Amino acid dipepetide frequency for Nocardia ignorata

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.826AlaAla: 20.826 ± 0.17
0.963AlaCys: 0.963 ± 0.023
8.972AlaAsp: 8.972 ± 0.079
8.72AlaGlu: 8.72 ± 0.079
3.419AlaPhe: 3.419 ± 0.043
12.007AlaGly: 12.007 ± 0.093
2.767AlaHis: 2.767 ± 0.039
5.068AlaIle: 5.068 ± 0.058
2.812AlaLys: 2.812 ± 0.046
13.661AlaLeu: 13.661 ± 0.095
2.768AlaMet: 2.768 ± 0.046
2.359AlaAsn: 2.359 ± 0.038
6.664AlaPro: 6.664 ± 0.085
3.987AlaGln: 3.987 ± 0.053
9.361AlaArg: 9.361 ± 0.077
5.428AlaSer: 5.428 ± 0.053
7.953AlaThr: 7.953 ± 0.074
12.142AlaVal: 12.142 ± 0.088
1.635AlaTrp: 1.635 ± 0.03
2.335AlaTyr: 2.335 ± 0.039
0.0AlaXaa: 0.0 ± 0.0
Cys
1.093CysAla: 1.093 ± 0.028
0.083CysCys: 0.083 ± 0.008
0.47CysAsp: 0.47 ± 0.014
0.39CysGlu: 0.39 ± 0.015
0.211CysPhe: 0.211 ± 0.009
0.895CysGly: 0.895 ± 0.024
0.174CysHis: 0.174 ± 0.009
0.199CysIle: 0.199 ± 0.01
0.107CysLys: 0.107 ± 0.008
0.709CysLeu: 0.709 ± 0.022
0.1CysMet: 0.1 ± 0.007
0.126CysAsn: 0.126 ± 0.009
0.456CysPro: 0.456 ± 0.015
0.167CysGln: 0.167 ± 0.009
0.529CysArg: 0.529 ± 0.017
0.446CysSer: 0.446 ± 0.015
0.483CysThr: 0.483 ± 0.015
0.647CysVal: 0.647 ± 0.018
0.114CysTrp: 0.114 ± 0.007
0.17CysTyr: 0.17 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
7.484AspAla: 7.484 ± 0.063
0.426AspCys: 0.426 ± 0.014
4.02AspAsp: 4.02 ± 0.051
3.792AspGlu: 3.792 ± 0.052
1.75AspPhe: 1.75 ± 0.027
5.654AspGly: 5.654 ± 0.059
1.471AspHis: 1.471 ± 0.027
2.573AspIle: 2.573 ± 0.039
1.256AspLys: 1.256 ± 0.029
6.676AspLeu: 6.676 ± 0.071
0.941AspMet: 0.941 ± 0.021
1.283AspAsn: 1.283 ± 0.027
4.689AspPro: 4.689 ± 0.057
1.831AspGln: 1.831 ± 0.028
5.06AspArg: 5.06 ± 0.069
3.009AspSer: 3.009 ± 0.043
3.553AspThr: 3.553 ± 0.045
4.55AspVal: 4.55 ± 0.055
0.936AspTrp: 0.936 ± 0.023
1.369AspTyr: 1.369 ± 0.023
0.0AspXaa: 0.0 ± 0.0
Glu
6.119GluAla: 6.119 ± 0.061
0.337GluCys: 0.337 ± 0.012
2.307GluAsp: 2.307 ± 0.038
2.449GluGlu: 2.449 ± 0.04
2.045GluPhe: 2.045 ± 0.033
3.31GluGly: 3.31 ± 0.046
1.672GluHis: 1.672 ± 0.031
2.709GluIle: 2.709 ± 0.036
1.23GluLys: 1.23 ± 0.034
7.185GluLeu: 7.185 ± 0.085
1.005GluMet: 1.005 ± 0.022
1.118GluAsn: 1.118 ± 0.023
3.41GluPro: 3.41 ± 0.048
2.512GluGln: 2.512 ± 0.039
4.679GluArg: 4.679 ± 0.051
2.888GluSer: 2.888 ± 0.038
2.938GluThr: 2.938 ± 0.039
4.598GluVal: 4.598 ± 0.059
0.785GluTrp: 0.785 ± 0.021
1.188GluTyr: 1.188 ± 0.025
0.0GluXaa: 0.0 ± 0.0
Phe
4.324PheAla: 4.324 ± 0.046
0.261PheCys: 0.261 ± 0.012
2.482PheAsp: 2.482 ± 0.042
1.548PheGlu: 1.548 ± 0.031
0.896PhePhe: 0.896 ± 0.021
3.526PheGly: 3.526 ± 0.043
0.606PheHis: 0.606 ± 0.017
0.885PheIle: 0.885 ± 0.022
0.411PheLys: 0.411 ± 0.015
2.588PheLeu: 2.588 ± 0.04
0.413PheMet: 0.413 ± 0.016
0.537PheAsn: 0.537 ± 0.017
1.393PhePro: 1.393 ± 0.025
0.721PheGln: 0.721 ± 0.023
1.773PheArg: 1.773 ± 0.034
1.439PheSer: 1.439 ± 0.027
2.174PheThr: 2.174 ± 0.036
2.586PheVal: 2.586 ± 0.04
0.423PheTrp: 0.423 ± 0.016
0.614PheTyr: 0.614 ± 0.017
0.0PheXaa: 0.0 ± 0.0
Gly
10.626GlyAla: 10.626 ± 0.082
0.779GlyCys: 0.779 ± 0.023
4.79GlyAsp: 4.79 ± 0.056
4.682GlyGlu: 4.682 ± 0.063
3.023GlyPhe: 3.023 ± 0.036
7.43GlyGly: 7.43 ± 0.106
1.997GlyHis: 1.997 ± 0.038
4.182GlyIle: 4.182 ± 0.05
2.364GlyLys: 2.364 ± 0.034
8.599GlyLeu: 8.599 ± 0.082
2.055GlyMet: 2.055 ± 0.031
1.884GlyAsn: 1.884 ± 0.038
4.502GlyPro: 4.502 ± 0.047
2.49GlyGln: 2.49 ± 0.046
6.297GlyArg: 6.297 ± 0.059
5.178GlySer: 5.178 ± 0.054
5.684GlyThr: 5.684 ± 0.062
7.4GlyVal: 7.4 ± 0.067
1.562GlyTrp: 1.562 ± 0.029
2.286GlyTyr: 2.286 ± 0.039
0.0GlyXaa: 0.0 ± 0.0
His
2.539HisAla: 2.539 ± 0.039
0.202HisCys: 0.202 ± 0.01
1.37HisAsp: 1.37 ± 0.029
1.099HisGlu: 1.099 ± 0.024
0.646HisPhe: 0.646 ± 0.017
2.057HisGly: 2.057 ± 0.031
0.702HisHis: 0.702 ± 0.025
0.787HisIle: 0.787 ± 0.021
0.328HisLys: 0.328 ± 0.013
2.263HisLeu: 2.263 ± 0.035
0.338HisMet: 0.338 ± 0.014
0.5HisAsn: 0.5 ± 0.018
1.716HisPro: 1.716 ± 0.029
0.616HisGln: 0.616 ± 0.016
2.085HisArg: 2.085 ± 0.034
1.088HisSer: 1.088 ± 0.022
1.382HisThr: 1.382 ± 0.032
1.558HisVal: 1.558 ± 0.027
0.335HisTrp: 0.335 ± 0.011
0.521HisTyr: 0.521 ± 0.016
0.0HisXaa: 0.0 ± 0.0
Ile
6.479IleAla: 6.479 ± 0.056
0.324IleCys: 0.324 ± 0.012
3.483IleAsp: 3.483 ± 0.045
2.711IleGlu: 2.711 ± 0.04
0.933IlePhe: 0.933 ± 0.021
4.578IleGly: 4.578 ± 0.062
0.727IleHis: 0.727 ± 0.022
1.28IleIle: 1.28 ± 0.033
0.696IleLys: 0.696 ± 0.022
2.997IleLeu: 2.997 ± 0.041
0.585IleMet: 0.585 ± 0.018
0.846IleAsn: 0.846 ± 0.02
2.263IlePro: 2.263 ± 0.036
0.832IleGln: 0.832 ± 0.02
2.617IleArg: 2.617 ± 0.04
2.128IleSer: 2.128 ± 0.034
2.881IleThr: 2.881 ± 0.037
3.738IleVal: 3.738 ± 0.052
0.437IleTrp: 0.437 ± 0.015
0.731IleTyr: 0.731 ± 0.018
0.0IleXaa: 0.0 ± 0.0
Lys
2.475LysAla: 2.475 ± 0.046
0.108LysCys: 0.108 ± 0.007
0.948LysAsp: 0.948 ± 0.024
0.862LysGlu: 0.862 ± 0.023
0.651LysPhe: 0.651 ± 0.019
1.364LysGly: 1.364 ± 0.029
0.456LysHis: 0.456 ± 0.017
0.958LysIle: 0.958 ± 0.021
0.625LysLys: 0.625 ± 0.024
2.098LysLeu: 2.098 ± 0.037
0.463LysMet: 0.463 ± 0.016
0.498LysAsn: 0.498 ± 0.018
1.355LysPro: 1.355 ± 0.029
0.747LysGln: 0.747 ± 0.018
1.35LysArg: 1.35 ± 0.033
1.147LysSer: 1.147 ± 0.024
1.275LysThr: 1.275 ± 0.03
1.748LysVal: 1.748 ± 0.036
0.271LysTrp: 0.271 ± 0.011
0.473LysTyr: 0.473 ± 0.014
0.0LysXaa: 0.0 ± 0.0
Leu
15.014LeuAla: 15.014 ± 0.102
0.817LeuCys: 0.817 ± 0.022
7.162LeuAsp: 7.162 ± 0.085
4.458LeuGlu: 4.458 ± 0.049
2.795LeuPhe: 2.795 ± 0.039
9.117LeuGly: 9.117 ± 0.07
2.16LeuHis: 2.16 ± 0.037
4.108LeuIle: 4.108 ± 0.053
1.374LeuLys: 1.374 ± 0.028
10.424LeuLeu: 10.424 ± 0.093
1.62LeuMet: 1.62 ± 0.027
1.808LeuAsn: 1.808 ± 0.033
6.079LeuPro: 6.079 ± 0.068
2.056LeuGln: 2.056 ± 0.029
8.389LeuArg: 8.389 ± 0.066
5.511LeuSer: 5.511 ± 0.053
6.953LeuThr: 6.953 ± 0.065
8.87LeuVal: 8.87 ± 0.085
1.194LeuTrp: 1.194 ± 0.025
1.641LeuTyr: 1.641 ± 0.03
0.0LeuXaa: 0.0 ± 0.0
Met
2.263MetAla: 2.263 ± 0.036
0.148MetCys: 0.148 ± 0.008
0.838MetAsp: 0.838 ± 0.02
0.641MetGlu: 0.641 ± 0.019
0.621MetPhe: 0.621 ± 0.018
1.32MetGly: 1.32 ± 0.028
0.372MetHis: 0.372 ± 0.014
0.968MetIle: 0.968 ± 0.024
0.395MetLys: 0.395 ± 0.014
2.008MetLeu: 2.008 ± 0.03
0.367MetMet: 0.367 ± 0.014
0.547MetAsn: 0.547 ± 0.018
1.145MetPro: 1.145 ± 0.024
0.514MetGln: 0.514 ± 0.016
1.504MetArg: 1.504 ± 0.025
1.547MetSer: 1.547 ± 0.031
1.666MetThr: 1.666 ± 0.028
1.611MetVal: 1.611 ± 0.026
0.231MetTrp: 0.231 ± 0.011
0.336MetTyr: 0.336 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
2.435AsnAla: 2.435 ± 0.033
0.164AsnCys: 0.164 ± 0.008
1.061AsnAsp: 1.061 ± 0.025
0.928AsnGlu: 0.928 ± 0.025
0.58AsnPhe: 0.58 ± 0.015
1.959AsnGly: 1.959 ± 0.039
0.428AsnHis: 0.428 ± 0.015
0.85AsnIle: 0.85 ± 0.021
0.433AsnLys: 0.433 ± 0.016
1.884AsnLeu: 1.884 ± 0.031
0.375AsnMet: 0.375 ± 0.012
0.526AsnAsn: 0.526 ± 0.018
1.644AsnPro: 1.644 ± 0.032
0.602AsnGln: 0.602 ± 0.016
1.485AsnArg: 1.485 ± 0.029
1.107AsnSer: 1.107 ± 0.025
1.284AsnThr: 1.284 ± 0.029
1.459AsnVal: 1.459 ± 0.029
0.334AsnTrp: 0.334 ± 0.014
0.508AsnTyr: 0.508 ± 0.015
0.0AsnXaa: 0.0 ± 0.0
Pro
7.904ProAla: 7.904 ± 0.074
0.283ProCys: 0.283 ± 0.011
4.362ProAsp: 4.362 ± 0.053
4.05ProGlu: 4.05 ± 0.048
1.528ProPhe: 1.528 ± 0.026
5.894ProGly: 5.894 ± 0.064
1.228ProHis: 1.228 ± 0.025
2.183ProIle: 2.183 ± 0.034
1.2ProLys: 1.2 ± 0.027
5.025ProLeu: 5.025 ± 0.056
1.134ProMet: 1.134 ± 0.026
1.175ProAsn: 1.175 ± 0.023
3.105ProPro: 3.105 ± 0.06
1.767ProGln: 1.767 ± 0.039
3.602ProArg: 3.602 ± 0.049
3.077ProSer: 3.077 ± 0.048
3.73ProThr: 3.73 ± 0.055
5.385ProVal: 5.385 ± 0.068
0.783ProTrp: 0.783 ± 0.021
1.091ProTyr: 1.091 ± 0.025
0.0ProXaa: 0.0 ± 0.0
Gln
3.581GlnAla: 3.581 ± 0.051
0.188GlnCys: 0.188 ± 0.01
1.103GlnAsp: 1.103 ± 0.024
1.127GlnGlu: 1.127 ± 0.023
0.887GlnPhe: 0.887 ± 0.021
1.861GlnGly: 1.861 ± 0.039
0.671GlnHis: 0.671 ± 0.018
1.349GlnIle: 1.349 ± 0.025
0.539GlnLys: 0.539 ± 0.017
3.438GlnLeu: 3.438 ± 0.041
0.564GlnMet: 0.564 ± 0.019
0.568GlnAsn: 0.568 ± 0.019
1.827GlnPro: 1.827 ± 0.04
1.244GlnGln: 1.244 ± 0.032
2.757GlnArg: 2.757 ± 0.044
1.262GlnSer: 1.262 ± 0.023
1.398GlnThr: 1.398 ± 0.03
2.73GlnVal: 2.73 ± 0.046
0.531GlnTrp: 0.531 ± 0.018
0.6GlnTyr: 0.6 ± 0.018
0.0GlnXaa: 0.0 ± 0.0
Arg
9.262ArgAla: 9.262 ± 0.074
0.577ArgCys: 0.577 ± 0.018
4.297ArgAsp: 4.297 ± 0.052
4.286ArgGlu: 4.286 ± 0.045
2.439ArgPhe: 2.439 ± 0.037
5.152ArgGly: 5.152 ± 0.052
1.787ArgHis: 1.787 ± 0.031
3.651ArgIle: 3.651 ± 0.044
1.739ArgLys: 1.739 ± 0.036
7.615ArgLeu: 7.615 ± 0.072
1.894ArgMet: 1.894 ± 0.028
1.548ArgAsn: 1.548 ± 0.027
4.235ArgPro: 4.235 ± 0.063
2.067ArgGln: 2.067 ± 0.038
6.581ArgArg: 6.581 ± 0.088
3.996ArgSer: 3.996 ± 0.046
5.099ArgThr: 5.099 ± 0.056
5.855ArgVal: 5.855 ± 0.057
1.451ArgTrp: 1.451 ± 0.029
1.772ArgTyr: 1.772 ± 0.027
0.0ArgXaa: 0.0 ± 0.0
Ser
7.056SerAla: 7.056 ± 0.064
0.379SerCys: 0.379 ± 0.015
2.838SerAsp: 2.838 ± 0.04
2.593SerGlu: 2.593 ± 0.039
1.592SerPhe: 1.592 ± 0.028
5.487SerGly: 5.487 ± 0.059
0.98SerHis: 0.98 ± 0.025
2.093SerIle: 2.093 ± 0.034
1.055SerLys: 1.055 ± 0.024
4.693SerLeu: 4.693 ± 0.046
1.314SerMet: 1.314 ± 0.026
1.003SerAsn: 1.003 ± 0.024
3.005SerPro: 3.005 ± 0.039
1.26SerGln: 1.26 ± 0.025
3.448SerArg: 3.448 ± 0.04
2.97SerSer: 2.97 ± 0.047
3.68SerThr: 3.68 ± 0.048
4.534SerVal: 4.534 ± 0.049
0.901SerTrp: 0.901 ± 0.021
1.121SerTyr: 1.121 ± 0.022
0.0SerXaa: 0.0 ± 0.0
Thr
8.769ThrAla: 8.769 ± 0.08
0.424ThrCys: 0.424 ± 0.014
4.178ThrAsp: 4.178 ± 0.062
3.857ThrGlu: 3.857 ± 0.046
1.799ThrPhe: 1.799 ± 0.032
6.426ThrGly: 6.426 ± 0.064
1.274ThrHis: 1.274 ± 0.027
2.542ThrIle: 2.542 ± 0.042
1.223ThrLys: 1.223 ± 0.03
5.858ThrLeu: 5.858 ± 0.05
1.144ThrMet: 1.144 ± 0.029
1.119ThrAsn: 1.119 ± 0.023
4.093ThrPro: 4.093 ± 0.056
1.487ThrGln: 1.487 ± 0.025
4.045ThrArg: 4.045 ± 0.047
3.233ThrSer: 3.233 ± 0.044
4.503ThrThr: 4.503 ± 0.068
6.392ThrVal: 6.392 ± 0.062
0.868ThrTrp: 0.868 ± 0.022
1.274ThrTyr: 1.274 ± 0.027
0.0ThrXaa: 0.0 ± 0.0
Val
11.645ValAla: 11.645 ± 0.101
0.753ValCys: 0.753 ± 0.019
5.612ValAsp: 5.612 ± 0.055
4.605ValGlu: 4.605 ± 0.047
2.6ValPhe: 2.6 ± 0.037
6.871ValGly: 6.871 ± 0.07
1.888ValHis: 1.888 ± 0.029
3.645ValIle: 3.645 ± 0.045
1.436ValLys: 1.436 ± 0.028
9.747ValLeu: 9.747 ± 0.076
1.368ValMet: 1.368 ± 0.025
1.796ValAsn: 1.796 ± 0.032
4.982ValPro: 4.982 ± 0.065
2.054ValGln: 2.054 ± 0.031
6.57ValArg: 6.57 ± 0.06
4.499ValSer: 4.499 ± 0.047
5.716ValThr: 5.716 ± 0.057
8.602ValVal: 8.602 ± 0.08
1.054ValTrp: 1.054 ± 0.023
1.578ValTyr: 1.578 ± 0.028
0.0ValXaa: 0.0 ± 0.0
Trp
1.588TrpAla: 1.588 ± 0.027
0.146TrpCys: 0.146 ± 0.009
0.73TrpAsp: 0.73 ± 0.023
0.66TrpGlu: 0.66 ± 0.019
0.507TrpPhe: 0.507 ± 0.019
0.937TrpGly: 0.937 ± 0.023
0.36TrpHis: 0.36 ± 0.016
0.612TrpIle: 0.612 ± 0.018
0.322TrpLys: 0.322 ± 0.013
1.669TrpLeu: 1.669 ± 0.032
0.327TrpMet: 0.327 ± 0.014
0.4TrpAsn: 0.4 ± 0.015
0.745TrpPro: 0.745 ± 0.019
0.635TrpGln: 0.635 ± 0.016
1.241TrpArg: 1.241 ± 0.026
0.971TrpSer: 0.971 ± 0.022
0.956TrpThr: 0.956 ± 0.024
1.071TrpVal: 1.071 ± 0.024
0.357TrpTrp: 0.357 ± 0.013
0.3TrpTyr: 0.3 ± 0.012
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.367TyrAla: 2.367 ± 0.039
0.208TyrCys: 0.208 ± 0.01
1.299TyrAsp: 1.299 ± 0.027
1.025TyrGlu: 1.025 ± 0.024
0.679TyrPhe: 0.679 ± 0.018
1.966TyrGly: 1.966 ± 0.033
0.413TyrHis: 0.413 ± 0.015
0.622TyrIle: 0.622 ± 0.017
0.327TyrLys: 0.327 ± 0.014
2.414TyrLeu: 2.414 ± 0.033
0.268TyrMet: 0.268 ± 0.012
0.405TyrAsn: 0.405 ± 0.015
1.198TyrPro: 1.198 ± 0.023
0.637TyrGln: 0.637 ± 0.019
1.931TyrArg: 1.931 ± 0.033
1.076TyrSer: 1.076 ± 0.024
1.199TyrThr: 1.199 ± 0.026
1.542TyrVal: 1.542 ± 0.034
0.332TyrTrp: 0.332 ± 0.014
0.451TyrTyr: 0.451 ± 0.015
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6616 proteins (2102982 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski