Amino acid dipepetide frequency for Bacteroides nordii CL02T12C05

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.175AlaAla: 5.175 ± 0.083	0.914AlaCys: 0.914 ± 0.027	4.012AlaAsp: 4.012 ± 0.055	4.468AlaGlu: 4.468 ± 0.066	3.061AlaPhe: 3.061 ± 0.043	4.966AlaGly: 4.966 ± 0.06	1.113AlaHis: 1.113 ± 0.025	4.685AlaIle: 4.685 ± 0.063	3.822AlaLys: 3.822 ± 0.05	6.23AlaLeu: 6.23 ± 0.068	1.89AlaMet: 1.89 ± 0.031	3.207AlaAsn: 3.207 ± 0.046	2.233AlaPro: 2.233 ± 0.037	2.572AlaGln: 2.572 ± 0.044	2.894AlaArg: 2.894 ± 0.043	4.199AlaSer: 4.199 ± 0.052	3.968AlaThr: 3.968 ± 0.058	4.485AlaVal: 4.485 ± 0.057	0.824AlaTrp: 0.824 ± 0.026	2.911AlaTyr: 2.911 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.737CysAla: 0.737 ± 0.021	0.207CysCys: 0.207 ± 0.012	0.642CysAsp: 0.642 ± 0.018	0.641CysGlu: 0.641 ± 0.02	0.638CysPhe: 0.638 ± 0.019	0.944CysGly: 0.944 ± 0.024	0.287CysHis: 0.287 ± 0.016	0.968CysIle: 0.968 ± 0.028	0.699CysLys: 0.699 ± 0.022	1.07CysLeu: 1.07 ± 0.027	0.323CysMet: 0.323 ± 0.015	0.603CysAsn: 0.603 ± 0.017	0.485CysPro: 0.485 ± 0.02	0.349CysGln: 0.349 ± 0.014	0.618CysArg: 0.618 ± 0.019	0.786CysSer: 0.786 ± 0.023	0.703CysThr: 0.703 ± 0.022	0.697CysVal: 0.697 ± 0.021	0.155CysTrp: 0.155 ± 0.01	0.598CysTyr: 0.598 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.69AspAla: 3.69 ± 0.053	0.616AspCys: 0.616 ± 0.023	2.687AspAsp: 2.687 ± 0.044	3.743AspGlu: 3.743 ± 0.052	2.93AspPhe: 2.93 ± 0.043	4.299AspGly: 4.299 ± 0.063	0.802AspHis: 0.802 ± 0.021	4.262AspIle: 4.262 ± 0.052	4.137AspLys: 4.137 ± 0.05	4.456AspLeu: 4.456 ± 0.054	1.57AspMet: 1.57 ± 0.034	2.972AspAsn: 2.972 ± 0.049	1.889AspPro: 1.889 ± 0.037	1.26AspGln: 1.26 ± 0.031	2.376AspArg: 2.376 ± 0.042	3.08AspSer: 3.08 ± 0.046	2.773AspThr: 2.773 ± 0.042	3.523AspVal: 3.523 ± 0.047	0.859AspTrp: 0.859 ± 0.021	2.869AspTyr: 2.869 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	4.63GluAla: 4.63 ± 0.063	0.601GluCys: 0.601 ± 0.018	3.168GluAsp: 3.168 ± 0.044	5.049GluGlu: 5.049 ± 0.071	2.482GluPhe: 2.482 ± 0.04	4.181GluGly: 4.181 ± 0.057	1.206GluHis: 1.206 ± 0.027	4.642GluIle: 4.642 ± 0.048	5.187GluLys: 5.187 ± 0.067	6.205GluLeu: 6.205 ± 0.073	1.977GluMet: 1.977 ± 0.033	3.73GluAsn: 3.73 ± 0.05	1.721GluPro: 1.721 ± 0.037	2.526GluGln: 2.526 ± 0.043	3.123GluArg: 3.123 ± 0.051	3.298GluSer: 3.298 ± 0.054	3.364GluThr: 3.364 ± 0.041	4.376GluVal: 4.376 ± 0.055	0.858GluTrp: 0.858 ± 0.023	2.906GluTyr: 2.906 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	2.921PheAla: 2.921 ± 0.047	0.68PheCys: 0.68 ± 0.021	2.728PheAsp: 2.728 ± 0.044	2.497PheGlu: 2.497 ± 0.04	2.268PhePhe: 2.268 ± 0.045	3.073PheGly: 3.073 ± 0.044	0.846PheHis: 0.846 ± 0.023	3.388PheIle: 3.388 ± 0.049	2.423PheLys: 2.423 ± 0.038	3.969PheLeu: 3.969 ± 0.05	1.22PheMet: 1.22 ± 0.026	2.52PheAsn: 2.52 ± 0.04	1.734PhePro: 1.734 ± 0.034	1.236PheGln: 1.236 ± 0.027	2.131PheArg: 2.131 ± 0.04	3.629PheSer: 3.629 ± 0.049	2.922PheThr: 2.922 ± 0.046	2.893PheVal: 2.893 ± 0.047	0.561PheTrp: 0.561 ± 0.019	2.146PheTyr: 2.146 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	4.255GlyAla: 4.255 ± 0.062	0.872GlyCys: 0.872 ± 0.021	3.547GlyAsp: 3.547 ± 0.051	4.268GlyGlu: 4.268 ± 0.059	3.119GlyPhe: 3.119 ± 0.045	4.857GlyGly: 4.857 ± 0.074	1.197GlyHis: 1.197 ± 0.029	5.43GlyIle: 5.43 ± 0.061	5.221GlyLys: 5.221 ± 0.063	5.72GlyLeu: 5.72 ± 0.061	2.071GlyMet: 2.071 ± 0.038	3.778GlyAsn: 3.778 ± 0.058	1.23GlyPro: 1.23 ± 0.028	2.072GlyGln: 2.072 ± 0.036	2.874GlyArg: 2.874 ± 0.045	4.047GlySer: 4.047 ± 0.06	4.544GlyThr: 4.544 ± 0.061	4.848GlyVal: 4.848 ± 0.053	1.036GlyTrp: 1.036 ± 0.025	3.416GlyTyr: 3.416 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	1.082HisAla: 1.082 ± 0.023	0.277HisCys: 0.277 ± 0.013	0.831HisAsp: 0.831 ± 0.019	0.974HisGlu: 0.974 ± 0.025	1.002HisPhe: 1.002 ± 0.021	1.151HisGly: 1.151 ± 0.03	0.437HisHis: 0.437 ± 0.016	1.403HisIle: 1.403 ± 0.028	1.005HisLys: 1.005 ± 0.025	1.746HisLeu: 1.746 ± 0.038	0.359HisMet: 0.359 ± 0.015	0.914HisAsn: 0.914 ± 0.027	1.019HisPro: 1.019 ± 0.025	0.586HisGln: 0.586 ± 0.02	0.812HisArg: 0.812 ± 0.021	1.117HisSer: 1.117 ± 0.032	1.049HisThr: 1.049 ± 0.026	0.974HisVal: 0.974 ± 0.024	0.263HisTrp: 0.263 ± 0.013	0.898HisTyr: 0.898 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.141IleAla: 5.141 ± 0.061	1.008IleCys: 1.008 ± 0.025	4.314IleAsp: 4.314 ± 0.052	4.602IleGlu: 4.602 ± 0.056	2.848IlePhe: 2.848 ± 0.049	4.644IleGly: 4.644 ± 0.059	1.357IleHis: 1.357 ± 0.031	4.825IleIle: 4.825 ± 0.069	4.369IleLys: 4.369 ± 0.058	6.128IleLeu: 6.128 ± 0.069	1.492IleMet: 1.492 ± 0.032	3.814IleAsn: 3.814 ± 0.049	3.243IlePro: 3.243 ± 0.044	2.257IleGln: 2.257 ± 0.038	3.488IleArg: 3.488 ± 0.048	4.953IleSer: 4.953 ± 0.063	4.359IleThr: 4.359 ± 0.056	4.44IleVal: 4.44 ± 0.051	0.778IleTrp: 0.778 ± 0.023	3.112IleTyr: 3.112 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	4.681LysAla: 4.681 ± 0.063	0.563LysCys: 0.563 ± 0.018	4.003LysAsp: 4.003 ± 0.053	5.859LysGlu: 5.859 ± 0.066	2.157LysPhe: 2.157 ± 0.033	4.559LysGly: 4.559 ± 0.057	1.174LysHis: 1.174 ± 0.029	4.376LysIle: 4.376 ± 0.056	5.056LysLys: 5.056 ± 0.066	5.399LysLeu: 5.399 ± 0.057	2.034LysMet: 2.034 ± 0.034	3.666LysAsn: 3.666 ± 0.048	2.159LysPro: 2.159 ± 0.039	2.554LysGln: 2.554 ± 0.046	3.045LysArg: 3.045 ± 0.045	3.474LysSer: 3.474 ± 0.044	3.619LysThr: 3.619 ± 0.044	4.318LysVal: 4.318 ± 0.058	0.787LysTrp: 0.787 ± 0.02	3.061LysTyr: 3.061 ± 0.05	0.0LysXaa: 0.0 ± 0.0
Leu	5.964LeuAla: 5.964 ± 0.068	1.316LeuCys: 1.316 ± 0.032	4.493LeuAsp: 4.493 ± 0.058	4.917LeuGlu: 4.917 ± 0.057	4.632LeuPhe: 4.632 ± 0.061	5.39LeuGly: 5.39 ± 0.071	1.658LeuHis: 1.658 ± 0.03	5.816LeuIle: 5.816 ± 0.071	6.368LeuLys: 6.368 ± 0.055	8.998LeuLeu: 8.998 ± 0.104	2.308LeuMet: 2.308 ± 0.033	4.868LeuAsn: 4.868 ± 0.054	4.161LeuPro: 4.161 ± 0.053	3.211LeuGln: 3.211 ± 0.047	4.003LeuArg: 4.003 ± 0.051	6.857LeuSer: 6.857 ± 0.08	5.348LeuThr: 5.348 ± 0.059	4.956LeuVal: 4.956 ± 0.058	1.055LeuTrp: 1.055 ± 0.027	3.807LeuTyr: 3.807 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	1.911MetAla: 1.911 ± 0.039	0.242MetCys: 0.242 ± 0.012	1.438MetAsp: 1.438 ± 0.029	1.769MetGlu: 1.769 ± 0.036	0.99MetPhe: 0.99 ± 0.024	1.783MetGly: 1.783 ± 0.031	0.434MetHis: 0.434 ± 0.016	1.688MetIle: 1.688 ± 0.034	2.545MetLys: 2.545 ± 0.04	2.341MetLeu: 2.341 ± 0.037	0.744MetMet: 0.744 ± 0.024	1.682MetAsn: 1.682 ± 0.033	1.09MetPro: 1.09 ± 0.026	1.001MetGln: 1.001 ± 0.026	1.258MetArg: 1.258 ± 0.028	1.512MetSer: 1.512 ± 0.034	1.429MetThr: 1.429 ± 0.029	1.479MetVal: 1.479 ± 0.031	0.258MetTrp: 0.258 ± 0.013	0.917MetTyr: 0.917 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.429AsnAla: 3.429 ± 0.045	0.571AsnCys: 0.571 ± 0.021	2.73AsnAsp: 2.73 ± 0.043	3.302AsnGlu: 3.302 ± 0.043	2.32AsnPhe: 2.32 ± 0.039	4.169AsnGly: 4.169 ± 0.06	0.91AsnHis: 0.91 ± 0.025	4.14AsnIle: 4.14 ± 0.057	3.466AsnLys: 3.466 ± 0.047	4.557AsnLeu: 4.557 ± 0.06	1.437AsnMet: 1.437 ± 0.029	3.022AsnAsn: 3.022 ± 0.052	2.569AsnPro: 2.569 ± 0.041	1.695AsnGln: 1.695 ± 0.036	2.483AsnArg: 2.483 ± 0.04	3.151AsnSer: 3.151 ± 0.041	3.025AsnThr: 3.025 ± 0.049	3.292AsnVal: 3.292 ± 0.049	0.738AsnTrp: 0.738 ± 0.024	2.643AsnTyr: 2.643 ± 0.045	0.0AsnXaa: 0.0 ± 0.0
Pro	2.796ProAla: 2.796 ± 0.045	0.367ProCys: 0.367 ± 0.016	2.546ProAsp: 2.546 ± 0.041	3.292ProGlu: 3.292 ± 0.046	1.85ProPhe: 1.85 ± 0.035	2.537ProGly: 2.537 ± 0.04	0.674ProHis: 0.674 ± 0.021	2.31ProIle: 2.31 ± 0.039	1.965ProLys: 1.965 ± 0.036	3.214ProLeu: 3.214 ± 0.049	0.872ProMet: 0.872 ± 0.023	1.707ProAsn: 1.707 ± 0.037	0.842ProPro: 0.842 ± 0.024	1.407ProGln: 1.407 ± 0.027	1.274ProArg: 1.274 ± 0.029	2.197ProSer: 2.197 ± 0.039	2.005ProThr: 2.005 ± 0.037	3.177ProVal: 3.177 ± 0.041	0.46ProTrp: 0.46 ± 0.018	1.75ProTyr: 1.75 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	2.339GlnAla: 2.339 ± 0.038	0.318GlnCys: 0.318 ± 0.013	1.52GlnAsp: 1.52 ± 0.033	2.386GlnGlu: 2.386 ± 0.042	1.301GlnPhe: 1.301 ± 0.029	2.117GlnGly: 2.117 ± 0.039	0.607GlnHis: 0.607 ± 0.022	2.356GlnIle: 2.356 ± 0.037	2.439GlnLys: 2.439 ± 0.048	3.226GlnLeu: 3.226 ± 0.049	0.996GlnMet: 0.996 ± 0.023	1.787GlnAsn: 1.787 ± 0.034	1.245GlnPro: 1.245 ± 0.03	1.542GlnGln: 1.542 ± 0.037	1.575GlnArg: 1.575 ± 0.033	2.001GlnSer: 2.001 ± 0.037	2.053GlnThr: 2.053 ± 0.034	2.118GlnVal: 2.118 ± 0.037	0.443GlnTrp: 0.443 ± 0.017	1.472GlnTyr: 1.472 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	2.682ArgAla: 2.682 ± 0.038	0.489ArgCys: 0.489 ± 0.017	2.127ArgAsp: 2.127 ± 0.04	2.996ArgGlu: 2.996 ± 0.047	2.257ArgPhe: 2.257 ± 0.039	2.43ArgGly: 2.43 ± 0.039	0.838ArgHis: 0.838 ± 0.024	3.593ArgIle: 3.593 ± 0.049	3.234ArgLys: 3.234 ± 0.048	4.266ArgLeu: 4.266 ± 0.052	1.463ArgMet: 1.463 ± 0.031	2.476ArgAsn: 2.476 ± 0.043	1.573ArgPro: 1.573 ± 0.037	1.747ArgGln: 1.747 ± 0.036	2.154ArgArg: 2.154 ± 0.041	2.405ArgSer: 2.405 ± 0.036	2.487ArgThr: 2.487 ± 0.04	2.568ArgVal: 2.568 ± 0.038	0.63ArgTrp: 0.63 ± 0.02	2.216ArgTyr: 2.216 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	4.141SerAla: 4.141 ± 0.048	0.872SerCys: 0.872 ± 0.021	3.461SerAsp: 3.461 ± 0.048	3.614SerGlu: 3.614 ± 0.044	3.352SerPhe: 3.352 ± 0.045	4.71SerGly: 4.71 ± 0.06	1.123SerHis: 1.123 ± 0.027	4.63SerIle: 4.63 ± 0.063	3.494SerLys: 3.494 ± 0.046	6.046SerLeu: 6.046 ± 0.07	1.453SerMet: 1.453 ± 0.029	3.046SerAsn: 3.046 ± 0.046	2.33SerPro: 2.33 ± 0.043	1.956SerGln: 1.956 ± 0.035	2.591SerArg: 2.591 ± 0.039	4.157SerSer: 4.157 ± 0.068	3.447SerThr: 3.447 ± 0.053	4.496SerVal: 4.496 ± 0.06	0.83SerTrp: 0.83 ± 0.028	3.039SerTyr: 3.039 ± 0.047	0.001SerXaa: 0.001 ± 0.001
Thr	3.912ThrAla: 3.912 ± 0.054	0.582ThrCys: 0.582 ± 0.019	3.566ThrAsp: 3.566 ± 0.048	3.572ThrGlu: 3.572 ± 0.05	2.916ThrPhe: 2.916 ± 0.039	4.651ThrGly: 4.651 ± 0.057	1.027ThrHis: 1.027 ± 0.027	4.124ThrIle: 4.124 ± 0.057	3.029ThrLys: 3.029 ± 0.043	5.581ThrLeu: 5.581 ± 0.064	1.194ThrMet: 1.194 ± 0.029	2.779ThrAsn: 2.779 ± 0.043	2.905ThrPro: 2.905 ± 0.049	1.779ThrGln: 1.779 ± 0.037	2.164ThrArg: 2.164 ± 0.035	3.564ThrSer: 3.564 ± 0.053	3.434ThrThr: 3.434 ± 0.06	4.137ThrVal: 4.137 ± 0.061	0.682ThrTrp: 0.682 ± 0.022	2.606ThrTyr: 2.606 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	4.408ValAla: 4.408 ± 0.061	0.914ValCys: 0.914 ± 0.026	3.582ValAsp: 3.582 ± 0.044	3.93ValGlu: 3.93 ± 0.056	2.86ValPhe: 2.86 ± 0.04	3.961ValGly: 3.961 ± 0.05	1.05ValHis: 1.05 ± 0.027	4.566ValIle: 4.566 ± 0.054	4.291ValLys: 4.291 ± 0.057	5.701ValLeu: 5.701 ± 0.071	1.572ValMet: 1.572 ± 0.033	3.503ValAsn: 3.503 ± 0.043	2.515ValPro: 2.515 ± 0.041	1.972ValGln: 1.972 ± 0.037	2.925ValArg: 2.925 ± 0.048	4.599ValSer: 4.599 ± 0.057	4.012ValThr: 4.012 ± 0.053	4.456ValVal: 4.456 ± 0.063	0.789ValTrp: 0.789 ± 0.022	2.848ValTyr: 2.848 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.768TrpAla: 0.768 ± 0.022	0.172TrpCys: 0.172 ± 0.011	0.754TrpAsp: 0.754 ± 0.026	0.818TrpGlu: 0.818 ± 0.02	0.58TrpPhe: 0.58 ± 0.019	0.968TrpGly: 0.968 ± 0.026	0.237TrpHis: 0.237 ± 0.013	0.89TrpIle: 0.89 ± 0.026	0.902TrpLys: 0.902 ± 0.024	1.13TrpLeu: 1.13 ± 0.028	0.43TrpMet: 0.43 ± 0.018	0.818TrpAsn: 0.818 ± 0.02	0.294TrpPro: 0.294 ± 0.015	0.498TrpGln: 0.498 ± 0.017	0.593TrpArg: 0.593 ± 0.019	0.711TrpSer: 0.711 ± 0.022	0.727TrpThr: 0.727 ± 0.023	0.74TrpVal: 0.74 ± 0.02	0.195TrpTrp: 0.195 ± 0.011	0.568TrpTyr: 0.568 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.966TyrAla: 2.966 ± 0.051	0.572TyrCys: 0.572 ± 0.02	2.64TyrAsp: 2.64 ± 0.048	2.532TyrGlu: 2.532 ± 0.041	2.222TyrPhe: 2.222 ± 0.035	3.013TyrGly: 3.013 ± 0.052	0.922TyrHis: 0.922 ± 0.023	3.08TyrIle: 3.08 ± 0.043	2.893TyrLys: 2.893 ± 0.042	4.144TyrLeu: 4.144 ± 0.052	1.105TyrMet: 1.105 ± 0.027	2.759TyrAsn: 2.759 ± 0.043	2.006TyrPro: 2.006 ± 0.033	1.619TyrGln: 1.619 ± 0.033	2.249TyrArg: 2.249 ± 0.041	3.053TyrSer: 3.053 ± 0.049	2.936TyrThr: 2.936 ± 0.047	2.479TyrVal: 2.479 ± 0.04	0.591TyrTrp: 0.591 ± 0.019	2.363TyrTyr: 2.363 ± 0.045	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4388 proteins (1679095 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---