84 ± 0.016	1.073MetAsn: 1.073 ± 0.019	1.131MetPro: 1.131 ± 0.017	1.332MetGln: 1.332 ± 0.019	1.491MetArg: 1.491 ± 0.02	2.062MetSer: 2.062 ± 0.023	1.772MetThr: 1.772 ± 0.023	1.623MetVal: 1.623 ± 0.02	0.304MetTrp: 0.304 ± 0.01	0.707MetTyr: 0.707 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.368AsnAla: 3.368 ± 0.037	0.636AsnCys: 0.636 ± 0.013	2.418AsnAsp: 2.418 ± 0.028	2.744AsnGlu: 2.744 ± 0.023	1.433AsnPhe: 1.433 ± 0.019	2.836AsnGly: 2.836 ± 0.029	0.863AsnHis: 0.863 ± 0.016	1.714AsnIle: 1.714 ± 0.021	1.936AsnLys: 1.936 ± 0.022	3.113AsnLeu: 3.113 ± 0.03	1.004AsnMet: 1.004 ± 0.017	1.496AsnAsn: 1.496 ± 0.022	1.704AsnPro: 1.704 ± 0.026	1.343AsnGln: 1.343 ± 0.02	1.974AsnArg: 1.974 ± 0.024	2.837AsnSer: 2.837 ± 0.028	2.055AsnThr: 2.055 ± 0.027	3.109AsnVal: 3.109 ± 0.031	0.447AsnTrp: 0.447 ± 0.011	1.023AsnTyr: 1.023 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	3.266ProAla: 3.266 ± 0.041	0.541ProCys: 0.541 ± 0.014	2.18ProAsp: 2.18 ± 0.027	2.679ProGlu: 2.679 ± 0.028	1.697ProPhe: 1.697 ± 0.02	2.199ProGly: 2.199 ± 0.03	1.011ProHis: 1.011 ± 0.019	1.944ProIle: 1.944 ± 0.022	2.127ProLys: 2.127 ± 0.026	4.104ProLeu: 4.104 ± 0.04	1.124ProMet: 1.124 ± 0.018	1.554ProAsn: 1.554 ± 0.023	2.644ProPro: 2.644 ± 0.04	1.677ProGln: 1.677 ± 0.022	2.405ProArg: 2.405 ± 0.03	4.201ProSer: 4.201 ± 0.036	2.913ProThr: 2.913 ± 0.03	3.197ProVal: 3.197 ± 0.03	0.447ProTrp: 0.447 ± 0.01	0.998ProTyr: 0.998 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	2.979GlnAla: 2.979 ± 0.029	0.659GlnCys: 0.659 ± 0.014	1.999GlnAsp: 1.999 ± 0.023	2.989GlnGlu: 2.989 ± 0.035	1.499GlnPhe: 1.499 ± 0.02	1.745GlnGly: 1.745 ± 0.021	1.312GlnHis: 1.312 ± 0.017	1.836GlnIle: 1.836 ± 0.024	2.415GlnLys: 2.415 ± 0.029	4.599GlnLeu: 4.599 ± 0.04	1.203GlnMet: 1.203 ± 0.017	1.487GlnAsn: 1.487 ± 0.022	1.638GlnPro: 1.638 ± 0.022	3.222GlnGln: 3.222 ± 0.077	2.983GlnArg: 2.983 ± 0.03	2.97GlnSer: 2.97 ± 0.029	2.243GlnThr: 2.243 ± 0.026	2.851GlnVal: 2.851 ± 0.031	0.553GlnTrp: 0.553 ± 0.012	1.133GlnTyr: 1.133 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	4.352ArgAla: 4.352 ± 0.035	1.014ArgCys: 1.014 ± 0.018	3.09ArgAsp: 3.09 ± 0.033	3.713ArgGlu: 3.713 ± 0.037	2.31ArgPhe: 2.31 ± 0.024	3.314ArgGly: 3.314 ± 0.041	1.663ArgHis: 1.663 ± 0.021	2.578ArgIle: 2.578 ± 0.026	3.78ArgLys: 3.78 ± 0.042	5.685ArgLeu: 5.685 ± 0.04	1.555ArgMet: 1.555 ± 0.021	2.327ArgAsn: 2.327 ± 0.026	2.281ArgPro: 2.281 ± 0.028	2.748ArgGln: 2.748 ± 0.029	4.852ArgArg: 4.852 ± 0.052	4.714ArgSer: 4.714 ± 0.053	2.979ArgThr: 2.979 ± 0.029	4.175ArgVal: 4.175 ± 0.035	0.746ArgTrp: 0.746 ± 0.013	1.601ArgTyr: 1.601 ± 0.021	0.0ArgXaa: 0.0 ± 0.0
Ser	6.288SerAla: 6.288 ± 0.048	1.347SerCys: 1.347 ± 0.02	4.608SerAsp: 4.608 ± 0.035	4.399SerGlu: 4.399 ± 0.041	3.243SerPhe: 3.243 ± 0.032	5.004SerGly: 5.004 ± 0.044	1.762SerHis: 1.762 ± 0.022	3.875SerIle: 3.875 ± 0.033	4.223SerLys: 4.223 ± 0.038	7.168SerLeu: 7.168 ± 0.045	2.166SerMet: 2.166 ± 0.025	3.212SerAsn: 3.212 ± 0.029	3.773SerPro: 3.773 ± 0.04	2.698SerGln: 2.698 ± 0.028	4.654SerArg: 4.654 ± 0.046	9.646SerSer: 9.646 ± 0.08	5.557SerThr: 5.557 ± 0.047	5.57SerVal: 5.57 ± 0.041	0.877SerTrp: 0.877 ± 0.016	1.986SerTyr: 1.986 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	4.742ThrAla: 4.742 ± 0.047	1.026ThrCys: 1.026 ± 0.019	2.943ThrAsp: 2.943 ± 0.03	3.309ThrGlu: 3.309 ± 0.031	2.221ThrPhe: 2.221 ± 0.025	3.444ThrGly: 3.444 ± 0.031	1.268ThrHis: 1.268 ± 0.017	2.764ThrIle: 2.764 ± 0.028	3.411ThrLys: 3.411 ± 0.039	5.537ThrLeu: 5.537 ± 0.036	1.537ThrMet: 1.537 ± 0.02	2.221ThrAsn: 2.221 ± 0.024	3.16ThrPro: 3.16 ± 0.042	2.184ThrGln: 2.184 ± 0.029	3.194ThrArg: 3.194 ± 0.027	5.664ThrSer: 5.664 ± 0.046	4.166ThrThr: 4.166 ± 0.039	3.752ThrVal: 3.752 ± 0.033	0.62ThrTrp: 0.62 ± 0.015	1.381ThrTyr: 1.381 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	6.334ValAla: 6.334 ± 0.045	1.326ValCys: 1.326 ± 0.021	4.341ValAsp: 4.341 ± 0.037	4.725ValGlu: 4.725 ± 0.042	2.824ValPhe: 2.824 ± 0.027	3.922ValGly: 3.922 ± 0.039	1.688ValHis: 1.688 ± 0.022	3.124ValIle: 3.124 ± 0.03	3.817ValLys: 3.817 ± 0.035	7.257ValLeu: 7.257 ± 0.049	1.838ValMet: 1.838 ± 0.02	2.693ValAsn: 2.693 ± 0.028	3.183ValPro: 3.183 ± 0.032	2.906ValGln: 2.906 ± 0.028	3.774ValArg: 3.774 ± 0.034	5.533ValSer: 5.533 ± 0.035	4.197ValThr: 4.197 ± 0.034	5.837ValVal: 5.837 ± 0.047	0.766ValTrp: 0.766 ± 0.015	1.878ValTyr: 1.878 ± 0.023	0.0ValXaa: 0.0 ± 0.0
Trp	0.659TrpAla: 0.659 ± 0.013	0.203TrpCys: 0.203 ± 0.007	0.613TrpAsp: 0.613 ± 0.014	0.614TrpGlu: 0.614 ± 0.013	0.447TrpPhe: 0.447 ± 0.011	0.59TrpGly: 0.59 ± 0.013	0.295TrpHis: 0.295 ± 0.009	0.585TrpIle: 0.585 ± 0.013	0.834TrpLys: 0.834 ± 0.018	1.179TrpLeu: 1.179 ± 0.02	0.399TrpMet: 0.399 ± 0.011	0.549TrpAsn: 0.549 ± 0.013	0.354TrpPro: 0.354 ± 0.009	0.481TrpGln: 0.481 ± 0.011	0.736TrpArg: 0.736 ± 0.014	0.86TrpSer: 0.86 ± 0.014	0.697TrpThr: 0.697 ± 0.013	0.691TrpVal: 0.691 ± 0.015	0.163TrpTrp: 0.163 ± 0.007	0.335TrpTyr: 0.335 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.058TyrAla: 2.058 ± 0.022	0.538TyrCys: 0.538 ± 0.012	1.614TyrAsp: 1.614 ± 0.02	1.687TyrGlu: 1.687 ± 0.021	1.172TyrPhe: 1.172 ± 0.018	1.806TyrGly: 1.806 ± 0.025	0.672TyrHis: 0.672 ± 0.012	1.134TyrIle: 1.134 ± 0.019	1.264TyrLys: 1.264 ± 0.021	2.525TyrLeu: 2.525 ± 0.029	0.725TyrMet: 0.725 ± 0.015	1.029TyrAsn: 1.029 ± 0.017	1.066TyrPro: 1.066 ± 0.02	1.048TyrGln: 1.048 ± 0.019	1.566TyrArg: 1.566 ± 0.02	1.889TyrSer: 1.889 ± 0.028	1.394TyrThr: 1.394 ± 0.021	1.981TyrVal: 1.981 ± 0.028	0.349TyrTrp: 0.349 ± 0.011	0.866TyrTyr: 0.866 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8522 proteins (4034935 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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