Amino acid dipepetide frequency for Microviridae sp.

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.704AlaAla: 0.704 ± 0.591
1.407AlaCys: 1.407 ± 1.315
2.815AlaAsp: 2.815 ± 1.099
2.815AlaGlu: 2.815 ± 1.099
1.407AlaPhe: 1.407 ± 0.95
6.334AlaGly: 6.334 ± 1.485
0.0AlaHis: 0.0 ± 0.0
4.926AlaIle: 4.926 ± 1.979
4.222AlaLys: 4.222 ± 1.696
4.926AlaLeu: 4.926 ± 1.678
2.111AlaMet: 2.111 ± 0.904
5.63AlaAsn: 5.63 ± 2.57
2.111AlaPro: 2.111 ± 0.951
3.519AlaGln: 3.519 ± 1.439
4.926AlaArg: 4.926 ± 1.444
1.407AlaSer: 1.407 ± 0.533
3.519AlaThr: 3.519 ± 1.807
2.815AlaVal: 2.815 ± 0.706
0.704AlaTrp: 0.704 ± 0.475
4.222AlaTyr: 4.222 ± 1.035
0.0AlaXaa: 0.0 ± 0.0
Cys
0.704CysAla: 0.704 ± 0.782
0.704CysCys: 0.704 ± 0.782
0.0CysAsp: 0.0 ± 0.0
0.704CysGlu: 0.704 ± 0.658
1.407CysPhe: 1.407 ± 1.564
0.704CysGly: 0.704 ± 0.658
0.0CysHis: 0.0 ± 0.0
1.407CysIle: 1.407 ± 1.13
0.0CysLys: 0.0 ± 0.0
2.111CysLeu: 2.111 ± 0.692
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
1.407CysArg: 1.407 ± 0.954
0.704CysSer: 0.704 ± 0.658
0.704CysThr: 0.704 ± 0.782
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
3.519AspAla: 3.519 ± 1.733
0.704AspCys: 0.704 ± 0.782
2.815AspAsp: 2.815 ± 1.333
4.926AspGlu: 4.926 ± 1.968
4.926AspPhe: 4.926 ± 1.001
2.111AspGly: 2.111 ± 0.515
0.704AspHis: 0.704 ± 0.658
3.519AspIle: 3.519 ± 1.121
4.926AspLys: 4.926 ± 0.748
5.63AspLeu: 5.63 ± 1.209
0.0AspMet: 0.0 ± 0.0
2.815AspAsn: 2.815 ± 1.152
2.815AspPro: 2.815 ± 0.851
2.815AspGln: 2.815 ± 1.067
0.704AspArg: 0.704 ± 0.591
0.704AspSer: 0.704 ± 0.475
1.407AspThr: 1.407 ± 0.954
1.407AspVal: 1.407 ± 0.704
0.0AspTrp: 0.0 ± 0.0
0.704AspTyr: 0.704 ± 0.475
0.0AspXaa: 0.0 ± 0.0
Glu
2.111GluAla: 2.111 ± 0.943
0.0GluCys: 0.0 ± 0.0
5.63GluAsp: 5.63 ± 3.406
3.519GluGlu: 3.519 ± 2.044
4.926GluPhe: 4.926 ± 2.641
4.926GluGly: 4.926 ± 0.775
2.815GluHis: 2.815 ± 0.706
1.407GluIle: 1.407 ± 1.315
8.445GluLys: 8.445 ± 2.994
6.334GluLeu: 6.334 ± 2.382
2.815GluMet: 2.815 ± 1.687
7.037GluAsn: 7.037 ± 2.656
0.0GluPro: 0.0 ± 0.0
4.926GluGln: 4.926 ± 1.508
2.815GluArg: 2.815 ± 1.152
3.519GluSer: 3.519 ± 1.121
2.111GluThr: 2.111 ± 1.425
6.334GluVal: 6.334 ± 2.441
0.704GluTrp: 0.704 ± 0.475
2.815GluTyr: 2.815 ± 0.997
0.0GluXaa: 0.0 ± 0.0
Phe
3.519PheAla: 3.519 ± 0.372
0.704PheCys: 0.704 ± 0.658
2.815PheAsp: 2.815 ± 0.629
1.407PheGlu: 1.407 ± 0.95
0.704PhePhe: 0.704 ± 0.782
4.926PheGly: 4.926 ± 2.023
0.0PheHis: 0.0 ± 0.0
3.519PheIle: 3.519 ± 0.987
2.815PheLys: 2.815 ± 1.307
4.926PheLeu: 4.926 ± 2.162
1.407PheMet: 1.407 ± 0.95
2.815PheAsn: 2.815 ± 0.629
4.222PhePro: 4.222 ± 1.005
1.407PheGln: 1.407 ± 0.813
4.222PheArg: 4.222 ± 1.443
2.111PheSer: 2.111 ± 0.515
2.111PheThr: 2.111 ± 0.766
2.111PheVal: 2.111 ± 1.083
1.407PheTrp: 1.407 ± 0.816
0.704PheTyr: 0.704 ± 0.475
0.0PheXaa: 0.0 ± 0.0
Gly
3.519GlyAla: 3.519 ± 1.523
0.0GlyCys: 0.0 ± 0.0
2.815GlyAsp: 2.815 ± 1.408
6.334GlyGlu: 6.334 ± 0.717
3.519GlyPhe: 3.519 ± 0.866
5.63GlyGly: 5.63 ± 2.474
1.407GlyHis: 1.407 ± 0.533
4.926GlyIle: 4.926 ± 1.645
2.111GlyLys: 2.111 ± 0.709
8.445GlyLeu: 8.445 ± 2.183
2.111GlyMet: 2.111 ± 0.939
3.519GlyAsn: 3.519 ± 1.523
0.0GlyPro: 0.0 ± 0.0
4.222GlyGln: 4.222 ± 1.451
1.407GlyArg: 1.407 ± 0.766
4.222GlySer: 4.222 ± 1.417
4.222GlyThr: 4.222 ± 1.903
2.111GlyVal: 2.111 ± 0.951
0.0GlyTrp: 0.0 ± 0.0
3.519GlyTyr: 3.519 ± 1.596
0.0GlyXaa: 0.0 ± 0.0
His
1.407HisAla: 1.407 ± 0.954
0.704HisCys: 0.704 ± 0.743
1.407HisAsp: 1.407 ± 0.704
0.704HisGlu: 0.704 ± 0.475
2.111HisPhe: 2.111 ± 2.346
2.815HisGly: 2.815 ± 1.9
0.0HisHis: 0.0 ± 0.0
1.407HisIle: 1.407 ± 1.13
0.704HisLys: 0.704 ± 0.743
2.111HisLeu: 2.111 ± 1.46
0.704HisMet: 0.704 ± 0.658
1.407HisAsn: 1.407 ± 0.634
0.704HisPro: 0.704 ± 0.782
0.704HisGln: 0.704 ± 0.591
1.407HisArg: 1.407 ± 0.704
0.704HisSer: 0.704 ± 0.658
0.704HisThr: 0.704 ± 0.743
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
2.815HisTyr: 2.815 ± 1.731
0.0HisXaa: 0.0 ± 0.0
Ile
3.519IleAla: 3.519 ± 0.972
0.0IleCys: 0.0 ± 0.0
7.037IleAsp: 7.037 ± 2.431
5.63IleGlu: 5.63 ± 1.018
2.815IlePhe: 2.815 ± 0.997
2.815IleGly: 2.815 ± 0.54
2.815IleHis: 2.815 ± 1.689
8.445IleIle: 8.445 ± 3.203
5.63IleLys: 5.63 ± 2.553
4.926IleLeu: 4.926 ± 1.979
3.519IleMet: 3.519 ± 1.193
7.741IleAsn: 7.741 ± 2.061
3.519IlePro: 3.519 ± 1.807
4.222IleGln: 4.222 ± 2.095
3.519IleArg: 3.519 ± 0.985
4.222IleSer: 4.222 ± 1.886
2.111IleThr: 2.111 ± 0.692
2.111IleVal: 2.111 ± 0.979
0.704IleTrp: 0.704 ± 0.658
2.111IleTyr: 2.111 ± 1.425
0.0IleXaa: 0.0 ± 0.0
Lys
7.037LysAla: 7.037 ± 1.081
0.704LysCys: 0.704 ± 0.658
4.222LysAsp: 4.222 ± 2.298
7.741LysGlu: 7.741 ± 2.727
4.222LysPhe: 4.222 ± 2.263
4.222LysGly: 4.222 ± 2.096
1.407LysHis: 1.407 ± 0.704
5.63LysIle: 5.63 ± 1.079
8.445LysLys: 8.445 ± 4.94
4.222LysLeu: 4.222 ± 0.689
3.519LysMet: 3.519 ± 0.372
4.222LysAsn: 4.222 ± 1.897
0.704LysPro: 0.704 ± 0.743
5.63LysGln: 5.63 ± 3.039
5.63LysArg: 5.63 ± 2.876
2.815LysSer: 2.815 ± 1.9
6.334LysThr: 6.334 ± 2.015
0.704LysVal: 0.704 ± 0.743
1.407LysTrp: 1.407 ± 0.813
6.334LysTyr: 6.334 ± 2.048
0.0LysXaa: 0.0 ± 0.0
Leu
4.926LeuAla: 4.926 ± 2.198
1.407LeuCys: 1.407 ± 1.04
2.815LeuAsp: 2.815 ± 1.166
9.852LeuGlu: 9.852 ± 3.479
3.519LeuPhe: 3.519 ± 0.988
5.63LeuGly: 5.63 ± 1.873
2.815LeuHis: 2.815 ± 1.466
4.926LeuIle: 4.926 ± 2.04
7.741LeuLys: 7.741 ± 3.461
11.26LeuLeu: 11.26 ± 7.916
2.111LeuMet: 2.111 ± 0.786
4.926LeuAsn: 4.926 ± 1.506
6.334LeuPro: 6.334 ± 1.628
7.741LeuGln: 7.741 ± 1.433
4.926LeuArg: 4.926 ± 0.879
2.815LeuSer: 2.815 ± 1.038
4.926LeuThr: 4.926 ± 1.25
5.63LeuVal: 5.63 ± 2.393
1.407LeuTrp: 1.407 ± 0.533
0.704LeuTyr: 0.704 ± 0.782
0.0LeuXaa: 0.0 ± 0.0
Met
3.519MetAla: 3.519 ± 1.216
0.0MetCys: 0.0 ± 0.0
1.407MetAsp: 1.407 ± 0.856
2.111MetGlu: 2.111 ± 0.951
0.0MetPhe: 0.0 ± 0.0
4.222MetGly: 4.222 ± 1.451
0.0MetHis: 0.0 ± 0.0
0.704MetIle: 0.704 ± 0.591
4.222MetLys: 4.222 ± 2.186
2.111MetLeu: 2.111 ± 1.527
0.704MetMet: 0.704 ± 0.591
1.407MetAsn: 1.407 ± 0.856
2.111MetPro: 2.111 ± 0.692
0.704MetGln: 0.704 ± 0.743
2.111MetArg: 2.111 ± 0.515
0.704MetSer: 0.704 ± 0.475
0.704MetThr: 0.704 ± 0.591
0.704MetVal: 0.704 ± 0.475
0.704MetTrp: 0.704 ± 0.591
0.704MetTyr: 0.704 ± 0.658
0.0MetXaa: 0.0 ± 0.0
Asn
4.222AsnAla: 4.222 ± 1.03
0.704AsnCys: 0.704 ± 0.782
1.407AsnAsp: 1.407 ± 0.95
5.63AsnGlu: 5.63 ± 1.875
2.111AsnPhe: 2.111 ± 0.946
1.407AsnGly: 1.407 ± 0.766
1.407AsnHis: 1.407 ± 1.04
9.148AsnIle: 9.148 ± 2.964
7.741AsnLys: 7.741 ± 2.354
7.741AsnLeu: 7.741 ± 1.557
0.704AsnMet: 0.704 ± 0.591
1.407AsnAsn: 1.407 ± 0.95
2.111AsnPro: 2.111 ± 1.129
1.407AsnGln: 1.407 ± 0.856
3.519AsnArg: 3.519 ± 1.324
4.222AsnSer: 4.222 ± 1.451
1.407AsnThr: 1.407 ± 0.766
2.111AsnVal: 2.111 ± 1.425
2.815AsnTrp: 2.815 ± 0.8
0.704AsnTyr: 0.704 ± 0.475
0.0AsnXaa: 0.0 ± 0.0
Pro
1.407ProAla: 1.407 ± 0.704
1.407ProCys: 1.407 ± 1.13
0.704ProAsp: 0.704 ± 0.591
2.111ProGlu: 2.111 ± 0.943
1.407ProPhe: 1.407 ± 0.816
1.407ProGly: 1.407 ± 0.95
1.407ProHis: 1.407 ± 0.766
4.222ProIle: 4.222 ± 0.979
4.926ProLys: 4.926 ± 1.473
2.111ProLeu: 2.111 ± 1.083
2.111ProMet: 2.111 ± 0.766
4.926ProAsn: 4.926 ± 0.547
1.407ProPro: 1.407 ± 0.95
1.407ProGln: 1.407 ± 0.634
1.407ProArg: 1.407 ± 0.634
1.407ProSer: 1.407 ± 0.954
1.407ProThr: 1.407 ± 0.95
2.111ProVal: 2.111 ± 1.425
0.0ProTrp: 0.0 ± 0.0
0.704ProTyr: 0.704 ± 0.475
0.0ProXaa: 0.0 ± 0.0
Gln
2.815GlnAla: 2.815 ± 1.267
0.0GlnCys: 0.0 ± 0.0
1.407GlnAsp: 1.407 ± 0.95
4.222GlnGlu: 4.222 ± 1.035
2.815GlnPhe: 2.815 ± 0.8
4.222GlnGly: 4.222 ± 1.866
2.111GlnHis: 2.111 ± 1.46
4.926GlnIle: 4.926 ± 1.753
5.63GlnLys: 5.63 ± 1.744
3.519GlnLeu: 3.519 ± 1.699
2.111GlnMet: 2.111 ± 1.695
1.407GlnAsn: 1.407 ± 0.704
0.704GlnPro: 0.704 ± 0.475
2.111GlnGln: 2.111 ± 1.129
3.519GlnArg: 3.519 ± 0.985
0.704GlnSer: 0.704 ± 0.591
4.222GlnThr: 4.222 ± 1.384
1.407GlnVal: 1.407 ± 0.704
0.0GlnTrp: 0.0 ± 0.0
2.111GlnTyr: 2.111 ± 1.187
0.0GlnXaa: 0.0 ± 0.0
Arg
7.037ArgAla: 7.037 ± 1.32
0.704ArgCys: 0.704 ± 0.658
2.111ArgAsp: 2.111 ± 0.515
3.519ArgGlu: 3.519 ± 2.377
1.407ArgPhe: 1.407 ± 0.634
0.704ArgGly: 0.704 ± 0.475
0.0ArgHis: 0.0 ± 0.0
4.926ArgIle: 4.926 ± 1.979
2.815ArgLys: 2.815 ± 1.158
7.741ArgLeu: 7.741 ± 1.567
1.407ArgMet: 1.407 ± 0.704
3.519ArgAsn: 3.519 ± 1.953
3.519ArgPro: 3.519 ± 1.232
2.111ArgGln: 2.111 ± 0.946
3.519ArgArg: 3.519 ± 2.995
2.815ArgSer: 2.815 ± 1.466
1.407ArgThr: 1.407 ± 0.954
1.407ArgVal: 1.407 ± 0.766
0.0ArgTrp: 0.0 ± 0.0
2.815ArgTyr: 2.815 ± 1.9
0.0ArgXaa: 0.0 ± 0.0
Ser
4.222SerAla: 4.222 ± 2.85
0.704SerCys: 0.704 ± 0.475
0.704SerAsp: 0.704 ± 0.475
6.334SerGlu: 6.334 ± 2.714
1.407SerPhe: 1.407 ± 0.704
2.815SerGly: 2.815 ± 0.54
1.407SerHis: 1.407 ± 0.704
4.926SerIle: 4.926 ± 1.657
4.926SerLys: 4.926 ± 1.465
2.815SerLeu: 2.815 ± 1.381
2.111SerMet: 2.111 ± 1.129
1.407SerAsn: 1.407 ± 0.766
1.407SerPro: 1.407 ± 0.634
2.111SerGln: 2.111 ± 0.692
1.407SerArg: 1.407 ± 0.634
3.519SerSer: 3.519 ± 1.881
2.815SerThr: 2.815 ± 1.035
2.111SerVal: 2.111 ± 0.943
0.0SerTrp: 0.0 ± 0.0
0.0SerTyr: 0.0 ± 0.0
0.0SerXaa: 0.0 ± 0.0
Thr
4.222ThrAla: 4.222 ± 1.404
0.0ThrCys: 0.0 ± 0.0
2.111ThrAsp: 2.111 ± 1.425
3.519ThrGlu: 3.519 ± 0.866
2.111ThrPhe: 2.111 ± 0.515
2.815ThrGly: 2.815 ± 1.364
0.0ThrHis: 0.0 ± 0.0
3.519ThrIle: 3.519 ± 1.231
4.926ThrLys: 4.926 ± 2.538
4.926ThrLeu: 4.926 ± 1.315
0.704ThrMet: 0.704 ± 0.475
0.704ThrAsn: 0.704 ± 0.475
3.519ThrPro: 3.519 ± 0.985
0.704ThrGln: 0.704 ± 0.475
2.111ThrArg: 2.111 ± 1.491
4.926ThrSer: 4.926 ± 1.247
3.519ThrThr: 3.519 ± 0.985
3.519ThrVal: 3.519 ± 1.01
0.0ThrTrp: 0.0 ± 0.0
2.111ThrTyr: 2.111 ± 0.692
0.0ThrXaa: 0.0 ± 0.0
Val
1.407ValAla: 1.407 ± 0.634
0.704ValCys: 0.704 ± 0.782
1.407ValAsp: 1.407 ± 0.856
0.0ValGlu: 0.0 ± 0.0
2.111ValPhe: 2.111 ± 0.979
4.222ValGly: 4.222 ± 1.122
0.704ValHis: 0.704 ± 0.475
1.407ValIle: 1.407 ± 0.533
2.111ValLys: 2.111 ± 1.368
5.63ValLeu: 5.63 ± 2.314
0.0ValMet: 0.0 ± 0.0
3.519ValAsn: 3.519 ± 0.783
2.815ValPro: 2.815 ± 0.8
2.111ValGln: 2.111 ± 1.425
2.815ValArg: 2.815 ± 1.317
0.704ValSer: 0.704 ± 0.475
2.111ValThr: 2.111 ± 1.425
1.407ValVal: 1.407 ± 0.816
2.111ValTrp: 2.111 ± 0.943
0.704ValTyr: 0.704 ± 0.591
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
2.111TrpAsp: 2.111 ± 0.951
1.407TrpGlu: 1.407 ± 0.95
0.704TrpPhe: 0.704 ± 0.475
0.0TrpGly: 0.0 ± 0.0
0.704TrpHis: 0.704 ± 0.782
0.704TrpIle: 0.704 ± 0.658
0.0TrpLys: 0.0 ± 0.0
1.407TrpLeu: 1.407 ± 0.813
0.0TrpMet: 0.0 ± 0.0
2.111TrpAsn: 2.111 ± 0.709
0.0TrpPro: 0.0 ± 0.0
0.704TrpGln: 0.704 ± 0.782
0.704TrpArg: 0.704 ± 0.658
0.704TrpSer: 0.704 ± 0.475
2.111TrpThr: 2.111 ± 1.099
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.704TyrAla: 0.704 ± 0.475
0.0TyrCys: 0.0 ± 0.0
1.407TyrAsp: 1.407 ± 0.533
0.704TyrGlu: 0.704 ± 0.475
4.222TyrPhe: 4.222 ± 1.533
2.111TyrGly: 2.111 ± 0.515
2.815TyrHis: 2.815 ± 0.997
2.815TyrIle: 2.815 ± 1.317
2.815TyrLys: 2.815 ± 0.706
4.222TyrLeu: 4.222 ± 2.65
0.0TyrMet: 0.0 ± 0.0
1.407TyrAsn: 1.407 ± 0.634
0.0TyrPro: 0.0 ± 0.0
1.407TyrGln: 1.407 ± 0.766
1.407TyrArg: 1.407 ± 0.95
4.222TyrSer: 4.222 ± 1.056
2.111TyrThr: 2.111 ± 0.692
0.0TyrVal: 0.0 ± 0.0
1.407TyrTrp: 1.407 ± 0.533
0.704TyrTyr: 0.704 ± 0.591
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (1422 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski