Amino acid dipepetide frequency for Lachnoclostridium sp. An14

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.774AlaAla: 10.774 ± 0.132	1.286AlaCys: 1.286 ± 0.036	4.69AlaAsp: 4.69 ± 0.069	6.423AlaGlu: 6.423 ± 0.094	3.277AlaPhe: 3.277 ± 0.059	8.003AlaGly: 8.003 ± 0.084	1.232AlaHis: 1.232 ± 0.033	4.743AlaIle: 4.743 ± 0.082	4.313AlaLys: 4.313 ± 0.07	8.034AlaLeu: 8.034 ± 0.109	2.778AlaMet: 2.778 ± 0.053	2.327AlaAsn: 2.327 ± 0.05	2.752AlaPro: 2.752 ± 0.058	2.483AlaGln: 2.483 ± 0.049	3.863AlaArg: 3.863 ± 0.064	3.951AlaSer: 3.951 ± 0.059	3.295AlaThr: 3.295 ± 0.057	7.729AlaVal: 7.729 ± 0.101	0.811AlaTrp: 0.811 ± 0.024	2.888AlaTyr: 2.888 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	1.154CysAla: 1.154 ± 0.035	0.292CysCys: 0.292 ± 0.018	0.766CysAsp: 0.766 ± 0.027	0.826CysGlu: 0.826 ± 0.029	0.645CysPhe: 0.645 ± 0.027	1.733CysGly: 1.733 ± 0.044	0.324CysHis: 0.324 ± 0.016	0.88CysIle: 0.88 ± 0.029	0.549CysLys: 0.549 ± 0.023	1.327CysLeu: 1.327 ± 0.035	0.406CysMet: 0.406 ± 0.017	0.446CysAsn: 0.446 ± 0.022	0.728CysPro: 0.728 ± 0.028	0.457CysGln: 0.457 ± 0.018	0.972CysArg: 0.972 ± 0.03	0.87CysSer: 0.87 ± 0.027	0.66CysThr: 0.66 ± 0.025	1.052CysVal: 1.052 ± 0.031	0.148CysTrp: 0.148 ± 0.01	0.549CysTyr: 0.549 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	4.016AspAla: 4.016 ± 0.058	0.839AspCys: 0.839 ± 0.026	2.503AspAsp: 2.503 ± 0.066	4.209AspGlu: 4.209 ± 0.068	2.443AspPhe: 2.443 ± 0.045	5.684AspGly: 5.684 ± 0.109	0.9AspHis: 0.9 ± 0.028	3.303AspIle: 3.303 ± 0.051	2.407AspLys: 2.407 ± 0.059	4.666AspLeu: 4.666 ± 0.067	1.688AspMet: 1.688 ± 0.035	1.557AspAsn: 1.557 ± 0.034	2.153AspPro: 2.153 ± 0.043	1.576AspGln: 1.576 ± 0.032	3.054AspArg: 3.054 ± 0.055	2.908AspSer: 2.908 ± 0.057	2.717AspThr: 2.717 ± 0.052	3.736AspVal: 3.736 ± 0.057	0.677AspTrp: 0.677 ± 0.025	2.533AspTyr: 2.533 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	5.989GluAla: 5.989 ± 0.082	0.79GluCys: 0.79 ± 0.026	4.388GluAsp: 4.388 ± 0.079	7.616GluGlu: 7.616 ± 0.115	2.615GluPhe: 2.615 ± 0.045	5.11GluGly: 5.11 ± 0.074	1.272GluHis: 1.272 ± 0.036	4.951GluIle: 4.951 ± 0.066	5.55GluLys: 5.55 ± 0.085	7.122GluLeu: 7.122 ± 0.082	2.554GluMet: 2.554 ± 0.044	3.629GluAsn: 3.629 ± 0.058	2.585GluPro: 2.585 ± 0.051	3.0GluGln: 3.0 ± 0.072	4.801GluArg: 4.801 ± 0.073	3.322GluSer: 3.322 ± 0.063	5.004GluThr: 5.004 ± 0.088	4.435GluVal: 4.435 ± 0.062	0.778GluTrp: 0.778 ± 0.03	2.778GluTyr: 2.778 ± 0.051	0.0GluXaa: 0.0 ± 0.0
Phe	3.161PheAla: 3.161 ± 0.052	0.768PheCys: 0.768 ± 0.028	2.371PheAsp: 2.371 ± 0.045	2.28PheGlu: 2.28 ± 0.04	1.729PhePhe: 1.729 ± 0.041	3.194PheGly: 3.194 ± 0.055	0.881PheHis: 0.881 ± 0.025	2.238PheIle: 2.238 ± 0.047	1.509PheLys: 1.509 ± 0.037	4.379PheLeu: 4.379 ± 0.07	1.013PheMet: 1.013 ± 0.032	1.205PheAsn: 1.205 ± 0.033	1.626PhePro: 1.626 ± 0.037	1.478PheGln: 1.478 ± 0.032	2.079PheArg: 2.079 ± 0.052	2.985PheSer: 2.985 ± 0.052	2.168PheThr: 2.168 ± 0.04	2.673PheVal: 2.673 ± 0.055	0.453PheTrp: 0.453 ± 0.023	1.568PheTyr: 1.568 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	6.455GlyAla: 6.455 ± 0.087	1.409GlyCys: 1.409 ± 0.04	4.024GlyAsp: 4.024 ± 0.067	6.254GlyGlu: 6.254 ± 0.09	3.252GlyPhe: 3.252 ± 0.056	6.244GlyGly: 6.244 ± 0.103	1.325GlyHis: 1.325 ± 0.037	5.906GlyIle: 5.906 ± 0.085	5.112GlyLys: 5.112 ± 0.067	6.924GlyLeu: 6.924 ± 0.083	2.795GlyMet: 2.795 ± 0.054	3.192GlyAsn: 3.192 ± 0.062	1.851GlyPro: 1.851 ± 0.045	2.573GlyGln: 2.573 ± 0.057	4.477GlyArg: 4.477 ± 0.075	4.431GlySer: 4.431 ± 0.071	4.916GlyThr: 4.916 ± 0.078	5.58GlyVal: 5.58 ± 0.072	0.99GlyTrp: 0.99 ± 0.035	3.259GlyTyr: 3.259 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	0.943HisAla: 0.943 ± 0.027	0.298HisCys: 0.298 ± 0.018	0.842HisAsp: 0.842 ± 0.026	1.006HisGlu: 1.006 ± 0.034	0.858HisPhe: 0.858 ± 0.027	1.418HisGly: 1.418 ± 0.043	0.406HisHis: 0.406 ± 0.025	1.225HisIle: 1.225 ± 0.032	0.699HisLys: 0.699 ± 0.023	1.499HisLeu: 1.499 ± 0.037	0.564HisMet: 0.564 ± 0.021	0.596HisAsn: 0.596 ± 0.021	1.006HisPro: 1.006 ± 0.031	0.527HisGln: 0.527 ± 0.022	0.937HisArg: 0.937 ± 0.031	1.003HisSer: 1.003 ± 0.028	0.922HisThr: 0.922 ± 0.029	1.03HisVal: 1.03 ± 0.029	0.216HisTrp: 0.216 ± 0.013	0.686HisTyr: 0.686 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.157IleAla: 5.157 ± 0.067	1.139IleCys: 1.139 ± 0.034	3.19IleAsp: 3.19 ± 0.058	3.629IleGlu: 3.629 ± 0.055	2.428IlePhe: 2.428 ± 0.054	4.622IleGly: 4.622 ± 0.075	1.203IleHis: 1.203 ± 0.035	3.595IleIle: 3.595 ± 0.081	2.664IleLys: 2.664 ± 0.055	6.409IleLeu: 6.409 ± 0.087	1.589IleMet: 1.589 ± 0.037	2.117IleAsn: 2.117 ± 0.044	3.214IlePro: 3.214 ± 0.055	2.209IleGln: 2.209 ± 0.042	3.885IleArg: 3.885 ± 0.06	4.198IleSer: 4.198 ± 0.071	3.425IleThr: 3.425 ± 0.062	4.141IleVal: 4.141 ± 0.077	0.595IleTrp: 0.595 ± 0.025	2.23IleTyr: 2.23 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	4.71LysAla: 4.71 ± 0.074	0.522LysCys: 0.522 ± 0.023	2.88LysAsp: 2.88 ± 0.05	5.317LysGlu: 5.317 ± 0.078	1.463LysPhe: 1.463 ± 0.04	3.951LysGly: 3.951 ± 0.059	0.759LysHis: 0.759 ± 0.026	3.221LysIle: 3.221 ± 0.059	4.378LysLys: 4.378 ± 0.072	4.45LysLeu: 4.45 ± 0.066	1.621LysMet: 1.621 ± 0.043	2.484LysAsn: 2.484 ± 0.05	1.862LysPro: 1.862 ± 0.043	1.962LysGln: 1.962 ± 0.047	3.35LysArg: 3.35 ± 0.062	2.512LysSer: 2.512 ± 0.051	3.164LysThr: 3.164 ± 0.051	3.342LysVal: 3.342 ± 0.06	0.597LysTrp: 0.597 ± 0.024	2.073LysTyr: 2.073 ± 0.039	0.0LysXaa: 0.0 ± 0.0
Leu	8.284LeuAla: 8.284 ± 0.088	1.608LeuCys: 1.608 ± 0.038	5.149LeuAsp: 5.149 ± 0.07	7.31LeuGlu: 7.31 ± 0.094	3.94LeuPhe: 3.94 ± 0.063	6.71LeuGly: 6.71 ± 0.097	1.412LeuHis: 1.412 ± 0.037	5.226LeuIle: 5.226 ± 0.083	5.44LeuLys: 5.44 ± 0.071	8.992LeuLeu: 8.992 ± 0.125	2.769LeuMet: 2.769 ± 0.058	3.287LeuAsn: 3.287 ± 0.059	4.08LeuPro: 4.08 ± 0.055	2.61LeuGln: 2.61 ± 0.047	4.702LeuArg: 4.702 ± 0.066	6.295LeuSer: 6.295 ± 0.078	5.301LeuThr: 5.301 ± 0.066	5.851LeuVal: 5.851 ± 0.077	0.922LeuTrp: 0.922 ± 0.03	3.352LeuTyr: 3.352 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	3.014MetAla: 3.014 ± 0.058	0.352MetCys: 0.352 ± 0.018	1.928MetAsp: 1.928 ± 0.037	3.018MetGlu: 3.018 ± 0.052	1.002MetPhe: 1.002 ± 0.032	2.399MetGly: 2.399 ± 0.046	0.298MetHis: 0.298 ± 0.017	1.901MetIle: 1.901 ± 0.043	2.159MetLys: 2.159 ± 0.047	2.447MetLeu: 2.447 ± 0.048	0.972MetMet: 0.972 ± 0.033	1.294MetAsn: 1.294 ± 0.032	1.15MetPro: 1.15 ± 0.035	0.784MetGln: 0.784 ± 0.025	1.485MetArg: 1.485 ± 0.034	1.639MetSer: 1.639 ± 0.037	1.823MetThr: 1.823 ± 0.037	2.152MetVal: 2.152 ± 0.048	0.193MetTrp: 0.193 ± 0.012	0.771MetTyr: 0.771 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	2.688AsnAla: 2.688 ± 0.051	0.487AsnCys: 0.487 ± 0.022	1.662AsnAsp: 1.662 ± 0.042	2.148AsnGlu: 2.148 ± 0.044	1.278AsnPhe: 1.278 ± 0.03	3.549AsnGly: 3.549 ± 0.068	0.756AsnHis: 0.756 ± 0.024	2.37AsnIle: 2.37 ± 0.047	1.541AsnLys: 1.541 ± 0.039	3.301AsnLeu: 3.301 ± 0.058	1.098AsnMet: 1.098 ± 0.032	1.197AsnAsn: 1.197 ± 0.036	1.924AsnPro: 1.924 ± 0.042	1.235AsnGln: 1.235 ± 0.035	2.266AsnArg: 2.266 ± 0.052	1.863AsnSer: 1.863 ± 0.039	1.849AsnThr: 1.849 ± 0.038	2.499AsnVal: 2.499 ± 0.053	0.393AsnTrp: 0.393 ± 0.019	1.362AsnTyr: 1.362 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	3.554ProAla: 3.554 ± 0.064	0.485ProCys: 0.485 ± 0.022	2.494ProAsp: 2.494 ± 0.054	4.242ProGlu: 4.242 ± 0.063	1.752ProPhe: 1.752 ± 0.041	3.156ProGly: 3.156 ± 0.059	0.647ProHis: 0.647 ± 0.023	2.022ProIle: 2.022 ± 0.043	1.742ProLys: 1.742 ± 0.04	3.236ProLeu: 3.236 ± 0.054	1.027ProMet: 1.027 ± 0.026	1.121ProAsn: 1.121 ± 0.033	1.175ProPro: 1.175 ± 0.039	1.213ProGln: 1.213 ± 0.034	1.331ProArg: 1.331 ± 0.031	2.142ProSer: 2.142 ± 0.047	1.672ProThr: 1.672 ± 0.036	3.426ProVal: 3.426 ± 0.055	0.449ProTrp: 0.449 ± 0.022	1.587ProTyr: 1.587 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.112GlnAla: 3.112 ± 0.054	0.35GlnCys: 0.35 ± 0.018	1.523GlnAsp: 1.523 ± 0.037	2.812GlnGlu: 2.812 ± 0.061	1.179GlnPhe: 1.179 ± 0.029	2.196GlnGly: 2.196 ± 0.043	0.416GlnHis: 0.416 ± 0.02	2.224GlnIle: 2.224 ± 0.046	2.091GlnLys: 2.091 ± 0.044	2.808GlnLeu: 2.808 ± 0.05	1.149GlnMet: 1.149 ± 0.027	1.335GlnAsn: 1.335 ± 0.037	1.166GlnPro: 1.166 ± 0.035	1.137GlnGln: 1.137 ± 0.036	1.554GlnArg: 1.554 ± 0.04	1.601GlnSer: 1.601 ± 0.037	1.779GlnThr: 1.779 ± 0.049	2.61GlnVal: 2.61 ± 0.046	0.361GlnTrp: 0.361 ± 0.018	1.328GlnTyr: 1.328 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	3.891ArgAla: 3.891 ± 0.062	0.701ArgCys: 0.701 ± 0.022	2.83ArgAsp: 2.83 ± 0.059	5.281ArgGlu: 5.281 ± 0.084	2.192ArgPhe: 2.192 ± 0.044	3.418ArgGly: 3.418 ± 0.052	0.931ArgHis: 0.931 ± 0.03	3.531ArgIle: 3.531 ± 0.054	3.444ArgLys: 3.444 ± 0.054	5.635ArgLeu: 5.635 ± 0.092	1.919ArgMet: 1.919 ± 0.041	2.046ArgAsn: 2.046 ± 0.038	1.951ArgPro: 1.951 ± 0.045	2.213ArgGln: 2.213 ± 0.042	3.721ArgArg: 3.721 ± 0.07	2.474ArgSer: 2.474 ± 0.048	2.641ArgThr: 2.641 ± 0.048	3.266ArgVal: 3.266 ± 0.057	0.539ArgTrp: 0.539 ± 0.025	2.207ArgTyr: 2.207 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	4.5SerAla: 4.5 ± 0.067	0.848SerCys: 0.848 ± 0.028	2.729SerAsp: 2.729 ± 0.055	3.303SerGlu: 3.303 ± 0.056	2.394SerPhe: 2.394 ± 0.043	5.506SerGly: 5.506 ± 0.086	1.072SerHis: 1.072 ± 0.028	3.472SerIle: 3.472 ± 0.059	2.284SerLys: 2.284 ± 0.049	5.49SerLeu: 5.49 ± 0.073	1.765SerMet: 1.765 ± 0.04	1.687SerAsn: 1.687 ± 0.039	2.138SerPro: 2.138 ± 0.051	2.116SerGln: 2.116 ± 0.048	3.392SerArg: 3.392 ± 0.051	3.363SerSer: 3.363 ± 0.073	2.524SerThr: 2.524 ± 0.055	4.209SerVal: 4.209 ± 0.059	0.669SerTrp: 0.669 ± 0.024	2.241SerTyr: 2.241 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	5.501ThrAla: 5.501 ± 0.083	0.618ThrCys: 0.618 ± 0.023	2.996ThrAsp: 2.996 ± 0.058	3.931ThrGlu: 3.931 ± 0.063	2.055ThrPhe: 2.055 ± 0.034	5.301ThrGly: 5.301 ± 0.079	0.824ThrHis: 0.824 ± 0.025	3.332ThrIle: 3.332 ± 0.058	2.363ThrLys: 2.363 ± 0.051	4.619ThrLeu: 4.619 ± 0.061	1.515ThrMet: 1.515 ± 0.035	1.565ThrAsn: 1.565 ± 0.038	2.498ThrPro: 2.498 ± 0.053	1.338ThrGln: 1.338 ± 0.035	2.208ThrArg: 2.208 ± 0.044	2.717ThrSer: 2.717 ± 0.044	2.619ThrThr: 2.619 ± 0.051	4.972ThrVal: 4.972 ± 0.076	0.509ThrTrp: 0.509 ± 0.023	1.887ThrTyr: 1.887 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	5.393ValAla: 5.393 ± 0.076	1.215ValCys: 1.215 ± 0.032	3.697ValAsp: 3.697 ± 0.064	4.889ValGlu: 4.889 ± 0.066	3.1ValPhe: 3.1 ± 0.054	4.761ValGly: 4.761 ± 0.079	1.074ValHis: 1.074 ± 0.029	4.723ValIle: 4.723 ± 0.069	3.947ValLys: 3.947 ± 0.055	7.153ValLeu: 7.153 ± 0.096	2.215ValMet: 2.215 ± 0.043	2.553ValAsn: 2.553 ± 0.047	2.883ValPro: 2.883 ± 0.047	1.969ValGln: 1.969 ± 0.042	3.682ValArg: 3.682 ± 0.061	4.815ValSer: 4.815 ± 0.067	4.364ValThr: 4.364 ± 0.061	4.928ValVal: 4.928 ± 0.074	0.743ValTrp: 0.743 ± 0.027	2.678ValTyr: 2.678 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.714TrpAla: 0.714 ± 0.028	0.154TrpCys: 0.154 ± 0.011	0.675TrpAsp: 0.675 ± 0.026	0.856TrpGlu: 0.856 ± 0.028	0.425TrpPhe: 0.425 ± 0.02	0.77TrpGly: 0.77 ± 0.028	0.182TrpHis: 0.182 ± 0.013	0.63TrpIle: 0.63 ± 0.026	0.771TrpLys: 0.771 ± 0.025	1.047TrpLeu: 1.047 ± 0.031	0.375TrpMet: 0.375 ± 0.018	0.522TrpAsn: 0.522 ± 0.023	0.267TrpPro: 0.267 ± 0.016	0.426TrpGln: 0.426 ± 0.019	0.562TrpArg: 0.562 ± 0.023	0.514TrpSer: 0.514 ± 0.021	0.496TrpThr: 0.496 ± 0.021	0.612TrpVal: 0.612 ± 0.024	0.13TrpTrp: 0.13 ± 0.011	0.432TrpTyr: 0.432 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.643TyrAla: 2.643 ± 0.047	0.625TyrCys: 0.625 ± 0.022	2.236TyrAsp: 2.236 ± 0.051	2.937TyrGlu: 2.937 ± 0.061	1.734TyrPhe: 1.734 ± 0.04	3.245TyrGly: 3.245 ± 0.05	0.767TyrHis: 0.767 ± 0.025	2.145TyrIle: 2.145 ± 0.046	1.652TyrLys: 1.652 ± 0.035	3.704TyrLeu: 3.704 ± 0.067	0.969TyrMet: 0.969 ± 0.026	1.304TyrAsn: 1.304 ± 0.037	1.466TyrPro: 1.466 ± 0.038	1.426TyrGln: 1.426 ± 0.038	2.51TyrArg: 2.51 ± 0.056	2.098TyrSer: 2.098 ± 0.045	2.03TyrThr: 2.03 ± 0.048	2.537TyrVal: 2.537 ± 0.053	0.385TyrTrp: 0.385 ± 0.02	1.695TyrTyr: 1.695 ± 0.054	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3897 proteins (1232716 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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