Amino acid dipepetide frequency for Mesorhizobium sp. YM1C-6-2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.607AlaAla: 17.607 ± 0.163
0.922AlaCys: 0.922 ± 0.029
7.068AlaAsp: 7.068 ± 0.069
8.151AlaGlu: 8.151 ± 0.092
4.649AlaPhe: 4.649 ± 0.061
11.495AlaGly: 11.495 ± 0.092
2.038AlaHis: 2.038 ± 0.037
6.704AlaIle: 6.704 ± 0.076
4.482AlaLys: 4.482 ± 0.061
12.735AlaLeu: 12.735 ± 0.131
3.468AlaMet: 3.468 ± 0.044
2.909AlaAsn: 2.909 ± 0.043
5.062AlaPro: 5.062 ± 0.06
3.4AlaGln: 3.4 ± 0.05
8.108AlaArg: 8.108 ± 0.084
6.478AlaSer: 6.478 ± 0.063
5.903AlaThr: 5.903 ± 0.063
9.094AlaVal: 9.094 ± 0.094
1.459AlaTrp: 1.459 ± 0.033
2.651AlaTyr: 2.651 ± 0.041
0.0AlaXaa: 0.0 ± 0.0
Cys
0.856CysAla: 0.856 ± 0.027
0.096CysCys: 0.096 ± 0.008
0.49CysAsp: 0.49 ± 0.019
0.413CysGlu: 0.413 ± 0.016
0.322CysPhe: 0.322 ± 0.014
0.846CysGly: 0.846 ± 0.024
0.215CysHis: 0.215 ± 0.01
0.367CysIle: 0.367 ± 0.016
0.172CysLys: 0.172 ± 0.011
0.696CysLeu: 0.696 ± 0.021
0.165CysMet: 0.165 ± 0.009
0.192CysAsn: 0.192 ± 0.01
0.377CysPro: 0.377 ± 0.015
0.19CysGln: 0.19 ± 0.012
0.573CysArg: 0.573 ± 0.02
0.45CysSer: 0.45 ± 0.016
0.38CysThr: 0.38 ± 0.016
0.568CysVal: 0.568 ± 0.021
0.102CysTrp: 0.102 ± 0.008
0.197CysTyr: 0.197 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
6.854AspAla: 6.854 ± 0.073
0.446AspCys: 0.446 ± 0.016
3.144AspAsp: 3.144 ± 0.062
3.754AspGlu: 3.754 ± 0.051
2.348AspPhe: 2.348 ± 0.036
5.387AspGly: 5.387 ± 0.069
1.202AspHis: 1.202 ± 0.033
3.225AspIle: 3.225 ± 0.045
1.763AspLys: 1.763 ± 0.038
5.536AspLeu: 5.536 ± 0.066
1.39AspMet: 1.39 ± 0.031
1.354AspAsn: 1.354 ± 0.032
3.432AspPro: 3.432 ± 0.05
1.593AspGln: 1.593 ± 0.03
4.472AspArg: 4.472 ± 0.061
2.107AspSer: 2.107 ± 0.036
2.545AspThr: 2.545 ± 0.045
4.19AspVal: 4.19 ± 0.058
0.95AspTrp: 0.95 ± 0.025
1.476AspTyr: 1.476 ± 0.03
0.0AspXaa: 0.0 ± 0.0
Glu
8.021GluAla: 8.021 ± 0.076
0.36GluCys: 0.36 ± 0.014
2.821GluAsp: 2.821 ± 0.046
3.547GluGlu: 3.547 ± 0.062
1.993GluPhe: 1.993 ± 0.039
4.492GluGly: 4.492 ± 0.06
1.171GluHis: 1.171 ± 0.027
3.879GluIle: 3.879 ± 0.049
2.799GluLys: 2.799 ± 0.047
5.517GluLeu: 5.517 ± 0.07
1.564GluMet: 1.564 ± 0.034
1.762GluAsn: 1.762 ± 0.036
2.976GluPro: 2.976 ± 0.05
1.942GluGln: 1.942 ± 0.041
4.935GluArg: 4.935 ± 0.062
2.346GluSer: 2.346 ± 0.041
3.68GluThr: 3.68 ± 0.047
3.971GluVal: 3.971 ± 0.052
0.741GluTrp: 0.741 ± 0.022
1.062GluTyr: 1.062 ± 0.03
0.0GluXaa: 0.0 ± 0.0
Phe
4.746PheAla: 4.746 ± 0.073
0.384PheCys: 0.384 ± 0.015
2.768PheAsp: 2.768 ± 0.044
2.271PheGlu: 2.271 ± 0.046
1.545PhePhe: 1.545 ± 0.039
3.947PheGly: 3.947 ± 0.05
0.769PheHis: 0.769 ± 0.024
1.784PheIle: 1.784 ± 0.04
0.978PheLys: 0.978 ± 0.025
3.597PheLeu: 3.597 ± 0.052
0.864PheMet: 0.864 ± 0.027
1.062PheAsn: 1.062 ± 0.025
1.679PhePro: 1.679 ± 0.032
1.041PheGln: 1.041 ± 0.025
2.46PheArg: 2.46 ± 0.044
2.395PheSer: 2.395 ± 0.041
1.932PheThr: 1.932 ± 0.04
3.118PheVal: 3.118 ± 0.047
0.602PheTrp: 0.602 ± 0.022
0.953PheTyr: 0.953 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
9.177GlyAla: 9.177 ± 0.085
0.799GlyCys: 0.799 ± 0.025
4.629GlyAsp: 4.629 ± 0.072
5.185GlyGlu: 5.185 ± 0.062
3.826GlyPhe: 3.826 ± 0.054
7.688GlyGly: 7.688 ± 0.096
1.845GlyHis: 1.845 ± 0.035
4.915GlyIle: 4.915 ± 0.065
3.823GlyLys: 3.823 ± 0.053
8.647GlyLeu: 8.647 ± 0.078
2.509GlyMet: 2.509 ± 0.041
2.361GlyAsn: 2.361 ± 0.051
3.51GlyPro: 3.51 ± 0.052
2.765GlyGln: 2.765 ± 0.042
6.216GlyArg: 6.216 ± 0.064
4.915GlySer: 4.915 ± 0.06
4.608GlyThr: 4.608 ± 0.056
6.508GlyVal: 6.508 ± 0.071
1.422GlyTrp: 1.422 ± 0.034
2.376GlyTyr: 2.376 ± 0.035
0.0GlyXaa: 0.0 ± 0.0
His
2.199HisAla: 2.199 ± 0.042
0.225HisCys: 0.225 ± 0.011
1.171HisAsp: 1.171 ± 0.028
1.083HisGlu: 1.083 ± 0.026
0.859HisPhe: 0.859 ± 0.022
1.843HisGly: 1.843 ± 0.041
0.521HisHis: 0.521 ± 0.021
0.915HisIle: 0.915 ± 0.022
0.508HisLys: 0.508 ± 0.017
1.924HisLeu: 1.924 ± 0.034
0.505HisMet: 0.505 ± 0.02
0.429HisAsn: 0.429 ± 0.015
1.25HisPro: 1.25 ± 0.025
0.527HisGln: 0.527 ± 0.019
1.346HisArg: 1.346 ± 0.032
0.934HisSer: 0.934 ± 0.026
0.767HisThr: 0.767 ± 0.022
1.501HisVal: 1.501 ± 0.032
0.315HisTrp: 0.315 ± 0.016
0.522HisTyr: 0.522 ± 0.017
0.0HisXaa: 0.0 ± 0.0
Ile
7.512IleAla: 7.512 ± 0.068
0.484IleCys: 0.484 ± 0.018
3.76IleAsp: 3.76 ± 0.051
3.661IleGlu: 3.661 ± 0.051
1.893IlePhe: 1.893 ± 0.036
5.255IleGly: 5.255 ± 0.071
0.922IleHis: 0.922 ± 0.021
2.397IleIle: 2.397 ± 0.044
1.497IleLys: 1.497 ± 0.033
4.496IleLeu: 4.496 ± 0.061
1.04IleMet: 1.04 ± 0.027
1.401IleAsn: 1.401 ± 0.033
2.328IlePro: 2.328 ± 0.039
1.162IleGln: 1.162 ± 0.03
3.406IleArg: 3.406 ± 0.049
3.017IleSer: 3.017 ± 0.048
2.547IleThr: 2.547 ± 0.04
4.839IleVal: 4.839 ± 0.054
0.616IleTrp: 0.616 ± 0.021
1.18IleTyr: 1.18 ± 0.026
0.0IleXaa: 0.0 ± 0.0
Lys
4.712LysAla: 4.712 ± 0.072
0.152LysCys: 0.152 ± 0.009
1.845LysAsp: 1.845 ± 0.041
1.852LysGlu: 1.852 ± 0.036
1.057LysPhe: 1.057 ± 0.026
2.869LysGly: 2.869 ± 0.042
0.665LysHis: 0.665 ± 0.019
1.896LysIle: 1.896 ± 0.038
1.62LysLys: 1.62 ± 0.037
3.607LysLeu: 3.607 ± 0.053
0.831LysMet: 0.831 ± 0.024
0.995LysAsn: 0.995 ± 0.027
2.384LysPro: 2.384 ± 0.045
1.074LysGln: 1.074 ± 0.027
2.545LysArg: 2.545 ± 0.046
2.056LysSer: 2.056 ± 0.041
2.073LysThr: 2.073 ± 0.034
2.717LysVal: 2.717 ± 0.043
0.414LysTrp: 0.414 ± 0.016
0.703LysTyr: 0.703 ± 0.02
0.0LysXaa: 0.0 ± 0.0
Leu
13.342LeuAla: 13.342 ± 0.131
0.764LeuCys: 0.764 ± 0.024
5.956LeuAsp: 5.956 ± 0.057
5.174LeuGlu: 5.174 ± 0.066
3.675LeuPhe: 3.675 ± 0.054
8.232LeuGly: 8.232 ± 0.081
1.726LeuHis: 1.726 ± 0.034
4.857LeuIle: 4.857 ± 0.071
3.938LeuLys: 3.938 ± 0.055
9.171LeuLeu: 9.171 ± 0.099
2.217LeuMet: 2.217 ± 0.036
2.406LeuAsn: 2.406 ± 0.044
5.307LeuPro: 5.307 ± 0.067
2.574LeuGln: 2.574 ± 0.039
6.175LeuArg: 6.175 ± 0.065
6.408LeuSer: 6.408 ± 0.064
5.146LeuThr: 5.146 ± 0.061
7.713LeuVal: 7.713 ± 0.075
1.101LeuTrp: 1.101 ± 0.029
2.059LeuTyr: 2.059 ± 0.035
0.0LeuXaa: 0.0 ± 0.0
Met
3.157MetAla: 3.157 ± 0.047
0.139MetCys: 0.139 ± 0.01
1.117MetAsp: 1.117 ± 0.028
1.212MetGlu: 1.212 ± 0.026
0.772MetPhe: 0.772 ± 0.025
1.758MetGly: 1.758 ± 0.039
0.416MetHis: 0.416 ± 0.017
1.442MetIle: 1.442 ± 0.024
1.1MetLys: 1.1 ± 0.027
2.596MetLeu: 2.596 ± 0.04
0.665MetMet: 0.665 ± 0.024
0.833MetAsn: 0.833 ± 0.02
1.516MetPro: 1.516 ± 0.031
0.787MetGln: 0.787 ± 0.022
1.824MetArg: 1.824 ± 0.04
1.656MetSer: 1.656 ± 0.033
1.806MetThr: 1.806 ± 0.032
1.707MetVal: 1.707 ± 0.036
0.228MetTrp: 0.228 ± 0.013
0.302MetTyr: 0.302 ± 0.013
0.0MetXaa: 0.0 ± 0.0
Asn
3.172AsnAla: 3.172 ± 0.047
0.225AsnCys: 0.225 ± 0.013
1.416AsnAsp: 1.416 ± 0.033
1.334AsnGlu: 1.334 ± 0.036
1.048AsnPhe: 1.048 ± 0.027
2.452AsnGly: 2.452 ± 0.039
0.494AsnHis: 0.494 ± 0.017
1.41AsnIle: 1.41 ± 0.031
0.696AsnLys: 0.696 ± 0.024
2.448AsnLeu: 2.448 ± 0.041
0.662AsnMet: 0.662 ± 0.021
0.677AsnAsn: 0.677 ± 0.021
1.866AsnPro: 1.866 ± 0.037
0.688AsnGln: 0.688 ± 0.022
1.836AsnArg: 1.836 ± 0.038
1.278AsnSer: 1.278 ± 0.032
1.229AsnThr: 1.229 ± 0.03
2.005AsnVal: 2.005 ± 0.039
0.472AsnTrp: 0.472 ± 0.017
0.708AsnTyr: 0.708 ± 0.024
0.0AsnXaa: 0.0 ± 0.0
Pro
6.318ProAla: 6.318 ± 0.067
0.274ProCys: 0.274 ± 0.014
3.614ProAsp: 3.614 ± 0.051
3.796ProGlu: 3.796 ± 0.047
2.032ProPhe: 2.032 ± 0.036
4.569ProGly: 4.569 ± 0.057
0.951ProHis: 0.951 ± 0.024
2.223ProIle: 2.223 ± 0.043
1.842ProLys: 1.842 ± 0.033
4.581ProLeu: 4.581 ± 0.062
1.136ProMet: 1.136 ± 0.027
1.332ProAsn: 1.332 ± 0.031
2.38ProPro: 2.38 ± 0.047
1.489ProGln: 1.489 ± 0.034
2.783ProArg: 2.783 ± 0.045
2.76ProSer: 2.76 ± 0.039
2.354ProThr: 2.354 ± 0.042
4.237ProVal: 4.237 ± 0.057
0.676ProTrp: 0.676 ± 0.021
1.24ProTyr: 1.24 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
3.778GlnAla: 3.778 ± 0.043
0.177GlnCys: 0.177 ± 0.011
1.354GlnAsp: 1.354 ± 0.029
1.512GlnGlu: 1.512 ± 0.033
1.024GlnPhe: 1.024 ± 0.027
2.222GlnGly: 2.222 ± 0.041
0.58GlnHis: 0.58 ± 0.019
1.697GlnIle: 1.697 ± 0.035
1.201GlnLys: 1.201 ± 0.029
2.568GlnLeu: 2.568 ± 0.04
0.843GlnMet: 0.843 ± 0.023
0.791GlnAsn: 0.791 ± 0.021
1.724GlnPro: 1.724 ± 0.04
1.155GlnGln: 1.155 ± 0.042
2.177GlnArg: 2.177 ± 0.039
1.588GlnSer: 1.588 ± 0.032
1.519GlnThr: 1.519 ± 0.032
2.068GlnVal: 2.068 ± 0.037
0.355GlnTrp: 0.355 ± 0.015
0.558GlnTyr: 0.558 ± 0.021
0.0GlnXaa: 0.0 ± 0.0
Arg
7.329ArgAla: 7.329 ± 0.077
0.469ArgCys: 0.469 ± 0.021
3.907ArgAsp: 3.907 ± 0.051
4.195ArgGlu: 4.195 ± 0.054
2.902ArgPhe: 2.902 ± 0.047
4.776ArgGly: 4.776 ± 0.063
1.656ArgHis: 1.656 ± 0.034
4.051ArgIle: 4.051 ± 0.052
2.62ArgLys: 2.62 ± 0.044
7.517ArgLeu: 7.517 ± 0.079
1.888ArgMet: 1.888 ± 0.035
1.916ArgAsn: 1.916 ± 0.039
3.36ArgPro: 3.36 ± 0.046
2.607ArgGln: 2.607 ± 0.046
5.543ArgArg: 5.543 ± 0.076
3.813ArgSer: 3.813 ± 0.047
3.373ArgThr: 3.373 ± 0.039
4.388ArgVal: 4.388 ± 0.05
0.94ArgTrp: 0.94 ± 0.025
1.719ArgTyr: 1.719 ± 0.035
0.0ArgXaa: 0.0 ± 0.0
Ser
6.215SerAla: 6.215 ± 0.066
0.423SerCys: 0.423 ± 0.02
2.957SerAsp: 2.957 ± 0.046
2.99SerGlu: 2.99 ± 0.052
2.423SerPhe: 2.423 ± 0.043
5.848SerGly: 5.848 ± 0.07
1.018SerHis: 1.018 ± 0.025
2.948SerIle: 2.948 ± 0.046
1.741SerLys: 1.741 ± 0.031
5.413SerLeu: 5.413 ± 0.056
1.389SerMet: 1.389 ± 0.031
1.389SerAsn: 1.389 ± 0.03
2.804SerPro: 2.804 ± 0.037
1.506SerGln: 1.506 ± 0.03
3.67SerArg: 3.67 ± 0.049
2.9SerSer: 2.9 ± 0.046
2.755SerThr: 2.755 ± 0.041
4.125SerVal: 4.125 ± 0.049
0.759SerTrp: 0.759 ± 0.024
1.321SerTyr: 1.321 ± 0.031
0.0SerXaa: 0.0 ± 0.0
Thr
6.075ThrAla: 6.075 ± 0.072
0.37ThrCys: 0.37 ± 0.015
2.806ThrAsp: 2.806 ± 0.046
2.713ThrGlu: 2.713 ± 0.041
2.012ThrPhe: 2.012 ± 0.039
5.136ThrGly: 5.136 ± 0.066
0.949ThrHis: 0.949 ± 0.026
3.088ThrIle: 3.088 ± 0.047
1.574ThrLys: 1.574 ± 0.033
5.482ThrLeu: 5.482 ± 0.052
1.213ThrMet: 1.213 ± 0.028
1.235ThrAsn: 1.235 ± 0.029
3.048ThrPro: 3.048 ± 0.049
1.23ThrGln: 1.23 ± 0.028
3.067ThrArg: 3.067 ± 0.045
2.762ThrSer: 2.762 ± 0.045
2.692ThrThr: 2.692 ± 0.047
4.51ThrVal: 4.51 ± 0.057
0.622ThrTrp: 0.622 ± 0.02
1.174ThrTyr: 1.174 ± 0.029
0.0ThrXaa: 0.0 ± 0.0
Val
9.549ValAla: 9.549 ± 0.079
0.594ValCys: 0.594 ± 0.021
4.306ValAsp: 4.306 ± 0.059
4.846ValGlu: 4.846 ± 0.062
2.995ValPhe: 2.995 ± 0.05
5.865ValGly: 5.865 ± 0.071
1.405ValHis: 1.405 ± 0.032
4.044ValIle: 4.044 ± 0.054
2.547ValLys: 2.547 ± 0.047
7.536ValLeu: 7.536 ± 0.087
1.847ValMet: 1.847 ± 0.036
1.997ValAsn: 1.997 ± 0.035
3.757ValPro: 3.757 ± 0.049
1.919ValGln: 1.919 ± 0.034
4.932ValArg: 4.932 ± 0.059
4.62ValSer: 4.62 ± 0.05
4.509ValThr: 4.509 ± 0.053
6.234ValVal: 6.234 ± 0.074
0.921ValTrp: 0.921 ± 0.021
1.545ValTyr: 1.545 ± 0.03
0.0ValXaa: 0.0 ± 0.0
Trp
1.232TrpAla: 1.232 ± 0.032
0.127TrpCys: 0.127 ± 0.009
0.59TrpAsp: 0.59 ± 0.021
0.566TrpGlu: 0.566 ± 0.019
0.573TrpPhe: 0.573 ± 0.018
0.876TrpGly: 0.876 ± 0.025
0.315TrpHis: 0.315 ± 0.015
0.644TrpIle: 0.644 ± 0.021
0.529TrpLys: 0.529 ± 0.016
1.62TrpLeu: 1.62 ± 0.037
0.363TrpMet: 0.363 ± 0.015
0.477TrpAsn: 0.477 ± 0.017
0.712TrpPro: 0.712 ± 0.024
0.555TrpGln: 0.555 ± 0.022
1.089TrpArg: 1.089 ± 0.028
0.838TrpSer: 0.838 ± 0.029
0.823TrpThr: 0.823 ± 0.023
0.782TrpVal: 0.782 ± 0.022
0.218TrpTrp: 0.218 ± 0.013
0.322TrpTyr: 0.322 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.529TyrAla: 2.529 ± 0.038
0.237TyrCys: 0.237 ± 0.014
1.451TyrAsp: 1.451 ± 0.035
1.326TyrGlu: 1.326 ± 0.032
0.947TyrPhe: 0.947 ± 0.024
2.165TyrGly: 2.165 ± 0.039
0.484TyrHis: 0.484 ± 0.018
0.929TyrIle: 0.929 ± 0.024
0.637TyrLys: 0.637 ± 0.02
2.253TyrLeu: 2.253 ± 0.042
0.472TyrMet: 0.472 ± 0.016
0.597TyrAsn: 0.597 ± 0.021
1.115TyrPro: 1.115 ± 0.032
0.687TyrGln: 0.687 ± 0.022
1.815TyrArg: 1.815 ± 0.035
1.272TyrSer: 1.272 ± 0.029
1.119TyrThr: 1.119 ± 0.03
1.692TyrVal: 1.692 ± 0.033
0.341TyrTrp: 0.341 ± 0.012
0.58TyrTyr: 0.58 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5230 proteins (1606736 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski