Amino acid dipepetide frequency for Fontibacillus phaseoli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.227AlaAla: 8.227 ± 0.108
0.726AlaCys: 0.726 ± 0.024
4.085AlaAsp: 4.085 ± 0.05
5.974AlaGlu: 5.974 ± 0.073
3.228AlaPhe: 3.228 ± 0.052
7.068AlaGly: 7.068 ± 0.09
1.277AlaHis: 1.277 ± 0.029
4.974AlaIle: 4.974 ± 0.062
4.397AlaLys: 4.397 ± 0.058
8.056AlaLeu: 8.056 ± 0.093
2.302AlaMet: 2.302 ± 0.036
2.536AlaAsn: 2.536 ± 0.05
2.603AlaPro: 2.603 ± 0.05
2.438AlaGln: 2.438 ± 0.039
3.47AlaArg: 3.47 ± 0.054
4.796AlaSer: 4.796 ± 0.064
3.466AlaThr: 3.466 ± 0.056
6.635AlaVal: 6.635 ± 0.087
0.957AlaTrp: 0.957 ± 0.026
2.536AlaTyr: 2.536 ± 0.042
0.0AlaXaa: 0.0 ± 0.0
Cys
0.478CysAla: 0.478 ± 0.019
0.115CysCys: 0.115 ± 0.008
0.424CysAsp: 0.424 ± 0.025
0.45CysGlu: 0.45 ± 0.021
0.337CysPhe: 0.337 ± 0.016
0.834CysGly: 0.834 ± 0.024
0.194CysHis: 0.194 ± 0.012
0.518CysIle: 0.518 ± 0.017
0.335CysLys: 0.335 ± 0.017
0.777CysLeu: 0.777 ± 0.023
0.187CysMet: 0.187 ± 0.01
0.294CysAsn: 0.294 ± 0.014
0.358CysPro: 0.358 ± 0.016
0.216CysGln: 0.216 ± 0.012
0.506CysArg: 0.506 ± 0.021
0.586CysSer: 0.586 ± 0.02
0.391CysThr: 0.391 ± 0.017
0.491CysVal: 0.491 ± 0.019
0.089CysTrp: 0.089 ± 0.008
0.267CysTyr: 0.267 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
3.711AspAla: 3.711 ± 0.062
0.37AspCys: 0.37 ± 0.017
2.474AspAsp: 2.474 ± 0.043
3.865AspGlu: 3.865 ± 0.051
2.293AspPhe: 2.293 ± 0.037
4.159AspGly: 4.159 ± 0.07
1.112AspHis: 1.112 ± 0.025
3.622AspIle: 3.622 ± 0.053
2.803AspLys: 2.803 ± 0.047
5.217AspLeu: 5.217 ± 0.064
1.389AspMet: 1.389 ± 0.031
1.913AspAsn: 1.913 ± 0.04
2.367AspPro: 2.367 ± 0.039
1.844AspGln: 1.844 ± 0.032
2.8AspArg: 2.8 ± 0.047
2.877AspSer: 2.877 ± 0.044
2.461AspThr: 2.461 ± 0.04
3.368AspVal: 3.368 ± 0.055
0.816AspTrp: 0.816 ± 0.024
2.152AspTyr: 2.152 ± 0.044
0.0AspXaa: 0.0 ± 0.0
Glu
6.036GluAla: 6.036 ± 0.076
0.418GluCys: 0.418 ± 0.016
3.385GluAsp: 3.385 ± 0.055
5.651GluGlu: 5.651 ± 0.08
2.245GluPhe: 2.245 ± 0.042
4.729GluGly: 4.729 ± 0.056
1.484GluHis: 1.484 ± 0.033
4.792GluIle: 4.792 ± 0.064
4.185GluLys: 4.185 ± 0.062
7.259GluLeu: 7.259 ± 0.079
2.109GluMet: 2.109 ± 0.047
2.724GluAsn: 2.724 ± 0.045
2.326GluPro: 2.326 ± 0.041
3.511GluGln: 3.511 ± 0.049
4.004GluArg: 4.004 ± 0.055
3.91GluSer: 3.91 ± 0.055
3.45GluThr: 3.45 ± 0.041
4.712GluVal: 4.712 ± 0.064
0.916GluTrp: 0.916 ± 0.025
2.118GluTyr: 2.118 ± 0.037
0.0GluXaa: 0.0 ± 0.0
Phe
3.375PheAla: 3.375 ± 0.052
0.379PheCys: 0.379 ± 0.014
2.294PheAsp: 2.294 ± 0.039
2.461PheGlu: 2.461 ± 0.04
1.905PhePhe: 1.905 ± 0.046
3.486PheGly: 3.486 ± 0.047
0.912PheHis: 0.912 ± 0.026
2.935PheIle: 2.935 ± 0.053
2.02PheLys: 2.02 ± 0.037
4.084PheLeu: 4.084 ± 0.068
1.173PheMet: 1.173 ± 0.028
1.624PheAsn: 1.624 ± 0.037
1.635PhePro: 1.635 ± 0.037
1.366PheGln: 1.366 ± 0.028
2.101PheArg: 2.101 ± 0.041
2.955PheSer: 2.955 ± 0.043
2.424PheThr: 2.424 ± 0.041
2.918PheVal: 2.918 ± 0.044
0.546PheTrp: 0.546 ± 0.018
1.558PheTyr: 1.558 ± 0.034
0.0PheXaa: 0.0 ± 0.0
Gly
5.661GlyAla: 5.661 ± 0.076
0.718GlyCys: 0.718 ± 0.024
3.886GlyAsp: 3.886 ± 0.054
5.029GlyGlu: 5.029 ± 0.062
3.427GlyPhe: 3.427 ± 0.047
5.955GlyGly: 5.955 ± 0.093
1.465GlyHis: 1.465 ± 0.034
5.931GlyIle: 5.931 ± 0.059
4.815GlyLys: 4.815 ± 0.061
7.676GlyLeu: 7.676 ± 0.074
2.367GlyMet: 2.367 ± 0.038
3.135GlyAsn: 3.135 ± 0.063
2.081GlyPro: 2.081 ± 0.041
2.761GlyGln: 2.761 ± 0.048
3.659GlyArg: 3.659 ± 0.063
4.911GlySer: 4.911 ± 0.071
4.498GlyThr: 4.498 ± 0.073
5.285GlyVal: 5.285 ± 0.057
1.088GlyTrp: 1.088 ± 0.024
3.094GlyTyr: 3.094 ± 0.043
0.0GlyXaa: 0.0 ± 0.0
His
1.407HisAla: 1.407 ± 0.033
0.201HisCys: 0.201 ± 0.011
0.996HisAsp: 0.996 ± 0.029
1.279HisGlu: 1.279 ± 0.028
0.999HisPhe: 0.999 ± 0.026
1.538HisGly: 1.538 ± 0.035
0.575HisHis: 0.575 ± 0.022
1.332HisIle: 1.332 ± 0.034
0.807HisLys: 0.807 ± 0.024
2.163HisLeu: 2.163 ± 0.073
0.528HisMet: 0.528 ± 0.018
0.647HisAsn: 0.647 ± 0.021
1.169HisPro: 1.169 ± 0.028
0.777HisGln: 0.777 ± 0.022
1.1HisArg: 1.1 ± 0.033
1.149HisSer: 1.149 ± 0.026
0.993HisThr: 0.993 ± 0.025
1.309HisVal: 1.309 ± 0.031
0.304HisTrp: 0.304 ± 0.015
0.836HisTyr: 0.836 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
5.757IleAla: 5.757 ± 0.073
0.626IleCys: 0.626 ± 0.021
3.575IleAsp: 3.575 ± 0.051
4.175IleGlu: 4.175 ± 0.053
2.548IlePhe: 2.548 ± 0.051
5.476IleGly: 5.476 ± 0.065
1.493IleHis: 1.493 ± 0.034
4.127IleIle: 4.127 ± 0.074
3.136IleLys: 3.136 ± 0.044
6.257IleLeu: 6.257 ± 0.082
1.667IleMet: 1.667 ± 0.032
2.472IleAsn: 2.472 ± 0.047
3.199IlePro: 3.199 ± 0.047
2.413IleGln: 2.413 ± 0.039
3.631IleArg: 3.631 ± 0.049
4.803IleSer: 4.803 ± 0.055
3.809IleThr: 3.809 ± 0.043
4.955IleVal: 4.955 ± 0.064
0.698IleTrp: 0.698 ± 0.02
2.177IleTyr: 2.177 ± 0.039
0.0IleXaa: 0.0 ± 0.0
Lys
4.251LysAla: 4.251 ± 0.054
0.278LysCys: 0.278 ± 0.013
2.929LysAsp: 2.929 ± 0.046
4.52LysGlu: 4.52 ± 0.064
1.733LysPhe: 1.733 ± 0.035
3.62LysGly: 3.62 ± 0.058
1.057LysHis: 1.057 ± 0.029
3.461LysIle: 3.461 ± 0.049
3.366LysLys: 3.366 ± 0.058
5.462LysLeu: 5.462 ± 0.063
1.656LysMet: 1.656 ± 0.033
2.21LysAsn: 2.21 ± 0.041
2.231LysPro: 2.231 ± 0.034
2.407LysGln: 2.407 ± 0.04
2.791LysArg: 2.791 ± 0.04
3.237LysSer: 3.237 ± 0.053
2.899LysThr: 2.899 ± 0.04
3.718LysVal: 3.718 ± 0.055
0.738LysTrp: 0.738 ± 0.023
1.968LysTyr: 1.968 ± 0.038
0.0LysXaa: 0.0 ± 0.0
Leu
8.194LeuAla: 8.194 ± 0.087
0.832LeuCys: 0.832 ± 0.025
5.21LeuAsp: 5.21 ± 0.068
6.736LeuGlu: 6.736 ± 0.071
4.634LeuPhe: 4.634 ± 0.074
7.121LeuGly: 7.121 ± 0.079
2.049LeuHis: 2.049 ± 0.038
6.812LeuIle: 6.812 ± 0.083
5.556LeuLys: 5.556 ± 0.068
11.139LeuLeu: 11.139 ± 0.133
2.645LeuMet: 2.645 ± 0.045
3.997LeuAsn: 3.997 ± 0.056
4.574LeuPro: 4.574 ± 0.056
3.888LeuGln: 3.888 ± 0.059
5.127LeuArg: 5.127 ± 0.063
7.222LeuSer: 7.222 ± 0.068
5.561LeuThr: 5.561 ± 0.058
6.439LeuVal: 6.439 ± 0.071
1.049LeuTrp: 1.049 ± 0.031
3.181LeuTyr: 3.181 ± 0.049
0.0LeuXaa: 0.0 ± 0.0
Met
2.223MetAla: 2.223 ± 0.037
0.16MetCys: 0.16 ± 0.01
1.571MetAsp: 1.571 ± 0.03
1.974MetGlu: 1.974 ± 0.039
1.066MetPhe: 1.066 ± 0.026
1.78MetGly: 1.78 ± 0.035
0.447MetHis: 0.447 ± 0.018
1.982MetIle: 1.982 ± 0.04
1.984MetLys: 1.984 ± 0.037
2.92MetLeu: 2.92 ± 0.058
0.881MetMet: 0.881 ± 0.028
1.533MetAsn: 1.533 ± 0.031
1.103MetPro: 1.103 ± 0.028
0.936MetGln: 0.936 ± 0.022
1.226MetArg: 1.226 ± 0.029
1.811MetSer: 1.811 ± 0.037
1.621MetThr: 1.621 ± 0.032
1.776MetVal: 1.776 ± 0.034
0.228MetTrp: 0.228 ± 0.012
0.74MetTyr: 0.74 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
2.801AsnAla: 2.801 ± 0.051
0.281AsnCys: 0.281 ± 0.012
1.919AsnAsp: 1.919 ± 0.036
2.681AsnGlu: 2.681 ± 0.049
1.416AsnPhe: 1.416 ± 0.031
3.414AsnGly: 3.414 ± 0.058
0.837AsnHis: 0.837 ± 0.024
2.435AsnIle: 2.435 ± 0.049
2.104AsnLys: 2.104 ± 0.038
3.643AsnLeu: 3.643 ± 0.056
1.054AsnMet: 1.054 ± 0.028
1.638AsnAsn: 1.638 ± 0.039
2.064AsnPro: 2.064 ± 0.038
1.474AsnGln: 1.474 ± 0.034
2.181AsnArg: 2.181 ± 0.044
2.254AsnSer: 2.254 ± 0.04
1.926AsnThr: 1.926 ± 0.045
2.542AsnVal: 2.542 ± 0.045
0.543AsnTrp: 0.543 ± 0.016
1.449AsnTyr: 1.449 ± 0.036
0.0AsnXaa: 0.0 ± 0.0
Pro
3.27ProAla: 3.27 ± 0.049
0.273ProCys: 0.273 ± 0.014
2.618ProAsp: 2.618 ± 0.041
3.647ProGlu: 3.647 ± 0.05
1.86ProPhe: 1.86 ± 0.037
3.315ProGly: 3.315 ± 0.048
0.813ProHis: 0.813 ± 0.022
2.208ProIle: 2.208 ± 0.034
1.822ProLys: 1.822 ± 0.039
3.929ProLeu: 3.929 ± 0.051
0.921ProMet: 0.921 ± 0.024
1.44ProAsn: 1.44 ± 0.035
1.238ProPro: 1.238 ± 0.029
1.422ProGln: 1.422 ± 0.034
1.461ProArg: 1.461 ± 0.03
2.472ProSer: 2.472 ± 0.039
1.748ProThr: 1.748 ± 0.036
3.477ProVal: 3.477 ± 0.052
0.531ProTrp: 0.531 ± 0.017
1.509ProTyr: 1.509 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
3.102GlnAla: 3.102 ± 0.052
0.199GlnCys: 0.199 ± 0.012
1.722GlnAsp: 1.722 ± 0.033
2.614GlnGlu: 2.614 ± 0.047
1.511GlnPhe: 1.511 ± 0.036
2.828GlnGly: 2.828 ± 0.05
0.733GlnHis: 0.733 ± 0.027
2.513GlnIle: 2.513 ± 0.041
1.897GlnLys: 1.897 ± 0.037
3.764GlnLeu: 3.764 ± 0.055
1.112GlnMet: 1.112 ± 0.026
1.449GlnAsn: 1.449 ± 0.032
1.422GlnPro: 1.422 ± 0.033
1.647GlnGln: 1.647 ± 0.037
1.842GlnArg: 1.842 ± 0.038
2.21GlnSer: 2.21 ± 0.046
1.795GlnThr: 1.795 ± 0.032
2.516GlnVal: 2.516 ± 0.043
0.433GlnTrp: 0.433 ± 0.018
1.271GlnTyr: 1.271 ± 0.026
0.0GlnXaa: 0.0 ± 0.0
Arg
3.112ArgAla: 3.112 ± 0.049
0.352ArgCys: 0.352 ± 0.018
2.643ArgAsp: 2.643 ± 0.042
4.079ArgGlu: 4.079 ± 0.05
2.202ArgPhe: 2.202 ± 0.035
3.22ArgGly: 3.22 ± 0.053
1.135ArgHis: 1.135 ± 0.028
3.597ArgIle: 3.597 ± 0.049
3.193ArgLys: 3.193 ± 0.053
5.256ArgLeu: 5.256 ± 0.076
1.608ArgMet: 1.608 ± 0.035
2.093ArgAsn: 2.093 ± 0.04
1.776ArgPro: 1.776 ± 0.041
2.073ArgGln: 2.073 ± 0.039
2.892ArgArg: 2.892 ± 0.052
3.175ArgSer: 3.175 ± 0.049
2.47ArgThr: 2.47 ± 0.04
3.145ArgVal: 3.145 ± 0.044
0.646ArgTrp: 0.646 ± 0.019
1.862ArgTyr: 1.862 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
5.011SerAla: 5.011 ± 0.069
0.504SerCys: 0.504 ± 0.019
3.17SerAsp: 3.17 ± 0.042
3.903SerGlu: 3.903 ± 0.058
3.097SerPhe: 3.097 ± 0.048
5.907SerGly: 5.907 ± 0.077
1.212SerHis: 1.212 ± 0.027
4.2SerIle: 4.2 ± 0.055
3.307SerLys: 3.307 ± 0.048
6.643SerLeu: 6.643 ± 0.062
1.779SerMet: 1.779 ± 0.033
2.268SerAsn: 2.268 ± 0.047
2.551SerPro: 2.551 ± 0.039
2.008SerGln: 2.008 ± 0.038
3.376SerArg: 3.376 ± 0.047
4.244SerSer: 4.244 ± 0.073
2.975SerThr: 2.975 ± 0.047
4.618SerVal: 4.618 ± 0.056
0.81SerTrp: 0.81 ± 0.024
2.241SerTyr: 2.241 ± 0.04
0.0SerXaa: 0.0 ± 0.0
Thr
4.577ThrAla: 4.577 ± 0.062
0.359ThrCys: 0.359 ± 0.017
2.575ThrAsp: 2.575 ± 0.047
3.354ThrGlu: 3.354 ± 0.048
2.268ThrPhe: 2.268 ± 0.039
4.799ThrGly: 4.799 ± 0.066
0.898ThrHis: 0.898 ± 0.025
3.443ThrIle: 3.443 ± 0.049
2.463ThrLys: 2.463 ± 0.04
5.453ThrLeu: 5.453 ± 0.069
1.285ThrMet: 1.285 ± 0.032
1.697ThrAsn: 1.697 ± 0.034
2.438ThrPro: 2.438 ± 0.046
1.405ThrGln: 1.405 ± 0.031
2.269ThrArg: 2.269 ± 0.037
3.167ThrSer: 3.167 ± 0.05
2.676ThrThr: 2.676 ± 0.053
4.523ThrVal: 4.523 ± 0.07
0.639ThrTrp: 0.639 ± 0.022
1.826ThrTyr: 1.826 ± 0.036
0.0ThrXaa: 0.0 ± 0.0
Val
5.23ValAla: 5.23 ± 0.07
0.631ValCys: 0.631 ± 0.025
3.533ValAsp: 3.533 ± 0.053
4.373ValGlu: 4.373 ± 0.059
3.058ValPhe: 3.058 ± 0.043
4.553ValGly: 4.553 ± 0.064
1.413ValHis: 1.413 ± 0.031
5.028ValIle: 5.028 ± 0.06
3.896ValLys: 3.896 ± 0.049
7.403ValLeu: 7.403 ± 0.078
2.013ValMet: 2.013 ± 0.038
2.87ValAsn: 2.87 ± 0.044
2.991ValPro: 2.991 ± 0.05
2.413ValGln: 2.413 ± 0.047
3.351ValArg: 3.351 ± 0.049
4.949ValSer: 4.949 ± 0.064
4.523ValThr: 4.523 ± 0.076
4.95ValVal: 4.95 ± 0.07
0.837ValTrp: 0.837 ± 0.02
2.423ValTyr: 2.423 ± 0.046
0.0ValXaa: 0.0 ± 0.0
Trp
0.775TrpAla: 0.775 ± 0.024
0.111TrpCys: 0.111 ± 0.008
0.692TrpAsp: 0.692 ± 0.021
0.827TrpGlu: 0.827 ± 0.022
0.595TrpPhe: 0.595 ± 0.019
0.878TrpGly: 0.878 ± 0.025
0.244TrpHis: 0.244 ± 0.013
0.951TrpIle: 0.951 ± 0.025
0.725TrpLys: 0.725 ± 0.024
1.35TrpLeu: 1.35 ± 0.03
0.411TrpMet: 0.411 ± 0.015
0.726TrpAsn: 0.726 ± 0.025
0.34TrpPro: 0.34 ± 0.015
0.439TrpGln: 0.439 ± 0.02
0.604TrpArg: 0.604 ± 0.022
0.857TrpSer: 0.857 ± 0.027
0.653TrpThr: 0.653 ± 0.024
0.754TrpVal: 0.754 ± 0.023
0.194TrpTrp: 0.194 ± 0.011
0.385TrpTyr: 0.385 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.55TyrAla: 2.55 ± 0.041
0.311TyrCys: 0.311 ± 0.015
1.913TyrAsp: 1.913 ± 0.04
2.372TyrGlu: 2.372 ± 0.039
1.728TyrPhe: 1.728 ± 0.033
2.764TyrGly: 2.764 ± 0.046
0.76TyrHis: 0.76 ± 0.025
2.136TyrIle: 2.136 ± 0.04
1.722TyrLys: 1.722 ± 0.037
3.514TyrLeu: 3.514 ± 0.052
0.875TyrMet: 0.875 ± 0.024
1.389TyrAsn: 1.389 ± 0.032
1.509TyrPro: 1.509 ± 0.034
1.143TyrGln: 1.143 ± 0.031
2.142TyrArg: 2.142 ± 0.041
2.241TyrSer: 2.241 ± 0.045
1.772TyrThr: 1.772 ± 0.045
2.307TyrVal: 2.307 ± 0.037
0.444TyrTrp: 0.444 ± 0.019
1.438TyrTyr: 1.438 ± 0.034
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4966 proteins (1564184 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski