Amino acid dipepetide frequency for Myoviridae sp. ctThM1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.986AlaAla: 4.986 ± 0.618
1.205AlaCys: 1.205 ± 0.301
3.033AlaAsp: 3.033 ± 0.435
4.653AlaGlu: 4.653 ± 0.522
2.784AlaPhe: 2.784 ± 0.292
4.57AlaGly: 4.57 ± 0.574
1.288AlaHis: 1.288 ± 0.217
4.155AlaIle: 4.155 ± 0.421
4.737AlaLys: 4.737 ± 0.454
6.108AlaLeu: 6.108 ± 0.581
1.246AlaMet: 1.246 ± 0.257
3.033AlaAsn: 3.033 ± 0.355
1.953AlaPro: 1.953 ± 0.311
2.451AlaGln: 2.451 ± 0.381
3.033AlaArg: 3.033 ± 0.338
3.906AlaSer: 3.906 ± 0.455
3.199AlaThr: 3.199 ± 0.515
4.82AlaVal: 4.82 ± 0.437
0.789AlaTrp: 0.789 ± 0.183
3.033AlaTyr: 3.033 ± 0.312
0.0AlaXaa: 0.0 ± 0.0
Cys
0.831CysAla: 0.831 ± 0.258
0.54CysCys: 0.54 ± 0.159
0.956CysAsp: 0.956 ± 0.201
1.039CysGlu: 1.039 ± 0.23
0.831CysPhe: 0.831 ± 0.249
1.87CysGly: 1.87 ± 0.298
0.291CysHis: 0.291 ± 0.103
0.789CysIle: 0.789 ± 0.179
1.33CysLys: 1.33 ± 0.238
1.039CysLeu: 1.039 ± 0.232
0.208CysMet: 0.208 ± 0.092
1.122CysAsn: 1.122 ± 0.216
0.706CysPro: 0.706 ± 0.274
0.665CysGln: 0.665 ± 0.156
0.706CysArg: 0.706 ± 0.15
1.371CysSer: 1.371 ± 0.311
0.665CysThr: 0.665 ± 0.13
1.039CysVal: 1.039 ± 0.244
0.083CysTrp: 0.083 ± 0.062
0.873CysTyr: 0.873 ± 0.208
0.0CysXaa: 0.0 ± 0.0
Asp
3.906AspAla: 3.906 ± 0.414
1.08AspCys: 1.08 ± 0.233
3.158AspAsp: 3.158 ± 0.412
4.695AspGlu: 4.695 ± 0.419
2.825AspPhe: 2.825 ± 0.321
4.612AspGly: 4.612 ± 0.478
1.205AspHis: 1.205 ± 0.209
3.656AspIle: 3.656 ± 0.32
4.487AspLys: 4.487 ± 0.433
5.36AspLeu: 5.36 ± 0.567
1.288AspMet: 1.288 ± 0.209
2.493AspAsn: 2.493 ± 0.329
1.745AspPro: 1.745 ± 0.277
1.371AspGln: 1.371 ± 0.221
2.077AspArg: 2.077 ± 0.322
3.739AspSer: 3.739 ± 0.446
2.867AspThr: 2.867 ± 0.424
4.612AspVal: 4.612 ± 0.425
1.454AspTrp: 1.454 ± 0.25
3.49AspTyr: 3.49 ± 0.415
0.0AspXaa: 0.0 ± 0.0
Glu
5.277GluAla: 5.277 ± 0.421
1.246GluCys: 1.246 ± 0.248
4.944GluAsp: 4.944 ± 0.561
7.23GluGlu: 7.23 ± 0.713
3.615GluPhe: 3.615 ± 0.35
4.196GluGly: 4.196 ± 0.414
1.122GluHis: 1.122 ± 0.197
5.443GluIle: 5.443 ± 0.439
6.232GluLys: 6.232 ± 0.595
6.149GluLeu: 6.149 ± 0.546
2.451GluMet: 2.451 ± 0.337
4.03GluAsn: 4.03 ± 0.362
1.704GluPro: 1.704 ± 0.303
3.075GluGln: 3.075 ± 0.36
3.282GluArg: 3.282 ± 0.449
3.698GluSer: 3.698 ± 0.376
3.656GluThr: 3.656 ± 0.448
4.82GluVal: 4.82 ± 0.474
1.454GluTrp: 1.454 ± 0.281
3.656GluTyr: 3.656 ± 0.336
0.0GluXaa: 0.0 ± 0.0
Phe
2.576PheAla: 2.576 ± 0.3
0.748PheCys: 0.748 ± 0.152
2.742PheAsp: 2.742 ± 0.347
4.28PheGlu: 4.28 ± 0.382
1.704PhePhe: 1.704 ± 0.276
2.825PheGly: 2.825 ± 0.365
0.748PheHis: 0.748 ± 0.188
3.158PheIle: 3.158 ± 0.379
2.742PheLys: 2.742 ± 0.368
3.199PheLeu: 3.199 ± 0.346
1.039PheMet: 1.039 ± 0.246
2.244PheAsn: 2.244 ± 0.275
1.205PhePro: 1.205 ± 0.191
1.704PheGln: 1.704 ± 0.269
1.496PheArg: 1.496 ± 0.246
3.947PheSer: 3.947 ± 0.368
2.618PheThr: 2.618 ± 0.376
2.825PheVal: 2.825 ± 0.347
0.54PheTrp: 0.54 ± 0.17
1.953PheTyr: 1.953 ± 0.304
0.0PheXaa: 0.0 ± 0.0
Gly
3.075GlyAla: 3.075 ± 0.409
1.163GlyCys: 1.163 ± 0.26
4.28GlyAsp: 4.28 ± 0.434
3.449GlyGlu: 3.449 ± 0.389
3.49GlyPhe: 3.49 ± 0.343
3.864GlyGly: 3.864 ± 0.554
1.039GlyHis: 1.039 ± 0.199
4.196GlyIle: 4.196 ± 0.443
4.321GlyLys: 4.321 ± 0.467
5.775GlyLeu: 5.775 ± 0.447
1.33GlyMet: 1.33 ± 0.267
3.158GlyAsn: 3.158 ± 0.387
1.33GlyPro: 1.33 ± 0.283
2.161GlyGln: 2.161 ± 0.317
3.158GlyArg: 3.158 ± 0.447
3.947GlySer: 3.947 ± 0.453
3.947GlyThr: 3.947 ± 0.413
4.695GlyVal: 4.695 ± 0.39
1.911GlyTrp: 1.911 ± 0.29
2.992GlyTyr: 2.992 ± 0.369
0.0GlyXaa: 0.0 ± 0.0
His
0.914HisAla: 0.914 ± 0.192
0.457HisCys: 0.457 ± 0.137
0.914HisAsp: 0.914 ± 0.206
1.08HisGlu: 1.08 ± 0.231
0.831HisPhe: 0.831 ± 0.162
1.08HisGly: 1.08 ± 0.307
0.415HisHis: 0.415 ± 0.172
1.039HisIle: 1.039 ± 0.202
1.537HisLys: 1.537 ± 0.256
1.87HisLeu: 1.87 ± 0.281
0.706HisMet: 0.706 ± 0.212
0.623HisAsn: 0.623 ± 0.171
0.789HisPro: 0.789 ± 0.17
0.665HisGln: 0.665 ± 0.194
0.623HisArg: 0.623 ± 0.139
0.873HisSer: 0.873 ± 0.203
0.748HisThr: 0.748 ± 0.165
0.748HisVal: 0.748 ± 0.172
0.706HisTrp: 0.706 ± 0.163
0.997HisTyr: 0.997 ± 0.202
0.0HisXaa: 0.0 ± 0.0
Ile
3.823IleAla: 3.823 ± 0.36
0.997IleCys: 0.997 ± 0.184
3.823IleAsp: 3.823 ± 0.454
5.568IleGlu: 5.568 ± 0.456
1.662IlePhe: 1.662 ± 0.297
3.532IleGly: 3.532 ± 0.48
1.163IleHis: 1.163 ± 0.215
3.365IleIle: 3.365 ± 0.388
4.404IleLys: 4.404 ± 0.431
4.28IleLeu: 4.28 ± 0.544
1.205IleMet: 1.205 ± 0.208
3.282IleAsn: 3.282 ± 0.401
2.95IlePro: 2.95 ± 0.352
2.285IleGln: 2.285 ± 0.316
3.033IleArg: 3.033 ± 0.354
4.653IleSer: 4.653 ± 0.477
3.739IleThr: 3.739 ± 0.51
4.28IleVal: 4.28 ± 0.387
0.748IleTrp: 0.748 ± 0.166
2.202IleTyr: 2.202 ± 0.27
0.0IleXaa: 0.0 ± 0.0
Lys
6.066LysAla: 6.066 ± 0.481
1.205LysCys: 1.205 ± 0.248
5.069LysAsp: 5.069 ± 0.462
6.731LysGlu: 6.731 ± 0.583
2.908LysPhe: 2.908 ± 0.342
3.781LysGly: 3.781 ± 0.354
1.454LysHis: 1.454 ± 0.254
4.113LysIle: 4.113 ± 0.405
4.986LysLys: 4.986 ± 0.549
5.941LysLeu: 5.941 ± 0.546
2.701LysMet: 2.701 ± 0.31
3.532LysAsn: 3.532 ± 0.33
2.244LysPro: 2.244 ± 0.337
3.365LysGln: 3.365 ± 0.425
3.449LysArg: 3.449 ± 0.437
4.446LysSer: 4.446 ± 0.414
3.739LysThr: 3.739 ± 0.437
5.069LysVal: 5.069 ± 0.472
1.039LysTrp: 1.039 ± 0.186
2.659LysTyr: 2.659 ± 0.346
0.0LysXaa: 0.0 ± 0.0
Leu
6.108LeuAla: 6.108 ± 0.598
1.33LeuCys: 1.33 ± 0.268
5.526LeuAsp: 5.526 ± 0.495
6.731LeuGlu: 6.731 ± 0.556
3.365LeuPhe: 3.365 ± 0.337
3.906LeuGly: 3.906 ± 0.405
1.122LeuHis: 1.122 ± 0.198
5.152LeuIle: 5.152 ± 0.513
6.772LeuLys: 6.772 ± 0.598
5.277LeuLeu: 5.277 ± 0.569
2.119LeuMet: 2.119 ± 0.369
4.321LeuAsn: 4.321 ± 0.429
2.327LeuPro: 2.327 ± 0.322
3.116LeuGln: 3.116 ± 0.439
3.49LeuArg: 3.49 ± 0.326
6.066LeuSer: 6.066 ± 0.506
4.82LeuThr: 4.82 ± 0.467
4.196LeuVal: 4.196 ± 0.422
0.748LeuTrp: 0.748 ± 0.19
3.781LeuTyr: 3.781 ± 0.458
0.0LeuXaa: 0.0 ± 0.0
Met
1.787MetAla: 1.787 ± 0.247
0.208MetCys: 0.208 ± 0.093
1.08MetAsp: 1.08 ± 0.189
1.953MetGlu: 1.953 ± 0.312
0.914MetPhe: 0.914 ± 0.213
1.08MetGly: 1.08 ± 0.173
0.291MetHis: 0.291 ± 0.115
1.662MetIle: 1.662 ± 0.286
2.244MetLys: 2.244 ± 0.313
2.327MetLeu: 2.327 ± 0.318
0.457MetMet: 0.457 ± 0.139
1.371MetAsn: 1.371 ± 0.239
0.914MetPro: 0.914 ± 0.188
1.163MetGln: 1.163 ± 0.188
1.205MetArg: 1.205 ± 0.215
2.077MetSer: 2.077 ± 0.298
1.62MetThr: 1.62 ± 0.287
0.997MetVal: 0.997 ± 0.194
0.457MetTrp: 0.457 ± 0.147
0.789MetTyr: 0.789 ± 0.175
0.0MetXaa: 0.0 ± 0.0
Asn
2.908AsnAla: 2.908 ± 0.424
0.997AsnCys: 0.997 ± 0.202
2.742AsnAsp: 2.742 ± 0.291
2.701AsnGlu: 2.701 ± 0.412
1.911AsnPhe: 1.911 ± 0.276
4.321AsnGly: 4.321 ± 0.384
1.205AsnHis: 1.205 ± 0.269
3.075AsnIle: 3.075 ± 0.399
4.404AsnLys: 4.404 ± 0.45
4.113AsnLeu: 4.113 ± 0.416
0.956AsnMet: 0.956 ± 0.232
2.659AsnAsn: 2.659 ± 0.384
2.119AsnPro: 2.119 ± 0.297
1.994AsnGln: 1.994 ± 0.269
2.202AsnArg: 2.202 ± 0.298
3.324AsnSer: 3.324 ± 0.368
3.407AsnThr: 3.407 ± 0.427
2.451AsnVal: 2.451 ± 0.316
0.831AsnTrp: 0.831 ± 0.206
1.87AsnTyr: 1.87 ± 0.288
0.0AsnXaa: 0.0 ± 0.0
Pro
1.579ProAla: 1.579 ± 0.214
0.374ProCys: 0.374 ± 0.135
2.244ProAsp: 2.244 ± 0.319
3.324ProGlu: 3.324 ± 0.394
1.745ProPhe: 1.745 ± 0.223
1.288ProGly: 1.288 ± 0.222
0.291ProHis: 0.291 ± 0.114
1.745ProIle: 1.745 ± 0.246
2.41ProLys: 2.41 ± 0.287
2.867ProLeu: 2.867 ± 0.334
0.623ProMet: 0.623 ± 0.165
1.662ProAsn: 1.662 ± 0.237
0.789ProPro: 0.789 ± 0.18
1.039ProGln: 1.039 ± 0.213
1.537ProArg: 1.537 ± 0.253
2.119ProSer: 2.119 ± 0.318
1.87ProThr: 1.87 ± 0.29
2.618ProVal: 2.618 ± 0.341
0.665ProTrp: 0.665 ± 0.16
1.288ProTyr: 1.288 ± 0.253
0.0ProXaa: 0.0 ± 0.0
Gln
2.908GlnAla: 2.908 ± 0.524
0.582GlnCys: 0.582 ± 0.125
2.368GlnAsp: 2.368 ± 0.28
2.493GlnGlu: 2.493 ± 0.45
1.205GlnPhe: 1.205 ± 0.239
2.327GlnGly: 2.327 ± 0.267
0.831GlnHis: 0.831 ± 0.244
2.41GlnIle: 2.41 ± 0.318
2.244GlnLys: 2.244 ± 0.282
3.365GlnLeu: 3.365 ± 0.343
0.831GlnMet: 0.831 ± 0.196
2.285GlnAsn: 2.285 ± 0.363
1.205GlnPro: 1.205 ± 0.236
2.202GlnGln: 2.202 ± 0.396
1.828GlnArg: 1.828 ± 0.267
2.493GlnSer: 2.493 ± 0.3
2.036GlnThr: 2.036 ± 0.325
2.41GlnVal: 2.41 ± 0.279
0.582GlnTrp: 0.582 ± 0.158
1.62GlnTyr: 1.62 ± 0.298
0.0GlnXaa: 0.0 ± 0.0
Arg
2.534ArgAla: 2.534 ± 0.381
0.706ArgCys: 0.706 ± 0.199
1.911ArgAsp: 1.911 ± 0.273
3.615ArgGlu: 3.615 ± 0.421
2.161ArgPhe: 2.161 ± 0.284
2.368ArgGly: 2.368 ± 0.25
0.831ArgHis: 0.831 ± 0.185
2.992ArgIle: 2.992 ± 0.375
3.823ArgLys: 3.823 ± 0.496
3.282ArgLeu: 3.282 ± 0.378
1.371ArgMet: 1.371 ± 0.235
2.41ArgAsn: 2.41 ± 0.326
1.08ArgPro: 1.08 ± 0.202
1.911ArgGln: 1.911 ± 0.297
1.953ArgArg: 1.953 ± 0.246
2.992ArgSer: 2.992 ± 0.414
2.368ArgThr: 2.368 ± 0.349
2.701ArgVal: 2.701 ± 0.368
0.54ArgTrp: 0.54 ± 0.133
2.493ArgTyr: 2.493 ± 0.372
0.0ArgXaa: 0.0 ± 0.0
Ser
4.404SerAla: 4.404 ± 0.454
1.413SerCys: 1.413 ± 0.273
3.781SerAsp: 3.781 ± 0.354
4.113SerGlu: 4.113 ± 0.372
3.698SerPhe: 3.698 ± 0.445
4.82SerGly: 4.82 ± 0.607
1.08SerHis: 1.08 ± 0.203
3.739SerIle: 3.739 ± 0.324
5.111SerLys: 5.111 ± 0.448
5.194SerLeu: 5.194 ± 0.453
1.371SerMet: 1.371 ± 0.263
3.116SerAsn: 3.116 ± 0.332
2.036SerPro: 2.036 ± 0.285
2.285SerGln: 2.285 ± 0.341
2.659SerArg: 2.659 ± 0.347
3.532SerSer: 3.532 ± 0.444
3.739SerThr: 3.739 ± 0.439
4.861SerVal: 4.861 ± 0.451
0.789SerTrp: 0.789 ± 0.18
3.282SerTyr: 3.282 ± 0.41
0.0SerXaa: 0.0 ± 0.0
Thr
3.739ThrAla: 3.739 ± 0.455
0.789ThrCys: 0.789 ± 0.183
3.158ThrAsp: 3.158 ± 0.427
3.781ThrGlu: 3.781 ± 0.386
2.742ThrPhe: 2.742 ± 0.383
4.653ThrGly: 4.653 ± 0.603
1.163ThrHis: 1.163 ± 0.237
3.282ThrIle: 3.282 ± 0.344
3.656ThrLys: 3.656 ± 0.398
3.947ThrLeu: 3.947 ± 0.422
1.246ThrMet: 1.246 ± 0.224
2.992ThrAsn: 2.992 ± 0.376
2.618ThrPro: 2.618 ± 0.416
2.493ThrGln: 2.493 ± 0.38
2.244ThrArg: 2.244 ± 0.308
3.656ThrSer: 3.656 ± 0.567
3.282ThrThr: 3.282 ± 0.422
3.989ThrVal: 3.989 ± 0.486
0.873ThrTrp: 0.873 ± 0.198
2.202ThrTyr: 2.202 ± 0.372
0.0ThrXaa: 0.0 ± 0.0
Val
4.529ValAla: 4.529 ± 0.401
0.997ValCys: 0.997 ± 0.24
4.57ValAsp: 4.57 ± 0.417
5.235ValGlu: 5.235 ± 0.491
3.324ValPhe: 3.324 ± 0.356
4.113ValGly: 4.113 ± 0.338
1.205ValHis: 1.205 ± 0.213
3.823ValIle: 3.823 ± 0.373
4.321ValLys: 4.321 ± 0.411
5.069ValLeu: 5.069 ± 0.394
2.036ValMet: 2.036 ± 0.326
2.576ValAsn: 2.576 ± 0.383
2.368ValPro: 2.368 ± 0.297
1.994ValGln: 1.994 ± 0.346
3.158ValArg: 3.158 ± 0.378
3.739ValSer: 3.739 ± 0.452
4.196ValThr: 4.196 ± 0.362
5.858ValVal: 5.858 ± 0.528
0.956ValTrp: 0.956 ± 0.263
3.199ValTyr: 3.199 ± 0.382
0.0ValXaa: 0.0 ± 0.0
Trp
0.873TrpAla: 0.873 ± 0.195
0.208TrpCys: 0.208 ± 0.086
1.039TrpAsp: 1.039 ± 0.189
1.246TrpGlu: 1.246 ± 0.222
0.914TrpPhe: 0.914 ± 0.202
0.748TrpGly: 0.748 ± 0.185
0.249TrpHis: 0.249 ± 0.101
0.831TrpIle: 0.831 ± 0.188
1.163TrpLys: 1.163 ± 0.278
1.537TrpLeu: 1.537 ± 0.285
0.789TrpMet: 0.789 ± 0.205
0.706TrpAsn: 0.706 ± 0.161
0.332TrpPro: 0.332 ± 0.122
0.748TrpGln: 0.748 ± 0.162
0.748TrpArg: 0.748 ± 0.163
0.956TrpSer: 0.956 ± 0.229
0.914TrpThr: 0.914 ± 0.181
0.956TrpVal: 0.956 ± 0.221
0.166TrpTrp: 0.166 ± 0.096
0.873TrpTyr: 0.873 ± 0.183
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.161TyrAla: 2.161 ± 0.281
0.706TyrCys: 0.706 ± 0.194
2.784TyrAsp: 2.784 ± 0.392
3.365TyrGlu: 3.365 ± 0.42
1.662TyrPhe: 1.662 ± 0.254
3.365TyrGly: 3.365 ± 0.42
0.623TyrHis: 0.623 ± 0.164
2.368TyrIle: 2.368 ± 0.302
3.573TyrLys: 3.573 ± 0.368
3.573TyrLeu: 3.573 ± 0.346
0.582TyrMet: 0.582 ± 0.155
2.576TyrAsn: 2.576 ± 0.35
1.662TyrPro: 1.662 ± 0.283
1.537TyrGln: 1.537 ± 0.251
2.161TyrArg: 2.161 ± 0.322
3.49TyrSer: 3.49 ± 0.395
3.075TyrThr: 3.075 ± 0.323
3.324TyrVal: 3.324 ± 0.37
0.665TyrTrp: 0.665 ± 0.147
2.534TyrTyr: 2.534 ± 0.364
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 156 proteins (24069 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski