Amino acid dipepetide frequency for Pseudomonas phage tabernarius

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.607AlaAla: 10.607 ± 1.04
0.737AlaCys: 0.737 ± 0.188
6.138AlaAsp: 6.138 ± 0.576
6.089AlaGlu: 6.089 ± 1.022
3.781AlaPhe: 3.781 ± 0.425
7.022AlaGly: 7.022 ± 0.733
1.522AlaHis: 1.522 ± 0.325
5.598AlaIle: 5.598 ± 0.476
5.795AlaLys: 5.795 ± 1.07
7.022AlaLeu: 7.022 ± 0.654
3.192AlaMet: 3.192 ± 0.469
4.37AlaAsn: 4.37 ± 0.698
3.732AlaPro: 3.732 ± 0.527
3.241AlaGln: 3.241 ± 0.367
4.125AlaArg: 4.125 ± 0.474
6.089AlaSer: 6.089 ± 0.663
6.678AlaThr: 6.678 ± 0.685
7.317AlaVal: 7.317 ± 0.594
1.08AlaTrp: 1.08 ± 0.247
3.045AlaTyr: 3.045 ± 0.388
0.0AlaXaa: 0.0 ± 0.0
Cys
1.228CysAla: 1.228 ± 0.243
0.147CysCys: 0.147 ± 0.081
0.54CysAsp: 0.54 ± 0.152
0.589CysGlu: 0.589 ± 0.178
0.393CysPhe: 0.393 ± 0.131
0.491CysGly: 0.491 ± 0.175
0.196CysHis: 0.196 ± 0.104
0.344CysIle: 0.344 ± 0.108
0.786CysLys: 0.786 ± 0.185
0.687CysLeu: 0.687 ± 0.215
0.147CysMet: 0.147 ± 0.079
0.491CysAsn: 0.491 ± 0.185
0.491CysPro: 0.491 ± 0.149
0.246CysGln: 0.246 ± 0.112
0.835CysArg: 0.835 ± 0.221
0.982CysSer: 0.982 ± 0.255
0.442CysThr: 0.442 ± 0.173
1.031CysVal: 1.031 ± 0.215
0.049CysTrp: 0.049 ± 0.05
0.246CysTyr: 0.246 ± 0.105
0.0CysXaa: 0.0 ± 0.0
Asp
6.187AspAla: 6.187 ± 0.683
0.638AspCys: 0.638 ± 0.156
4.616AspAsp: 4.616 ± 0.585
4.272AspGlu: 4.272 ± 0.451
2.848AspPhe: 2.848 ± 0.394
4.812AspGly: 4.812 ± 0.478
1.129AspHis: 1.129 ± 0.196
2.652AspIle: 2.652 ± 0.387
3.192AspLys: 3.192 ± 0.423
4.665AspLeu: 4.665 ± 0.507
1.621AspMet: 1.621 ± 0.309
1.866AspAsn: 1.866 ± 0.35
4.076AspPro: 4.076 ± 0.545
1.866AspGln: 1.866 ± 0.325
2.112AspArg: 2.112 ± 0.345
4.174AspSer: 4.174 ± 0.429
2.652AspThr: 2.652 ± 0.398
3.585AspVal: 3.585 ± 0.424
0.835AspTrp: 0.835 ± 0.224
2.062AspTyr: 2.062 ± 0.302
0.0AspXaa: 0.0 ± 0.0
Glu
5.795GluAla: 5.795 ± 1.173
0.491GluCys: 0.491 ± 0.152
3.83GluAsp: 3.83 ± 0.412
3.29GluGlu: 3.29 ± 0.478
2.75GluPhe: 2.75 ± 0.353
3.929GluGly: 3.929 ± 0.432
1.571GluHis: 1.571 ± 0.297
3.045GluIle: 3.045 ± 0.396
3.192GluLys: 3.192 ± 0.714
6.629GluLeu: 6.629 ± 0.588
2.21GluMet: 2.21 ± 0.356
3.241GluAsn: 3.241 ± 0.493
2.161GluPro: 2.161 ± 0.342
2.554GluGln: 2.554 ± 0.384
3.536GluArg: 3.536 ± 0.518
4.518GluSer: 4.518 ± 0.496
2.75GluThr: 2.75 ± 0.317
3.094GluVal: 3.094 ± 0.341
0.786GluTrp: 0.786 ± 0.173
1.817GluTyr: 1.817 ± 0.3
0.0GluXaa: 0.0 ± 0.0
Phe
4.125PheAla: 4.125 ± 0.483
0.54PheCys: 0.54 ± 0.156
3.094PheAsp: 3.094 ± 0.455
2.455PheGlu: 2.455 ± 0.415
1.228PhePhe: 1.228 ± 0.339
4.125PheGly: 4.125 ± 0.415
0.589PheHis: 0.589 ± 0.183
2.112PheIle: 2.112 ± 0.312
2.062PheLys: 2.062 ± 0.349
2.799PheLeu: 2.799 ± 0.394
1.031PheMet: 1.031 ± 0.231
2.013PheAsn: 2.013 ± 0.34
1.719PhePro: 1.719 ± 0.313
1.179PheGln: 1.179 ± 0.244
1.964PheArg: 1.964 ± 0.342
3.29PheSer: 3.29 ± 0.432
2.161PheThr: 2.161 ± 0.387
4.027PheVal: 4.027 ± 0.459
0.687PheTrp: 0.687 ± 0.175
1.768PheTyr: 1.768 ± 0.283
0.0PheXaa: 0.0 ± 0.0
Gly
7.268GlyAla: 7.268 ± 0.877
0.687GlyCys: 0.687 ± 0.197
4.567GlyAsp: 4.567 ± 0.412
4.076GlyGlu: 4.076 ± 0.57
4.616GlyPhe: 4.616 ± 0.552
5.009GlyGly: 5.009 ± 0.756
1.031GlyHis: 1.031 ± 0.268
4.125GlyIle: 4.125 ± 0.441
4.42GlyLys: 4.42 ± 0.412
5.451GlyLeu: 5.451 ± 0.577
2.406GlyMet: 2.406 ± 0.275
3.437GlyAsn: 3.437 ± 0.454
2.013GlyPro: 2.013 ± 0.331
2.848GlyGln: 2.848 ± 0.409
3.683GlyArg: 3.683 ± 0.397
4.665GlySer: 4.665 ± 0.557
4.812GlyThr: 4.812 ± 0.595
6.777GlyVal: 6.777 ± 0.662
1.866GlyTrp: 1.866 ± 0.326
2.21GlyTyr: 2.21 ± 0.384
0.0GlyXaa: 0.0 ± 0.0
His
1.424HisAla: 1.424 ± 0.269
0.196HisCys: 0.196 ± 0.108
1.08HisAsp: 1.08 ± 0.22
1.08HisGlu: 1.08 ± 0.219
0.884HisPhe: 0.884 ± 0.266
1.031HisGly: 1.031 ± 0.225
0.196HisHis: 0.196 ± 0.106
0.982HisIle: 0.982 ± 0.195
0.933HisLys: 0.933 ± 0.22
1.571HisLeu: 1.571 ± 0.284
0.442HisMet: 0.442 ± 0.141
0.786HisAsn: 0.786 ± 0.232
1.08HisPro: 1.08 ± 0.22
0.786HisGln: 0.786 ± 0.179
1.228HisArg: 1.228 ± 0.238
0.982HisSer: 0.982 ± 0.189
1.375HisThr: 1.375 ± 0.282
1.129HisVal: 1.129 ± 0.276
0.295HisTrp: 0.295 ± 0.096
0.884HisTyr: 0.884 ± 0.223
0.0HisXaa: 0.0 ± 0.0
Ile
4.665IleAla: 4.665 ± 0.487
0.589IleCys: 0.589 ± 0.136
4.027IleAsp: 4.027 ± 0.455
3.388IleGlu: 3.388 ± 0.454
2.161IlePhe: 2.161 ± 0.313
4.027IleGly: 4.027 ± 0.569
0.589IleHis: 0.589 ± 0.178
2.946IleIle: 2.946 ± 0.35
3.094IleLys: 3.094 ± 0.386
3.192IleLeu: 3.192 ± 0.391
1.326IleMet: 1.326 ± 0.256
2.848IleAsn: 2.848 ± 0.411
2.701IlePro: 2.701 ± 0.309
1.719IleGln: 1.719 ± 0.283
3.094IleArg: 3.094 ± 0.406
3.339IleSer: 3.339 ± 0.402
3.487IleThr: 3.487 ± 0.495
2.848IleVal: 2.848 ± 0.375
0.295IleTrp: 0.295 ± 0.114
1.326IleTyr: 1.326 ± 0.337
0.0IleXaa: 0.0 ± 0.0
Lys
7.12LysAla: 7.12 ± 0.894
0.589LysCys: 0.589 ± 0.168
3.29LysAsp: 3.29 ± 0.478
4.42LysGlu: 4.42 ± 0.745
1.866LysPhe: 1.866 ± 0.314
4.469LysGly: 4.469 ± 0.58
1.179LysHis: 1.179 ± 0.292
2.013LysIle: 2.013 ± 0.412
3.929LysLys: 3.929 ± 0.695
4.469LysLeu: 4.469 ± 0.548
2.259LysMet: 2.259 ± 0.392
2.308LysAsn: 2.308 ± 0.39
2.406LysPro: 2.406 ± 0.472
2.161LysGln: 2.161 ± 0.398
3.143LysArg: 3.143 ± 0.475
2.799LysSer: 2.799 ± 0.453
3.143LysThr: 3.143 ± 0.419
4.223LysVal: 4.223 ± 0.591
0.638LysTrp: 0.638 ± 0.18
1.964LysTyr: 1.964 ± 0.349
0.0LysXaa: 0.0 ± 0.0
Leu
7.366LeuAla: 7.366 ± 0.686
0.786LeuCys: 0.786 ± 0.197
4.174LeuAsp: 4.174 ± 0.378
4.42LeuGlu: 4.42 ± 0.541
2.995LeuPhe: 2.995 ± 0.373
4.616LeuGly: 4.616 ± 0.484
1.375LeuHis: 1.375 ± 0.339
3.929LeuIle: 3.929 ± 0.446
4.616LeuLys: 4.616 ± 0.531
5.5LeuLeu: 5.5 ± 0.535
2.308LeuMet: 2.308 ± 0.286
4.42LeuAsn: 4.42 ± 0.513
3.781LeuPro: 3.781 ± 0.414
2.946LeuGln: 2.946 ± 0.454
3.29LeuArg: 3.29 ± 0.439
6.531LeuSer: 6.531 ± 0.723
4.812LeuThr: 4.812 ± 0.465
4.567LeuVal: 4.567 ± 0.456
0.687LeuTrp: 0.687 ± 0.204
1.964LeuTyr: 1.964 ± 0.303
0.0LeuXaa: 0.0 ± 0.0
Met
3.192MetAla: 3.192 ± 0.421
0.344MetCys: 0.344 ± 0.124
1.768MetAsp: 1.768 ± 0.332
1.031MetGlu: 1.031 ± 0.216
1.129MetPhe: 1.129 ± 0.214
1.621MetGly: 1.621 ± 0.353
0.737MetHis: 0.737 ± 0.206
1.375MetIle: 1.375 ± 0.272
2.062MetLys: 2.062 ± 0.298
1.964MetLeu: 1.964 ± 0.303
0.687MetMet: 0.687 ± 0.231
1.375MetAsn: 1.375 ± 0.262
1.277MetPro: 1.277 ± 0.269
1.129MetGln: 1.129 ± 0.259
1.67MetArg: 1.67 ± 0.339
2.455MetSer: 2.455 ± 0.342
2.21MetThr: 2.21 ± 0.31
1.719MetVal: 1.719 ± 0.302
0.246MetTrp: 0.246 ± 0.108
0.786MetTyr: 0.786 ± 0.201
0.0MetXaa: 0.0 ± 0.0
Asn
5.058AsnAla: 5.058 ± 0.563
0.638AsnCys: 0.638 ± 0.181
2.701AsnAsp: 2.701 ± 0.358
2.897AsnGlu: 2.897 ± 0.388
2.848AsnPhe: 2.848 ± 0.392
4.616AsnGly: 4.616 ± 0.719
0.933AsnHis: 0.933 ± 0.266
2.554AsnIle: 2.554 ± 0.408
2.161AsnLys: 2.161 ± 0.383
3.045AsnLeu: 3.045 ± 0.433
0.786AsnMet: 0.786 ± 0.184
2.062AsnAsn: 2.062 ± 0.355
3.192AsnPro: 3.192 ± 0.419
1.866AsnGln: 1.866 ± 0.272
2.308AsnArg: 2.308 ± 0.344
2.21AsnSer: 2.21 ± 0.396
2.062AsnThr: 2.062 ± 0.376
3.781AsnVal: 3.781 ± 0.445
0.589AsnTrp: 0.589 ± 0.176
0.884AsnTyr: 0.884 ± 0.218
0.0AsnXaa: 0.0 ± 0.0
Pro
4.272ProAla: 4.272 ± 0.628
0.344ProCys: 0.344 ± 0.15
2.455ProAsp: 2.455 ± 0.307
3.29ProGlu: 3.29 ± 0.515
1.964ProPhe: 1.964 ± 0.272
2.897ProGly: 2.897 ± 0.307
1.031ProHis: 1.031 ± 0.269
2.357ProIle: 2.357 ± 0.41
2.799ProLys: 2.799 ± 0.35
2.848ProLeu: 2.848 ± 0.398
0.933ProMet: 0.933 ± 0.244
2.259ProAsn: 2.259 ± 0.305
1.473ProPro: 1.473 ± 0.335
1.473ProGln: 1.473 ± 0.332
1.964ProArg: 1.964 ± 0.288
2.897ProSer: 2.897 ± 0.39
2.701ProThr: 2.701 ± 0.336
3.585ProVal: 3.585 ± 0.429
0.54ProTrp: 0.54 ± 0.184
1.375ProTyr: 1.375 ± 0.278
0.0ProXaa: 0.0 ± 0.0
Gln
3.634GlnAla: 3.634 ± 0.479
0.246GlnCys: 0.246 ± 0.096
1.129GlnAsp: 1.129 ± 0.256
1.719GlnGlu: 1.719 ± 0.282
2.013GlnPhe: 2.013 ± 0.247
3.143GlnGly: 3.143 ± 0.423
0.638GlnHis: 0.638 ± 0.222
1.915GlnIle: 1.915 ± 0.343
2.455GlnLys: 2.455 ± 0.387
3.683GlnLeu: 3.683 ± 0.413
0.835GlnMet: 0.835 ± 0.172
2.406GlnAsn: 2.406 ± 0.424
1.424GlnPro: 1.424 ± 0.231
2.357GlnGln: 2.357 ± 0.349
1.571GlnArg: 1.571 ± 0.297
2.406GlnSer: 2.406 ± 0.444
2.308GlnThr: 2.308 ± 0.292
2.799GlnVal: 2.799 ± 0.371
0.786GlnTrp: 0.786 ± 0.187
0.737GlnTyr: 0.737 ± 0.205
0.0GlnXaa: 0.0 ± 0.0
Arg
4.027ArgAla: 4.027 ± 0.521
0.884ArgCys: 0.884 ± 0.267
2.112ArgAsp: 2.112 ± 0.352
3.29ArgGlu: 3.29 ± 0.623
1.915ArgPhe: 1.915 ± 0.336
3.585ArgGly: 3.585 ± 0.373
1.67ArgHis: 1.67 ± 0.257
3.143ArgIle: 3.143 ± 0.483
2.897ArgLys: 2.897 ± 0.48
3.781ArgLeu: 3.781 ± 0.506
1.571ArgMet: 1.571 ± 0.284
2.259ArgAsn: 2.259 ± 0.318
1.621ArgPro: 1.621 ± 0.29
1.915ArgGln: 1.915 ± 0.306
2.554ArgArg: 2.554 ± 0.422
2.75ArgSer: 2.75 ± 0.368
3.143ArgThr: 3.143 ± 0.329
3.29ArgVal: 3.29 ± 0.402
0.687ArgTrp: 0.687 ± 0.19
1.571ArgTyr: 1.571 ± 0.225
0.0ArgXaa: 0.0 ± 0.0
Ser
5.549SerAla: 5.549 ± 0.658
0.687SerCys: 0.687 ± 0.211
4.518SerAsp: 4.518 ± 0.418
3.585SerGlu: 3.585 ± 0.522
2.799SerPhe: 2.799 ± 0.355
6.629SerGly: 6.629 ± 0.763
1.228SerHis: 1.228 ± 0.272
3.388SerIle: 3.388 ± 0.466
3.585SerLys: 3.585 ± 0.32
5.205SerLeu: 5.205 ± 0.543
1.719SerMet: 1.719 ± 0.289
2.995SerAsn: 2.995 ± 0.449
2.848SerPro: 2.848 ± 0.332
2.848SerGln: 2.848 ± 0.365
3.585SerArg: 3.585 ± 0.399
4.027SerSer: 4.027 ± 0.46
3.83SerThr: 3.83 ± 0.546
5.205SerVal: 5.205 ± 0.615
0.933SerTrp: 0.933 ± 0.2
2.357SerTyr: 2.357 ± 0.398
0.0SerXaa: 0.0 ± 0.0
Thr
5.156ThrAla: 5.156 ± 0.735
0.589ThrCys: 0.589 ± 0.171
3.437ThrAsp: 3.437 ± 0.441
3.732ThrGlu: 3.732 ± 0.448
2.21ThrPhe: 2.21 ± 0.373
5.549ThrGly: 5.549 ± 0.528
0.982ThrHis: 0.982 ± 0.221
3.241ThrIle: 3.241 ± 0.467
2.946ThrLys: 2.946 ± 0.391
3.879ThrLeu: 3.879 ± 0.492
1.522ThrMet: 1.522 ± 0.316
2.799ThrAsn: 2.799 ± 0.574
2.946ThrPro: 2.946 ± 0.308
2.603ThrGln: 2.603 ± 0.388
2.603ThrArg: 2.603 ± 0.363
3.929ThrSer: 3.929 ± 0.482
4.125ThrThr: 4.125 ± 0.47
4.42ThrVal: 4.42 ± 0.542
0.786ThrTrp: 0.786 ± 0.232
1.768ThrTyr: 1.768 ± 0.387
0.0ThrXaa: 0.0 ± 0.0
Val
6.728ValAla: 6.728 ± 0.574
0.638ValCys: 0.638 ± 0.165
4.027ValAsp: 4.027 ± 0.452
4.567ValGlu: 4.567 ± 0.575
2.995ValPhe: 2.995 ± 0.348
5.451ValGly: 5.451 ± 0.595
0.835ValHis: 0.835 ± 0.22
3.781ValIle: 3.781 ± 0.48
4.567ValLys: 4.567 ± 0.468
5.107ValLeu: 5.107 ± 0.551
2.504ValMet: 2.504 ± 0.327
3.143ValAsn: 3.143 ± 0.419
2.897ValPro: 2.897 ± 0.353
2.603ValGln: 2.603 ± 0.443
3.045ValArg: 3.045 ± 0.337
6.433ValSer: 6.433 ± 0.569
4.37ValThr: 4.37 ± 0.383
5.745ValVal: 5.745 ± 0.585
0.786ValTrp: 0.786 ± 0.213
2.357ValTyr: 2.357 ± 0.313
0.0ValXaa: 0.0 ± 0.0
Trp
1.179TrpAla: 1.179 ± 0.259
0.196TrpCys: 0.196 ± 0.093
0.687TrpAsp: 0.687 ± 0.199
1.375TrpGlu: 1.375 ± 0.214
0.491TrpPhe: 0.491 ± 0.155
0.589TrpGly: 0.589 ± 0.163
0.196TrpHis: 0.196 ± 0.096
0.589TrpIle: 0.589 ± 0.156
0.884TrpLys: 0.884 ± 0.219
1.08TrpLeu: 1.08 ± 0.248
0.491TrpMet: 0.491 ± 0.135
0.442TrpAsn: 0.442 ± 0.125
0.491TrpPro: 0.491 ± 0.16
0.835TrpGln: 0.835 ± 0.19
0.54TrpArg: 0.54 ± 0.162
1.031TrpSer: 1.031 ± 0.256
0.737TrpThr: 0.737 ± 0.165
0.982TrpVal: 0.982 ± 0.228
0.049TrpTrp: 0.049 ± 0.047
0.393TrpTyr: 0.393 ± 0.11
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.603TyrAla: 2.603 ± 0.375
0.393TyrCys: 0.393 ± 0.153
1.719TyrAsp: 1.719 ± 0.343
1.621TyrGlu: 1.621 ± 0.275
1.08TyrPhe: 1.08 ± 0.22
2.357TyrGly: 2.357 ± 0.385
0.737TyrHis: 0.737 ± 0.219
1.571TyrIle: 1.571 ± 0.347
2.013TyrLys: 2.013 ± 0.3
2.504TyrLeu: 2.504 ± 0.381
0.737TyrMet: 0.737 ± 0.199
1.67TyrAsn: 1.67 ± 0.302
1.129TyrPro: 1.129 ± 0.231
1.031TyrGln: 1.031 ± 0.198
1.817TyrArg: 1.817 ± 0.268
2.013TyrSer: 2.013 ± 0.354
1.424TyrThr: 1.424 ± 0.226
2.455TyrVal: 2.455 ± 0.369
0.638TyrTrp: 0.638 ± 0.178
0.589TyrTyr: 0.589 ± 0.192
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 89 proteins (20365 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski