Amino acid dipepetide frequency for Rosa rugosa leaf distortion virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.317AlaAla: 6.317 ± 2.058
3.159AlaCys: 3.159 ± 1.519
3.159AlaAsp: 3.159 ± 1.243
2.527AlaGlu: 2.527 ± 1.46
5.054AlaPhe: 5.054 ± 1.272
4.422AlaGly: 4.422 ± 1.47
2.527AlaHis: 2.527 ± 1.46
1.895AlaIle: 1.895 ± 0.959
7.581AlaLys: 7.581 ± 1.383
2.527AlaLeu: 2.527 ± 1.125
1.263AlaMet: 1.263 ± 0.59
2.527AlaAsn: 2.527 ± 1.038
3.79AlaPro: 3.79 ± 1.221
1.263AlaGln: 1.263 ± 1.324
2.527AlaArg: 2.527 ± 1.582
7.581AlaSer: 7.581 ± 6.752
3.79AlaThr: 3.79 ± 1.622
2.527AlaVal: 2.527 ± 1.1
1.263AlaTrp: 1.263 ± 0.722
4.422AlaTyr: 4.422 ± 1.162
0.0AlaXaa: 0.0 ± 0.0
Cys
1.263CysAla: 1.263 ± 1.324
0.632CysCys: 0.632 ± 0.417
1.263CysAsp: 1.263 ± 0.722
0.632CysGlu: 0.632 ± 0.417
0.632CysPhe: 0.632 ± 0.417
1.263CysGly: 1.263 ± 0.834
0.0CysHis: 0.0 ± 0.0
3.159CysIle: 3.159 ± 1.153
1.263CysLys: 1.263 ± 0.722
6.317CysLeu: 6.317 ± 1.657
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.632CysPro: 0.632 ± 0.417
0.632CysGln: 0.632 ± 0.417
2.527CysArg: 2.527 ± 1.125
1.263CysSer: 1.263 ± 0.59
1.895CysThr: 1.895 ± 0.686
0.632CysVal: 0.632 ± 0.417
1.263CysTrp: 1.263 ± 0.722
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
3.159AspAla: 3.159 ± 0.829
1.895AspCys: 1.895 ± 0.848
1.263AspAsp: 1.263 ± 0.59
2.527AspGlu: 2.527 ± 0.636
0.0AspPhe: 0.0 ± 0.0
3.159AspGly: 3.159 ± 0.983
0.632AspHis: 0.632 ± 0.662
2.527AspIle: 2.527 ± 1.312
3.159AspLys: 3.159 ± 0.73
6.949AspLeu: 6.949 ± 2.287
0.632AspMet: 0.632 ± 0.417
1.263AspAsn: 1.263 ± 1.659
2.527AspPro: 2.527 ± 0.636
1.895AspGln: 1.895 ± 1.25
3.159AspArg: 3.159 ± 1.45
4.422AspSer: 4.422 ± 1.47
1.263AspThr: 1.263 ± 0.59
3.159AspVal: 3.159 ± 1.45
0.0AspTrp: 0.0 ± 0.0
2.527AspTyr: 2.527 ± 1.125
0.0AspXaa: 0.0 ± 0.0
Glu
3.79GluAla: 3.79 ± 1.551
2.527GluCys: 2.527 ± 1.125
1.895GluAsp: 1.895 ± 0.848
5.685GluGlu: 5.685 ± 2.057
1.895GluPhe: 1.895 ± 1.25
3.159GluGly: 3.159 ± 1.471
3.159GluHis: 3.159 ± 2.084
4.422GluIle: 4.422 ± 1.346
1.895GluLys: 1.895 ± 1.25
6.317GluLeu: 6.317 ± 2.787
0.0GluMet: 0.0 ± 0.0
1.895GluAsn: 1.895 ± 1.25
2.527GluPro: 2.527 ± 2.649
0.0GluGln: 0.0 ± 0.0
4.422GluArg: 4.422 ± 1.949
4.422GluSer: 4.422 ± 1.346
2.527GluThr: 2.527 ± 2.395
4.422GluVal: 4.422 ± 1.277
1.263GluTrp: 1.263 ± 0.834
1.895GluTyr: 1.895 ± 0.778
0.0GluXaa: 0.0 ± 0.0
Phe
1.895PheAla: 1.895 ± 0.848
2.527PheCys: 2.527 ± 0.636
1.895PheAsp: 1.895 ± 1.25
6.317PheGlu: 6.317 ± 2.328
2.527PhePhe: 2.527 ± 1.038
3.79PheGly: 3.79 ± 1.697
1.263PheHis: 1.263 ± 0.59
1.263PheIle: 1.263 ± 1.141
0.0PheLys: 0.0 ± 0.0
5.054PheLeu: 5.054 ± 1.466
0.632PheMet: 0.632 ± 0.963
1.263PheAsn: 1.263 ± 0.59
0.632PhePro: 0.632 ± 0.662
1.895PheGln: 1.895 ± 1.987
3.79PheArg: 3.79 ± 1.147
3.159PheSer: 3.159 ± 1.153
3.159PheThr: 3.159 ± 1.126
7.581PheVal: 7.581 ± 2.448
0.0PheTrp: 0.0 ± 0.0
1.263PheTyr: 1.263 ± 0.834
0.0PheXaa: 0.0 ± 0.0
Gly
2.527GlyAla: 2.527 ± 1.449
0.632GlyCys: 0.632 ± 0.417
4.422GlyAsp: 4.422 ± 1.514
3.79GlyGlu: 3.79 ± 0.992
3.159GlyPhe: 3.159 ± 0.829
5.685GlyGly: 5.685 ± 1.417
0.632GlyHis: 0.632 ± 0.417
3.159GlyIle: 3.159 ± 0.829
3.79GlyLys: 3.79 ± 1.283
2.527GlyLeu: 2.527 ± 1.667
1.263GlyMet: 1.263 ± 1.063
4.422GlyAsn: 4.422 ± 2.211
3.159GlyPro: 3.159 ± 0.983
0.632GlyGln: 0.632 ± 1.405
4.422GlyArg: 4.422 ± 2.233
2.527GlySer: 2.527 ± 2.196
0.632GlyThr: 0.632 ± 0.662
7.581GlyVal: 7.581 ± 1.406
2.527GlyTrp: 2.527 ± 1.116
1.895GlyTyr: 1.895 ± 1.183
0.0GlyXaa: 0.0 ± 0.0
His
0.632HisAla: 0.632 ± 0.662
1.263HisCys: 1.263 ± 0.59
0.0HisAsp: 0.0 ± 0.0
2.527HisGlu: 2.527 ± 0.636
2.527HisPhe: 2.527 ± 1.125
0.632HisGly: 0.632 ± 0.662
0.632HisHis: 0.632 ± 0.417
2.527HisIle: 2.527 ± 1.39
0.0HisLys: 0.0 ± 0.0
1.895HisLeu: 1.895 ± 1.214
0.0HisMet: 0.0 ± 0.0
0.632HisAsn: 0.632 ± 0.417
0.632HisPro: 0.632 ± 0.417
0.632HisGln: 0.632 ± 0.417
1.895HisArg: 1.895 ± 1.25
3.79HisSer: 3.79 ± 1.702
0.0HisThr: 0.0 ± 0.0
0.632HisVal: 0.632 ± 0.417
0.632HisTrp: 0.632 ± 0.417
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
1.895IleAla: 1.895 ± 1.25
0.632IleCys: 0.632 ± 0.662
1.895IleAsp: 1.895 ± 0.686
0.0IleGlu: 0.0 ± 0.0
1.263IlePhe: 1.263 ± 1.141
1.263IleGly: 1.263 ± 0.834
0.632IleHis: 0.632 ± 0.662
1.895IleIle: 1.895 ± 0.686
2.527IleLys: 2.527 ± 1.138
4.422IleLeu: 4.422 ± 1.346
1.263IleMet: 1.263 ± 1.284
1.895IleAsn: 1.895 ± 0.778
2.527IlePro: 2.527 ± 0.636
2.527IleGln: 2.527 ± 0.636
1.895IleArg: 1.895 ± 1.456
3.79IleSer: 3.79 ± 2.29
2.527IleThr: 2.527 ± 1.32
3.79IleVal: 3.79 ± 1.882
0.0IleTrp: 0.0 ± 0.0
1.895IleTyr: 1.895 ± 0.848
0.0IleXaa: 0.0 ± 0.0
Lys
3.159LysAla: 3.159 ± 1.243
1.895LysCys: 1.895 ± 0.848
1.895LysAsp: 1.895 ± 1.25
5.054LysGlu: 5.054 ± 1.91
3.79LysPhe: 3.79 ± 2.453
3.79LysGly: 3.79 ± 0.992
0.0LysHis: 0.0 ± 0.0
0.632LysIle: 0.632 ± 0.417
1.895LysLys: 1.895 ± 0.848
8.844LysLeu: 8.844 ± 1.998
0.632LysMet: 0.632 ± 1.615
2.527LysAsn: 2.527 ± 1.601
1.895LysPro: 1.895 ± 0.778
1.263LysGln: 1.263 ± 0.59
5.054LysArg: 5.054 ± 2.919
6.949LysSer: 6.949 ± 3.224
1.895LysThr: 1.895 ± 1.183
3.159LysVal: 3.159 ± 0.829
1.263LysTrp: 1.263 ± 0.834
3.159LysTyr: 3.159 ± 0.983
0.632LysXaa: 0.632 ± 0.417
Leu
10.107LeuAla: 10.107 ± 3.274
1.895LeuCys: 1.895 ± 0.959
3.159LeuAsp: 3.159 ± 1.676
5.054LeuGlu: 5.054 ± 1.896
3.159LeuPhe: 3.159 ± 1.519
4.422LeuGly: 4.422 ± 1.73
1.895LeuHis: 1.895 ± 0.848
1.263LeuIle: 1.263 ± 1.324
4.422LeuLys: 4.422 ± 1.614
6.949LeuLeu: 6.949 ± 2.678
1.895LeuMet: 1.895 ± 1.25
5.685LeuAsn: 5.685 ± 2.1
1.895LeuPro: 1.895 ± 0.848
1.895LeuGln: 1.895 ± 0.686
5.685LeuArg: 5.685 ± 1.042
10.739LeuSer: 10.739 ± 2.875
5.685LeuThr: 5.685 ± 1.518
10.107LeuVal: 10.107 ± 1.67
1.263LeuTrp: 1.263 ± 1.245
1.895LeuTyr: 1.895 ± 1.214
0.0LeuXaa: 0.0 ± 0.0
Met
1.263MetAla: 1.263 ± 1.509
0.0MetCys: 0.0 ± 0.0
1.263MetAsp: 1.263 ± 1.659
2.527MetGlu: 2.527 ± 1.1
0.0MetPhe: 0.0 ± 0.0
0.632MetGly: 0.632 ± 0.417
0.632MetHis: 0.632 ± 1.405
0.0MetIle: 0.0 ± 0.0
1.263MetLys: 1.263 ± 0.59
0.632MetLeu: 0.632 ± 1.405
0.632MetMet: 0.632 ± 0.595
0.0MetAsn: 0.0 ± 0.0
0.0MetPro: 0.0 ± 0.0
3.159MetGln: 3.159 ± 0.829
0.0MetArg: 0.0 ± 0.0
2.527MetSer: 2.527 ± 1.125
0.632MetThr: 0.632 ± 0.662
0.0MetVal: 0.0 ± 0.0
0.0MetTrp: 0.0 ± 0.0
0.632MetTyr: 0.632 ± 0.662
0.0MetXaa: 0.0 ± 0.0
Asn
3.159AsnAla: 3.159 ± 0.829
0.632AsnCys: 0.632 ± 0.417
3.79AsnAsp: 3.79 ± 1.226
1.895AsnGlu: 1.895 ± 0.848
1.895AsnPhe: 1.895 ± 1.506
4.422AsnGly: 4.422 ± 2.376
2.527AsnHis: 2.527 ± 1.125
0.0AsnIle: 0.0 ± 0.0
0.632AsnLys: 0.632 ± 0.662
3.159AsnLeu: 3.159 ± 2.316
0.0AsnMet: 0.0 ± 0.0
1.895AsnAsn: 1.895 ± 1.506
3.79AsnPro: 3.79 ± 1.551
2.527AsnGln: 2.527 ± 1.449
0.632AsnArg: 0.632 ± 0.417
4.422AsnSer: 4.422 ± 2.334
1.263AsnThr: 1.263 ± 1.245
2.527AsnVal: 2.527 ± 1.18
0.632AsnTrp: 0.632 ± 0.417
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
2.527ProAla: 2.527 ± 1.18
0.0ProCys: 0.0 ± 0.0
3.79ProAsp: 3.79 ± 1.697
0.632ProGlu: 0.632 ± 0.417
3.159ProPhe: 3.159 ± 1.469
1.895ProGly: 1.895 ± 1.987
0.632ProHis: 0.632 ± 1.405
1.263ProIle: 1.263 ± 0.59
2.527ProLys: 2.527 ± 1.138
1.895ProLeu: 1.895 ± 1.183
0.0ProMet: 0.0 ± 0.0
0.632ProAsn: 0.632 ± 1.045
3.79ProPro: 3.79 ± 2.169
3.79ProGln: 3.79 ± 0.992
6.317ProArg: 6.317 ± 2.634
3.159ProSer: 3.159 ± 1.473
3.159ProThr: 3.159 ± 0.983
3.159ProVal: 3.159 ± 1.471
1.263ProTrp: 1.263 ± 0.722
0.632ProTyr: 0.632 ± 0.417
0.0ProXaa: 0.0 ± 0.0
Gln
3.159GlnAla: 3.159 ± 1.855
1.263GlnCys: 1.263 ± 0.59
1.895GlnAsp: 1.895 ± 0.686
3.79GlnGlu: 3.79 ± 0.992
1.895GlnPhe: 1.895 ± 0.686
1.895GlnGly: 1.895 ± 0.848
1.895GlnHis: 1.895 ± 1.25
1.895GlnIle: 1.895 ± 0.848
3.159GlnLys: 3.159 ± 1.473
1.895GlnLeu: 1.895 ± 0.686
1.895GlnMet: 1.895 ± 0.778
0.0GlnAsn: 0.0 ± 0.0
3.79GlnPro: 3.79 ± 1.283
1.263GlnGln: 1.263 ± 0.834
0.0GlnArg: 0.0 ± 0.0
2.527GlnSer: 2.527 ± 2.769
3.159GlnThr: 3.159 ± 1.243
3.79GlnVal: 3.79 ± 1.147
0.632GlnTrp: 0.632 ± 0.662
0.632GlnTyr: 0.632 ± 0.417
0.0GlnXaa: 0.0 ± 0.0
Arg
2.527ArgAla: 2.527 ± 0.636
1.263ArgCys: 1.263 ± 0.722
3.79ArgAsp: 3.79 ± 2.105
3.159ArgGlu: 3.159 ± 1.469
2.527ArgPhe: 2.527 ± 1.125
4.422ArgGly: 4.422 ± 1.95
1.263ArgHis: 1.263 ± 0.59
1.263ArgIle: 1.263 ± 1.245
6.317ArgLys: 6.317 ± 1.938
5.685ArgLeu: 5.685 ± 1.159
1.263ArgMet: 1.263 ± 0.59
4.422ArgAsn: 4.422 ± 1.162
1.263ArgPro: 1.263 ± 0.834
1.895ArgGln: 1.895 ± 0.848
8.844ArgArg: 8.844 ± 3.127
3.79ArgSer: 3.79 ± 1.85
3.159ArgThr: 3.159 ± 1.304
9.476ArgVal: 9.476 ± 2.894
0.0ArgTrp: 0.0 ± 0.0
2.527ArgTyr: 2.527 ± 1.18
0.0ArgXaa: 0.0 ± 0.0
Ser
6.317SerAla: 6.317 ± 3.988
2.527SerCys: 2.527 ± 0.636
3.79SerAsp: 3.79 ± 1.721
3.79SerGlu: 3.79 ± 1.147
5.054SerPhe: 5.054 ± 2.899
6.949SerGly: 6.949 ± 2.57
0.0SerHis: 0.0 ± 0.0
3.79SerIle: 3.79 ± 1.551
5.685SerLys: 5.685 ± 1.286
10.107SerLeu: 10.107 ± 2.502
1.895SerMet: 1.895 ± 1.703
3.159SerAsn: 3.159 ± 1.676
5.685SerPro: 5.685 ± 0.997
3.79SerGln: 3.79 ± 1.226
4.422SerArg: 4.422 ± 3.291
8.844SerSer: 8.844 ± 2.465
3.79SerThr: 3.79 ± 4.322
8.844SerVal: 8.844 ± 3.81
0.632SerTrp: 0.632 ± 1.405
1.895SerTyr: 1.895 ± 0.959
0.0SerXaa: 0.0 ± 0.0
Thr
5.054ThrAla: 5.054 ± 1.019
1.263ThrCys: 1.263 ± 0.834
2.527ThrAsp: 2.527 ± 1.444
1.895ThrGlu: 1.895 ± 1.183
3.159ThrPhe: 3.159 ± 2.072
1.263ThrGly: 1.263 ± 1.509
0.632ThrHis: 0.632 ± 0.662
3.79ThrIle: 3.79 ± 1.85
5.685ThrLys: 5.685 ± 2.869
2.527ThrLeu: 2.527 ± 2.603
0.0ThrMet: 0.0 ± 0.0
0.0ThrAsn: 0.0 ± 0.0
2.527ThrPro: 2.527 ± 0.636
4.422ThrGln: 4.422 ± 2.594
3.159ThrArg: 3.159 ± 1.732
5.054ThrSer: 5.054 ± 1.843
3.159ThrThr: 3.159 ± 2.072
5.054ThrVal: 5.054 ± 1.905
0.0ThrTrp: 0.0 ± 0.0
1.263ThrTyr: 1.263 ± 0.59
0.0ThrXaa: 0.0 ± 0.0
Val
8.844ValAla: 8.844 ± 4.99
0.0ValCys: 0.0 ± 0.0
4.422ValAsp: 4.422 ± 2.087
5.054ValGlu: 5.054 ± 1.902
8.212ValPhe: 8.212 ± 2.941
3.79ValGly: 3.79 ± 2.169
1.895ValHis: 1.895 ± 0.848
3.159ValIle: 3.159 ± 0.829
6.317ValLys: 6.317 ± 1.657
3.79ValLeu: 3.79 ± 1.687
0.632ValMet: 0.632 ± 0.417
4.422ValAsn: 4.422 ± 1.315
2.527ValPro: 2.527 ± 0.636
3.159ValGln: 3.159 ± 0.829
6.317ValArg: 6.317 ± 1.816
7.581ValSer: 7.581 ± 2.038
8.212ValThr: 8.212 ± 4.836
8.844ValVal: 8.844 ± 1.122
0.0ValTrp: 0.0 ± 0.0
0.632ValTyr: 0.632 ± 0.417
0.0ValXaa: 0.0 ± 0.0
Trp
1.263TrpAla: 1.263 ± 0.59
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
1.263TrpGly: 1.263 ± 0.834
0.0TrpHis: 0.0 ± 0.0
0.632TrpIle: 0.632 ± 1.405
0.632TrpLys: 0.632 ± 1.405
1.263TrpLeu: 1.263 ± 0.834
1.263TrpMet: 1.263 ± 0.722
1.895TrpAsn: 1.895 ± 0.848
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
1.895TrpArg: 1.895 ± 0.686
0.632TrpSer: 0.632 ± 1.405
0.632TrpThr: 0.632 ± 0.417
1.263TrpVal: 1.263 ± 0.834
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.263TyrAla: 1.263 ± 0.834
1.263TyrCys: 1.263 ± 0.834
0.0TyrAsp: 0.0 ± 0.0
1.263TyrGlu: 1.263 ± 0.59
0.0TyrPhe: 0.0 ± 0.0
0.632TyrGly: 0.632 ± 0.417
0.632TyrHis: 0.632 ± 0.417
0.0TyrIle: 0.0 ± 0.0
1.263TyrLys: 1.263 ± 0.59
6.317TyrLeu: 6.317 ± 1.816
0.0TyrMet: 0.0 ± 0.0
1.263TyrAsn: 1.263 ± 0.59
0.632TyrPro: 0.632 ± 0.417
3.79TyrGln: 3.79 ± 0.723
1.895TyrArg: 1.895 ± 1.25
3.79TyrSer: 3.79 ± 1.85
1.895TyrThr: 1.895 ± 0.778
1.263TyrVal: 1.263 ± 1.324
0.0TyrTrp: 0.0 ± 0.0
1.895TyrTyr: 1.895 ± 1.99
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.632XaaGly: 0.632 ± 0.417
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (1584 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski