Amino acid dipepetide frequency for Passion fruit mosaic virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.828AlaAla: 2.828 ± 0.73
1.885AlaCys: 1.885 ± 0.281
4.398AlaAsp: 4.398 ± 1.064
2.828AlaGlu: 2.828 ± 1.255
1.885AlaPhe: 1.885 ± 0.837
2.828AlaGly: 2.828 ± 1.278
0.0AlaHis: 0.0 ± 0.0
0.628AlaIle: 0.628 ± 0.721
3.77AlaLys: 3.77 ± 1.07
6.283AlaLeu: 6.283 ± 0.811
2.513AlaMet: 2.513 ± 0.324
2.828AlaAsn: 2.828 ± 0.906
0.943AlaPro: 0.943 ± 0.637
0.628AlaGln: 0.628 ± 1.046
1.885AlaArg: 1.885 ± 0.517
4.084AlaSer: 4.084 ± 1.063
3.142AlaThr: 3.142 ± 1.872
5.341AlaVal: 5.341 ± 0.919
0.628AlaTrp: 0.628 ± 0.172
2.199AlaTyr: 2.199 ± 0.692
0.0AlaXaa: 0.0 ± 0.0
Cys
1.257CysAla: 1.257 ± 0.336
0.943CysCys: 0.943 ± 0.418
0.628CysAsp: 0.628 ± 0.454
0.628CysGlu: 0.628 ± 0.381
0.314CysPhe: 0.314 ± 0.191
1.885CysGly: 1.885 ± 0.535
0.628CysHis: 0.628 ± 0.172
0.314CysIle: 0.314 ± 0.191
2.199CysLys: 2.199 ± 0.565
1.885CysLeu: 1.885 ± 0.517
1.257CysMet: 1.257 ± 0.344
2.199CysAsn: 2.199 ± 0.565
0.628CysPro: 0.628 ± 0.172
0.0CysGln: 0.0 ± 0.0
0.943CysArg: 0.943 ± 0.267
2.199CysSer: 2.199 ± 0.565
0.0CysThr: 0.0 ± 0.0
2.199CysVal: 2.199 ± 1.073
0.0CysTrp: 0.0 ± 0.0
0.314CysTyr: 0.314 ± 0.191
0.0CysXaa: 0.0 ± 0.0
Asp
4.713AspAla: 4.713 ± 0.657
0.314AspCys: 0.314 ± 0.191
4.398AspAsp: 4.398 ± 1.011
3.77AspGlu: 3.77 ± 0.97
3.142AspPhe: 3.142 ± 0.469
1.571AspGly: 1.571 ± 0.407
0.314AspHis: 0.314 ± 0.191
3.142AspIle: 3.142 ± 0.956
2.513AspLys: 2.513 ± 0.324
4.398AspLeu: 4.398 ± 0.582
1.571AspMet: 1.571 ± 0.369
2.828AspAsn: 2.828 ± 0.823
1.571AspPro: 1.571 ± 0.654
2.199AspGln: 2.199 ± 0.395
2.199AspArg: 2.199 ± 0.604
3.77AspSer: 3.77 ± 1.097
7.226AspThr: 7.226 ± 0.78
9.111AspVal: 9.111 ± 0.558
0.314AspTrp: 0.314 ± 0.191
4.398AspTyr: 4.398 ± 0.473
0.0AspXaa: 0.0 ± 0.0
Glu
3.456GluAla: 3.456 ± 0.466
0.943GluCys: 0.943 ± 0.267
0.943GluAsp: 0.943 ± 0.267
3.456GluGlu: 3.456 ± 0.897
3.142GluPhe: 3.142 ± 0.436
3.456GluGly: 3.456 ± 1.183
0.628GluHis: 0.628 ± 0.172
2.828GluIle: 2.828 ± 0.465
2.513GluLys: 2.513 ± 0.324
4.398GluLeu: 4.398 ± 0.473
1.571GluMet: 1.571 ± 0.611
2.828GluAsn: 2.828 ± 0.802
2.199GluPro: 2.199 ± 0.395
0.314GluGln: 0.314 ± 0.742
4.713GluArg: 4.713 ± 2.273
6.283GluSer: 6.283 ± 0.946
5.969GluThr: 5.969 ± 1.234
5.341GluVal: 5.341 ± 1.033
0.943GluTrp: 0.943 ± 0.267
2.513GluTyr: 2.513 ± 0.667
0.0GluXaa: 0.0 ± 0.0
Phe
0.943PheAla: 0.943 ± 0.418
2.199PheCys: 2.199 ± 0.309
5.655PheAsp: 5.655 ± 1.479
2.513PheGlu: 2.513 ± 0.529
1.885PhePhe: 1.885 ± 0.535
1.571PheGly: 1.571 ± 0.351
0.628PheHis: 0.628 ± 0.381
1.257PheIle: 1.257 ± 0.431
5.027PheLys: 5.027 ± 0.895
4.398PheLeu: 4.398 ± 0.582
1.257PheMet: 1.257 ± 0.431
4.084PheAsn: 4.084 ± 0.699
1.571PhePro: 1.571 ± 0.757
4.084PheGln: 4.084 ± 0.312
1.571PheArg: 1.571 ± 0.407
5.027PheSer: 5.027 ± 0.648
2.828PheThr: 2.828 ± 0.73
4.713PheVal: 4.713 ± 0.697
0.0PheTrp: 0.0 ± 0.0
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
2.513GlyAla: 2.513 ± 0.529
3.142GlyCys: 3.142 ± 0.685
3.77GlyAsp: 3.77 ± 1.069
2.199GlyGlu: 2.199 ± 1.097
1.257GlyPhe: 1.257 ± 0.931
1.257GlyGly: 1.257 ± 0.344
0.314GlyHis: 0.314 ± 0.191
1.885GlyIle: 1.885 ± 0.535
5.027GlyLys: 5.027 ± 0.828
5.969GlyLeu: 5.969 ± 1.313
2.199GlyMet: 2.199 ± 0.565
3.142GlyAsn: 3.142 ± 1.112
2.199GlyPro: 2.199 ± 0.565
0.628GlyGln: 0.628 ± 0.454
2.199GlyArg: 2.199 ± 1.097
2.828GlySer: 2.828 ± 0.661
2.199GlyThr: 2.199 ± 0.565
4.713GlyVal: 4.713 ± 0.657
1.257GlyTrp: 1.257 ± 0.344
0.628GlyTyr: 0.628 ± 0.172
0.0GlyXaa: 0.0 ± 0.0
His
1.571HisAla: 1.571 ± 0.407
1.571HisCys: 1.571 ± 0.407
0.943HisAsp: 0.943 ± 0.267
0.943HisGlu: 0.943 ± 0.267
0.943HisPhe: 0.943 ± 0.267
1.571HisGly: 1.571 ± 0.566
0.0HisHis: 0.0 ± 0.0
0.628HisIle: 0.628 ± 0.172
0.314HisLys: 0.314 ± 0.191
0.314HisLeu: 0.314 ± 0.191
0.943HisMet: 0.943 ± 0.267
0.314HisAsn: 0.314 ± 0.191
0.314HisPro: 0.314 ± 0.523
0.0HisGln: 0.0 ± 0.0
0.628HisArg: 0.628 ± 0.172
1.571HisSer: 1.571 ± 0.407
1.885HisThr: 1.885 ± 0.517
1.885HisVal: 1.885 ± 0.837
0.0HisTrp: 0.0 ± 0.0
0.628HisTyr: 0.628 ± 0.172
0.0HisXaa: 0.0 ± 0.0
Ile
2.199IleAla: 2.199 ± 0.735
0.0IleCys: 0.0 ± 0.0
1.571IleAsp: 1.571 ± 0.407
2.513IleGlu: 2.513 ± 1.396
2.828IlePhe: 2.828 ± 0.802
3.456IleGly: 3.456 ± 0.931
0.628IleHis: 0.628 ± 0.454
2.199IleIle: 2.199 ± 0.594
1.885IleLys: 1.885 ± 0.814
6.912IleLeu: 6.912 ± 0.931
0.0IleMet: 0.0 ± 0.0
2.513IleAsn: 2.513 ± 0.529
2.828IlePro: 2.828 ± 0.73
3.142IleGln: 3.142 ± 0.815
5.027IleArg: 5.027 ± 1.065
2.199IleSer: 2.199 ± 0.604
3.77IleThr: 3.77 ± 1.033
1.571IleVal: 1.571 ± 0.407
0.943IleTrp: 0.943 ± 0.267
0.314IleTyr: 0.314 ± 0.191
0.0IleXaa: 0.0 ± 0.0
Lys
1.885LysAla: 1.885 ± 0.74
0.314LysCys: 0.314 ± 0.191
4.084LysAsp: 4.084 ± 0.64
3.456LysGlu: 3.456 ± 0.897
3.142LysPhe: 3.142 ± 0.436
4.713LysGly: 4.713 ± 1.975
1.571LysHis: 1.571 ± 0.407
5.969LysIle: 5.969 ± 0.907
5.655LysLys: 5.655 ± 0.844
5.969LysLeu: 5.969 ± 1.118
1.257LysMet: 1.257 ± 1.195
2.513LysAsn: 2.513 ± 0.692
1.571LysPro: 1.571 ± 0.369
2.828LysGln: 2.828 ± 0.802
5.027LysArg: 5.027 ± 0.828
3.456LysSer: 3.456 ± 0.587
6.598LysThr: 6.598 ± 0.632
2.513LysVal: 2.513 ± 0.667
0.0LysTrp: 0.0 ± 0.0
0.943LysTyr: 0.943 ± 0.459
0.0LysXaa: 0.0 ± 0.0
Leu
3.142LeuAla: 3.142 ± 0.413
0.314LeuCys: 0.314 ± 0.191
6.283LeuAsp: 6.283 ± 0.81
4.084LeuGlu: 4.084 ± 0.982
2.828LeuPhe: 2.828 ± 0.579
4.398LeuGly: 4.398 ± 1.632
1.257LeuHis: 1.257 ± 0.344
4.398LeuIle: 4.398 ± 1.131
6.598LeuLys: 6.598 ± 0.787
8.168LeuLeu: 8.168 ± 2.055
3.142LeuMet: 3.142 ± 0.715
5.341LeuAsn: 5.341 ± 0.919
3.456LeuPro: 3.456 ± 0.619
5.969LeuGln: 5.969 ± 0.685
7.854LeuArg: 7.854 ± 0.555
8.168LeuSer: 8.168 ± 1.163
4.398LeuThr: 4.398 ± 1.446
5.969LeuVal: 5.969 ± 0.8
0.628LeuTrp: 0.628 ± 0.381
4.713LeuTyr: 4.713 ± 1.336
0.0LeuXaa: 0.0 ± 0.0
Met
0.628MetAla: 0.628 ± 1.046
0.943MetCys: 0.943 ± 0.418
1.885MetAsp: 1.885 ± 0.281
0.943MetGlu: 0.943 ± 0.418
0.314MetPhe: 0.314 ± 0.523
0.0MetGly: 0.0 ± 0.0
1.257MetHis: 1.257 ± 0.344
2.828MetIle: 2.828 ± 0.802
2.199MetLys: 2.199 ± 0.309
0.628MetLeu: 0.628 ± 0.454
2.513MetMet: 2.513 ± 0.689
0.628MetAsn: 0.628 ± 0.172
1.257MetPro: 1.257 ± 0.882
0.314MetGln: 0.314 ± 0.523
0.628MetArg: 0.628 ± 0.172
2.199MetSer: 2.199 ± 0.395
3.142MetThr: 3.142 ± 0.861
0.943MetVal: 0.943 ± 0.418
0.0MetTrp: 0.0 ± 0.0
0.628MetTyr: 0.628 ± 0.172
0.0MetXaa: 0.0 ± 0.0
Asn
3.77AsnAla: 3.77 ± 2.172
0.943AsnCys: 0.943 ± 0.267
0.628AsnAsp: 0.628 ± 0.721
5.341AsnGlu: 5.341 ± 0.849
4.084AsnPhe: 4.084 ± 0.699
4.398AsnGly: 4.398 ± 1.131
1.257AsnHis: 1.257 ± 0.344
1.571AsnIle: 1.571 ± 0.611
1.257AsnLys: 1.257 ± 0.344
2.199AsnLeu: 2.199 ± 0.692
0.628AsnMet: 0.628 ± 0.478
1.571AsnAsn: 1.571 ± 0.566
1.885AsnPro: 1.885 ± 1.146
0.0AsnGln: 0.0 ± 0.0
2.199AsnArg: 2.199 ± 0.543
3.77AsnSer: 3.77 ± 0.792
1.571AsnThr: 1.571 ± 0.351
6.912AsnVal: 6.912 ± 0.859
0.943AsnTrp: 0.943 ± 0.637
1.885AsnTyr: 1.885 ± 0.78
0.0AsnXaa: 0.0 ± 0.0
Pro
4.084ProAla: 4.084 ± 0.697
1.257ProCys: 1.257 ± 0.344
3.77ProAsp: 3.77 ± 0.97
5.341ProGlu: 5.341 ± 0.934
0.628ProPhe: 0.628 ± 0.172
1.571ProGly: 1.571 ± 0.407
0.943ProHis: 0.943 ± 0.267
3.142ProIle: 3.142 ± 0.815
2.199ProLys: 2.199 ± 0.766
1.571ProLeu: 1.571 ± 1.999
0.0ProMet: 0.0 ± 0.0
0.628ProAsn: 0.628 ± 0.172
1.885ProPro: 1.885 ± 0.281
0.0ProGln: 0.0 ± 0.0
1.571ProArg: 1.571 ± 0.837
2.828ProSer: 2.828 ± 2.055
1.885ProThr: 1.885 ± 0.281
3.77ProVal: 3.77 ± 0.72
0.314ProTrp: 0.314 ± 0.742
0.943ProTyr: 0.943 ± 0.637
0.0ProXaa: 0.0 ± 0.0
Gln
2.199GlnAla: 2.199 ± 0.543
1.885GlnCys: 1.885 ± 0.535
2.199GlnAsp: 2.199 ± 0.735
0.943GlnGlu: 0.943 ± 0.459
2.199GlnPhe: 2.199 ± 0.565
1.257GlnGly: 1.257 ± 0.344
0.628GlnHis: 0.628 ± 0.172
1.571GlnIle: 1.571 ± 0.369
0.943GlnLys: 0.943 ± 0.267
4.713GlnLeu: 4.713 ± 0.431
0.943GlnMet: 0.943 ± 0.418
0.943GlnAsn: 0.943 ± 0.96
1.571GlnPro: 1.571 ± 0.654
2.199GlnGln: 2.199 ± 0.692
2.513GlnArg: 2.513 ± 0.667
1.571GlnSer: 1.571 ± 0.351
2.513GlnThr: 2.513 ± 1.234
1.885GlnVal: 1.885 ± 1.274
0.628GlnTrp: 0.628 ± 0.172
1.257GlnTyr: 1.257 ± 0.344
0.0GlnXaa: 0.0 ± 0.0
Arg
4.398ArgAla: 4.398 ± 0.98
1.257ArgCys: 1.257 ± 0.344
2.199ArgAsp: 2.199 ± 0.543
2.513ArgGlu: 2.513 ± 0.77
3.142ArgPhe: 3.142 ± 0.685
1.257ArgGly: 1.257 ± 0.344
0.943ArgHis: 0.943 ± 0.267
2.199ArgIle: 2.199 ± 1.394
4.398ArgLys: 4.398 ± 0.687
5.341ArgLeu: 5.341 ± 1.412
0.628ArgMet: 0.628 ± 0.172
1.885ArgAsn: 1.885 ± 0.548
1.571ArgPro: 1.571 ± 0.407
2.513ArgGln: 2.513 ± 0.689
5.655ArgArg: 5.655 ± 0.796
4.713ArgSer: 4.713 ± 0.356
5.655ArgThr: 5.655 ± 0.711
6.283ArgVal: 6.283 ± 0.81
0.628ArgTrp: 0.628 ± 0.987
1.257ArgTyr: 1.257 ± 0.838
0.0ArgXaa: 0.0 ± 0.0
Ser
1.571SerAla: 1.571 ± 2.326
0.628SerCys: 0.628 ± 0.172
5.027SerAsp: 5.027 ± 0.925
5.027SerGlu: 5.027 ± 0.925
4.398SerPhe: 4.398 ± 0.758
5.027SerGly: 5.027 ± 0.346
0.943SerHis: 0.943 ± 0.267
2.828SerIle: 2.828 ± 1.278
4.084SerLys: 4.084 ± 1.139
8.168SerLeu: 8.168 ± 0.882
0.943SerMet: 0.943 ± 1.398
5.969SerAsn: 5.969 ± 1.475
2.513SerPro: 2.513 ± 1.244
2.828SerGln: 2.828 ± 0.582
2.828SerArg: 2.828 ± 0.485
3.77SerSer: 3.77 ± 0.562
7.226SerThr: 7.226 ± 1.096
7.226SerVal: 7.226 ± 1.667
0.943SerTrp: 0.943 ± 0.267
3.456SerTyr: 3.456 ± 0.897
0.0SerXaa: 0.0 ± 0.0
Thr
3.142ThrAla: 3.142 ± 0.436
0.0ThrCys: 0.0 ± 0.0
2.199ThrAsp: 2.199 ± 2.208
4.084ThrGlu: 4.084 ± 0.757
7.226ThrPhe: 7.226 ± 1.92
3.456ThrGly: 3.456 ± 0.622
0.0ThrHis: 0.0 ± 0.0
3.142ThrIle: 3.142 ± 0.815
6.598ThrLys: 6.598 ± 1.222
5.655ThrLeu: 5.655 ± 1.163
0.628ThrMet: 0.628 ± 0.172
1.571ThrAsn: 1.571 ± 0.351
3.77ThrPro: 3.77 ± 0.97
1.885ThrGln: 1.885 ± 0.699
3.456ThrArg: 3.456 ± 0.619
4.398ThrSer: 4.398 ± 2.782
3.77ThrThr: 3.77 ± 0.578
8.483ThrVal: 8.483 ± 1.066
0.628ThrTrp: 0.628 ± 0.172
5.027ThrTyr: 5.027 ± 1.378
0.0ThrXaa: 0.0 ± 0.0
Val
5.027ValAla: 5.027 ± 0.89
1.885ValCys: 1.885 ± 0.281
6.598ValAsp: 6.598 ± 1.282
5.655ValGlu: 5.655 ± 0.674
5.027ValPhe: 5.027 ± 0.869
1.571ValGly: 1.571 ± 0.837
3.77ValHis: 3.77 ± 0.453
3.142ValIle: 3.142 ± 0.596
4.713ValLys: 4.713 ± 2.092
10.368ValLeu: 10.368 ± 2.152
0.943ValMet: 0.943 ± 0.418
2.828ValAsn: 2.828 ± 1.271
4.398ValPro: 4.398 ± 0.582
3.142ValGln: 3.142 ± 0.685
6.283ValArg: 6.283 ± 0.81
9.739ValSer: 9.739 ± 1.541
2.828ValThr: 2.828 ± 0.582
8.168ValVal: 8.168 ± 1.964
2.828ValTrp: 2.828 ± 0.465
3.77ValTyr: 3.77 ± 1.097
0.0ValXaa: 0.0 ± 0.0
Trp
0.628TrpAla: 0.628 ± 1.484
0.0TrpCys: 0.0 ± 0.0
1.571TrpAsp: 1.571 ± 0.407
0.943TrpGlu: 0.943 ± 0.267
1.257TrpPhe: 1.257 ± 0.344
1.571TrpGly: 1.571 ± 0.566
0.314TrpHis: 0.314 ± 0.523
1.257TrpIle: 1.257 ± 0.344
0.0TrpLys: 0.0 ± 0.0
0.628TrpLeu: 0.628 ± 0.721
0.0TrpMet: 0.0 ± 0.0
0.314TrpAsn: 0.314 ± 0.191
0.0TrpPro: 0.0 ± 0.0
0.314TrpGln: 0.314 ± 0.191
0.314TrpArg: 0.314 ± 0.191
0.943TrpSer: 0.943 ± 0.418
0.628TrpThr: 0.628 ± 0.172
1.257TrpVal: 1.257 ± 0.344
0.0TrpTrp: 0.0 ± 0.0
0.314TrpTyr: 0.314 ± 0.191
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.571TyrAla: 1.571 ± 0.407
0.0TyrCys: 0.0 ± 0.0
4.713TyrAsp: 4.713 ± 0.918
1.257TyrGlu: 1.257 ± 0.344
1.571TyrPhe: 1.571 ± 0.611
2.513TyrGly: 2.513 ± 0.689
0.943TyrHis: 0.943 ± 0.267
1.571TyrIle: 1.571 ± 0.611
1.885TyrLys: 1.885 ± 0.718
3.142TyrLeu: 3.142 ± 0.49
0.628TyrMet: 0.628 ± 0.172
1.885TyrAsn: 1.885 ± 0.517
2.199TyrPro: 2.199 ± 0.565
1.571TyrGln: 1.571 ± 0.654
0.943TyrArg: 0.943 ± 0.267
1.885TyrSer: 1.885 ± 0.78
1.885TyrThr: 1.885 ± 0.535
4.398TyrVal: 4.398 ± 0.25
0.628TyrTrp: 0.628 ± 0.172
0.943TyrTyr: 0.943 ± 0.267
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (3184 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski