Amino acid dipepetide frequency for Bifidobacterium boum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.561AlaAla: 13.561 ± 0.243
1.39AlaCys: 1.39 ± 0.055
7.45AlaAsp: 7.45 ± 0.127
5.195AlaGlu: 5.195 ± 0.107
3.384AlaPhe: 3.384 ± 0.073
8.939AlaGly: 8.939 ± 0.128
2.33AlaHis: 2.33 ± 0.07
6.014AlaIle: 6.014 ± 0.108
4.582AlaLys: 4.582 ± 0.095
9.694AlaLeu: 9.694 ± 0.158
3.165AlaMet: 3.165 ± 0.075
3.261AlaAsn: 3.261 ± 0.083
4.131AlaPro: 4.131 ± 0.1
5.07AlaGln: 5.07 ± 0.108
6.156AlaArg: 6.156 ± 0.118
6.906AlaSer: 6.906 ± 0.14
6.31AlaThr: 6.31 ± 0.121
8.321AlaVal: 8.321 ± 0.147
1.521AlaTrp: 1.521 ± 0.054
2.799AlaTyr: 2.799 ± 0.061
0.0AlaXaa: 0.0 ± 0.0
Cys
1.19CysAla: 1.19 ± 0.049
0.198CysCys: 0.198 ± 0.018
0.629CysAsp: 0.629 ± 0.032
0.558CysGlu: 0.558 ± 0.034
0.35CysPhe: 0.35 ± 0.027
1.075CysGly: 1.075 ± 0.045
0.246CysHis: 0.246 ± 0.024
0.493CysIle: 0.493 ± 0.029
0.298CysLys: 0.298 ± 0.024
0.723CysLeu: 0.723 ± 0.039
0.259CysMet: 0.259 ± 0.022
0.243CysAsn: 0.243 ± 0.022
0.509CysPro: 0.509 ± 0.029
0.274CysGln: 0.274 ± 0.024
0.603CysArg: 0.603 ± 0.031
0.636CysSer: 0.636 ± 0.037
0.624CysThr: 0.624 ± 0.033
0.846CysVal: 0.846 ± 0.038
0.109CysTrp: 0.109 ± 0.014
0.217CysTyr: 0.217 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
7.562AspAla: 7.562 ± 0.136
0.566AspCys: 0.566 ± 0.029
4.923AspAsp: 4.923 ± 0.12
4.428AspGlu: 4.428 ± 0.107
2.194AspPhe: 2.194 ± 0.064
5.688AspGly: 5.688 ± 0.104
1.497AspHis: 1.497 ± 0.049
3.723AspIle: 3.723 ± 0.081
2.309AspLys: 2.309 ± 0.074
4.901AspLeu: 4.901 ± 0.115
1.758AspMet: 1.758 ± 0.057
2.027AspAsn: 2.027 ± 0.053
3.497AspPro: 3.497 ± 0.081
2.083AspGln: 2.083 ± 0.056
3.52AspArg: 3.52 ± 0.097
3.478AspSer: 3.478 ± 0.079
4.269AspThr: 4.269 ± 0.088
4.756AspVal: 4.756 ± 0.095
0.952AspTrp: 0.952 ± 0.036
1.882AspTyr: 1.882 ± 0.065
0.0AspXaa: 0.0 ± 0.0
Glu
5.495GluAla: 5.495 ± 0.107
0.43GluCys: 0.43 ± 0.027
3.095GluAsp: 3.095 ± 0.074
2.936GluGlu: 2.936 ± 0.088
1.649GluPhe: 1.649 ± 0.056
3.382GluGly: 3.382 ± 0.085
2.028GluHis: 2.028 ± 0.07
2.568GluIle: 2.568 ± 0.077
1.881GluLys: 1.881 ± 0.074
4.72GluLeu: 4.72 ± 0.112
1.253GluMet: 1.253 ± 0.044
1.66GluAsn: 1.66 ± 0.053
2.701GluPro: 2.701 ± 0.078
2.948GluGln: 2.948 ± 0.08
4.263GluArg: 4.263 ± 0.095
3.058GluSer: 3.058 ± 0.083
3.058GluThr: 3.058 ± 0.063
3.165GluVal: 3.165 ± 0.086
0.566GluTrp: 0.566 ± 0.033
1.617GluTyr: 1.617 ± 0.057
0.0GluXaa: 0.0 ± 0.0
Phe
3.661PheAla: 3.661 ± 0.095
0.383PheCys: 0.383 ± 0.029
2.541PheAsp: 2.541 ± 0.071
1.664PheGlu: 1.664 ± 0.053
1.125PhePhe: 1.125 ± 0.049
3.027PheGly: 3.027 ± 0.08
0.772PheHis: 0.772 ± 0.037
1.754PheIle: 1.754 ± 0.056
1.051PheLys: 1.051 ± 0.048
2.541PheLeu: 2.541 ± 0.074
0.7PheMet: 0.7 ± 0.036
1.244PheAsn: 1.244 ± 0.046
1.38PhePro: 1.38 ± 0.051
0.9PheGln: 0.9 ± 0.04
1.589PheArg: 1.589 ± 0.053
2.191PheSer: 2.191 ± 0.053
2.268PheThr: 2.268 ± 0.066
2.405PheVal: 2.405 ± 0.072
0.392PheTrp: 0.392 ± 0.025
0.832PheTyr: 0.832 ± 0.04
0.0PheXaa: 0.0 ± 0.0
Gly
7.128GlyAla: 7.128 ± 0.131
0.825GlyCys: 0.825 ± 0.038
4.632GlyAsp: 4.632 ± 0.095
4.426GlyGlu: 4.426 ± 0.098
2.878GlyPhe: 2.878 ± 0.068
5.853GlyGly: 5.853 ± 0.125
1.798GlyHis: 1.798 ± 0.056
4.829GlyIle: 4.829 ± 0.094
3.917GlyLys: 3.917 ± 0.091
6.63GlyLeu: 6.63 ± 0.115
2.307GlyMet: 2.307 ± 0.062
2.795GlyAsn: 2.795 ± 0.07
2.44GlyPro: 2.44 ± 0.072
2.682GlyGln: 2.682 ± 0.066
4.61GlyArg: 4.61 ± 0.099
5.334GlySer: 5.334 ± 0.101
5.425GlyThr: 5.425 ± 0.125
6.168GlyVal: 6.168 ± 0.118
1.208GlyTrp: 1.208 ± 0.045
2.693GlyTyr: 2.693 ± 0.066
0.0GlyXaa: 0.0 ± 0.0
His
2.82HisAla: 2.82 ± 0.083
0.237HisCys: 0.237 ± 0.02
1.912HisAsp: 1.912 ± 0.066
1.276HisGlu: 1.276 ± 0.046
0.606HisPhe: 0.606 ± 0.032
2.229HisGly: 2.229 ± 0.063
0.756HisHis: 0.756 ± 0.038
1.283HisIle: 1.283 ± 0.054
0.647HisLys: 0.647 ± 0.031
1.673HisLeu: 1.673 ± 0.051
0.658HisMet: 0.658 ± 0.037
0.754HisAsn: 0.754 ± 0.036
1.539HisPro: 1.539 ± 0.06
0.794HisGln: 0.794 ± 0.038
1.683HisArg: 1.683 ± 0.063
1.154HisSer: 1.154 ± 0.044
1.623HisThr: 1.623 ± 0.05
1.942HisVal: 1.942 ± 0.056
0.31HisTrp: 0.31 ± 0.022
0.621HisTyr: 0.621 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
7.016IleAla: 7.016 ± 0.112
0.624IleCys: 0.624 ± 0.034
4.094IleAsp: 4.094 ± 0.08
3.121IleGlu: 3.121 ± 0.091
1.5IlePhe: 1.5 ± 0.058
4.681IleGly: 4.681 ± 0.091
1.075IleHis: 1.075 ± 0.041
3.358IleIle: 3.358 ± 0.102
1.793IleLys: 1.793 ± 0.062
3.875IleLeu: 3.875 ± 0.081
1.266IleMet: 1.266 ± 0.058
1.785IleAsn: 1.785 ± 0.062
2.987IlePro: 2.987 ± 0.066
1.349IleGln: 1.349 ± 0.051
3.183IleArg: 3.183 ± 0.082
3.157IleSer: 3.157 ± 0.079
3.334IleThr: 3.334 ± 0.081
4.788IleVal: 4.788 ± 0.093
0.58IleTrp: 0.58 ± 0.034
1.103IleTyr: 1.103 ± 0.043
0.0IleXaa: 0.0 ± 0.0
Lys
4.371LysAla: 4.371 ± 0.102
0.159LysCys: 0.159 ± 0.017
2.372LysAsp: 2.372 ± 0.088
2.054LysGlu: 2.054 ± 0.079
0.937LysPhe: 0.937 ± 0.047
2.5LysGly: 2.5 ± 0.078
0.963LysHis: 0.963 ± 0.043
1.785LysIle: 1.785 ± 0.058
1.683LysLys: 1.683 ± 0.075
3.223LysLeu: 3.223 ± 0.085
0.819LysMet: 0.819 ± 0.035
1.428LysAsn: 1.428 ± 0.054
2.301LysPro: 2.301 ± 0.061
1.743LysGln: 1.743 ± 0.055
2.584LysArg: 2.584 ± 0.073
2.103LysSer: 2.103 ± 0.069
2.559LysThr: 2.559 ± 0.078
2.427LysVal: 2.427 ± 0.071
0.41LysTrp: 0.41 ± 0.027
1.052LysTyr: 1.052 ± 0.046
0.0LysXaa: 0.0 ± 0.0
Leu
9.866LeuAla: 9.866 ± 0.14
0.963LeuCys: 0.963 ± 0.036
6.098LeuAsp: 6.098 ± 0.128
4.183LeuGlu: 4.183 ± 0.093
2.834LeuPhe: 2.834 ± 0.087
6.666LeuGly: 6.666 ± 0.125
2.041LeuHis: 2.041 ± 0.061
4.503LeuIle: 4.503 ± 0.1
3.149LeuLys: 3.149 ± 0.096
7.593LeuLeu: 7.593 ± 0.161
2.127LeuMet: 2.127 ± 0.061
2.854LeuAsn: 2.854 ± 0.077
4.378LeuPro: 4.378 ± 0.093
2.536LeuGln: 2.536 ± 0.072
5.26LeuArg: 5.26 ± 0.096
5.475LeuSer: 5.475 ± 0.11
5.407LeuThr: 5.407 ± 0.095
6.33LeuVal: 6.33 ± 0.11
0.986LeuTrp: 0.986 ± 0.042
1.923LeuTyr: 1.923 ± 0.049
0.0LeuXaa: 0.0 ± 0.0
Met
2.664MetAla: 2.664 ± 0.072
0.246MetCys: 0.246 ± 0.018
1.401MetAsp: 1.401 ± 0.045
0.991MetGlu: 0.991 ± 0.041
0.866MetPhe: 0.866 ± 0.039
1.668MetGly: 1.668 ± 0.061
0.627MetHis: 0.627 ± 0.03
1.331MetIle: 1.331 ± 0.055
0.966MetLys: 0.966 ± 0.045
2.677MetLeu: 2.677 ± 0.074
0.645MetMet: 0.645 ± 0.035
0.866MetAsn: 0.866 ± 0.037
1.595MetPro: 1.595 ± 0.051
0.82MetGln: 0.82 ± 0.035
1.944MetArg: 1.944 ± 0.058
1.834MetSer: 1.834 ± 0.064
2.061MetThr: 2.061 ± 0.059
1.913MetVal: 1.913 ± 0.051
0.292MetTrp: 0.292 ± 0.025
0.566MetTyr: 0.566 ± 0.034
0.0MetXaa: 0.0 ± 0.0
Asn
3.734AsnAla: 3.734 ± 0.094
0.245AsnCys: 0.245 ± 0.023
2.025AsnAsp: 2.025 ± 0.058
1.649AsnGlu: 1.649 ± 0.056
0.803AsnPhe: 0.803 ± 0.038
3.05AsnGly: 3.05 ± 0.088
0.723AsnHis: 0.723 ± 0.033
1.698AsnIle: 1.698 ± 0.052
1.26AsnLys: 1.26 ± 0.061
2.525AsnLeu: 2.525 ± 0.061
0.799AsnMet: 0.799 ± 0.041
1.101AsnAsn: 1.101 ± 0.066
2.293AsnPro: 2.293 ± 0.065
1.176AsnGln: 1.176 ± 0.046
1.983AsnArg: 1.983 ± 0.061
1.675AsnSer: 1.675 ± 0.058
2.294AsnThr: 2.294 ± 0.069
2.225AsnVal: 2.225 ± 0.063
0.438AsnTrp: 0.438 ± 0.029
0.747AsnTyr: 0.747 ± 0.042
0.0AsnXaa: 0.0 ± 0.0
Pro
5.32ProAla: 5.32 ± 0.113
0.368ProCys: 0.368 ± 0.025
3.796ProAsp: 3.796 ± 0.091
3.095ProGlu: 3.095 ± 0.073
1.508ProPhe: 1.508 ± 0.051
3.65ProGly: 3.65 ± 0.085
1.211ProHis: 1.211 ± 0.053
2.299ProIle: 2.299 ± 0.069
1.824ProLys: 1.824 ± 0.058
3.664ProLeu: 3.664 ± 0.077
1.101ProMet: 1.101 ± 0.041
1.519ProAsn: 1.519 ± 0.049
1.513ProPro: 1.513 ± 0.056
2.405ProGln: 2.405 ± 0.083
2.594ProArg: 2.594 ± 0.07
3.313ProSer: 3.313 ± 0.079
2.944ProThr: 2.944 ± 0.077
4.089ProVal: 4.089 ± 0.09
0.705ProTrp: 0.705 ± 0.036
1.425ProTyr: 1.425 ± 0.049
0.0ProXaa: 0.0 ± 0.0
Gln
4.623GlnAla: 4.623 ± 0.099
0.3GlnCys: 0.3 ± 0.022
1.968GlnAsp: 1.968 ± 0.059
1.852GlnGlu: 1.852 ± 0.06
1.083GlnPhe: 1.083 ± 0.045
2.547GlnGly: 2.547 ± 0.074
1.099GlnHis: 1.099 ± 0.043
1.999GlnIle: 1.999 ± 0.062
1.026GlnLys: 1.026 ± 0.046
3.505GlnLeu: 3.505 ± 0.087
1.004GlnMet: 1.004 ± 0.04
1.08GlnAsn: 1.08 ± 0.045
2.109GlnPro: 2.109 ± 0.095
2.007GlnGln: 2.007 ± 0.066
2.713GlnArg: 2.713 ± 0.068
2.396GlnSer: 2.396 ± 0.069
2.333GlnThr: 2.333 ± 0.065
2.695GlnVal: 2.695 ± 0.061
0.606GlnTrp: 0.606 ± 0.029
1.184GlnTyr: 1.184 ± 0.046
0.0GlnXaa: 0.0 ± 0.0
Arg
5.402ArgAla: 5.402 ± 0.111
0.582ArgCys: 0.582 ± 0.033
3.791ArgAsp: 3.791 ± 0.093
3.642ArgGlu: 3.642 ± 0.096
2.32ArgPhe: 2.32 ± 0.071
4.036ArgGly: 4.036 ± 0.095
1.894ArgHis: 1.894 ± 0.071
3.783ArgIle: 3.783 ± 0.087
2.575ArgLys: 2.575 ± 0.064
5.569ArgLeu: 5.569 ± 0.101
2.002ArgMet: 2.002 ± 0.059
2.036ArgAsn: 2.036 ± 0.06
2.586ArgPro: 2.586 ± 0.075
2.734ArgGln: 2.734 ± 0.076
4.866ArgArg: 4.866 ± 0.14
3.415ArgSer: 3.415 ± 0.082
3.517ArgThr: 3.517 ± 0.076
4.409ArgVal: 4.409 ± 0.097
0.94ArgTrp: 0.94 ± 0.039
1.989ArgTyr: 1.989 ± 0.058
0.0ArgXaa: 0.0 ± 0.0
Ser
6.635SerAla: 6.635 ± 0.139
0.545SerCys: 0.545 ± 0.03
3.783SerAsp: 3.783 ± 0.085
2.816SerGlu: 2.816 ± 0.066
2.012SerPhe: 2.012 ± 0.061
5.871SerGly: 5.871 ± 0.114
1.409SerHis: 1.409 ± 0.05
3.29SerIle: 3.29 ± 0.072
2.239SerLys: 2.239 ± 0.057
5.258SerLeu: 5.258 ± 0.096
1.651SerMet: 1.651 ± 0.058
1.998SerAsn: 1.998 ± 0.068
2.816SerPro: 2.816 ± 0.081
2.426SerGln: 2.426 ± 0.07
3.7SerArg: 3.7 ± 0.077
4.522SerSer: 4.522 ± 0.145
3.802SerThr: 3.802 ± 0.102
4.522SerVal: 4.522 ± 0.099
0.843SerTrp: 0.843 ± 0.034
1.62SerTyr: 1.62 ± 0.049
0.0SerXaa: 0.0 ± 0.0
Thr
7.021ThrAla: 7.021 ± 0.128
0.589ThrCys: 0.589 ± 0.035
3.864ThrAsp: 3.864 ± 0.092
2.656ThrGlu: 2.656 ± 0.059
2.02ThrPhe: 2.02 ± 0.062
5.265ThrGly: 5.265 ± 0.107
1.367ThrHis: 1.367 ± 0.047
3.708ThrIle: 3.708 ± 0.083
2.064ThrLys: 2.064 ± 0.07
5.771ThrLeu: 5.771 ± 0.115
1.561ThrMet: 1.561 ± 0.051
1.926ThrAsn: 1.926 ± 0.049
3.919ThrPro: 3.919 ± 0.087
2.203ThrGln: 2.203 ± 0.064
3.411ThrArg: 3.411 ± 0.082
3.715ThrSer: 3.715 ± 0.106
4.263ThrThr: 4.263 ± 0.11
5.631ThrVal: 5.631 ± 0.138
0.82ThrTrp: 0.82 ± 0.042
1.715ThrTyr: 1.715 ± 0.06
0.0ThrXaa: 0.0 ± 0.0
Val
8.0ValAla: 8.0 ± 0.127
0.96ValCys: 0.96 ± 0.042
5.0ValAsp: 5.0 ± 0.104
3.948ValGlu: 3.948 ± 0.089
2.873ValPhe: 2.873 ± 0.08
5.107ValGly: 5.107 ± 0.105
1.652ValHis: 1.652 ± 0.051
4.371ValIle: 4.371 ± 0.092
2.771ValLys: 2.771 ± 0.071
6.8ValLeu: 6.8 ± 0.11
1.957ValMet: 1.957 ± 0.061
2.546ValAsn: 2.546 ± 0.074
3.872ValPro: 3.872 ± 0.084
2.212ValGln: 2.212 ± 0.064
4.433ValArg: 4.433 ± 0.096
5.083ValSer: 5.083 ± 0.1
5.068ValThr: 5.068 ± 0.112
6.255ValVal: 6.255 ± 0.116
0.95ValTrp: 0.95 ± 0.039
1.891ValTyr: 1.891 ± 0.057
0.0ValXaa: 0.0 ± 0.0
Trp
1.132TrpAla: 1.132 ± 0.044
0.167TrpCys: 0.167 ± 0.016
0.741TrpAsp: 0.741 ± 0.036
0.52TrpGlu: 0.52 ± 0.032
0.49TrpPhe: 0.49 ± 0.026
0.848TrpGly: 0.848 ± 0.04
0.394TrpHis: 0.394 ± 0.026
0.707TrpIle: 0.707 ± 0.035
0.606TrpLys: 0.606 ± 0.033
1.419TrpLeu: 1.419 ± 0.057
0.41TrpMet: 0.41 ± 0.025
0.514TrpAsn: 0.514 ± 0.033
0.512TrpPro: 0.512 ± 0.032
0.697TrpGln: 0.697 ± 0.03
0.979TrpArg: 0.979 ± 0.043
0.825TrpSer: 0.825 ± 0.04
0.785TrpThr: 0.785 ± 0.039
0.872TrpVal: 0.872 ± 0.04
0.279TrpTrp: 0.279 ± 0.024
0.42TrpTyr: 0.42 ± 0.029
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.978TyrAla: 2.978 ± 0.073
0.306TyrCys: 0.306 ± 0.024
1.897TyrAsp: 1.897 ± 0.059
1.462TyrGlu: 1.462 ± 0.052
0.986TyrPhe: 0.986 ± 0.035
2.497TyrGly: 2.497 ± 0.063
0.634TyrHis: 0.634 ± 0.028
1.174TyrIle: 1.174 ± 0.054
0.833TyrLys: 0.833 ± 0.041
2.409TyrLeu: 2.409 ± 0.066
0.529TyrMet: 0.529 ± 0.033
0.806TyrAsn: 0.806 ± 0.038
1.265TyrPro: 1.265 ± 0.041
1.072TyrGln: 1.072 ± 0.044
2.014TyrArg: 2.014 ± 0.051
1.488TyrSer: 1.488 ± 0.049
1.544TyrThr: 1.544 ± 0.059
1.991TyrVal: 1.991 ± 0.06
0.41TyrTrp: 0.41 ± 0.023
0.838TyrTyr: 0.838 ± 0.04
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1726 proteins (616755 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski