Amino acid dipepetide frequency for San Bernardo virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.417AlaAla: 4.417 ± 1.615
0.34AlaCys: 0.34 ± 0.847
2.039AlaAsp: 2.039 ± 1.547
4.417AlaGlu: 4.417 ± 0.75
3.058AlaPhe: 3.058 ± 0.968
2.718AlaGly: 2.718 ± 1.185
1.359AlaHis: 1.359 ± 0.724
2.039AlaIle: 2.039 ± 1.061
1.359AlaLys: 1.359 ± 1.084
8.835AlaLeu: 8.835 ± 3.673
3.058AlaMet: 3.058 ± 0.538
0.68AlaAsn: 0.68 ± 0.718
1.359AlaPro: 1.359 ± 1.084
1.019AlaGln: 1.019 ± 0.543
2.379AlaArg: 2.379 ± 2.174
3.738AlaSer: 3.738 ± 0.543
4.077AlaThr: 4.077 ± 1.415
4.757AlaVal: 4.757 ± 2.914
0.34AlaTrp: 0.34 ± 0.181
3.398AlaTyr: 3.398 ± 1.123
0.0AlaXaa: 0.0 ± 0.0
Cys
0.68CysAla: 0.68 ± 0.362
0.0CysCys: 0.0 ± 0.0
1.019CysAsp: 1.019 ± 0.543
1.019CysGlu: 1.019 ± 0.616
1.019CysPhe: 1.019 ± 0.543
0.34CysGly: 0.34 ± 0.181
1.359CysHis: 1.359 ± 1.436
0.34CysIle: 0.34 ± 0.181
1.359CysLys: 1.359 ± 0.724
2.718CysLeu: 2.718 ± 0.825
1.359CysMet: 1.359 ± 0.555
1.359CysAsn: 1.359 ± 0.724
0.68CysPro: 0.68 ± 0.362
0.68CysGln: 0.68 ± 0.362
2.379CysArg: 2.379 ± 1.267
2.379CysSer: 2.379 ± 1.267
0.34CysThr: 0.34 ± 0.181
2.039CysVal: 2.039 ± 1.232
0.0CysTrp: 0.0 ± 0.0
0.34CysTyr: 0.34 ± 0.847
0.0CysXaa: 0.0 ± 0.0
Asp
6.116AspAla: 6.116 ± 2.49
2.379AspCys: 2.379 ± 0.699
4.417AspAsp: 4.417 ± 2.354
2.718AspGlu: 2.718 ± 1.939
4.757AspPhe: 4.757 ± 0.105
3.058AspGly: 3.058 ± 1.629
2.039AspHis: 2.039 ± 1.086
2.718AspIle: 2.718 ± 1.448
2.718AspLys: 2.718 ± 0.825
3.398AspLeu: 3.398 ± 0.509
2.039AspMet: 2.039 ± 1.086
1.019AspAsn: 1.019 ± 0.543
2.039AspPro: 2.039 ± 1.232
1.019AspGln: 1.019 ± 0.543
3.738AspArg: 3.738 ± 1.751
4.757AspSer: 4.757 ± 1.79
3.398AspThr: 3.398 ± 1.811
4.757AspVal: 4.757 ± 0.105
0.68AspTrp: 0.68 ± 0.718
2.718AspTyr: 2.718 ± 1.448
0.0AspXaa: 0.0 ± 0.0
Glu
2.379GluAla: 2.379 ± 1.267
1.359GluCys: 1.359 ± 0.724
2.379GluAsp: 2.379 ± 1.267
2.718GluGlu: 2.718 ± 1.448
2.718GluPhe: 2.718 ± 3.836
2.718GluGly: 2.718 ± 0.825
1.699GluHis: 1.699 ± 0.551
5.097GluIle: 5.097 ± 1.519
7.136GluLys: 7.136 ± 1.17
6.456GluLeu: 6.456 ± 1.893
1.019GluMet: 1.019 ± 0.616
3.738GluAsn: 3.738 ± 1.465
0.68GluPro: 0.68 ± 0.362
2.039GluGln: 2.039 ± 1.086
3.398GluArg: 3.398 ± 1.101
2.379GluSer: 2.379 ± 0.699
2.379GluThr: 2.379 ± 1.366
4.757GluVal: 4.757 ± 1.095
0.68GluTrp: 0.68 ± 0.362
3.058GluTyr: 3.058 ± 0.538
0.0GluXaa: 0.0 ± 0.0
Phe
2.379PheAla: 2.379 ± 1.159
2.379PheCys: 2.379 ± 1.159
4.417PheAsp: 4.417 ± 0.75
3.058PheGlu: 3.058 ± 0.968
5.097PhePhe: 5.097 ± 2.263
3.398PheGly: 3.398 ± 1.123
1.699PheHis: 1.699 ± 1.326
2.718PheIle: 2.718 ± 2.096
1.699PheLys: 1.699 ± 0.905
6.456PheLeu: 6.456 ± 1.828
2.379PheMet: 2.379 ± 1.26
3.738PheAsn: 3.738 ± 1.284
1.699PhePro: 1.699 ± 0.551
1.359PheGln: 1.359 ± 0.724
3.738PheArg: 3.738 ± 0.643
5.437PheSer: 5.437 ± 1.793
3.058PheThr: 3.058 ± 1.94
6.116PheVal: 6.116 ± 2.868
0.68PheTrp: 0.68 ± 0.362
2.039PheTyr: 2.039 ± 3.12
0.0PheXaa: 0.0 ± 0.0
Gly
2.379GlyAla: 2.379 ± 2.552
0.68GlyCys: 0.68 ± 0.718
4.417GlyAsp: 4.417 ± 2.354
1.699GlyGlu: 1.699 ± 0.551
1.699GlyPhe: 1.699 ± 0.551
2.379GlyGly: 2.379 ± 1.267
0.68GlyHis: 0.68 ± 0.362
3.738GlyIle: 3.738 ± 1.284
3.058GlyLys: 3.058 ± 0.538
3.738GlyLeu: 3.738 ± 1.91
1.359GlyMet: 1.359 ± 0.555
1.699GlyAsn: 1.699 ± 0.551
0.68GlyPro: 0.68 ± 0.362
1.359GlyGln: 1.359 ± 0.555
1.699GlyArg: 1.699 ± 0.551
2.039GlySer: 2.039 ± 2.304
1.699GlyThr: 1.699 ± 0.551
5.437GlyVal: 5.437 ± 2.138
0.0GlyTrp: 0.0 ± 0.0
1.359GlyTyr: 1.359 ± 1.084
0.0GlyXaa: 0.0 ± 0.0
His
1.359HisAla: 1.359 ± 1.436
1.359HisCys: 1.359 ± 1.436
2.039HisAsp: 2.039 ± 0.603
1.359HisGlu: 1.359 ± 1.084
1.359HisPhe: 1.359 ± 0.724
0.34HisGly: 0.34 ± 0.181
0.34HisHis: 0.34 ± 0.181
1.019HisIle: 1.019 ± 0.543
0.34HisLys: 0.34 ± 0.181
0.68HisLeu: 0.68 ± 0.362
0.68HisMet: 0.68 ± 0.362
1.359HisAsn: 1.359 ± 0.724
1.699HisPro: 1.699 ± 2.277
1.019HisGln: 1.019 ± 1.139
1.359HisArg: 1.359 ± 0.724
3.398HisSer: 3.398 ± 1.839
2.039HisThr: 2.039 ± 0.603
3.738HisVal: 3.738 ± 1.284
0.0HisTrp: 0.0 ± 0.0
0.34HisTyr: 0.34 ± 0.847
0.0HisXaa: 0.0 ± 0.0
Ile
2.718IleAla: 2.718 ± 0.825
0.68IleCys: 0.68 ± 0.362
2.718IleAsp: 2.718 ± 0.825
5.097IleGlu: 5.097 ± 1.519
3.398IlePhe: 3.398 ± 0.509
2.718IleGly: 2.718 ± 2.096
0.68IleHis: 0.68 ± 0.362
1.359IleIle: 1.359 ± 0.724
3.058IleLys: 3.058 ± 1.629
1.699IleLeu: 1.699 ± 0.551
1.359IleMet: 1.359 ± 1.194
2.039IleAsn: 2.039 ± 1.086
2.379IlePro: 2.379 ± 0.699
1.699IleGln: 1.699 ± 1.326
5.097IleArg: 5.097 ± 2.036
4.757IleSer: 4.757 ± 1.399
2.718IleThr: 2.718 ± 1.939
4.417IleVal: 4.417 ± 0.75
0.0IleTrp: 0.0 ± 0.0
1.359IleTyr: 1.359 ± 0.555
0.0IleXaa: 0.0 ± 0.0
Lys
2.718LysAla: 2.718 ± 0.621
1.359LysCys: 1.359 ± 0.724
4.417LysAsp: 4.417 ± 1.619
4.077LysGlu: 4.077 ± 2.173
4.417LysPhe: 4.417 ± 2.242
2.039LysGly: 2.039 ± 1.086
0.68LysHis: 0.68 ± 0.362
4.417LysIle: 4.417 ± 1.615
3.738LysLys: 3.738 ± 1.14
6.796LysLeu: 6.796 ± 0.603
2.039LysMet: 2.039 ± 0.603
3.738LysAsn: 3.738 ± 0.643
3.398LysPro: 3.398 ± 1.811
1.359LysGln: 1.359 ± 1.084
3.058LysArg: 3.058 ± 1.242
4.077LysSer: 4.077 ± 1.415
3.738LysThr: 3.738 ± 1.465
4.077LysVal: 4.077 ± 1.206
1.019LysTrp: 1.019 ± 1.36
2.379LysTyr: 2.379 ± 1.095
0.0LysXaa: 0.0 ± 0.0
Leu
5.437LeuAla: 5.437 ± 4.104
2.039LeuCys: 2.039 ± 1.086
3.058LeuAsp: 3.058 ± 1.629
6.116LeuGlu: 6.116 ± 2.49
3.738LeuPhe: 3.738 ± 0.643
2.718LeuGly: 2.718 ± 0.621
2.718LeuHis: 2.718 ± 1.156
5.776LeuIle: 5.776 ± 1.79
5.437LeuLys: 5.437 ± 1.65
8.835LeuLeu: 8.835 ± 0.563
2.379LeuMet: 2.379 ± 0.699
6.456LeuAsn: 6.456 ± 4.244
2.379LeuPro: 2.379 ± 1.159
1.699LeuGln: 1.699 ± 2.353
6.456LeuArg: 6.456 ± 1.893
7.475LeuSer: 7.475 ± 0.781
3.738LeuThr: 3.738 ± 2.11
7.475LeuVal: 7.475 ± 4.326
0.68LeuTrp: 0.68 ± 1.22
3.398LeuTyr: 3.398 ± 1.751
0.0LeuXaa: 0.0 ± 0.0
Met
3.058MetAla: 3.058 ± 1.242
0.68MetCys: 0.68 ± 0.362
0.68MetAsp: 0.68 ± 0.362
0.68MetGlu: 0.68 ± 1.694
3.058MetPhe: 3.058 ± 1.091
1.019MetGly: 1.019 ± 1.36
0.34MetHis: 0.34 ± 0.181
1.019MetIle: 1.019 ± 0.616
0.68MetLys: 0.68 ± 0.718
3.058MetLeu: 3.058 ± 1.242
0.68MetMet: 0.68 ± 0.362
2.039MetAsn: 2.039 ± 1.086
1.019MetPro: 1.019 ± 0.543
0.34MetGln: 0.34 ± 0.181
1.699MetArg: 1.699 ± 0.905
3.058MetSer: 3.058 ± 1.242
1.359MetThr: 1.359 ± 0.555
2.718MetVal: 2.718 ± 4.247
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
2.718AsnAla: 2.718 ± 2.053
1.699AsnCys: 1.699 ± 0.905
3.738AsnAsp: 3.738 ± 0.543
2.039AsnGlu: 2.039 ± 0.603
2.379AsnPhe: 2.379 ± 0.699
3.738AsnGly: 3.738 ± 1.284
1.359AsnHis: 1.359 ± 0.555
4.077AsnIle: 4.077 ± 1.206
3.398AsnLys: 3.398 ± 3.26
3.738AsnLeu: 3.738 ± 1.14
1.019AsnMet: 1.019 ± 0.543
1.359AsnAsn: 1.359 ± 0.555
2.718AsnPro: 2.718 ± 1.448
0.68AsnGln: 0.68 ± 1.22
3.738AsnArg: 3.738 ± 2.11
4.077AsnSer: 4.077 ± 2.121
3.058AsnThr: 3.058 ± 3.371
3.058AsnVal: 3.058 ± 0.968
0.0AsnTrp: 0.0 ± 0.0
3.398AsnTyr: 3.398 ± 1.101
0.0AsnXaa: 0.0 ± 0.0
Pro
1.359ProAla: 1.359 ± 1.194
0.68ProCys: 0.68 ± 0.362
2.039ProAsp: 2.039 ± 1.232
1.359ProGlu: 1.359 ± 1.084
3.398ProPhe: 3.398 ± 2.651
1.699ProGly: 1.699 ± 1.057
0.34ProHis: 0.34 ± 0.181
1.019ProIle: 1.019 ± 0.616
3.058ProLys: 3.058 ± 1.923
2.379ProLeu: 2.379 ± 0.699
1.019ProMet: 1.019 ± 1.139
2.379ProAsn: 2.379 ± 1.267
0.68ProPro: 0.68 ± 0.362
0.68ProGln: 0.68 ± 1.22
2.039ProArg: 2.039 ± 1.086
3.398ProSer: 3.398 ± 1.771
2.379ProThr: 2.379 ± 0.699
4.417ProVal: 4.417 ± 1.619
0.34ProTrp: 0.34 ± 0.181
2.039ProTyr: 2.039 ± 1.232
0.0ProXaa: 0.0 ± 0.0
Gln
2.039GlnAla: 2.039 ± 2.279
0.34GlnCys: 0.34 ± 0.181
1.359GlnAsp: 1.359 ± 0.555
2.039GlnGlu: 2.039 ± 0.603
1.359GlnPhe: 1.359 ± 0.724
1.019GlnGly: 1.019 ± 0.616
0.68GlnHis: 0.68 ± 1.22
0.68GlnIle: 0.68 ± 0.718
1.359GlnLys: 1.359 ± 0.724
3.738GlnLeu: 3.738 ± 1.71
0.34GlnMet: 0.34 ± 0.181
1.359GlnAsn: 1.359 ± 0.555
0.34GlnPro: 0.34 ± 0.181
0.34GlnGln: 0.34 ± 0.181
1.699GlnArg: 1.699 ± 0.905
2.379GlnSer: 2.379 ± 2.217
2.379GlnThr: 2.379 ± 0.74
0.34GlnVal: 0.34 ± 0.181
0.0GlnTrp: 0.0 ± 0.0
1.019GlnTyr: 1.019 ± 0.543
0.0GlnXaa: 0.0 ± 0.0
Arg
2.379ArgAla: 2.379 ± 1.095
0.34ArgCys: 0.34 ± 0.181
2.718ArgAsp: 2.718 ± 1.448
4.077ArgGlu: 4.077 ± 1.45
2.379ArgPhe: 2.379 ± 0.699
1.699ArgGly: 1.699 ± 0.905
2.039ArgHis: 2.039 ± 0.603
2.718ArgIle: 2.718 ± 0.825
4.757ArgLys: 4.757 ± 1.399
6.796ArgLeu: 6.796 ± 2.849
1.019ArgMet: 1.019 ± 0.781
4.417ArgAsn: 4.417 ± 3.044
3.058ArgPro: 3.058 ± 1.004
1.019ArgGln: 1.019 ± 0.616
2.039ArgArg: 2.039 ± 1.086
4.077ArgSer: 4.077 ± 1.45
3.738ArgThr: 3.738 ± 0.643
5.437ArgVal: 5.437 ± 3.164
0.0ArgTrp: 0.0 ± 0.0
2.379ArgTyr: 2.379 ± 0.699
0.0ArgXaa: 0.0 ± 0.0
Ser
4.077SerAla: 4.077 ± 1.677
1.019SerCys: 1.019 ± 0.543
3.398SerAsp: 3.398 ± 1.839
5.097SerGlu: 5.097 ± 3.08
7.136SerPhe: 7.136 ± 1.229
4.077SerGly: 4.077 ± 1.677
1.699SerHis: 1.699 ± 1.326
3.398SerIle: 3.398 ± 1.123
5.097SerLys: 5.097 ± 1.519
7.475SerLeu: 7.475 ± 1.974
1.019SerMet: 1.019 ± 0.543
5.437SerAsn: 5.437 ± 1.65
4.417SerPro: 4.417 ± 2.913
2.718SerGln: 2.718 ± 0.825
2.718SerArg: 2.718 ± 1.156
7.815SerSer: 7.815 ± 3.716
5.776SerThr: 5.776 ± 1.148
5.776SerVal: 5.776 ± 1.439
0.68SerTrp: 0.68 ± 0.362
3.398SerTyr: 3.398 ± 1.346
0.0SerXaa: 0.0 ± 0.0
Thr
3.398ThrAla: 3.398 ± 1.811
0.34ThrCys: 0.34 ± 0.181
4.077ThrAsp: 4.077 ± 1.45
3.058ThrGlu: 3.058 ± 1.004
5.097ThrPhe: 5.097 ± 1.045
1.699ThrGly: 1.699 ± 1.326
1.359ThrHis: 1.359 ± 1.909
2.039ThrIle: 2.039 ± 1.086
5.437ThrLys: 5.437 ± 3.164
4.077ThrLeu: 4.077 ± 3.178
0.68ThrMet: 0.68 ± 0.362
3.398ThrAsn: 3.398 ± 4.88
2.039ThrPro: 2.039 ± 1.061
1.359ThrGln: 1.359 ± 0.555
3.398ThrArg: 3.398 ± 1.771
4.417ThrSer: 4.417 ± 1.619
3.738ThrThr: 3.738 ± 0.643
4.757ThrVal: 4.757 ± 2.318
0.34ThrTrp: 0.34 ± 0.181
2.039ThrTyr: 2.039 ± 1.232
0.0ThrXaa: 0.0 ± 0.0
Val
4.757ValAla: 4.757 ± 2.732
2.379ValCys: 2.379 ± 0.699
6.456ValAsp: 6.456 ± 2.667
4.077ValGlu: 4.077 ± 0.629
4.077ValPhe: 4.077 ± 2.4
2.039ValGly: 2.039 ± 1.061
3.058ValHis: 3.058 ± 1.242
4.417ValIle: 4.417 ± 0.282
7.815ValLys: 7.815 ± 1.104
5.437ValLeu: 5.437 ± 4.104
2.718ValMet: 2.718 ± 2.053
3.738ValAsn: 3.738 ± 0.643
4.757ValPro: 4.757 ± 1.095
2.379ValGln: 2.379 ± 0.699
3.738ValArg: 3.738 ± 0.543
9.514ValSer: 9.514 ± 5.465
3.738ValThr: 3.738 ± 1.284
9.514ValVal: 9.514 ± 5.827
0.0ValTrp: 0.0 ± 0.0
4.077ValTyr: 4.077 ± 1.206
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.34TrpAsp: 0.34 ± 0.181
0.68TrpGlu: 0.68 ± 0.362
0.68TrpPhe: 0.68 ± 0.718
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
0.34TrpLeu: 0.34 ± 0.181
0.0TrpMet: 0.0 ± 0.0
0.34TrpAsn: 0.34 ± 0.181
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.34TrpArg: 0.34 ± 0.181
0.34TrpSer: 0.34 ± 0.181
0.68TrpThr: 0.68 ± 0.362
1.019TrpVal: 1.019 ± 2.535
0.0TrpTrp: 0.0 ± 0.0
0.68TrpTyr: 0.68 ± 0.718
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.019TyrAla: 1.019 ± 0.616
1.359TyrCys: 1.359 ± 0.724
4.757TyrAsp: 4.757 ± 1.637
3.398TyrGlu: 3.398 ± 1.123
2.718TyrPhe: 2.718 ± 2.387
2.379TyrGly: 2.379 ± 1.159
1.699TyrHis: 1.699 ± 0.551
1.359TyrIle: 1.359 ± 0.555
2.039TyrLys: 2.039 ± 0.603
1.359TyrLeu: 1.359 ± 1.084
0.68TyrMet: 0.68 ± 0.718
1.699TyrAsn: 1.699 ± 0.551
0.68TyrPro: 0.68 ± 0.718
2.039TyrGln: 2.039 ± 1.232
2.718TyrArg: 2.718 ± 0.825
2.718TyrSer: 2.718 ± 1.448
2.718TyrThr: 2.718 ± 1.939
4.077TyrVal: 4.077 ± 1.677
0.0TyrTrp: 0.0 ± 0.0
1.019TyrTyr: 1.019 ± 0.616
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (2944 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski