Amino acid dipepetide frequency for Rhodoblastus sphagnicola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.368AlaAla: 19.368 ± 0.181	1.417AlaCys: 1.417 ± 0.035	6.989AlaAsp: 6.989 ± 0.081	8.135AlaGlu: 8.135 ± 0.102	4.968AlaPhe: 4.968 ± 0.064	10.735AlaGly: 10.735 ± 0.125	2.558AlaHis: 2.558 ± 0.048	6.142AlaIle: 6.142 ± 0.067	4.724AlaLys: 4.724 ± 0.065	16.032AlaLeu: 16.032 ± 0.136	3.275AlaMet: 3.275 ± 0.051	3.392AlaAsn: 3.392 ± 0.058	7.641AlaPro: 7.641 ± 0.081	4.97AlaGln: 4.97 ± 0.065	11.058AlaArg: 11.058 ± 0.13	7.178AlaSer: 7.178 ± 0.087	6.318AlaThr: 6.318 ± 0.075	8.372AlaVal: 8.372 ± 0.101	1.44AlaTrp: 1.44 ± 0.032	2.579AlaTyr: 2.579 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	1.451CysAla: 1.451 ± 0.036	0.142CysCys: 0.142 ± 0.011	0.596CysAsp: 0.596 ± 0.02	0.52CysGlu: 0.52 ± 0.021	0.342CysPhe: 0.342 ± 0.015	1.067CysGly: 1.067 ± 0.028	0.219CysHis: 0.219 ± 0.015	0.375CysIle: 0.375 ± 0.019	0.265CysLys: 0.265 ± 0.015	0.894CysLeu: 0.894 ± 0.027	0.175CysMet: 0.175 ± 0.011	0.239CysAsn: 0.239 ± 0.015	0.518CysPro: 0.518 ± 0.025	0.24CysGln: 0.24 ± 0.013	0.671CysArg: 0.671 ± 0.025	0.472CysSer: 0.472 ± 0.018	0.332CysThr: 0.332 ± 0.017	0.75CysVal: 0.75 ± 0.025	0.125CysTrp: 0.125 ± 0.009	0.215CysTyr: 0.215 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.48AspAla: 7.48 ± 0.086	0.547AspCys: 0.547 ± 0.021	3.081AspAsp: 3.081 ± 0.06	3.49AspGlu: 3.49 ± 0.056	2.478AspPhe: 2.478 ± 0.042	4.829AspGly: 4.829 ± 0.064	1.199AspHis: 1.199 ± 0.029	2.99AspIle: 2.99 ± 0.047	1.808AspLys: 1.808 ± 0.035	6.419AspLeu: 6.419 ± 0.081	1.199AspMet: 1.199 ± 0.029	1.289AspAsn: 1.289 ± 0.033	3.325AspPro: 3.325 ± 0.051	1.586AspGln: 1.586 ± 0.035	3.967AspArg: 3.967 ± 0.063	2.545AspSer: 2.545 ± 0.044	2.02AspThr: 2.02 ± 0.039	4.046AspVal: 4.046 ± 0.049	0.963AspTrp: 0.963 ± 0.029	1.439AspTyr: 1.439 ± 0.032	0.001AspXaa: 0.001 ± 0.001
Glu	8.042GluAla: 8.042 ± 0.094	0.365GluCys: 0.365 ± 0.017	2.778GluAsp: 2.778 ± 0.049	2.81GluGlu: 2.81 ± 0.058	1.876GluPhe: 1.876 ± 0.038	4.043GluGly: 4.043 ± 0.055	1.039GluHis: 1.039 ± 0.026	3.786GluIle: 3.786 ± 0.056	2.892GluLys: 2.892 ± 0.057	4.93GluLeu: 4.93 ± 0.069	1.289GluMet: 1.289 ± 0.035	1.676GluAsn: 1.676 ± 0.035	2.57GluPro: 2.57 ± 0.05	2.129GluGln: 2.129 ± 0.048	4.589GluArg: 4.589 ± 0.063	2.776GluSer: 2.776 ± 0.049	3.636GluThr: 3.636 ± 0.059	3.521GluVal: 3.521 ± 0.053	0.594GluTrp: 0.594 ± 0.02	0.789GluTyr: 0.789 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	5.328PheAla: 5.328 ± 0.075	0.523PheCys: 0.523 ± 0.02	2.778PheAsp: 2.778 ± 0.041	2.168PheGlu: 2.168 ± 0.043	1.56PhePhe: 1.56 ± 0.037	3.854PheGly: 3.854 ± 0.051	0.763PheHis: 0.763 ± 0.022	1.654PheIle: 1.654 ± 0.032	1.039PheLys: 1.039 ± 0.028	3.536PheLeu: 3.536 ± 0.046	0.689PheMet: 0.689 ± 0.022	1.134PheAsn: 1.134 ± 0.031	1.658PhePro: 1.658 ± 0.03	1.02PheGln: 1.02 ± 0.027	2.363PheArg: 2.363 ± 0.043	2.62PheSer: 2.62 ± 0.046	1.868PheThr: 1.868 ± 0.037	2.988PheVal: 2.988 ± 0.047	0.547PheTrp: 0.547 ± 0.021	0.913PheTyr: 0.913 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	11.976GlyAla: 11.976 ± 0.125	0.885GlyCys: 0.885 ± 0.028	4.806GlyAsp: 4.806 ± 0.061	4.789GlyGlu: 4.789 ± 0.056	3.846GlyPhe: 3.846 ± 0.054	7.585GlyGly: 7.585 ± 0.148	1.697GlyHis: 1.697 ± 0.036	3.078GlyIle: 3.078 ± 0.051	3.329GlyLys: 3.329 ± 0.061	8.993GlyLeu: 8.993 ± 0.092	1.817GlyMet: 1.817 ± 0.031	1.825GlyAsn: 1.825 ± 0.054	3.401GlyPro: 3.401 ± 0.047	2.654GlyGln: 2.654 ± 0.047	5.767GlyArg: 5.767 ± 0.069	4.263GlySer: 4.263 ± 0.103	2.9GlyThr: 2.9 ± 0.066	6.881GlyVal: 6.881 ± 0.073	1.202GlyTrp: 1.202 ± 0.026	2.142GlyTyr: 2.142 ± 0.046	0.001GlyXaa: 0.001 ± 0.001
His	2.376HisAla: 2.376 ± 0.044	0.247HisCys: 0.247 ± 0.013	1.179HisAsp: 1.179 ± 0.034	1.05HisGlu: 1.05 ± 0.033	0.936HisPhe: 0.936 ± 0.026	1.941HisGly: 1.941 ± 0.035	0.518HisHis: 0.518 ± 0.027	0.929HisIle: 0.929 ± 0.026	0.531HisLys: 0.531 ± 0.019	1.848HisLeu: 1.848 ± 0.037	0.433HisMet: 0.433 ± 0.016	0.453HisAsn: 0.453 ± 0.016	1.208HisPro: 1.208 ± 0.033	0.527HisGln: 0.527 ± 0.021	1.301HisArg: 1.301 ± 0.032	0.908HisSer: 0.908 ± 0.028	0.676HisThr: 0.676 ± 0.02	1.513HisVal: 1.513 ± 0.035	0.32HisTrp: 0.32 ± 0.016	0.521HisTyr: 0.521 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.308IleAla: 7.308 ± 0.079	0.55IleCys: 0.55 ± 0.021	3.554IleAsp: 3.554 ± 0.046	3.349IleGlu: 3.349 ± 0.055	1.801IlePhe: 1.801 ± 0.035	4.807IleGly: 4.807 ± 0.061	0.908IleHis: 0.908 ± 0.027	1.803IleIle: 1.803 ± 0.042	1.537IleLys: 1.537 ± 0.036	4.293IleLeu: 4.293 ± 0.059	0.785IleMet: 0.785 ± 0.026	1.326IleAsn: 1.326 ± 0.035	2.099IlePro: 2.099 ± 0.037	1.172IleGln: 1.172 ± 0.029	2.74IleArg: 2.74 ± 0.043	2.856IleSer: 2.856 ± 0.052	2.175IleThr: 2.175 ± 0.05	4.219IleVal: 4.219 ± 0.056	0.527IleTrp: 0.527 ± 0.021	1.043IleTyr: 1.043 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	4.519LysAla: 4.519 ± 0.064	0.231LysCys: 0.231 ± 0.014	1.65LysAsp: 1.65 ± 0.041	1.448LysGlu: 1.448 ± 0.038	1.247LysPhe: 1.247 ± 0.029	2.574LysGly: 2.574 ± 0.042	0.616LysHis: 0.616 ± 0.023	2.303LysIle: 2.303 ± 0.041	1.528LysLys: 1.528 ± 0.041	3.8LysLeu: 3.8 ± 0.061	0.828LysMet: 0.828 ± 0.026	1.003LysAsn: 1.003 ± 0.028	2.301LysPro: 2.301 ± 0.046	1.084LysGln: 1.084 ± 0.027	2.316LysArg: 2.316 ± 0.043	1.941LysSer: 1.941 ± 0.038	2.321LysThr: 2.321 ± 0.045	2.391LysVal: 2.391 ± 0.053	0.358LysTrp: 0.358 ± 0.017	0.699LysTyr: 0.699 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	15.474LeuAla: 15.474 ± 0.143	1.072LeuCys: 1.072 ± 0.026	6.289LeuAsp: 6.289 ± 0.069	5.213LeuGlu: 5.213 ± 0.067	3.856LeuPhe: 3.856 ± 0.059	8.154LeuGly: 8.154 ± 0.079	1.908LeuHis: 1.908 ± 0.038	4.897LeuIle: 4.897 ± 0.061	3.678LeuLys: 3.678 ± 0.055	9.706LeuLeu: 9.706 ± 0.109	1.989LeuMet: 1.989 ± 0.038	2.817LeuAsn: 2.817 ± 0.054	5.403LeuPro: 5.403 ± 0.062	2.628LeuGln: 2.628 ± 0.047	7.833LeuArg: 7.833 ± 0.085	6.502LeuSer: 6.502 ± 0.065	5.649LeuThr: 5.649 ± 0.074	6.944LeuVal: 6.944 ± 0.09	1.114LeuTrp: 1.114 ± 0.033	1.988LeuTyr: 1.988 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	2.838MetAla: 2.838 ± 0.042	0.153MetCys: 0.153 ± 0.009	0.971MetAsp: 0.971 ± 0.029	0.974MetGlu: 0.974 ± 0.031	0.622MetPhe: 0.622 ± 0.021	1.448MetGly: 1.448 ± 0.032	0.317MetHis: 0.317 ± 0.013	1.227MetIle: 1.227 ± 0.035	0.875MetLys: 0.875 ± 0.027	2.042MetLeu: 2.042 ± 0.039	0.493MetMet: 0.493 ± 0.02	0.717MetAsn: 0.717 ± 0.022	1.143MetPro: 1.143 ± 0.027	0.699MetGln: 0.699 ± 0.019	1.804MetArg: 1.804 ± 0.034	1.526MetSer: 1.526 ± 0.037	1.62MetThr: 1.62 ± 0.03	1.371MetVal: 1.371 ± 0.032	0.166MetTrp: 0.166 ± 0.01	0.232MetTyr: 0.232 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.501AsnAla: 3.501 ± 0.056	0.292AsnCys: 0.292 ± 0.015	1.346AsnAsp: 1.346 ± 0.033	1.222AsnGlu: 1.222 ± 0.028	1.14AsnPhe: 1.14 ± 0.029	2.425AsnGly: 2.425 ± 0.059	0.465AsnHis: 0.465 ± 0.019	1.437AsnIle: 1.437 ± 0.035	0.737AsnLys: 0.737 ± 0.023	2.822AsnLeu: 2.822 ± 0.047	0.551AsnMet: 0.551 ± 0.021	0.721AsnAsn: 0.721 ± 0.03	1.757AsnPro: 1.757 ± 0.039	0.755AsnGln: 0.755 ± 0.024	1.69AsnArg: 1.69 ± 0.032	1.339AsnSer: 1.339 ± 0.039	1.163AsnThr: 1.163 ± 0.032	2.027AsnVal: 2.027 ± 0.04	0.44AsnTrp: 0.44 ± 0.019	0.697AsnTyr: 0.697 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	6.671ProAla: 6.671 ± 0.076	0.401ProCys: 0.401 ± 0.015	3.521ProAsp: 3.521 ± 0.054	3.644ProGlu: 3.644 ± 0.055	2.0ProPhe: 2.0 ± 0.035	4.41ProGly: 4.41 ± 0.059	1.057ProHis: 1.057 ± 0.027	2.227ProIle: 2.227 ± 0.037	1.835ProLys: 1.835 ± 0.038	4.821ProLeu: 4.821 ± 0.06	1.057ProMet: 1.057 ± 0.025	1.407ProAsn: 1.407 ± 0.04	3.13ProPro: 3.13 ± 0.068	1.67ProGln: 1.67 ± 0.036	3.307ProArg: 3.307 ± 0.059	2.836ProSer: 2.836 ± 0.046	2.408ProThr: 2.408 ± 0.042	3.712ProVal: 3.712 ± 0.052	0.697ProTrp: 0.697 ± 0.024	1.068ProTyr: 1.068 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.465GlnAla: 4.465 ± 0.059	0.231GlnCys: 0.231 ± 0.015	1.505GlnAsp: 1.505 ± 0.036	1.427GlnGlu: 1.427 ± 0.037	1.102GlnPhe: 1.102 ± 0.03	2.505GlnGly: 2.505 ± 0.049	0.565GlnHis: 0.565 ± 0.018	1.848GlnIle: 1.848 ± 0.039	1.273GlnLys: 1.273 ± 0.031	2.668GlnLeu: 2.668 ± 0.038	0.752GlnMet: 0.752 ± 0.028	0.994GlnAsn: 0.994 ± 0.03	1.587GlnPro: 1.587 ± 0.035	1.08GlnGln: 1.08 ± 0.039	2.212GlnArg: 2.212 ± 0.041	1.8GlnSer: 1.8 ± 0.043	1.895GlnThr: 1.895 ± 0.051	2.003GlnVal: 2.003 ± 0.04	0.405GlnTrp: 0.405 ± 0.018	0.56GlnTyr: 0.56 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	9.995ArgAla: 9.995 ± 0.107	0.56ArgCys: 0.56 ± 0.023	4.385ArgAsp: 4.385 ± 0.063	4.436ArgGlu: 4.436 ± 0.06	2.879ArgPhe: 2.879 ± 0.051	5.108ArgGly: 5.108 ± 0.063	1.649ArgHis: 1.649 ± 0.038	3.827ArgIle: 3.827 ± 0.058	2.564ArgLys: 2.564 ± 0.046	8.359ArgLeu: 8.359 ± 0.079	1.582ArgMet: 1.582 ± 0.032	1.752ArgAsn: 1.752 ± 0.035	3.615ArgPro: 3.615 ± 0.058	2.51ArgGln: 2.51 ± 0.038	6.362ArgArg: 6.362 ± 0.099	3.192ArgSer: 3.192 ± 0.051	2.753ArgThr: 2.753 ± 0.047	4.75ArgVal: 4.75 ± 0.058	0.912ArgTrp: 0.912 ± 0.025	1.454ArgTyr: 1.454 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	7.11SerAla: 7.11 ± 0.096	0.486SerCys: 0.486 ± 0.019	2.918SerAsp: 2.918 ± 0.045	2.829SerGlu: 2.829 ± 0.05	2.212SerPhe: 2.212 ± 0.039	5.698SerGly: 5.698 ± 0.091	1.052SerHis: 1.052 ± 0.029	2.625SerIle: 2.625 ± 0.05	1.585SerLys: 1.585 ± 0.034	5.558SerLeu: 5.558 ± 0.075	1.151SerMet: 1.151 ± 0.027	1.428SerAsn: 1.428 ± 0.039	2.989SerPro: 2.989 ± 0.051	1.735SerGln: 1.735 ± 0.043	3.806SerArg: 3.806 ± 0.051	3.143SerSer: 3.143 ± 0.069	2.674SerThr: 2.674 ± 0.052	3.903SerVal: 3.903 ± 0.063	0.742SerTrp: 0.742 ± 0.023	1.325SerTyr: 1.325 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	5.659ThrAla: 5.659 ± 0.076	0.456ThrCys: 0.456 ± 0.02	2.405ThrAsp: 2.405 ± 0.044	2.274ThrGlu: 2.274 ± 0.042	1.897ThrPhe: 1.897 ± 0.037	4.514ThrGly: 4.514 ± 0.066	0.944ThrHis: 0.944 ± 0.028	2.578ThrIle: 2.578 ± 0.049	1.378ThrLys: 1.378 ± 0.031	5.793ThrLeu: 5.793 ± 0.081	0.961ThrMet: 0.961 ± 0.026	1.251ThrAsn: 1.251 ± 0.032	3.441ThrPro: 3.441 ± 0.059	1.501ThrGln: 1.501 ± 0.037	3.286ThrArg: 3.286 ± 0.047	2.669ThrSer: 2.669 ± 0.054	2.581ThrThr: 2.581 ± 0.064	3.543ThrVal: 3.543 ± 0.058	0.472ThrTrp: 0.472 ± 0.021	1.08ThrTyr: 1.08 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	10.035ValAla: 10.035 ± 0.079	0.671ValCys: 0.671 ± 0.022	3.999ValAsp: 3.999 ± 0.046	4.796ValGlu: 4.796 ± 0.06	2.831ValPhe: 2.831 ± 0.045	5.419ValGly: 5.419 ± 0.075	1.304ValHis: 1.304 ± 0.034	3.626ValIle: 3.626 ± 0.051	2.534ValLys: 2.534 ± 0.051	6.962ValLeu: 6.962 ± 0.076	1.512ValMet: 1.512 ± 0.034	2.115ValAsn: 2.115 ± 0.038	2.498ValPro: 2.498 ± 0.048	1.824ValGln: 1.824 ± 0.038	4.363ValArg: 4.363 ± 0.06	4.356ValSer: 4.356 ± 0.065	4.019ValThr: 4.019 ± 0.065	5.64ValVal: 5.64 ± 0.087	0.87ValTrp: 0.87 ± 0.024	1.384ValTyr: 1.384 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.188TrpAla: 1.188 ± 0.029	0.123TrpCys: 0.123 ± 0.01	0.553TrpAsp: 0.553 ± 0.021	0.485TrpGlu: 0.485 ± 0.018	0.497TrpPhe: 0.497 ± 0.02	0.816TrpGly: 0.816 ± 0.022	0.221TrpHis: 0.221 ± 0.015	0.623TrpIle: 0.623 ± 0.02	0.42TrpLys: 0.42 ± 0.019	1.577TrpLeu: 1.577 ± 0.039	0.308TrpMet: 0.308 ± 0.015	0.387TrpAsn: 0.387 ± 0.018	0.66TrpPro: 0.66 ± 0.021	0.359TrpGln: 0.359 ± 0.017	1.533TrpArg: 1.533 ± 0.038	0.844TrpSer: 0.844 ± 0.03	0.759TrpThr: 0.759 ± 0.025	0.658TrpVal: 0.658 ± 0.022	0.165TrpTrp: 0.165 ± 0.01	0.223TrpTyr: 0.223 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.509TyrAla: 2.509 ± 0.044	0.255TyrCys: 0.255 ± 0.012	1.398TyrAsp: 1.398 ± 0.033	1.072TyrGlu: 1.072 ± 0.026	0.915TyrPhe: 0.915 ± 0.027	1.902TyrGly: 1.902 ± 0.044	0.414TyrHis: 0.414 ± 0.018	0.876TyrIle: 0.876 ± 0.025	0.627TyrLys: 0.627 ± 0.025	2.061TyrLeu: 2.061 ± 0.039	0.391TyrMet: 0.391 ± 0.019	0.601TyrAsn: 0.601 ± 0.023	0.936TyrPro: 0.936 ± 0.029	0.732TyrGln: 0.732 ± 0.024	1.677TyrArg: 1.677 ± 0.031	1.201TyrSer: 1.201 ± 0.032	0.915TyrThr: 0.915 ± 0.027	1.527TyrVal: 1.527 ± 0.032	0.341TyrTrp: 0.341 ± 0.014	0.576TyrTyr: 0.576 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.001XaaCys: 0.001 ± 0.001	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4616 proteins (1435672 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---