Amino acid dipepetide frequency for Acidaminococcus intestini (strain RyC-MR95)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.884AlaAla: 9.884 ± 0.184
1.089AlaCys: 1.089 ± 0.047
4.586AlaAsp: 4.586 ± 0.085
5.059AlaGlu: 5.059 ± 0.087
3.767AlaPhe: 3.767 ± 0.079
6.849AlaGly: 6.849 ± 0.103
1.781AlaHis: 1.781 ± 0.055
5.703AlaIle: 5.703 ± 0.116
4.897AlaLys: 4.897 ± 0.088
9.812AlaLeu: 9.812 ± 0.154
3.083AlaMet: 3.083 ± 0.075
2.371AlaAsn: 2.371 ± 0.082
3.071AlaPro: 3.071 ± 0.073
2.98AlaGln: 2.98 ± 0.061
4.309AlaArg: 4.309 ± 0.091
4.883AlaSer: 4.883 ± 0.093
3.71AlaThr: 3.71 ± 0.087
6.883AlaVal: 6.883 ± 0.117
0.685AlaTrp: 0.685 ± 0.036
3.082AlaTyr: 3.082 ± 0.066
0.0AlaXaa: 0.0 ± 0.0
Cys
0.987CysAla: 0.987 ± 0.042
0.263CysCys: 0.263 ± 0.02
0.654CysAsp: 0.654 ± 0.031
0.675CysGlu: 0.675 ± 0.033
0.528CysPhe: 0.528 ± 0.03
1.362CysGly: 1.362 ± 0.049
0.442CysHis: 0.442 ± 0.027
0.702CysIle: 0.702 ± 0.029
0.575CysLys: 0.575 ± 0.027
1.205CysLeu: 1.205 ± 0.039
0.275CysMet: 0.275 ± 0.017
0.383CysAsn: 0.383 ± 0.026
0.672CysPro: 0.672 ± 0.039
0.374CysGln: 0.374 ± 0.032
0.74CysArg: 0.74 ± 0.039
0.727CysSer: 0.727 ± 0.036
0.571CysThr: 0.571 ± 0.026
0.822CysVal: 0.822 ± 0.037
0.114CysTrp: 0.114 ± 0.013
0.453CysTyr: 0.453 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
5.079AspAla: 5.079 ± 0.097
0.651AspCys: 0.651 ± 0.038
2.74AspAsp: 2.74 ± 0.08
4.096AspGlu: 4.096 ± 0.085
2.46AspPhe: 2.46 ± 0.053
4.332AspGly: 4.332 ± 0.083
1.362AspHis: 1.362 ± 0.042
3.493AspIle: 3.493 ± 0.074
2.96AspLys: 2.96 ± 0.074
5.428AspLeu: 5.428 ± 0.078
1.674AspMet: 1.674 ± 0.048
1.603AspAsn: 1.603 ± 0.058
2.394AspPro: 2.394 ± 0.059
1.417AspGln: 1.417 ± 0.045
2.938AspArg: 2.938 ± 0.071
2.638AspSer: 2.638 ± 0.063
2.902AspThr: 2.902 ± 0.067
4.018AspVal: 4.018 ± 0.098
0.626AspTrp: 0.626 ± 0.034
2.031AspTyr: 2.031 ± 0.048
0.0AspXaa: 0.0 ± 0.0
Glu
6.49GluAla: 6.49 ± 0.117
0.575GluCys: 0.575 ± 0.027
3.345GluAsp: 3.345 ± 0.084
5.38GluGlu: 5.38 ± 0.118
2.017GluPhe: 2.017 ± 0.054
4.823GluGly: 4.823 ± 0.088
1.219GluHis: 1.219 ± 0.048
3.987GluIle: 3.987 ± 0.087
5.816GluLys: 5.816 ± 0.105
5.722GluLeu: 5.722 ± 0.1
2.039GluMet: 2.039 ± 0.058
2.578GluAsn: 2.578 ± 0.056
1.931GluPro: 1.931 ± 0.053
1.877GluGln: 1.877 ± 0.057
3.674GluArg: 3.674 ± 0.081
2.915GluSer: 2.915 ± 0.058
3.929GluThr: 3.929 ± 0.072
4.083GluVal: 4.083 ± 0.079
0.528GluTrp: 0.528 ± 0.03
1.732GluTyr: 1.732 ± 0.053
0.0GluXaa: 0.0 ± 0.0
Phe
3.308PheAla: 3.308 ± 0.073
0.672PheCys: 0.672 ± 0.033
2.335PheAsp: 2.335 ± 0.057
2.059PheGlu: 2.059 ± 0.053
2.151PhePhe: 2.151 ± 0.066
3.309PheGly: 3.309 ± 0.083
0.982PheHis: 0.982 ± 0.04
2.599PheIle: 2.599 ± 0.063
1.845PheLys: 1.845 ± 0.051
4.525PheLeu: 4.525 ± 0.105
1.25PheMet: 1.25 ± 0.042
1.319PheAsn: 1.319 ± 0.044
1.599PhePro: 1.599 ± 0.048
1.171PheGln: 1.171 ± 0.044
1.914PheArg: 1.914 ± 0.052
2.758PheSer: 2.758 ± 0.066
2.51PheThr: 2.51 ± 0.061
2.856PheVal: 2.856 ± 0.071
0.452PheTrp: 0.452 ± 0.026
1.476PheTyr: 1.476 ± 0.044
0.0PheXaa: 0.0 ± 0.0
Gly
6.714GlyAla: 6.714 ± 0.129
1.193GlyCys: 1.193 ± 0.054
3.86GlyAsp: 3.86 ± 0.083
4.292GlyGlu: 4.292 ± 0.074
3.295GlyPhe: 3.295 ± 0.069
5.984GlyGly: 5.984 ± 0.102
1.78GlyHis: 1.78 ± 0.049
5.695GlyIle: 5.695 ± 0.091
5.754GlyLys: 5.754 ± 0.093
7.222GlyLeu: 7.222 ± 0.113
2.674GlyMet: 2.674 ± 0.066
2.767GlyAsn: 2.767 ± 0.088
2.281GlyPro: 2.281 ± 0.061
2.032GlyGln: 2.032 ± 0.05
3.965GlyArg: 3.965 ± 0.075
4.661GlySer: 4.661 ± 0.106
5.312GlyThr: 5.312 ± 0.122
5.421GlyVal: 5.421 ± 0.101
0.763GlyTrp: 0.763 ± 0.033
2.898GlyTyr: 2.898 ± 0.065
0.0GlyXaa: 0.0 ± 0.0
His
1.585HisAla: 1.585 ± 0.052
0.332HisCys: 0.332 ± 0.021
1.226HisAsp: 1.226 ± 0.043
1.295HisGlu: 1.295 ± 0.047
1.072HisPhe: 1.072 ± 0.041
1.736HisGly: 1.736 ± 0.051
0.737HisHis: 0.737 ± 0.034
1.304HisIle: 1.304 ± 0.045
1.143HisLys: 1.143 ± 0.038
2.193HisLeu: 2.193 ± 0.057
0.669HisMet: 0.669 ± 0.036
0.73HisAsn: 0.73 ± 0.032
1.343HisPro: 1.343 ± 0.047
0.696HisGln: 0.696 ± 0.03
1.066HisArg: 1.066 ± 0.04
1.071HisSer: 1.071 ± 0.042
1.136HisThr: 1.136 ± 0.04
1.548HisVal: 1.548 ± 0.043
0.267HisTrp: 0.267 ± 0.02
0.832HisTyr: 0.832 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
5.453IleAla: 5.453 ± 0.114
0.96IleCys: 0.96 ± 0.036
3.532IleAsp: 3.532 ± 0.074
3.333IleGlu: 3.333 ± 0.077
2.484IlePhe: 2.484 ± 0.077
5.085IleGly: 5.085 ± 0.114
1.47IleHis: 1.47 ± 0.048
3.941IleIle: 3.941 ± 0.086
3.736IleLys: 3.736 ± 0.073
6.412IleLeu: 6.412 ± 0.119
1.99IleMet: 1.99 ± 0.059
2.151IleAsn: 2.151 ± 0.058
3.251IlePro: 3.251 ± 0.064
1.753IleGln: 1.753 ± 0.052
3.222IleArg: 3.222 ± 0.063
3.84IleSer: 3.84 ± 0.074
3.546IleThr: 3.546 ± 0.077
4.469IleVal: 4.469 ± 0.078
0.542IleTrp: 0.542 ± 0.03
1.999IleTyr: 1.999 ± 0.063
0.0IleXaa: 0.0 ± 0.0
Lys
6.436LysAla: 6.436 ± 0.111
0.48LysCys: 0.48 ± 0.027
4.017LysAsp: 4.017 ± 0.079
6.12LysGlu: 6.12 ± 0.098
1.542LysPhe: 1.542 ± 0.056
5.144LysGly: 5.144 ± 0.092
0.945LysHis: 0.945 ± 0.033
3.753LysIle: 3.753 ± 0.069
5.84LysLys: 5.84 ± 0.111
4.669LysLeu: 4.669 ± 0.083
2.154LysMet: 2.154 ± 0.058
2.626LysAsn: 2.626 ± 0.059
1.91LysPro: 1.91 ± 0.054
1.664LysGln: 1.664 ± 0.048
3.274LysArg: 3.274 ± 0.079
2.911LysSer: 2.911 ± 0.065
3.58LysThr: 3.58 ± 0.07
4.453LysVal: 4.453 ± 0.07
0.621LysTrp: 0.621 ± 0.03
1.668LysTyr: 1.668 ± 0.058
0.0LysXaa: 0.0 ± 0.0
Leu
8.599LeuAla: 8.599 ± 0.123
1.282LeuCys: 1.282 ± 0.04
5.264LeuAsp: 5.264 ± 0.105
5.58LeuGlu: 5.58 ± 0.116
4.37LeuPhe: 4.37 ± 0.112
7.391LeuGly: 7.391 ± 0.118
2.076LeuHis: 2.076 ± 0.066
5.751LeuIle: 5.751 ± 0.121
5.675LeuLys: 5.675 ± 0.084
9.142LeuLeu: 9.142 ± 0.15
3.044LeuMet: 3.044 ± 0.068
2.907LeuAsn: 2.907 ± 0.066
4.623LeuPro: 4.623 ± 0.096
3.024LeuGln: 3.024 ± 0.062
4.723LeuArg: 4.723 ± 0.085
7.097LeuSer: 7.097 ± 0.117
6.031LeuThr: 6.031 ± 0.094
6.713LeuVal: 6.713 ± 0.121
0.921LeuTrp: 0.921 ± 0.038
3.135LeuTyr: 3.135 ± 0.072
0.0LeuXaa: 0.0 ± 0.0
Met
3.188MetAla: 3.188 ± 0.074
0.23MetCys: 0.23 ± 0.019
2.028MetAsp: 2.028 ± 0.05
2.339MetGlu: 2.339 ± 0.059
0.821MetPhe: 0.821 ± 0.037
2.631MetGly: 2.631 ± 0.067
0.51MetHis: 0.51 ± 0.026
1.856MetIle: 1.856 ± 0.057
2.482MetLys: 2.482 ± 0.059
2.585MetLeu: 2.585 ± 0.073
1.001MetMet: 1.001 ± 0.033
1.4MetAsn: 1.4 ± 0.045
1.332MetPro: 1.332 ± 0.043
0.911MetGln: 0.911 ± 0.033
1.342MetArg: 1.342 ± 0.046
1.552MetSer: 1.552 ± 0.038
2.23MetThr: 2.23 ± 0.054
2.051MetVal: 2.051 ± 0.061
0.205MetTrp: 0.205 ± 0.017
0.699MetTyr: 0.699 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
2.805AsnAla: 2.805 ± 0.077
0.484AsnCys: 0.484 ± 0.026
1.692AsnAsp: 1.692 ± 0.059
2.075AsnGlu: 2.075 ± 0.052
1.298AsnPhe: 1.298 ± 0.048
2.843AsnGly: 2.843 ± 0.082
0.842AsnHis: 0.842 ± 0.034
2.261AsnIle: 2.261 ± 0.067
1.976AsnLys: 1.976 ± 0.059
3.417AsnLeu: 3.417 ± 0.075
1.037AsnMet: 1.037 ± 0.04
1.123AsnAsn: 1.123 ± 0.057
1.939AsnPro: 1.939 ± 0.052
1.107AsnGln: 1.107 ± 0.039
1.787AsnArg: 1.787 ± 0.057
1.555AsnSer: 1.555 ± 0.05
1.797AsnThr: 1.797 ± 0.062
2.463AsnVal: 2.463 ± 0.07
0.364AsnTrp: 0.364 ± 0.025
1.199AsnTyr: 1.199 ± 0.043
0.0AsnXaa: 0.0 ± 0.0
Pro
2.908ProAla: 2.908 ± 0.069
0.521ProCys: 0.521 ± 0.027
2.62ProAsp: 2.62 ± 0.062
3.203ProGlu: 3.203 ± 0.067
2.01ProPhe: 2.01 ± 0.054
2.849ProGly: 2.849 ± 0.056
1.079ProHis: 1.079 ± 0.037
2.513ProIle: 2.513 ± 0.064
2.328ProLys: 2.328 ± 0.06
4.203ProLeu: 4.203 ± 0.085
1.208ProMet: 1.208 ± 0.046
1.308ProAsn: 1.308 ± 0.048
1.265ProPro: 1.265 ± 0.048
1.53ProGln: 1.53 ± 0.053
1.612ProArg: 1.612 ± 0.058
2.294ProSer: 2.294 ± 0.061
2.0ProThr: 2.0 ± 0.054
3.184ProVal: 3.184 ± 0.072
0.363ProTrp: 0.363 ± 0.023
1.72ProTyr: 1.72 ± 0.056
0.0ProXaa: 0.0 ± 0.0
Gln
2.652GlnAla: 2.652 ± 0.069
0.328GlnCys: 0.328 ± 0.023
1.449GlnAsp: 1.449 ± 0.043
2.302GlnGlu: 2.302 ± 0.06
1.123GlnPhe: 1.123 ± 0.04
2.184GlnGly: 2.184 ± 0.055
0.638GlnHis: 0.638 ± 0.033
1.842GlnIle: 1.842 ± 0.056
2.845GlnLys: 2.845 ± 0.073
2.554GlnLeu: 2.554 ± 0.068
1.001GlnMet: 1.001 ± 0.04
1.229GlnAsn: 1.229 ± 0.044
1.052GlnPro: 1.052 ± 0.038
1.147GlnGln: 1.147 ± 0.046
1.497GlnArg: 1.497 ± 0.054
1.511GlnSer: 1.511 ± 0.048
1.586GlnThr: 1.586 ± 0.048
1.97GlnVal: 1.97 ± 0.051
0.34GlnTrp: 0.34 ± 0.021
1.112GlnTyr: 1.112 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
3.613ArgAla: 3.613 ± 0.078
0.578ArgCys: 0.578 ± 0.029
2.717ArgAsp: 2.717 ± 0.061
3.458ArgGlu: 3.458 ± 0.074
2.27ArgPhe: 2.27 ± 0.065
3.055ArgGly: 3.055 ± 0.067
1.195ArgHis: 1.195 ± 0.038
3.387ArgIle: 3.387 ± 0.084
3.521ArgLys: 3.521 ± 0.092
4.811ArgLeu: 4.811 ± 0.091
1.662ArgMet: 1.662 ± 0.048
1.967ArgAsn: 1.967 ± 0.063
1.922ArgPro: 1.922 ± 0.051
1.87ArgGln: 1.87 ± 0.056
3.079ArgArg: 3.079 ± 0.075
2.754ArgSer: 2.754 ± 0.063
2.734ArgThr: 2.734 ± 0.057
3.28ArgVal: 3.28 ± 0.063
0.504ArgTrp: 0.504 ± 0.026
2.068ArgTyr: 2.068 ± 0.062
0.0ArgXaa: 0.0 ± 0.0
Ser
4.503SerAla: 4.503 ± 0.094
0.791SerCys: 0.791 ± 0.031
2.825SerAsp: 2.825 ± 0.072
2.9SerGlu: 2.9 ± 0.065
2.684SerPhe: 2.684 ± 0.072
4.962SerGly: 4.962 ± 0.097
1.395SerHis: 1.395 ± 0.048
3.507SerIle: 3.507 ± 0.081
2.671SerLys: 2.671 ± 0.072
6.213SerLeu: 6.213 ± 0.118
1.682SerMet: 1.682 ± 0.056
1.703SerAsn: 1.703 ± 0.057
2.282SerPro: 2.282 ± 0.052
1.799SerGln: 1.799 ± 0.049
3.02SerArg: 3.02 ± 0.058
3.114SerSer: 3.114 ± 0.071
2.869SerThr: 2.869 ± 0.08
4.14SerVal: 4.14 ± 0.078
0.619SerTrp: 0.619 ± 0.028
2.106SerTyr: 2.106 ± 0.058
0.0SerXaa: 0.0 ± 0.0
Thr
5.134ThrAla: 5.134 ± 0.1
0.627ThrCys: 0.627 ± 0.027
3.311ThrAsp: 3.311 ± 0.087
3.329ThrGlu: 3.329 ± 0.069
2.394ThrPhe: 2.394 ± 0.069
4.989ThrGly: 4.989 ± 0.082
1.117ThrHis: 1.117 ± 0.037
3.764ThrIle: 3.764 ± 0.073
3.003ThrLys: 3.003 ± 0.068
5.996ThrLeu: 5.996 ± 0.099
1.604ThrMet: 1.604 ± 0.048
1.751ThrAsn: 1.751 ± 0.061
2.648ThrPro: 2.648 ± 0.064
1.527ThrGln: 1.527 ± 0.044
2.38ThrArg: 2.38 ± 0.062
2.78ThrSer: 2.78 ± 0.068
2.777ThrThr: 2.777 ± 0.078
4.658ThrVal: 4.658 ± 0.101
0.569ThrTrp: 0.569 ± 0.033
2.072ThrTyr: 2.072 ± 0.059
0.0ThrXaa: 0.0 ± 0.0
Val
5.644ValAla: 5.644 ± 0.092
0.883ValCys: 0.883 ± 0.035
3.974ValAsp: 3.974 ± 0.086
4.144ValGlu: 4.144 ± 0.082
2.751ValPhe: 2.751 ± 0.058
5.246ValGly: 5.246 ± 0.111
1.319ValHis: 1.319 ± 0.039
4.669ValIle: 4.669 ± 0.09
4.466ValLys: 4.466 ± 0.084
6.964ValLeu: 6.964 ± 0.111
2.206ValMet: 2.206 ± 0.06
2.458ValAsn: 2.458 ± 0.063
3.486ValPro: 3.486 ± 0.077
1.818ValGln: 1.818 ± 0.048
3.585ValArg: 3.585 ± 0.071
4.513ValSer: 4.513 ± 0.097
4.812ValThr: 4.812 ± 0.097
4.976ValVal: 4.976 ± 0.104
0.593ValTrp: 0.593 ± 0.029
2.222ValTyr: 2.222 ± 0.051
0.0ValXaa: 0.0 ± 0.0
Trp
0.743TrpAla: 0.743 ± 0.034
0.112TrpCys: 0.112 ± 0.013
0.547TrpAsp: 0.547 ± 0.025
0.643TrpGlu: 0.643 ± 0.034
0.383TrpPhe: 0.383 ± 0.025
0.737TrpGly: 0.737 ± 0.033
0.237TrpHis: 0.237 ± 0.02
0.644TrpIle: 0.644 ± 0.034
0.657TrpLys: 0.657 ± 0.032
0.826TrpLeu: 0.826 ± 0.039
0.312TrpMet: 0.312 ± 0.021
0.453TrpAsn: 0.453 ± 0.03
0.308TrpPro: 0.308 ± 0.02
0.484TrpGln: 0.484 ± 0.025
0.476TrpArg: 0.476 ± 0.029
0.51TrpSer: 0.51 ± 0.025
0.492TrpThr: 0.492 ± 0.027
0.525TrpVal: 0.525 ± 0.027
0.102TrpTrp: 0.102 ± 0.013
0.319TrpTyr: 0.319 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.758TyrAla: 2.758 ± 0.056
0.473TyrCys: 0.473 ± 0.03
2.12TyrAsp: 2.12 ± 0.056
2.377TyrGlu: 2.377 ± 0.064
1.669TyrPhe: 1.669 ± 0.053
3.054TyrGly: 3.054 ± 0.073
0.854TyrHis: 0.854 ± 0.035
1.801TyrIle: 1.801 ± 0.054
1.62TyrLys: 1.62 ± 0.055
3.45TyrLeu: 3.45 ± 0.071
0.823TyrMet: 0.823 ± 0.037
1.237TyrAsn: 1.237 ± 0.042
1.407TyrPro: 1.407 ± 0.048
1.181TyrGln: 1.181 ± 0.044
1.845TyrArg: 1.845 ± 0.059
1.699TyrSer: 1.699 ± 0.047
1.905TyrThr: 1.905 ± 0.057
2.217TyrVal: 2.217 ± 0.057
0.33TyrTrp: 0.33 ± 0.023
1.282TyrTyr: 1.282 ± 0.047
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2386 proteins (708024 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski