Amino acid dipepetide frequency for Changjiang tombus-like virus 8

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.124AlaAla: 7.124 ± 0.828
0.89AlaCys: 0.89 ± 0.597
1.781AlaAsp: 1.781 ± 1.507
2.671AlaGlu: 2.671 ± 0.475
4.452AlaPhe: 4.452 ± 1.272
1.781AlaGly: 1.781 ± 1.507
0.89AlaHis: 0.89 ± 0.597
0.89AlaIle: 0.89 ± 0.597
3.562AlaLys: 3.562 ± 2.389
7.124AlaLeu: 7.124 ± 0.496
0.89AlaMet: 0.89 ± 0.646
2.671AlaAsn: 2.671 ± 0.475
7.124AlaPro: 7.124 ± 2.065
4.452AlaGln: 4.452 ± 1.517
5.343AlaArg: 5.343 ± 1.261
5.343AlaSer: 5.343 ± 2.315
5.343AlaThr: 5.343 ± 3.151
7.124AlaVal: 7.124 ± 1.659
0.89AlaTrp: 0.89 ± 0.869
7.124AlaTyr: 7.124 ± 3.68
0.0AlaXaa: 0.0 ± 0.0
Cys
1.781CysAla: 1.781 ± 1.195
1.781CysCys: 1.781 ± 1.737
0.89CysAsp: 0.89 ± 0.597
0.89CysGlu: 0.89 ± 0.597
0.0CysPhe: 0.0 ± 0.0
2.671CysGly: 2.671 ± 0.841
0.0CysHis: 0.0 ± 0.0
0.89CysIle: 0.89 ± 0.597
0.89CysLys: 0.89 ± 0.754
0.89CysLeu: 0.89 ± 0.597
0.0CysMet: 0.0 ± 0.0
1.781CysAsn: 1.781 ± 0.53
0.0CysPro: 0.0 ± 0.0
0.89CysGln: 0.89 ± 0.597
1.781CysArg: 1.781 ± 0.53
0.89CysSer: 0.89 ± 0.597
0.89CysThr: 0.89 ± 0.597
3.562CysVal: 3.562 ± 0.248
0.0CysTrp: 0.0 ± 0.0
0.89CysTyr: 0.89 ± 0.869
0.0CysXaa: 0.0 ± 0.0
Asp
6.233AspAla: 6.233 ± 1.633
1.781AspCys: 1.781 ± 1.195
1.781AspAsp: 1.781 ± 0.722
0.89AspGlu: 0.89 ± 0.869
0.89AspPhe: 0.89 ± 0.754
2.671AspGly: 2.671 ± 0.841
0.0AspHis: 0.0 ± 0.0
0.89AspIle: 0.89 ± 0.754
1.781AspLys: 1.781 ± 1.195
7.124AspLeu: 7.124 ± 1.716
1.781AspMet: 1.781 ± 0.53
1.781AspAsn: 1.781 ± 0.53
4.452AspPro: 4.452 ± 0.782
0.89AspGln: 0.89 ± 0.869
0.89AspArg: 0.89 ± 0.869
1.781AspSer: 1.781 ± 1.507
3.562AspThr: 3.562 ± 1.032
1.781AspVal: 1.781 ± 0.53
0.0AspTrp: 0.0 ± 0.0
2.671AspTyr: 2.671 ± 0.475
0.0AspXaa: 0.0 ± 0.0
Glu
3.562GluAla: 3.562 ± 1.444
0.0GluCys: 0.0 ± 0.0
2.671GluAsp: 2.671 ± 1.001
3.562GluGlu: 3.562 ± 1.359
3.562GluPhe: 3.562 ± 1.296
2.671GluGly: 2.671 ± 1.001
1.781GluHis: 1.781 ± 1.195
0.89GluIle: 0.89 ± 0.597
2.671GluLys: 2.671 ± 1.792
7.124GluLeu: 7.124 ± 1.454
0.0GluMet: 0.0 ± 0.0
0.0GluAsn: 0.0 ± 0.0
2.671GluPro: 2.671 ± 1.001
1.781GluGln: 1.781 ± 0.53
1.781GluArg: 1.781 ± 0.722
3.562GluSer: 3.562 ± 1.444
2.671GluThr: 2.671 ± 1.609
2.671GluVal: 2.671 ± 1.774
0.89GluTrp: 0.89 ± 0.597
2.671GluTyr: 2.671 ± 2.261
0.0GluXaa: 0.0 ± 0.0
Phe
1.781PheAla: 1.781 ± 1.05
1.781PheCys: 1.781 ± 1.195
3.562PheAsp: 3.562 ± 1.059
2.671PheGlu: 2.671 ± 0.841
0.0PhePhe: 0.0 ± 0.0
1.781PheGly: 1.781 ± 1.195
0.0PheHis: 0.0 ± 0.0
0.0PheIle: 0.0 ± 0.0
1.781PheLys: 1.781 ± 0.53
5.343PheLeu: 5.343 ± 0.403
1.781PheMet: 1.781 ± 1.043
0.0PheAsn: 0.0 ± 0.0
2.671PhePro: 2.671 ± 1.158
1.781PheGln: 1.781 ± 0.722
2.671PheArg: 2.671 ± 1.609
2.671PheSer: 2.671 ± 1.158
3.562PheThr: 3.562 ± 2.319
2.671PheVal: 2.671 ± 1.001
1.781PheTrp: 1.781 ± 1.737
0.89PheTyr: 0.89 ± 0.597
0.0PheXaa: 0.0 ± 0.0
Gly
5.343GlyAla: 5.343 ± 1.589
0.0GlyCys: 0.0 ± 0.0
5.343GlyAsp: 5.343 ± 1.369
2.671GlyGlu: 2.671 ± 1.609
1.781GlyPhe: 1.781 ± 0.53
3.562GlyGly: 3.562 ± 1.88
0.89GlyHis: 0.89 ± 0.869
1.781GlyIle: 1.781 ± 1.195
1.781GlyLys: 1.781 ± 1.195
6.233GlyLeu: 6.233 ± 3.09
1.781GlyMet: 1.781 ± 0.53
5.343GlyAsn: 5.343 ± 1.261
2.671GlyPro: 2.671 ± 0.475
1.781GlyGln: 1.781 ± 0.722
1.781GlyArg: 1.781 ± 1.195
2.671GlySer: 2.671 ± 1.158
7.124GlyThr: 7.124 ± 3.761
5.343GlyVal: 5.343 ± 1.681
0.0GlyTrp: 0.0 ± 0.0
0.89GlyTyr: 0.89 ± 0.597
0.0GlyXaa: 0.0 ± 0.0
His
1.781HisAla: 1.781 ± 0.722
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
0.89HisGlu: 0.89 ± 0.597
0.0HisPhe: 0.0 ± 0.0
0.89HisGly: 0.89 ± 0.597
1.781HisHis: 1.781 ± 0.722
0.89HisIle: 0.89 ± 0.597
0.0HisLys: 0.0 ± 0.0
3.562HisLeu: 3.562 ± 1.444
0.89HisMet: 0.89 ± 0.597
1.781HisAsn: 1.781 ± 0.722
0.0HisPro: 0.0 ± 0.0
0.0HisGln: 0.0 ± 0.0
0.89HisArg: 0.89 ± 0.754
1.781HisSer: 1.781 ± 1.195
3.562HisThr: 3.562 ± 1.482
2.671HisVal: 2.671 ± 1.001
0.0HisTrp: 0.0 ± 0.0
0.89HisTyr: 0.89 ± 0.869
0.0HisXaa: 0.0 ± 0.0
Ile
1.781IleAla: 1.781 ± 1.507
0.0IleCys: 0.0 ± 0.0
1.781IleAsp: 1.781 ± 0.53
2.671IleGlu: 2.671 ± 1.792
0.89IlePhe: 0.89 ± 0.597
0.0IleGly: 0.0 ± 0.0
0.0IleHis: 0.0 ± 0.0
2.671IleIle: 2.671 ± 1.482
2.671IleLys: 2.671 ± 0.841
0.89IleLeu: 0.89 ± 0.597
2.671IleMet: 2.671 ± 0.841
4.452IleAsn: 4.452 ± 0.507
1.781IlePro: 1.781 ± 0.722
0.89IleGln: 0.89 ± 0.754
0.89IleArg: 0.89 ± 0.597
1.781IleSer: 1.781 ± 0.722
3.562IleThr: 3.562 ± 1.444
2.671IleVal: 2.671 ± 1.774
0.0IleTrp: 0.0 ± 0.0
1.781IleTyr: 1.781 ± 0.53
0.0IleXaa: 0.0 ± 0.0
Lys
2.671LysAla: 2.671 ± 0.841
0.0LysCys: 0.0 ± 0.0
2.671LysAsp: 2.671 ± 1.792
0.89LysGlu: 0.89 ± 0.597
6.233LysPhe: 6.233 ± 2.457
3.562LysGly: 3.562 ± 1.359
0.89LysHis: 0.89 ± 0.597
0.0LysIle: 0.0 ± 0.0
2.671LysLys: 2.671 ± 1.158
2.671LysLeu: 2.671 ± 1.158
0.0LysMet: 0.0 ± 0.0
2.671LysAsn: 2.671 ± 0.841
1.781LysPro: 1.781 ± 1.05
2.671LysGln: 2.671 ± 0.841
1.781LysArg: 1.781 ± 1.195
0.89LysSer: 0.89 ± 0.869
0.89LysThr: 0.89 ± 0.754
0.89LysVal: 0.89 ± 0.597
1.781LysTrp: 1.781 ± 0.53
3.562LysTyr: 3.562 ± 1.482
0.0LysXaa: 0.0 ± 0.0
Leu
6.233LeuAla: 6.233 ± 0.466
2.671LeuCys: 2.671 ± 0.841
5.343LeuAsp: 5.343 ± 1.816
1.781LeuGlu: 1.781 ± 1.195
0.89LeuPhe: 0.89 ± 0.597
5.343LeuGly: 5.343 ± 2.002
4.452LeuHis: 4.452 ± 2.026
0.89LeuIle: 0.89 ± 0.869
0.0LeuLys: 0.0 ± 0.0
3.562LeuLeu: 3.562 ± 1.444
1.781LeuMet: 1.781 ± 1.05
3.562LeuAsn: 3.562 ± 0.248
3.562LeuPro: 3.562 ± 2.319
5.343LeuGln: 5.343 ± 2.593
11.576LeuArg: 11.576 ± 1.288
6.233LeuSer: 6.233 ± 0.884
5.343LeuThr: 5.343 ± 0.941
5.343LeuVal: 5.343 ± 0.403
0.89LeuTrp: 0.89 ± 0.754
2.671LeuTyr: 2.671 ± 0.475
0.0LeuXaa: 0.0 ± 0.0
Met
1.781MetAla: 1.781 ± 1.507
2.671MetCys: 2.671 ± 1.001
0.0MetAsp: 0.0 ± 0.0
2.671MetGlu: 2.671 ± 1.792
0.89MetPhe: 0.89 ± 0.597
0.89MetGly: 0.89 ± 0.754
0.89MetHis: 0.89 ± 0.597
0.0MetIle: 0.0 ± 0.0
1.781MetLys: 1.781 ± 1.195
1.781MetLeu: 1.781 ± 0.722
0.89MetMet: 0.89 ± 0.754
1.781MetAsn: 1.781 ± 1.05
0.89MetPro: 0.89 ± 0.754
1.781MetGln: 1.781 ± 1.195
0.89MetArg: 0.89 ± 0.869
1.781MetSer: 1.781 ± 1.05
2.671MetThr: 2.671 ± 1.158
4.452MetVal: 4.452 ± 0.782
0.89MetTrp: 0.89 ± 0.597
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
6.233AsnAla: 6.233 ± 0.466
0.89AsnCys: 0.89 ± 0.597
2.671AsnAsp: 2.671 ± 1.609
0.0AsnGlu: 0.0 ± 0.0
0.89AsnPhe: 0.89 ± 0.754
3.562AsnGly: 3.562 ± 1.359
0.89AsnHis: 0.89 ± 0.869
0.89AsnIle: 0.89 ± 0.597
2.671AsnLys: 2.671 ± 0.841
5.343AsnLeu: 5.343 ± 1.261
0.89AsnMet: 0.89 ± 0.597
7.124AsnAsn: 7.124 ± 2.119
3.562AsnPro: 3.562 ± 0.248
0.89AsnGln: 0.89 ± 0.754
0.0AsnArg: 0.0 ± 0.0
2.671AsnSer: 2.671 ± 0.475
4.452AsnThr: 4.452 ± 1.635
6.233AsnVal: 6.233 ± 2.137
0.0AsnTrp: 0.0 ± 0.0
0.89AsnTyr: 0.89 ± 0.754
0.0AsnXaa: 0.0 ± 0.0
Pro
4.452ProAla: 4.452 ± 2.163
1.781ProCys: 1.781 ± 0.53
1.781ProAsp: 1.781 ± 1.05
3.562ProGlu: 3.562 ± 1.296
0.89ProPhe: 0.89 ± 0.754
1.781ProGly: 1.781 ± 1.05
0.0ProHis: 0.0 ± 0.0
0.89ProIle: 0.89 ± 0.597
2.671ProLys: 2.671 ± 1.609
2.671ProLeu: 2.671 ± 1.482
0.89ProMet: 0.89 ± 0.597
1.781ProAsn: 1.781 ± 0.53
2.671ProPro: 2.671 ± 1.482
1.781ProGln: 1.781 ± 0.722
5.343ProArg: 5.343 ± 2.593
2.671ProSer: 2.671 ± 1.774
7.124ProThr: 7.124 ± 1.987
10.686ProVal: 10.686 ± 0.807
0.89ProTrp: 0.89 ± 0.754
0.89ProTyr: 0.89 ± 0.869
0.0ProXaa: 0.0 ± 0.0
Gln
2.671GlnAla: 2.671 ± 0.841
0.0GlnCys: 0.0 ± 0.0
1.781GlnAsp: 1.781 ± 0.722
0.89GlnGlu: 0.89 ± 0.597
0.89GlnPhe: 0.89 ± 0.597
0.0GlnGly: 0.0 ± 0.0
0.89GlnHis: 0.89 ± 0.869
0.89GlnIle: 0.89 ± 0.597
1.781GlnLys: 1.781 ± 0.53
4.452GlnLeu: 4.452 ± 2.163
1.781GlnMet: 1.781 ± 1.195
0.0GlnAsn: 0.0 ± 0.0
4.452GlnPro: 4.452 ± 3.43
1.781GlnGln: 1.781 ± 1.507
4.452GlnArg: 4.452 ± 2.026
2.671GlnSer: 2.671 ± 0.841
3.562GlnThr: 3.562 ± 1.88
0.89GlnVal: 0.89 ± 0.597
0.0GlnTrp: 0.0 ± 0.0
1.781GlnTyr: 1.781 ± 0.53
0.0GlnXaa: 0.0 ± 0.0
Arg
6.233ArgAla: 6.233 ± 0.884
1.781ArgCys: 1.781 ± 1.195
1.781ArgAsp: 1.781 ± 1.195
4.452ArgGlu: 4.452 ± 3.173
3.562ArgPhe: 3.562 ± 0.248
3.562ArgGly: 3.562 ± 0.248
0.89ArgHis: 0.89 ± 0.597
0.89ArgIle: 0.89 ± 0.754
3.562ArgLys: 3.562 ± 0.248
4.452ArgLeu: 4.452 ± 2.155
4.452ArgMet: 4.452 ± 0.962
4.452ArgAsn: 4.452 ± 0.507
0.89ArgPro: 0.89 ± 0.597
0.89ArgGln: 0.89 ± 0.869
7.124ArgArg: 7.124 ± 1.987
6.233ArgSer: 6.233 ± 1.419
1.781ArgThr: 1.781 ± 1.195
6.233ArgVal: 6.233 ± 1.963
2.671ArgTrp: 2.671 ± 1.482
5.343ArgTyr: 5.343 ± 1.589
0.0ArgXaa: 0.0 ± 0.0
Ser
1.781SerAla: 1.781 ± 1.507
0.89SerCys: 0.89 ± 0.869
0.89SerAsp: 0.89 ± 0.597
1.781SerGlu: 1.781 ± 0.722
7.124SerPhe: 7.124 ± 2.065
7.124SerGly: 7.124 ± 2.783
2.671SerHis: 2.671 ± 1.792
7.124SerIle: 7.124 ± 1.334
3.562SerLys: 3.562 ± 1.482
3.562SerLeu: 3.562 ± 1.482
0.89SerMet: 0.89 ± 0.597
0.89SerAsn: 0.89 ± 0.754
1.781SerPro: 1.781 ± 0.722
2.671SerGln: 2.671 ± 1.774
3.562SerArg: 3.562 ± 1.444
7.124SerSer: 7.124 ± 2.768
6.233SerThr: 6.233 ± 2.636
7.124SerVal: 7.124 ± 2.065
0.0SerTrp: 0.0 ± 0.0
0.0SerTyr: 0.0 ± 0.0
0.0SerXaa: 0.0 ± 0.0
Thr
8.014ThrAla: 8.014 ± 5.27
1.781ThrCys: 1.781 ± 1.507
0.89ThrAsp: 0.89 ± 0.754
0.89ThrGlu: 0.89 ± 0.754
2.671ThrPhe: 2.671 ± 1.482
7.124ThrGly: 7.124 ± 3.761
3.562ThrHis: 3.562 ± 1.296
6.233ThrIle: 6.233 ± 1.419
1.781ThrLys: 1.781 ± 0.53
4.452ThrLeu: 4.452 ± 2.155
1.781ThrMet: 1.781 ± 1.05
6.233ThrAsn: 6.233 ± 3.03
7.124ThrPro: 7.124 ± 1.334
0.89ThrGln: 0.89 ± 0.597
8.014ThrArg: 8.014 ± 2.203
7.124ThrSer: 7.124 ± 1.659
5.343ThrThr: 5.343 ± 3.217
6.233ThrVal: 6.233 ± 0.922
0.89ThrTrp: 0.89 ± 0.754
0.89ThrTyr: 0.89 ± 0.754
0.0ThrXaa: 0.0 ± 0.0
Val
3.562ValAla: 3.562 ± 1.059
1.781ValCys: 1.781 ± 0.53
4.452ValAsp: 4.452 ± 1.517
7.124ValGlu: 7.124 ± 1.334
0.0ValPhe: 0.0 ± 0.0
8.014ValGly: 8.014 ± 2.04
1.781ValHis: 1.781 ± 0.722
5.343ValIle: 5.343 ± 0.403
2.671ValLys: 2.671 ± 1.001
3.562ValLeu: 3.562 ± 1.359
3.562ValMet: 3.562 ± 0.39
2.671ValAsn: 2.671 ± 0.841
6.233ValPro: 6.233 ± 0.922
1.781ValGln: 1.781 ± 1.195
7.124ValArg: 7.124 ± 0.496
3.562ValSer: 3.562 ± 2.282
7.124ValThr: 7.124 ± 4.207
12.467ValVal: 12.467 ± 3.756
0.89ValTrp: 0.89 ± 0.754
7.124ValTyr: 7.124 ± 3.756
0.0ValXaa: 0.0 ± 0.0
Trp
0.89TrpAla: 0.89 ± 0.597
0.0TrpCys: 0.0 ± 0.0
0.89TrpAsp: 0.89 ± 0.869
0.0TrpGlu: 0.0 ± 0.0
0.89TrpPhe: 0.89 ± 0.597
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.89TrpLys: 0.89 ± 0.869
2.671TrpLeu: 2.671 ± 1.609
0.89TrpMet: 0.89 ± 0.754
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
1.781TrpGln: 1.781 ± 0.53
0.0TrpArg: 0.0 ± 0.0
1.781TrpSer: 1.781 ± 1.737
1.781TrpThr: 1.781 ± 1.05
0.89TrpVal: 0.89 ± 0.754
0.0TrpTrp: 0.0 ± 0.0
0.89TrpTyr: 0.89 ± 0.597
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.562TyrAla: 3.562 ± 2.389
0.89TyrCys: 0.89 ± 0.597
2.671TyrAsp: 2.671 ± 0.841
6.233TyrGlu: 6.233 ± 0.884
2.671TyrPhe: 2.671 ± 0.475
1.781TyrGly: 1.781 ± 0.53
0.0TyrHis: 0.0 ± 0.0
1.781TyrIle: 1.781 ± 0.53
0.0TyrLys: 0.0 ± 0.0
0.0TyrLeu: 0.0 ± 0.0
0.89TyrMet: 0.89 ± 0.597
1.781TyrAsn: 1.781 ± 1.195
0.89TyrPro: 0.89 ± 0.597
0.89TyrGln: 0.89 ± 0.597
5.343TyrArg: 5.343 ± 0.941
3.562TyrSer: 3.562 ± 1.482
5.343TyrThr: 5.343 ± 1.261
1.781TyrVal: 1.781 ± 1.507
1.781TyrTrp: 1.781 ± 1.05
1.781TyrTyr: 1.781 ± 1.195
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (1124 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski