Amino acid dipepetide frequency for Macaca nemestrina rhadinovirus 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.459AlaAla: 7.459 ± 0.575
2.162AlaCys: 2.162 ± 0.285
3.475AlaAsp: 3.475 ± 0.317
3.985AlaGlu: 3.985 ± 0.325
3.426AlaPhe: 3.426 ± 0.241
4.495AlaGly: 4.495 ± 0.408
2.09AlaHis: 2.09 ± 0.228
3.402AlaIle: 3.402 ± 0.284
3.086AlaLys: 3.086 ± 0.291
8.14AlaLeu: 8.14 ± 0.459
1.604AlaMet: 1.604 ± 0.184
2.648AlaAsn: 2.648 ± 0.289
5.807AlaPro: 5.807 ± 0.437
2.308AlaGln: 2.308 ± 0.234
4.738AlaArg: 4.738 ± 0.437
5.686AlaSer: 5.686 ± 0.443
5.175AlaThr: 5.175 ± 0.387
5.467AlaVal: 5.467 ± 0.376
1.215AlaTrp: 1.215 ± 0.176
2.527AlaTyr: 2.527 ± 0.311
0.0AlaXaa: 0.0 ± 0.0
Cys
1.506CysAla: 1.506 ± 0.217
0.753CysCys: 0.753 ± 0.137
1.069CysAsp: 1.069 ± 0.161
1.434CysGlu: 1.434 ± 0.205
1.069CysPhe: 1.069 ± 0.155
1.482CysGly: 1.482 ± 0.237
0.535CysHis: 0.535 ± 0.119
1.093CysIle: 1.093 ± 0.202
0.899CysLys: 0.899 ± 0.153
3.475CysLeu: 3.475 ± 0.314
0.559CysMet: 0.559 ± 0.118
0.923CysAsn: 0.923 ± 0.136
1.579CysPro: 1.579 ± 0.22
1.361CysGln: 1.361 ± 0.185
1.701CysArg: 1.701 ± 0.217
1.604CysSer: 1.604 ± 0.221
0.972CysThr: 0.972 ± 0.151
2.017CysVal: 2.017 ± 0.224
0.219CysTrp: 0.219 ± 0.071
0.607CysTyr: 0.607 ± 0.124
0.0CysXaa: 0.0 ± 0.0
Asp
4.398AspAla: 4.398 ± 0.366
0.875AspCys: 0.875 ± 0.132
3.061AspAsp: 3.061 ± 0.412
3.183AspGlu: 3.183 ± 0.325
1.919AspPhe: 1.919 ± 0.21
3.232AspGly: 3.232 ± 0.308
0.899AspHis: 0.899 ± 0.156
2.405AspIle: 2.405 ± 0.203
1.725AspLys: 1.725 ± 0.238
4.762AspLeu: 4.762 ± 0.324
1.215AspMet: 1.215 ± 0.147
1.895AspAsn: 1.895 ± 0.166
2.794AspPro: 2.794 ± 0.285
1.555AspGln: 1.555 ± 0.165
2.964AspArg: 2.964 ± 0.291
3.013AspSer: 3.013 ± 0.323
3.159AspThr: 3.159 ± 0.318
3.402AspVal: 3.402 ± 0.301
0.583AspTrp: 0.583 ± 0.109
1.361AspTyr: 1.361 ± 0.155
0.0AspXaa: 0.0 ± 0.0
Glu
3.645GluAla: 3.645 ± 0.262
1.482GluCys: 1.482 ± 0.196
2.916GluAsp: 2.916 ± 0.35
2.794GluGlu: 2.794 ± 0.287
1.749GluPhe: 1.749 ± 0.197
2.527GluGly: 2.527 ± 0.223
1.555GluHis: 1.555 ± 0.224
2.576GluIle: 2.576 ± 0.248
2.405GluLys: 2.405 ± 0.267
4.616GluLeu: 4.616 ± 0.347
1.409GluMet: 1.409 ± 0.191
2.454GluAsn: 2.454 ± 0.244
2.527GluPro: 2.527 ± 0.245
1.992GluGln: 1.992 ± 0.236
2.551GluArg: 2.551 ± 0.275
3.353GluSer: 3.353 ± 0.292
4.519GluThr: 4.519 ± 0.387
3.013GluVal: 3.013 ± 0.248
0.437GluTrp: 0.437 ± 0.085
1.531GluTyr: 1.531 ± 0.169
0.0GluXaa: 0.0 ± 0.0
Phe
2.576PheAla: 2.576 ± 0.194
1.166PheCys: 1.166 ± 0.176
2.162PheAsp: 2.162 ± 0.206
1.968PheGlu: 1.968 ± 0.196
2.187PhePhe: 2.187 ± 0.23
2.187PheGly: 2.187 ± 0.223
1.093PheHis: 1.093 ± 0.158
2.624PheIle: 2.624 ± 0.242
2.867PheLys: 2.867 ± 0.252
5.37PheLeu: 5.37 ± 0.388
1.02PheMet: 1.02 ± 0.158
1.725PheAsn: 1.725 ± 0.168
2.721PhePro: 2.721 ± 0.234
1.555PheGln: 1.555 ± 0.179
1.822PheArg: 1.822 ± 0.226
2.867PheSer: 2.867 ± 0.293
2.405PheThr: 2.405 ± 0.24
2.794PheVal: 2.794 ± 0.36
0.607PheTrp: 0.607 ± 0.133
2.187PheTyr: 2.187 ± 0.252
0.0PheXaa: 0.0 ± 0.0
Gly
5.054GlyAla: 5.054 ± 0.401
1.166GlyCys: 1.166 ± 0.201
3.207GlyAsp: 3.207 ± 0.24
2.746GlyGlu: 2.746 ± 0.296
2.916GlyPhe: 2.916 ± 0.237
3.426GlyGly: 3.426 ± 0.369
1.361GlyHis: 1.361 ± 0.176
2.697GlyIle: 2.697 ± 0.223
2.26GlyLys: 2.26 ± 0.251
6.123GlyLeu: 6.123 ± 0.564
0.948GlyMet: 0.948 ± 0.169
2.357GlyAsn: 2.357 ± 0.252
3.232GlyPro: 3.232 ± 0.305
2.867GlyGln: 2.867 ± 0.265
3.912GlyArg: 3.912 ± 0.372
4.301GlySer: 4.301 ± 0.35
3.888GlyThr: 3.888 ± 0.307
4.495GlyVal: 4.495 ± 0.426
0.559GlyTrp: 0.559 ± 0.134
1.677GlyTyr: 1.677 ± 0.211
0.0GlyXaa: 0.0 ± 0.0
His
1.604HisAla: 1.604 ± 0.199
0.559HisCys: 0.559 ± 0.111
1.045HisAsp: 1.045 ± 0.16
1.555HisGlu: 1.555 ± 0.217
1.045HisPhe: 1.045 ± 0.155
2.284HisGly: 2.284 ± 0.247
1.045HisHis: 1.045 ± 0.164
1.045HisIle: 1.045 ± 0.149
1.263HisLys: 1.263 ± 0.194
2.843HisLeu: 2.843 ± 0.315
0.535HisMet: 0.535 ± 0.123
0.85HisAsn: 0.85 ± 0.12
2.187HisPro: 2.187 ± 0.273
0.729HisGln: 0.729 ± 0.122
1.628HisArg: 1.628 ± 0.165
1.555HisSer: 1.555 ± 0.193
1.336HisThr: 1.336 ± 0.197
2.6HisVal: 2.6 ± 0.223
0.462HisTrp: 0.462 ± 0.115
0.899HisTyr: 0.899 ± 0.13
0.0HisXaa: 0.0 ± 0.0
Ile
3.45IleAla: 3.45 ± 0.313
1.385IleCys: 1.385 ± 0.174
2.284IleAsp: 2.284 ± 0.239
2.09IleGlu: 2.09 ± 0.273
2.478IlePhe: 2.478 ± 0.228
2.017IleGly: 2.017 ± 0.216
1.288IleHis: 1.288 ± 0.161
2.381IleIle: 2.381 ± 0.21
2.235IleLys: 2.235 ± 0.261
4.859IleLeu: 4.859 ± 0.346
1.215IleMet: 1.215 ± 0.14
2.527IleAsn: 2.527 ± 0.279
2.891IlePro: 2.891 ± 0.305
1.871IleGln: 1.871 ± 0.187
2.94IleArg: 2.94 ± 0.24
3.693IleSer: 3.693 ± 0.392
3.11IleThr: 3.11 ± 0.304
3.426IleVal: 3.426 ± 0.316
0.462IleTrp: 0.462 ± 0.084
1.555IleTyr: 1.555 ± 0.243
0.0IleXaa: 0.0 ± 0.0
Lys
2.333LysAla: 2.333 ± 0.252
0.705LysCys: 0.705 ± 0.135
1.895LysAsp: 1.895 ± 0.312
1.968LysGlu: 1.968 ± 0.19
1.434LysPhe: 1.434 ± 0.151
1.968LysGly: 1.968 ± 0.196
1.336LysHis: 1.336 ± 0.193
2.867LysIle: 2.867 ± 0.296
2.284LysLys: 2.284 ± 0.255
4.446LysLeu: 4.446 ± 0.349
1.239LysMet: 1.239 ± 0.136
2.381LysAsn: 2.381 ± 0.261
2.162LysPro: 2.162 ± 0.298
1.847LysGln: 1.847 ± 0.19
2.746LysArg: 2.746 ± 0.246
2.576LysSer: 2.576 ± 0.226
3.232LysThr: 3.232 ± 0.305
1.944LysVal: 1.944 ± 0.226
0.292LysTrp: 0.292 ± 0.078
1.215LysTyr: 1.215 ± 0.172
0.0LysXaa: 0.0 ± 0.0
Leu
7.338LeuAla: 7.338 ± 0.428
2.794LeuCys: 2.794 ± 0.318
4.276LeuAsp: 4.276 ± 0.25
5.807LeuGlu: 5.807 ± 0.416
4.859LeuPhe: 4.859 ± 0.399
5.831LeuGly: 5.831 ± 0.387
2.891LeuHis: 2.891 ± 0.297
3.839LeuIle: 3.839 ± 0.251
4.641LeuLys: 4.641 ± 0.292
9.403LeuLeu: 9.403 ± 0.661
2.114LeuMet: 2.114 ± 0.233
4.544LeuAsn: 4.544 ± 0.312
6.512LeuPro: 6.512 ± 0.425
4.033LeuGln: 4.033 ± 0.359
6.9LeuArg: 6.9 ± 0.56
7.751LeuSer: 7.751 ± 0.347
7.702LeuThr: 7.702 ± 0.414
5.734LeuVal: 5.734 ± 0.474
1.434LeuTrp: 1.434 ± 0.231
3.426LeuTyr: 3.426 ± 0.237
0.0LeuXaa: 0.0 ± 0.0
Met
2.041MetAla: 2.041 ± 0.227
0.607MetCys: 0.607 ± 0.124
0.875MetAsp: 0.875 ± 0.137
1.02MetGlu: 1.02 ± 0.14
1.385MetPhe: 1.385 ± 0.2
1.263MetGly: 1.263 ± 0.196
0.632MetHis: 0.632 ± 0.119
0.923MetIle: 0.923 ± 0.162
0.729MetLys: 0.729 ± 0.109
2.187MetLeu: 2.187 ± 0.219
0.389MetMet: 0.389 ± 0.094
0.51MetAsn: 0.51 ± 0.126
0.826MetPro: 0.826 ± 0.157
0.729MetGln: 0.729 ± 0.137
1.118MetArg: 1.118 ± 0.173
1.628MetSer: 1.628 ± 0.181
1.045MetThr: 1.045 ± 0.114
1.531MetVal: 1.531 ± 0.169
0.364MetTrp: 0.364 ± 0.097
0.85MetTyr: 0.85 ± 0.158
0.0MetXaa: 0.0 ± 0.0
Asn
2.964AsnAla: 2.964 ± 0.235
0.632AsnCys: 0.632 ± 0.128
1.847AsnAsp: 1.847 ± 0.197
1.482AsnGlu: 1.482 ± 0.205
1.531AsnPhe: 1.531 ± 0.236
2.381AsnGly: 2.381 ± 0.23
0.972AsnHis: 0.972 ± 0.139
2.843AsnIle: 2.843 ± 0.238
1.652AsnLys: 1.652 ± 0.175
4.544AsnLeu: 4.544 ± 0.327
0.778AsnMet: 0.778 ± 0.159
1.774AsnAsn: 1.774 ± 0.155
2.405AsnPro: 2.405 ± 0.268
1.361AsnGln: 1.361 ± 0.215
1.822AsnArg: 1.822 ± 0.201
3.402AsnSer: 3.402 ± 0.29
2.794AsnThr: 2.794 ± 0.245
3.28AsnVal: 3.28 ± 0.276
0.437AsnTrp: 0.437 ± 0.107
1.288AsnTyr: 1.288 ± 0.188
0.0AsnXaa: 0.0 ± 0.0
Pro
4.641ProAla: 4.641 ± 0.436
1.288ProCys: 1.288 ± 0.17
3.086ProAsp: 3.086 ± 0.263
3.329ProGlu: 3.329 ± 0.39
2.187ProPhe: 2.187 ± 0.188
4.738ProGly: 4.738 ± 0.365
1.895ProHis: 1.895 ± 0.252
2.77ProIle: 2.77 ± 0.282
2.065ProLys: 2.065 ± 0.275
5.977ProLeu: 5.977 ± 0.345
1.02ProMet: 1.02 ± 0.198
1.992ProAsn: 1.992 ± 0.273
5.831ProPro: 5.831 ± 0.732
2.454ProGln: 2.454 ± 0.274
4.009ProArg: 4.009 ± 0.383
5.224ProSer: 5.224 ± 0.468
4.276ProThr: 4.276 ± 0.369
5.418ProVal: 5.418 ± 0.282
0.85ProTrp: 0.85 ± 0.149
1.288ProTyr: 1.288 ± 0.207
0.0ProXaa: 0.0 ± 0.0
Gln
2.891GlnAla: 2.891 ± 0.362
1.02GlnCys: 1.02 ± 0.147
1.774GlnAsp: 1.774 ± 0.226
1.847GlnGlu: 1.847 ± 0.199
1.506GlnPhe: 1.506 ± 0.289
2.017GlnGly: 2.017 ± 0.223
0.996GlnHis: 0.996 ± 0.149
1.992GlnIle: 1.992 ± 0.191
1.749GlnLys: 1.749 ± 0.224
3.086GlnLeu: 3.086 ± 0.25
0.632GlnMet: 0.632 ± 0.15
1.749GlnAsn: 1.749 ± 0.231
2.357GlnPro: 2.357 ± 0.294
1.725GlnGln: 1.725 ± 0.231
2.624GlnArg: 2.624 ± 0.34
2.43GlnSer: 2.43 ± 0.313
3.061GlnThr: 3.061 ± 0.33
2.138GlnVal: 2.138 ± 0.211
0.413GlnTrp: 0.413 ± 0.123
1.045GlnTyr: 1.045 ± 0.164
0.0GlnXaa: 0.0 ± 0.0
Arg
5.491ArgAla: 5.491 ± 0.362
1.458ArgCys: 1.458 ± 0.172
3.304ArgAsp: 3.304 ± 0.284
2.989ArgGlu: 2.989 ± 0.283
2.09ArgPhe: 2.09 ± 0.213
4.689ArgGly: 4.689 ± 0.394
2.041ArgHis: 2.041 ± 0.222
2.843ArgIle: 2.843 ± 0.298
2.09ArgLys: 2.09 ± 0.201
6.269ArgLeu: 6.269 ± 0.365
0.826ArgMet: 0.826 ± 0.145
1.919ArgAsn: 1.919 ± 0.202
3.693ArgPro: 3.693 ± 0.341
2.235ArgGln: 2.235 ± 0.207
4.033ArgArg: 4.033 ± 0.359
4.058ArgSer: 4.058 ± 0.412
2.673ArgThr: 2.673 ± 0.263
4.738ArgVal: 4.738 ± 0.378
0.85ArgTrp: 0.85 ± 0.124
1.506ArgTyr: 1.506 ± 0.207
0.0ArgXaa: 0.0 ± 0.0
Ser
6.682SerAla: 6.682 ± 0.421
1.604SerCys: 1.604 ± 0.196
3.912SerAsp: 3.912 ± 0.384
3.402SerGlu: 3.402 ± 0.242
2.867SerPhe: 2.867 ± 0.294
4.811SerGly: 4.811 ± 0.405
1.822SerHis: 1.822 ± 0.225
3.572SerIle: 3.572 ± 0.236
2.576SerLys: 2.576 ± 0.258
7.265SerLeu: 7.265 ± 0.403
1.385SerMet: 1.385 ± 0.182
2.6SerAsn: 2.6 ± 0.251
5.054SerPro: 5.054 ± 0.614
2.648SerGln: 2.648 ± 0.291
4.446SerArg: 4.446 ± 0.356
6.779SerSer: 6.779 ± 0.648
3.936SerThr: 3.936 ± 0.267
5.613SerVal: 5.613 ± 0.408
0.899SerTrp: 0.899 ± 0.133
2.017SerTyr: 2.017 ± 0.242
0.0SerXaa: 0.0 ± 0.0
Thr
5.005ThrAla: 5.005 ± 0.478
1.652ThrCys: 1.652 ± 0.3
3.256ThrAsp: 3.256 ± 0.307
3.547ThrGlu: 3.547 ± 0.288
2.746ThrPhe: 2.746 ± 0.278
3.596ThrGly: 3.596 ± 0.237
1.749ThrHis: 1.749 ± 0.232
2.721ThrIle: 2.721 ± 0.271
1.847ThrLys: 1.847 ± 0.275
5.88ThrLeu: 5.88 ± 0.359
0.972ThrMet: 0.972 ± 0.177
2.333ThrAsn: 2.333 ± 0.294
5.224ThrPro: 5.224 ± 0.574
1.968ThrGln: 1.968 ± 0.232
3.28ThrArg: 3.28 ± 0.281
5.297ThrSer: 5.297 ± 0.347
4.957ThrThr: 4.957 ± 0.487
5.734ThrVal: 5.734 ± 0.354
0.996ThrTrp: 0.996 ± 0.137
2.454ThrTyr: 2.454 ± 0.21
0.0ThrXaa: 0.0 ± 0.0
Val
6.074ValAla: 6.074 ± 0.455
2.138ValCys: 2.138 ± 0.303
3.159ValAsp: 3.159 ± 0.328
3.086ValGlu: 3.086 ± 0.211
4.131ValPhe: 4.131 ± 0.286
3.766ValGly: 3.766 ± 0.371
1.822ValHis: 1.822 ± 0.187
3.353ValIle: 3.353 ± 0.316
2.794ValLys: 2.794 ± 0.281
7.022ValLeu: 7.022 ± 0.406
1.652ValMet: 1.652 ± 0.181
2.989ValAsn: 2.989 ± 0.259
4.568ValPro: 4.568 ± 0.431
2.09ValGln: 2.09 ± 0.243
4.106ValArg: 4.106 ± 0.32
5.856ValSer: 5.856 ± 0.455
4.762ValThr: 4.762 ± 0.332
5.224ValVal: 5.224 ± 0.442
0.535ValTrp: 0.535 ± 0.101
2.867ValTyr: 2.867 ± 0.28
0.0ValXaa: 0.0 ± 0.0
Trp
1.045TrpAla: 1.045 ± 0.148
0.364TrpCys: 0.364 ± 0.095
0.389TrpAsp: 0.389 ± 0.102
0.486TrpGlu: 0.486 ± 0.104
0.778TrpPhe: 0.778 ± 0.155
0.51TrpGly: 0.51 ± 0.108
0.316TrpHis: 0.316 ± 0.093
0.632TrpIle: 0.632 ± 0.123
0.559TrpLys: 0.559 ± 0.113
1.725TrpLeu: 1.725 ± 0.241
0.292TrpMet: 0.292 ± 0.07
0.656TrpAsn: 0.656 ± 0.134
0.705TrpPro: 0.705 ± 0.123
0.583TrpGln: 0.583 ± 0.116
0.656TrpArg: 0.656 ± 0.139
0.632TrpSer: 0.632 ± 0.121
0.705TrpThr: 0.705 ± 0.107
0.656TrpVal: 0.656 ± 0.115
0.024TrpTrp: 0.024 ± 0.025
0.292TrpTyr: 0.292 ± 0.077
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.697TyrAla: 2.697 ± 0.228
1.069TyrCys: 1.069 ± 0.172
1.409TyrAsp: 1.409 ± 0.166
1.336TyrGlu: 1.336 ± 0.19
1.604TyrPhe: 1.604 ± 0.167
1.968TyrGly: 1.968 ± 0.201
0.729TyrHis: 0.729 ± 0.137
1.579TyrIle: 1.579 ± 0.213
1.142TyrLys: 1.142 ± 0.171
3.839TyrLeu: 3.839 ± 0.268
0.826TyrMet: 0.826 ± 0.161
1.361TyrAsn: 1.361 ± 0.201
1.263TyrPro: 1.263 ± 0.182
1.142TyrGln: 1.142 ± 0.171
1.798TyrArg: 1.798 ± 0.189
2.187TyrSer: 2.187 ± 0.227
1.506TyrThr: 1.506 ± 0.174
2.77TyrVal: 2.77 ± 0.243
0.364TyrTrp: 0.364 ± 0.121
1.069TyrTyr: 1.069 ± 0.193
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 95 proteins (41158 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski