Amino acid dipepetide frequency for Arsenicicoccus sp. MKL-02

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.105AlaAla: 19.105 ± 0.233	1.118AlaCys: 1.118 ± 0.042	7.895AlaAsp: 7.895 ± 0.087	7.235AlaGlu: 7.235 ± 0.108	3.243AlaPhe: 3.243 ± 0.072	12.617AlaGly: 12.617 ± 0.142	2.688AlaHis: 2.688 ± 0.052	4.312AlaIle: 4.312 ± 0.08	2.594AlaLys: 2.594 ± 0.062	13.726AlaLeu: 13.726 ± 0.162	2.838AlaMet: 2.838 ± 0.063	1.861AlaAsn: 1.861 ± 0.061	6.541AlaPro: 6.541 ± 0.111	3.91AlaGln: 3.91 ± 0.064	10.361AlaArg: 10.361 ± 0.156	6.659AlaSer: 6.659 ± 0.089	8.103AlaThr: 8.103 ± 0.128	11.576AlaVal: 11.576 ± 0.123	2.0AlaTrp: 2.0 ± 0.05	2.68AlaTyr: 2.68 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	1.011CysAla: 1.011 ± 0.032	0.107CysCys: 0.107 ± 0.011	0.5CysAsp: 0.5 ± 0.023	0.374CysGlu: 0.374 ± 0.019	0.213CysPhe: 0.213 ± 0.013	0.935CysGly: 0.935 ± 0.044	0.205CysHis: 0.205 ± 0.015	0.236CysIle: 0.236 ± 0.016	0.106CysLys: 0.106 ± 0.011	0.725CysLeu: 0.725 ± 0.026	0.1CysMet: 0.1 ± 0.01	0.136CysAsn: 0.136 ± 0.012	0.493CysPro: 0.493 ± 0.025	0.184CysGln: 0.184 ± 0.014	0.626CysArg: 0.626 ± 0.026	0.455CysSer: 0.455 ± 0.024	0.506CysThr: 0.506 ± 0.026	0.668CysVal: 0.668 ± 0.027	0.128CysTrp: 0.128 ± 0.012	0.159CysTyr: 0.159 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	8.021AspAla: 8.021 ± 0.119	0.385AspCys: 0.385 ± 0.02	4.262AspAsp: 4.262 ± 0.068	4.529AspGlu: 4.529 ± 0.081	1.397AspPhe: 1.397 ± 0.04	6.219AspGly: 6.219 ± 0.092	1.591AspHis: 1.591 ± 0.044	1.744AspIle: 1.744 ± 0.044	1.318AspLys: 1.318 ± 0.054	7.081AspLeu: 7.081 ± 0.093	0.838AspMet: 0.838 ± 0.029	0.98AspAsn: 0.98 ± 0.039	4.669AspPro: 4.669 ± 0.066	2.041AspGln: 2.041 ± 0.046	5.083AspArg: 5.083 ± 0.082	2.259AspSer: 2.259 ± 0.058	2.959AspThr: 2.959 ± 0.096	5.962AspVal: 5.962 ± 0.079	0.87AspTrp: 0.87 ± 0.029	1.227AspTyr: 1.227 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	7.108GluAla: 7.108 ± 0.119	0.331GluCys: 0.331 ± 0.019	3.101GluAsp: 3.101 ± 0.057	2.883GluGlu: 2.883 ± 0.075	1.208GluPhe: 1.208 ± 0.039	4.399GluGly: 4.399 ± 0.081	1.79GluHis: 1.79 ± 0.05	2.219GluIle: 2.219 ± 0.055	0.846GluLys: 0.846 ± 0.035	6.397GluLeu: 6.397 ± 0.101	0.948GluMet: 0.948 ± 0.031	0.604GluAsn: 0.604 ± 0.024	2.885GluPro: 2.885 ± 0.064	2.477GluGln: 2.477 ± 0.052	5.461GluArg: 5.461 ± 0.099	2.398GluSer: 2.398 ± 0.052	2.589GluThr: 2.589 ± 0.058	5.152GluVal: 5.152 ± 0.088	0.674GluTrp: 0.674 ± 0.028	0.776GluTyr: 0.776 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	3.229PheAla: 3.229 ± 0.063	0.235PheCys: 0.235 ± 0.014	1.816PheAsp: 1.816 ± 0.05	1.297PheGlu: 1.297 ± 0.04	0.784PhePhe: 0.784 ± 0.036	2.612PheGly: 2.612 ± 0.061	0.535PheHis: 0.535 ± 0.027	0.718PheIle: 0.718 ± 0.026	0.432PheLys: 0.432 ± 0.024	2.189PheLeu: 2.189 ± 0.064	0.433PheMet: 0.433 ± 0.024	0.496PheAsn: 0.496 ± 0.022	1.188PhePro: 1.188 ± 0.036	0.558PheGln: 0.558 ± 0.022	1.487PheArg: 1.487 ± 0.042	1.163PheSer: 1.163 ± 0.038	1.782PheThr: 1.782 ± 0.046	2.461PheVal: 2.461 ± 0.052	0.355PheTrp: 0.355 ± 0.02	0.564PheTyr: 0.564 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	10.996GlyAla: 10.996 ± 0.13	0.858GlyCys: 0.858 ± 0.034	5.474GlyAsp: 5.474 ± 0.081	4.857GlyGlu: 4.857 ± 0.076	2.704GlyPhe: 2.704 ± 0.06	8.264GlyGly: 8.264 ± 0.121	2.298GlyHis: 2.298 ± 0.041	3.611GlyIle: 3.611 ± 0.06	2.136GlyLys: 2.136 ± 0.054	9.667GlyLeu: 9.667 ± 0.118	2.073GlyMet: 2.073 ± 0.053	1.556GlyAsn: 1.556 ± 0.054	4.576GlyPro: 4.576 ± 0.076	2.94GlyGln: 2.94 ± 0.06	7.91GlyArg: 7.91 ± 0.113	5.684GlySer: 5.684 ± 0.092	5.786GlyThr: 5.786 ± 0.125	8.12GlyVal: 8.12 ± 0.096	1.76GlyTrp: 1.76 ± 0.051	2.249GlyTyr: 2.249 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.726HisAla: 2.726 ± 0.061	0.19HisCys: 0.19 ± 0.013	1.724HisAsp: 1.724 ± 0.044	1.439HisGlu: 1.439 ± 0.039	0.535HisPhe: 0.535 ± 0.026	2.381HisGly: 2.381 ± 0.05	0.707HisHis: 0.707 ± 0.029	0.503HisIle: 0.503 ± 0.024	0.357HisLys: 0.357 ± 0.019	2.658HisLeu: 2.658 ± 0.06	0.336HisMet: 0.336 ± 0.019	0.354HisAsn: 0.354 ± 0.022	1.747HisPro: 1.747 ± 0.047	0.728HisGln: 0.728 ± 0.028	2.075HisArg: 2.075 ± 0.05	0.831HisSer: 0.831 ± 0.031	1.127HisThr: 1.127 ± 0.04	2.251HisVal: 2.251 ± 0.053	0.32HisTrp: 0.32 ± 0.019	0.483HisTyr: 0.483 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	4.536IleAla: 4.536 ± 0.078	0.308IleCys: 0.308 ± 0.018	2.47IleAsp: 2.47 ± 0.059	1.979IleGlu: 1.979 ± 0.056	0.793IlePhe: 0.793 ± 0.033	3.482IleGly: 3.482 ± 0.082	0.663IleHis: 0.663 ± 0.027	1.094IleIle: 1.094 ± 0.041	0.774IleLys: 0.774 ± 0.029	2.634IleLeu: 2.634 ± 0.064	0.539IleMet: 0.539 ± 0.026	0.736IleAsn: 0.736 ± 0.032	1.887IlePro: 1.887 ± 0.043	0.772IleGln: 0.772 ± 0.029	2.188IleArg: 2.188 ± 0.051	1.659IleSer: 1.659 ± 0.042	2.33IleThr: 2.33 ± 0.066	3.137IleVal: 3.137 ± 0.059	0.325IleTrp: 0.325 ± 0.018	0.634IleTyr: 0.634 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	2.673LysAla: 2.673 ± 0.062	0.078LysCys: 0.078 ± 0.008	1.36LysAsp: 1.36 ± 0.046	1.002LysGlu: 1.002 ± 0.036	0.401LysPhe: 0.401 ± 0.022	1.765LysGly: 1.765 ± 0.052	0.39LysHis: 0.39 ± 0.022	0.705LysIle: 0.705 ± 0.027	0.654LysLys: 0.654 ± 0.038	1.449LysLeu: 1.449 ± 0.045	0.349LysMet: 0.349 ± 0.022	0.423LysAsn: 0.423 ± 0.027	1.112LysPro: 1.112 ± 0.036	0.662LysGln: 0.662 ± 0.029	1.238LysArg: 1.238 ± 0.043	0.942LysSer: 0.942 ± 0.035	1.158LysThr: 1.158 ± 0.053	1.943LysVal: 1.943 ± 0.057	0.17LysTrp: 0.17 ± 0.012	0.369LysTyr: 0.369 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	14.978LeuAla: 14.978 ± 0.159	0.717LeuCys: 0.717 ± 0.028	7.132LeuAsp: 7.132 ± 0.088	4.945LeuGlu: 4.945 ± 0.098	1.91LeuPhe: 1.91 ± 0.058	9.944LeuGly: 9.944 ± 0.12	2.275LeuHis: 2.275 ± 0.05	2.727LeuIle: 2.727 ± 0.06	1.669LeuLys: 1.669 ± 0.054	10.561LeuLeu: 10.561 ± 0.175	1.754LeuMet: 1.754 ± 0.049	1.34LeuAsn: 1.34 ± 0.043	5.834LeuPro: 5.834 ± 0.088	2.638LeuGln: 2.638 ± 0.05	8.221LeuArg: 8.221 ± 0.117	5.136LeuSer: 5.136 ± 0.065	6.589LeuThr: 6.589 ± 0.115	10.95LeuVal: 10.95 ± 0.163	1.286LeuTrp: 1.286 ± 0.043	1.55LeuTyr: 1.55 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	2.478MetAla: 2.478 ± 0.049	0.159MetCys: 0.159 ± 0.012	0.906MetAsp: 0.906 ± 0.031	0.723MetGlu: 0.723 ± 0.03	0.523MetPhe: 0.523 ± 0.028	1.549MetGly: 1.549 ± 0.044	0.37MetHis: 0.37 ± 0.02	0.723MetIle: 0.723 ± 0.027	0.404MetLys: 0.404 ± 0.024	1.799MetLeu: 1.799 ± 0.044	0.376MetMet: 0.376 ± 0.022	0.368MetAsn: 0.368 ± 0.017	1.263MetPro: 1.263 ± 0.036	0.497MetGln: 0.497 ± 0.02	1.499MetArg: 1.499 ± 0.039	1.462MetSer: 1.462 ± 0.039	1.891MetThr: 1.891 ± 0.047	1.483MetVal: 1.483 ± 0.045	0.19MetTrp: 0.19 ± 0.014	0.3MetTyr: 0.3 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.035AsnAla: 2.035 ± 0.059	0.113AsnCys: 0.113 ± 0.011	0.962AsnAsp: 0.962 ± 0.034	0.692AsnGlu: 0.692 ± 0.029	0.383AsnPhe: 0.383 ± 0.022	1.515AsnGly: 1.515 ± 0.073	0.356AsnHis: 0.356 ± 0.019	0.565AsnIle: 0.565 ± 0.025	0.363AsnLys: 0.363 ± 0.022	1.602AsnLeu: 1.602 ± 0.034	0.241AsnMet: 0.241 ± 0.018	0.402AsnAsn: 0.402 ± 0.031	1.355AsnPro: 1.355 ± 0.041	0.457AsnGln: 0.457 ± 0.023	1.027AsnArg: 1.027 ± 0.034	0.648AsnSer: 0.648 ± 0.032	0.9AsnThr: 0.9 ± 0.098	1.447AsnVal: 1.447 ± 0.059	0.183AsnTrp: 0.183 ± 0.014	0.342AsnTyr: 0.342 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	7.695ProAla: 7.695 ± 0.109	0.355ProCys: 0.355 ± 0.022	4.227ProAsp: 4.227 ± 0.067	3.724ProGlu: 3.724 ± 0.074	1.322ProPhe: 1.322 ± 0.038	6.065ProGly: 6.065 ± 0.099	1.374ProHis: 1.374 ± 0.038	1.545ProIle: 1.545 ± 0.036	0.932ProLys: 0.932 ± 0.035	4.887ProLeu: 4.887 ± 0.067	1.075ProMet: 1.075 ± 0.033	0.706ProAsn: 0.706 ± 0.025	2.806ProPro: 2.806 ± 0.073	1.817ProGln: 1.817 ± 0.042	4.314ProArg: 4.314 ± 0.078	3.381ProSer: 3.381 ± 0.066	3.879ProThr: 3.879 ± 0.073	5.351ProVal: 5.351 ± 0.073	0.99ProTrp: 0.99 ± 0.034	1.134ProTyr: 1.134 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.094GlnAla: 4.094 ± 0.086	0.183GlnCys: 0.183 ± 0.014	1.666GlnAsp: 1.666 ± 0.05	1.49GlnGlu: 1.49 ± 0.035	0.578GlnPhe: 0.578 ± 0.024	2.695GlnGly: 2.695 ± 0.055	0.849GlnHis: 0.849 ± 0.03	1.178GlnIle: 1.178 ± 0.039	0.446GlnLys: 0.446 ± 0.024	3.146GlnLeu: 3.146 ± 0.061	0.565GlnMet: 0.565 ± 0.022	0.358GlnAsn: 0.358 ± 0.02	1.752GlnPro: 1.752 ± 0.047	1.342GlnGln: 1.342 ± 0.05	2.716GlnArg: 2.716 ± 0.054	1.236GlnSer: 1.236 ± 0.034	1.606GlnThr: 1.606 ± 0.044	3.343GlnVal: 3.343 ± 0.065	0.432GlnTrp: 0.432 ± 0.02	0.468GlnTyr: 0.468 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	9.487ArgAla: 9.487 ± 0.141	0.64ArgCys: 0.64 ± 0.027	4.753ArgAsp: 4.753 ± 0.078	4.688ArgGlu: 4.688 ± 0.084	2.037ArgPhe: 2.037 ± 0.051	6.289ArgGly: 6.289 ± 0.096	2.241ArgHis: 2.241 ± 0.051	2.859ArgIle: 2.859 ± 0.059	1.397ArgLys: 1.397 ± 0.044	8.726ArgLeu: 8.726 ± 0.116	1.842ArgMet: 1.842 ± 0.052	1.159ArgAsn: 1.159 ± 0.038	4.95ArgPro: 4.95 ± 0.091	2.391ArgGln: 2.391 ± 0.048	8.205ArgArg: 8.205 ± 0.16	4.585ArgSer: 4.585 ± 0.081	4.824ArgThr: 4.824 ± 0.078	6.748ArgVal: 6.748 ± 0.081	1.494ArgTrp: 1.494 ± 0.041	1.686ArgTyr: 1.686 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	6.444SerAla: 6.444 ± 0.098	0.428SerCys: 0.428 ± 0.022	2.695SerAsp: 2.695 ± 0.057	2.339SerGlu: 2.339 ± 0.055	1.507SerPhe: 1.507 ± 0.038	5.503SerGly: 5.503 ± 0.083	1.016SerHis: 1.016 ± 0.03	1.775SerIle: 1.775 ± 0.044	0.948SerLys: 0.948 ± 0.037	5.098SerLeu: 5.098 ± 0.074	1.236SerMet: 1.236 ± 0.036	0.815SerAsn: 0.815 ± 0.031	3.225SerPro: 3.225 ± 0.066	1.384SerGln: 1.384 ± 0.037	4.084SerArg: 4.084 ± 0.07	3.248SerSer: 3.248 ± 0.083	3.748SerThr: 3.748 ± 0.083	4.457SerVal: 4.457 ± 0.082	0.975SerTrp: 0.975 ± 0.034	1.24SerTyr: 1.24 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	7.607ThrAla: 7.607 ± 0.147	0.514ThrCys: 0.514 ± 0.035	3.78ThrAsp: 3.78 ± 0.082	2.752ThrGlu: 2.752 ± 0.051	1.817ThrPhe: 1.817 ± 0.057	6.041ThrGly: 6.041 ± 0.119	1.288ThrHis: 1.288 ± 0.04	2.338ThrIle: 2.338 ± 0.08	1.192ThrLys: 1.192 ± 0.041	5.911ThrLeu: 5.911 ± 0.094	1.157ThrMet: 1.157 ± 0.034	1.083ThrAsn: 1.083 ± 0.076	4.302ThrPro: 4.302 ± 0.089	1.645ThrGln: 1.645 ± 0.065	4.341ThrArg: 4.341 ± 0.07	3.887ThrSer: 3.887 ± 0.088	4.814ThrThr: 4.814 ± 0.12	5.98ThrVal: 5.98 ± 0.137	0.999ThrTrp: 0.999 ± 0.033	1.558ThrTyr: 1.558 ± 0.077	0.0ThrXaa: 0.0 ± 0.0
Val	12.411ValAla: 12.411 ± 0.146	0.811ValCys: 0.811 ± 0.027	6.379ValAsp: 6.379 ± 0.097	5.702ValGlu: 5.702 ± 0.086	1.953ValPhe: 1.953 ± 0.046	8.211ValGly: 8.211 ± 0.105	2.035ValHis: 2.035 ± 0.052	3.142ValIle: 3.142 ± 0.066	1.713ValLys: 1.713 ± 0.044	9.969ValLeu: 9.969 ± 0.131	1.719ValMet: 1.719 ± 0.044	1.56ValAsn: 1.56 ± 0.068	5.16ValPro: 5.16 ± 0.077	2.548ValGln: 2.548 ± 0.051	7.23ValArg: 7.23 ± 0.11	4.647ValSer: 4.647 ± 0.075	6.291ValThr: 6.291 ± 0.156	10.874ValVal: 10.874 ± 0.155	1.195ValTrp: 1.195 ± 0.039	1.429ValTyr: 1.429 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.646TrpAla: 1.646 ± 0.046	0.187TrpCys: 0.187 ± 0.015	0.809TrpAsp: 0.809 ± 0.033	0.629TrpGlu: 0.629 ± 0.025	0.481TrpPhe: 0.481 ± 0.021	1.12TrpGly: 1.12 ± 0.037	0.4TrpHis: 0.4 ± 0.019	0.519TrpIle: 0.519 ± 0.023	0.229TrpLys: 0.229 ± 0.017	1.799TrpLeu: 1.799 ± 0.046	0.33TrpMet: 0.33 ± 0.02	0.279TrpAsn: 0.279 ± 0.016	0.799TrpPro: 0.799 ± 0.031	0.561TrpGln: 0.561 ± 0.024	1.377TrpArg: 1.377 ± 0.042	0.963TrpSer: 0.963 ± 0.031	0.997TrpThr: 0.997 ± 0.037	1.252TrpVal: 1.252 ± 0.043	0.462TrpTrp: 0.462 ± 0.026	0.271TrpTyr: 0.271 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.784TyrAla: 2.784 ± 0.047	0.152TyrCys: 0.152 ± 0.012	1.524TyrAsp: 1.524 ± 0.05	0.968TyrGlu: 0.968 ± 0.034	0.545TyrPhe: 0.545 ± 0.026	1.911TyrGly: 1.911 ± 0.042	0.4TyrHis: 0.4 ± 0.022	0.427TyrIle: 0.427 ± 0.022	0.335TyrLys: 0.335 ± 0.022	2.131TyrLeu: 2.131 ± 0.057	0.216TyrMet: 0.216 ± 0.014	0.372TyrAsn: 0.372 ± 0.022	1.034TyrPro: 1.034 ± 0.03	0.592TyrGln: 0.592 ± 0.023	1.56TyrArg: 1.56 ± 0.045	0.919TyrSer: 0.919 ± 0.029	1.123TyrThr: 1.123 ± 0.077	1.823TyrVal: 1.823 ± 0.047	0.302TyrTrp: 0.302 ± 0.015	0.471TyrTyr: 0.471 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3030 proteins (1004058 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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